ATE110773T1 - Verfahren zur züchtung rekombinanter zellen. - Google Patents

Verfahren zur züchtung rekombinanter zellen.

Info

Publication number
ATE110773T1
ATE110773T1 AT88308386T AT88308386T ATE110773T1 AT E110773 T1 ATE110773 T1 AT E110773T1 AT 88308386 T AT88308386 T AT 88308386T AT 88308386 T AT88308386 T AT 88308386T AT E110773 T1 ATE110773 T1 AT E110773T1
Authority
AT
Austria
Prior art keywords
host cell
methods
recombinant cells
polypeptide factor
growing recombinant
Prior art date
Application number
AT88308386T
Other languages
English (en)
Inventor
Jennie P Mather
Axel Ullrich
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE110773T1 publication Critical patent/ATE110773T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT88308386T 1987-09-11 1988-09-12 Verfahren zur züchtung rekombinanter zellen. ATE110773T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9747287A 1987-09-11 1987-09-11

Publications (1)

Publication Number Publication Date
ATE110773T1 true ATE110773T1 (de) 1994-09-15

Family

ID=22263548

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88308386T ATE110773T1 (de) 1987-09-11 1988-09-12 Verfahren zur züchtung rekombinanter zellen.

Country Status (13)

Country Link
US (4) US6232117B1 (de)
EP (1) EP0307247B1 (de)
JP (1) JP2774996B2 (de)
AT (1) ATE110773T1 (de)
AU (1) AU616201B2 (de)
CA (1) CA1307484C (de)
DE (1) DE3851289T2 (de)
DK (1) DK175589B1 (de)
ES (1) ES2064355T3 (de)
IE (1) IE63589B1 (de)
IL (1) IL87737A (de)
NZ (1) NZ226136A (de)
PT (1) PT88479B (de)

Families Citing this family (188)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
JP3008208B2 (ja) * 1990-06-01 2000-02-14 武田薬品工業株式会社 新規ハイブリドーマ，その製造法および生理活性物質の製造法
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
US5986067A (en) * 1991-02-08 1999-11-16 The University Of Vermont And State Agricultural College Recombinant transferrins, transferrin half-molecules and mutants thereof
WO1992013550A1 (en) * 1991-02-08 1992-08-20 The University Of Vermont And State Agricultural College Recombinant transferrins, transferrin half-molecules and mutants thereof
US6825037B1 (en) 1991-02-08 2004-11-30 University Of Vermont Recombinant transferrins, transferrin half-molecules and mutants thereof
DE4115722A1 (de) * 1991-05-14 1992-11-19 Boehringer Mannheim Gmbh Serumfreies medium zur kultivierung von saeugerzellen
US6348327B1 (en) * 1991-12-06 2002-02-19 Genentech, Inc. Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
CA2123430C (en) * 1991-12-06 2004-02-10 Cornelia M. Gorman Prohormone convertase transformed cells
WO1993013196A2 (en) * 1991-12-24 1993-07-08 Genzyme Corporation Method for increasing recombinant protein production
JPH0763363B2 (ja) * 1991-12-25 1995-07-12 萩原 義秀 融合細胞の取得方法
US5877016A (en) 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
US5708142A (en) 1994-05-27 1998-01-13 Genentech, Inc. Tumor necrosis factor receptor-associated factors
US5705364A (en) * 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
US5721121A (en) * 1995-06-06 1998-02-24 Genentech, Inc. Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein
US6656466B1 (en) 1995-06-06 2003-12-02 Genetech, Inc. Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition
AUPN442295A0 (en) 1995-07-26 1995-08-17 Commonwealth Scientific And Industrial Research Organisation Regulated autocrine growth of mammalian cells
PT848755E (pt) 1995-09-08 2003-12-31 Genentech Inc Proteina relacionada com o vegf
US6998116B1 (en) 1996-01-09 2006-02-14 Genentech, Inc. Apo-2 ligand
US6030945A (en) 1996-01-09 2000-02-29 Genentech, Inc. Apo-2 ligand
CA2249206A1 (en) 1996-04-01 1997-10-09 Genentech, Inc. Apo-2li and apo-3 apoptosis polypeptides
US5851984A (en) * 1996-08-16 1998-12-22 Genentech, Inc. Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides
US6159462A (en) * 1996-08-16 2000-12-12 Genentech, Inc. Uses of Wnt polypeptides
US6462176B1 (en) 1996-09-23 2002-10-08 Genentech, Inc. Apo-3 polypeptide
US7696327B1 (en) 1997-10-17 2010-04-13 Genentech, Inc. Antibodies to human Toll homologues
DK0942992T3 (da) 1997-01-31 2007-07-02 Genentech Inc O-fucosyltransferase
US6100076A (en) 1997-01-31 2000-08-08 Genentech, Inc. O-fucosyltransferase
US6136569A (en) * 1997-02-27 2000-10-24 Genentech, Inc. Method of creating a cDNA library enriched in signal sequences
US6342369B1 (en) 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
US6551799B2 (en) 1999-12-07 2003-04-22 Genentech, Inc. Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
WO1999014330A1 (en) 1997-09-18 1999-03-25 Genentech, Inc. DcR3 POLYPEPTIDE, A TNFR HOMOLOG
AU749948B2 (en) 1997-10-10 2002-07-04 Genentech Inc. APO-3 ligand
EP2033970A3 (de) 1997-10-29 2009-06-17 Genentech, Inc. WNT-1-induzierbare Gene
ATE406441T1 (de) 1997-10-29 2008-09-15 Genentech Inc Verwendung des wnt-1 induzierten sekretierten polypeptids wisp-1
US7192589B2 (en) 1998-09-16 2007-03-20 Genentech, Inc. Treatment of inflammatory disorders with STIgMA immunoadhesins
DK1481990T3 (da) 1997-11-21 2007-10-01 Genentech Inc A33-beslægtede antigener og deres farmakologiske anvendelser
NZ522634A (en) 1997-12-03 2004-02-27 Genentech Inc PRO243 encoding a polypeptide with homology to chordin and antibodies and vectors
CA2311681A1 (en) 1997-12-08 1999-06-17 Genentech, Inc. Human interferon-epsilon: a type i interferon
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
US6455250B1 (en) * 1997-12-11 2002-09-24 The Regents Of The University Of California Endonuclease compositions and methods of use
CA2318029C (en) 1998-01-15 2009-05-19 Genentech, Inc. Apo-2 ligand
NZ525914A (en) 1998-03-10 2004-03-26 Genentech Inc Novel polypeptides and nucleic acids encoding the same
WO1999049028A1 (en) 1998-03-23 1999-09-30 Genentech, Inc. Method of selection for genes encoding secreted and transmembrane proteins
US7026138B1 (en) 1998-03-23 2006-04-11 Genentech, Inc. Polynucleotides encoding GFRα3
NZ506748A (en) 1998-03-23 2002-10-25 Genentech Inc Nucleic acids encoding a GFR alpha 3 polypeptide; host cell and vectors for production of the GRF alpha 3 protein and an assay for detecting GRFalpha 3 production
EP3112468A1 (de) 1998-05-15 2017-01-04 Genentech, Inc. Il-17-homologe polypeptide und therapeutische verwendung davon
ES2292242T5 (es) 1998-05-15 2011-05-04 Genentech, Inc. Utilizaciones terapéuticas de polipéptidos homólogos de il-17.
EP1865061A3 (de) 1998-05-15 2007-12-19 Genentech, Inc. IL-17-homologe Polypeptide und ihre therapeutische Verwendung
WO2001060397A1 (en) 2000-02-16 2001-08-23 Genentech, Inc. Uses of agonists and antagonists to modulate activity of tnf-related molecules
US20020172678A1 (en) 2000-06-23 2002-11-21 Napoleone Ferrara EG-VEGF nucleic acids and polypeptides and methods of use
PT1115863E (pt) 1998-09-22 2008-03-07 Genentech Inc Ucp4
US7399751B2 (en) * 1999-11-04 2008-07-15 Sertoli Technologies, Inc. Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
DE69943058D1 (de) 1998-11-30 2011-02-03 Genentech Inc Loslösendes protein 5 - ucp5
US7342102B2 (en) 1998-11-30 2008-03-11 Genentech, Inc. Uncoupling protein 5 (UCP5)
CA2450402A1 (en) 1998-12-22 2000-06-29 Genentech, Inc. Methods and compositions for inhibiting cancer cell growth comprising pro224
CA2354027A1 (en) 1998-12-23 2000-07-06 Genentech, Inc. Il-1 related polypeptides
AU779402B2 (en) 1999-04-12 2005-01-20 Genentech Inc. Tumor necrosis factor homologs and nucleic acids encoding the same
DE60043367D1 (de) 1999-06-15 2009-12-31 Genentech Inc Sekretierte und Transmembran-Polypeptide sowie Nukleinsäuren zu deren Kodierung
NZ529329A (en) * 1999-08-25 2005-06-24 Immunex Corp Compositions and methods for improved cell culture
WO2001029070A2 (en) 1999-10-20 2001-04-26 Genentech, Inc. Modulation of t cell differentiation for the treatment of t helper cell mediated diseases
CA2391455A1 (en) 1999-12-01 2001-06-07 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7226591B2 (en) 2000-05-22 2007-06-05 Genentech, Inc. Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
DK1897944T3 (da) 1999-12-23 2011-10-24 Genentech Inc IL-17 homologe polypeptider og terapeutisk anvendelse deraf
US7608681B2 (en) 1999-12-24 2009-10-27 Genentech, Inc. Methods and compositions for prolonging elimination half-times of bioactive compounds
EP1757311B1 (de) 1999-12-24 2009-02-11 Genentech, Inc. Verfahren und Zusammensetzungen zur Verlängerung der Entsorgungshalbwertszeit von biowirksamen Verbindungen
CN1425066B (zh) 2000-01-13 2010-05-26 杰南技术公司 新的stra6多肽
PT2857516T (pt) 2000-04-11 2017-08-28 Genentech Inc Anticorpos multivalentes e utilizações dos mesmos
EP2075253A1 (de) 2000-06-23 2009-07-01 Genentech, Inc. Methoden und Verbindungen zur Diagnose und Behandlung von Krankheiten, an denen Angiogenese beteiligt ist
EP2792747A1 (de) 2000-06-23 2014-10-22 Genentech, Inc. Zusammensetzungen und Verfahren zur Diagnose und Behandlung von Erkrankungen in Verbindung mit Angiogenese
DE60136281D1 (de) 2000-08-24 2008-12-04 Genentech Inc Methode zur inhibierung von il-22 induziertem pap1
EP1944317A3 (de) 2000-09-01 2008-09-17 Genentech, Inc. Sekretierte und Transmembran-Polypeptide sowie Nukleinsäure zu deren Kodierung
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
AU3323002A (en) 2000-12-20 2002-07-01 Hoffmann La Roche Erythropoietin conjugates
US7087726B2 (en) 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
WO2002076448A1 (en) * 2001-03-23 2002-10-03 Napro Biotherapeutics, Inc. Molecular conjugates for use in treatment of cancer
WO2002099070A2 (en) * 2001-06-04 2002-12-12 Corixa Corporation Compositions and methods for high-level, large-scale production of recombinant proteins
US20070160576A1 (en) 2001-06-05 2007-07-12 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
EP1409549A4 (de) 2001-06-20 2007-10-24 Genentech Inc Zusammensetzungen und verfahren für die diagnose und behandlung von tumoren
KR100942880B1 (ko) 2001-08-29 2010-02-17 제넨테크, 인크. 유사분열촉진 활성을 가진 Ｂｖ８ 핵산 및 폴리펩티드
NZ573739A (en) 2001-09-18 2010-07-30 Genentech Inc Compositions and methods for the diagnosis and treatment of tumor, particularly colorectal tumor - TAT201
US20030228319A1 (en) 2002-04-16 2003-12-11 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
EP1575571A4 (de) 2002-01-02 2008-06-25 Genentech Inc Zusammensetzungen und verfahren zur diagnose und behandlung eines tumors
US7164002B2 (en) 2002-02-06 2007-01-16 Genentech, Inc. FVIIa antagonists
US20040258678A1 (en) 2002-02-22 2004-12-23 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
WO2004004649A2 (en) 2002-07-08 2004-01-15 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
WO2004024076A2 (en) 2002-09-11 2004-03-25 Genentech, Inc. Novel compositions and methods for the treatment of immune related diseases
EP2277532A1 (de) 2002-09-11 2011-01-26 Genentech, Inc. Neuartige Zusammensetzung und Verfahren zur Behandlung von Immunerkrankungen
JP2006521082A (ja) 2002-09-11 2006-09-21 ジェネンテック・インコーポレーテッド 免疫関連疾患の治療のための新規組成物と方法
AU2003291625B2 (en) 2002-09-16 2009-10-08 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
WO2004028479A2 (en) 2002-09-25 2004-04-08 Genentech, Inc. Nouvelles compositions et methodes de traitement du psoriasis
AU2003298607B9 (en) 2002-10-29 2011-08-04 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
AU2003295401B2 (en) 2002-11-08 2010-04-29 Genentech, Inc. Compositions and methods for the treatment of natural killer cell related diseases
EP1572116A4 (de) 2002-11-26 2007-12-12 Genentech Inc Zusammensetzungen und verfahren für die behandlung von immunkrankheiten
JP4754219B2 (ja) * 2002-12-02 2011-08-24 アムジエン・フレモント・インコーポレイテツド 腫瘍壊死因子を対象とする抗体、およびそれらの使用
CN102225194B (zh) 2003-03-12 2014-07-16 健泰科生物技术公司 Bv8和/或EG-VEGF促进造血的用途
PT1610820E (pt) 2003-04-04 2010-12-16 Novartis Ag Formulações de elevada concentração de anticorpos e proteínas
EP1648380B1 (de) * 2003-07-03 2015-04-08 Sertoli Technologies, LLC Zusammensetzungen mit sertoli-zellen und myoid-zellen und ihre verwendung in zellulären transplanten
DK1641822T3 (da) 2003-07-08 2013-07-22 Genentech Inc Heterologe il-17-a/f-polypeptider og terapeutiske anvendelser deraf.
WO2005019258A2 (en) 2003-08-11 2005-03-03 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
NZ576411A (en) 2003-11-17 2010-04-30 Genentech Inc Compositions and methods for the treatment of tumor of hematopoietic origin
WO2006132788A2 (en) 2005-06-06 2006-12-14 Genentech, Inc. Transgenic models for different genes and their use for gene characterization
CA2628340A1 (en) * 2005-11-02 2007-05-18 Wyeth Methods for adapting mammalian cells
US20070231895A1 (en) * 2005-11-02 2007-10-04 Lee Gene W Methods for adapting mammalian cells
CA2629306A1 (en) 2005-11-23 2007-05-31 Genentech, Inc. Methods and compositions related to b cell assays
US20070190057A1 (en) 2006-01-23 2007-08-16 Jian Wu Methods for modulating mannose content of recombinant proteins
CA2647277A1 (en) 2006-04-05 2007-11-08 Genentech, Inc. Method for using boc/cdo to modulate hedgehog signaling
CA2649387A1 (en) 2006-04-19 2008-03-27 Genentech, Inc. Novel gene disruptions, compositions and methods relating thereto
CA2650730A1 (en) 2006-04-27 2007-11-08 Pikamab, Inc. Methods and compositions for antibody therapy
CN101534847A (zh) 2006-08-04 2009-09-16 普罗龙药品公司 修饰型促红细胞生成素
ES2651268T3 (es) 2006-09-12 2018-01-25 Beth Israel Deaconess Medical Center, Inc. Composiciones que contienen alfa-1-antitripsina y métodos para su uso
WO2008140477A2 (en) 2006-11-02 2008-11-20 Capon Daniel J Hybrid immunoglobulins with moving parts
JP5581485B2 (ja) 2007-03-22 2014-09-03 インダストリーアカデミック コーポレーション ファンデーション， ザ カトリックユニバーシティ オブ コリア Ｅｃ−ｓｏｄの新規な用途及びその製造方法
US9089564B2 (en) 2007-03-22 2015-07-28 The Catholic University of Korea Industry-Academic Cooperatior Use of EC-SOD for treating angiogenesis-mediated eye diseases
EP2586788B1 (de) 2007-07-09 2017-11-29 Genentech, Inc. Verhindern der Disulfid-Bindungsreduktion während der rekombinanten Herstellung von Polypeptiden
CN104844690B (zh) 2007-09-05 2019-08-16 健泰科生物技术公司 有生物学活性的、含c-端精氨酸的肽
EP2235063B1 (de) 2007-12-28 2015-09-02 Genentech, Inc. Anti-hedgehog-antikörper
EP2283043B1 (de) 2008-04-07 2014-08-13 Bayer HealthCare, LLC Verfahren zur rekombinanten herstellung von glycoproteinen
AU2008360729A1 (en) 2008-08-18 2010-02-25 Seoul National University Industry Foundation Method for controlling cancer metastasis or cancer cell migration by modulating the cellular level of lysyl tRNA synthetase
AU2009290563A1 (en) 2008-09-15 2010-03-18 Genentech, Inc. Compositions and methods for regulating cell osmolarity
KR101102485B1 (ko) 2008-10-10 2012-01-05 서울대학교산학협력단 Ｇｒｓ단백질 또는 이의 단편의 신규한 용도
MX356367B (es) 2008-12-09 2018-05-25 Genentech Inc Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t.
MX355650B (es) 2009-08-11 2018-04-26 Genentech Inc Produccion de proteinas en medios de cultivo de celulas libres de glutamina.
KR20120117728A (ko) 2009-09-23 2012-10-24 바이오제너릭스 에이지 재조합 인간 에리트로포이에틴(ｅｐｏ)의 정제 방법, 이렇게 정제된 ｅｐｏ 및 이를 포함하는 약학적 조성물
TWI507524B (zh) 2009-11-30 2015-11-11 建南德克公司 診斷及治療腫瘤之組合物及方法
CN102958941A (zh) 2010-05-03 2013-03-06 霍夫曼-拉罗奇有限公司 用于肿瘤诊断和治疗的组合物和方法
EP2593126B1 (de) 2010-07-12 2017-09-20 aTyr Pharma, Inc. Innovative erkennung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen in zusammenhang mit proteinfragmenten von histidyl-trna-synthetasen
CN104474546A (zh) 2010-08-13 2015-04-01 弗·哈夫曼-拉罗切有限公司 用于疾病治疗的针对IL-1β和IL-18的抗体
ES2592937T3 (es) 2010-12-02 2016-12-02 F. Hoffmann-La Roche Ag Anticuerpos que bloquean la interacción entre IGFL1 y TMEM149
WO2012088383A2 (en) 2010-12-23 2012-06-28 Genentech, Inc. PILR alpha INTERACTIONS AND METHODS OF MODIFYING SAME
CN102586190B (zh) * 2011-01-11 2014-01-01 北京华安科创生物技术有限公司 高效表达重组人神经生长因子的cho细胞株及其构建方法
EP2751129B1 (de) 2011-11-23 2018-01-24 Cell Biotech Co., Ltd. Protein p14 mit krebshemmender sowie antiallergischer wirkung und pharmazeutische zusammensetzung damit
CA2859556C (en) 2011-12-16 2022-01-11 Braskem S.A. Modified microorganisms and methods of making butadiene using same
EP2814514B1 (de) 2012-02-16 2017-09-13 Atyr Pharma, Inc. Histidyl-trna-synthetasen zur behandlung von autoimmun- und entzündungserkrankungen
US9493744B2 (en) 2012-06-20 2016-11-15 Genentech, Inc. Methods for viral inactivation and other adventitious agents
US20130281355A1 (en) 2012-04-24 2013-10-24 Genentech, Inc. Cell culture compositions and methods for polypeptide production
EP2841087B1 (de) 2012-04-27 2017-08-23 The United States of America, as represented by The Secretary, Department of Health and Human Services Antagonisten gegen den vaskulären endothelialen wachstumsfaktor und verfahren zu deren verwendung
EP2749569A1 (de) * 2012-12-28 2014-07-02 Annibale Alessandro Puca Variante des BPIFB4-Proteins
US20160312179A1 (en) 2013-03-15 2016-10-27 Glaxosmithkline Intellechtual Property (No.2) Limited Use of tricarboxylic acid (tca) intermediates to control ammonia generation in cell culture
DK3611180T3 (da) 2013-03-15 2022-02-28 Biomolecular Holdings Llc Hybrid immunoglobulin indeholdende ikke-peptidyl-binding
SG10201809452RA (en) 2013-03-15 2018-11-29 Genentech Inc Cell culture compositions with antioxidants and methods for polypeptide production
CN114717206A (zh) 2013-03-15 2022-07-08 Atyr 医药公司 组氨酰-trna合成酶-fc缀合物
EP2829608A1 (de) 2013-07-23 2015-01-28 Universität Bielefeld Verfahren zur Herstellung von rekombinanten Proteinen in Säugerzellen
WO2015042588A1 (en) 2013-09-23 2015-03-26 Braskem S.A. Engineered enzyme having acetoacetyl-coa hydrolase activity, microorganisms comprising same, and methods of using same
CN115177759B (zh) 2013-11-15 2024-07-23 豪夫迈·罗氏有限公司 使用环保洗涤剂的病毒灭活方法
RS59881B1 (sr) 2014-02-27 2020-03-31 Hoffmann La Roche Modulacija ćelijskog rasta i glikozilacije u rekombinantnoj proizvodnji glikoproteina
EP4169944A1 (de) 2014-03-14 2023-04-26 Biomolecular Holdings LLC Verfahren zur herstellung von hybridimmunglobulin mit nichtpeptidylverbindung
CA2945390A1 (en) 2014-04-10 2015-10-15 Bayer Healthcare Llc Compounded media powder formulation and method of preparation of liquid medium for cell culture
KR101619863B1 (ko) 2014-05-23 2016-05-24 주식회사 제노포커스 신규 베타-갈락토시다아제
WO2015184327A1 (en) 2014-05-30 2015-12-03 Braskem S.A. Modified microorganisms comprising an optimized system for oligosaccharide utilization and methods of using same
KR101730035B1 (ko) 2015-03-20 2017-04-26 한국과학기술원 L-아스파르트산 유도체를 생산하는 변이미생물 및 이를 이용한 l-아스파르트산 유도체의 제조방법
KR101839595B1 (ko) 2015-04-13 2018-04-26 한국과학기술원 락탐의 제조방법
KR20160141123A (ko) 2015-05-28 2016-12-08 주식회사 제노포커스 고당전이 활성의 베타-갈락토시다제 변이체 및 그 용도
KR101702906B1 (ko) 2015-07-15 2017-02-22 주식회사 제노포커스 신규 알파-1,3-글루카나제
TW202440903A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法（一）
KR101756338B1 (ko) 2016-01-15 2017-07-10 고려대학교 산학협력단 L-시스테인 생산용 변이미생물 및 이를 이용한 l-시스테인의 제조방법
SG11201900595YA (en) 2016-08-02 2019-02-27 Vaccinex Inc Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells
EP3339444A1 (de) 2016-12-20 2018-06-27 Mabxience Research, S.L. Verfahren zur herstellung eines glycoproteins mit erhöhtem prozentualem anteil an afucosylierten glycanen
ES2994451T3 (en) 2017-04-20 2025-01-24 Atyr Pharma Inc Compositions for treating lung inflammation
JP2021519073A (ja) 2018-03-29 2021-08-10 ジェネンテック， インコーポレイテッド 哺乳動物細胞におけるラクトジェニック活性の制御
KR102658830B1 (ko) 2018-08-02 2024-04-19 에스케이이노베이션 주식회사 내열성 탄산무수화효소 변이체 및 이를 포함하는 이산화탄소 포집용 조성물
AR117327A1 (es) 2018-12-20 2021-07-28 23Andme Inc Anticuerpos anti-cd96 y métodos de uso de estos
MX2021007589A (es) 2018-12-21 2021-12-10 23Andme Inc Anticuerpos anti il-36 y procedimientos de uso de estos.
KR102346050B1 (ko) 2019-01-25 2022-01-03 주식회사 네오믹스 미백 활성을 갖는 신규 폴리펩타이드 및 이의 용도
KR102796684B1 (ko) * 2019-02-28 2025-04-18 보에 테크놀로지 그룹 컴퍼니 리미티드 망막 색소 상피 세포 막 및 그의 제조 방법
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
US12098365B2 (en) 2020-03-26 2024-09-24 Genentech, Inc. Modified mammalian cells
AU2021257609A1 (en) 2020-04-15 2022-11-10 F. Hoffmann-La Roche Ag Method for medium treatment before inoculation
PE20230460A1 (es) 2020-05-29 2023-03-10 23Andme Inc Anticuerpos anti-cd200r1 y metodos de uso de estos
US20230235040A1 (en) 2020-06-22 2023-07-27 Almirall, S.A. Anti-il-36 antibodies and methods of use thereof
EP4172192A1 (de) 2020-06-24 2023-05-03 Genentech, Inc. Apoptoseresistente zelllinien
TW202221016A (zh) 2020-08-07 2022-06-01 美商建南德克公司 Ｆｌｔ３配位體融合蛋白及使用方法
JP2023539201A (ja) 2020-08-28 2023-09-13 ジェネンテック， インコーポレイテッド 宿主細胞タンパク質のＣＲＩＳＰＲ／Ｃａｓ９マルチプレックスノックアウト
CN116963769A (zh) 2020-09-07 2023-10-27 吉爱希公司 具有降低的ace 2的结合亲和力的冠状病毒衍生的受体结合域变体及包含其的疫苗组合物
US12134793B2 (en) 2020-11-02 2024-11-05 Korea Advanced Institute Of Science And Technology Recombinant microorganism having increased ability to produce hydrophobic material and cell-membrane engineering method for preparation thereof
CR20230253A (es) 2020-11-16 2023-07-26 Hoffmann La Roche Glucoformas de fab ricas en manosa
KR102661294B1 (ko) 2020-12-24 2024-04-30 한국과학기술원 글루타르산 수송체 유전자가 도입된 재조합 미생물 및 이를 이용한 글루타르산의 제조방법
JP2024514222A (ja) 2021-04-19 2024-03-28 ジェネンテック， インコーポレイテッド 改変された哺乳動物細胞
EP4348258A1 (de) 2021-06-04 2024-04-10 Genentech, Inc. Identifizierung und quantifizierung von restlichen wirtszellenproteinen in proteinproben
JP2024534389A (ja) 2021-09-15 2024-09-20 ジェネンテック， インコーポレイテッド メタボロミクス解析
EP4624488A1 (de) 2022-11-25 2025-10-01 Gil Medical Center Verwendung des fgf5-transkriptvarianten-2-gens und proteins davon zur prävention, hemmung und behandlung von leberfibrose
EP4634397A1 (de) 2022-12-12 2025-10-22 Genentech Inc. Optimierung des sialinsäuregehalts von polypeptiden
WO2025048616A1 (ko) 2023-08-31 2025-03-06 주식회사 지아이셀 Il-2 단백질 및 il-15 단백질의 키메라 단백질 또는 변이체, 이를 포함하는 융합단백질, 및 이를 발현하는 유전자 조작된 세포
CN122374330A (zh) 2023-12-14 2026-07-10 基因泰克公司 二硫亚型调节
WO2025137086A1 (en) 2023-12-20 2025-06-26 Genentech, Inc. Reducing alpha-gal
TW202609044A (zh) 2024-04-19 2026-03-01 美商建南德克公司 監測及控制容器內的泡沫之方法
WO2026006162A2 (en) 2024-06-24 2026-01-02 Genentech, Inc. B vitamin modulation
WO2026117553A1 (en) 2024-11-27 2026-06-04 Genentech, Inc. Eukaryotic cell media

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55156591A (en) * 1979-05-23 1980-12-05 Ajinomoto Co Inc Method for stabilizing property of bacteria containing plasmid
US4673649A (en) 1983-07-15 1987-06-16 University Patents, Inc. Process and defined medium for growth of human epidermal keratinocyte cells
US4740461A (en) 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
AU600885B2 (en) 1984-05-25 1990-08-30 Zymogenetics Inc. Stable DNA constructs
EP0163404B1 (de) 1984-05-28 1990-06-27 MITSUI TOATSU CHEMICALS, Inc. Mittel für die Absorption und Entweichung von Wasserdampf
EP0189481B1 (de) 1984-07-13 1991-01-23 Chiron Corporation Insulinähnlicher Wachstumsfaktor II
JPS6328386A (ja) 1986-07-21 1988-02-06 Asahi Chem Ind Co Ltd 細胞培養方法
AU612404B2 (en) * 1987-09-11 1991-07-11 Genentech Inc. Method for increasing the expression of polypeptides in recombinant cell culture
JPH01217488A (ja) * 1988-02-26 1989-08-31 Canon Inc 板書記録装置

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JPH02467A (ja) 1990-01-05
EP0307247A2 (de) 1989-03-15
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US20020142467A1 (en) 2002-10-03
IL87737A (en) 1993-08-18
DK506488D0 (da) 1988-09-12
US6399331B2 (en) 2002-06-04
PT88479B (pt) 1993-05-31
DK506488A (da) 1989-03-12
EP0307247A3 (en) 1990-08-22
US6232117B1 (en) 2001-05-15
ES2064355T3 (es) 1995-02-01
DE3851289D1 (de) 1994-10-06
AU2212088A (en) 1989-05-25
US6235498B1 (en) 2001-05-22
PT88479A (pt) 1989-07-31
IE882768L (en) 1989-03-11
DK175589B1 (da) 2004-12-13
IE63589B1 (en) 1995-05-17
IL87737A0 (en) 1989-02-28
JP2774996B2 (ja) 1998-07-09
AU616201B2 (en) 1991-10-24
US20010000488A1 (en) 2001-04-26
CA1307484C (en) 1992-09-15
EP0307247B1 (de) 1994-08-31

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