ATE111918T1 - Spezifische spaltung von peptidbindungen durch organische tertiäre phosphine mit nukleophilen seitenketten. - Google Patents

Spezifische spaltung von peptidbindungen durch organische tertiäre phosphine mit nukleophilen seitenketten.

Info

Publication number
ATE111918T1
ATE111918T1 AT89103906T AT89103906T ATE111918T1 AT E111918 T1 ATE111918 T1 AT E111918T1 AT 89103906 T AT89103906 T AT 89103906T AT 89103906 T AT89103906 T AT 89103906T AT E111918 T1 ATE111918 T1 AT E111918T1
Authority
AT
Austria
Prior art keywords
peptide bonds
specific cleavage
side chains
tertiary phosphines
organic tertiary
Prior art date
Application number
AT89103906T
Other languages
English (en)
Inventor
Lois M Hinman
Libby S Miller
Original Assignee
Carter Wallace
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carter Wallace filed Critical Carter Wallace
Application granted granted Critical
Publication of ATE111918T1 publication Critical patent/ATE111918T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5004—Acyclic saturated phosphines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/128—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT89103906T 1988-04-01 1989-03-06 Spezifische spaltung von peptidbindungen durch organische tertiäre phosphine mit nukleophilen seitenketten. ATE111918T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17657188A 1988-04-01 1988-04-01
US17657388A 1988-04-01 1988-04-01

Publications (1)

Publication Number Publication Date
ATE111918T1 true ATE111918T1 (de) 1994-10-15

Family

ID=26872381

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89103906T ATE111918T1 (de) 1988-04-01 1989-03-06 Spezifische spaltung von peptidbindungen durch organische tertiäre phosphine mit nukleophilen seitenketten.

Country Status (6)

Country Link
EP (1) EP0339217B1 (de)
JP (1) JPH0215092A (de)
AT (1) ATE111918T1 (de)
CA (1) CA1330800C (de)
DE (1) DE68918323T2 (de)
ES (1) ES2064374T3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL213309B1 (pl) 2006-02-09 2013-02-28 Polska Akademia Nauk Inst Biochemii I Biofizyki Sposób hydrolizy wiazania peptydowego
CA2756244A1 (en) 2009-04-02 2010-10-07 Roche Glycart Ag Multispecific antibodies comprising full length antibodies and single chain fab fragments
EP2478013B1 (de) 2009-09-16 2018-10-24 F.Hoffmann-La Roche Ag Coiled-coil- und/oder tether-haltige proteinkomplexe und verwendungen davon
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
CN103068846B9 (zh) 2010-08-24 2016-09-28 弗·哈夫曼-拉罗切有限公司 包含二硫键稳定性Fv片段的双特异性抗体
SG191153A1 (en) 2010-12-23 2013-07-31 Hoffmann La Roche Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
CA2861124A1 (en) 2012-02-10 2013-08-15 Genentech, Inc. Single-chain antibodies and other heteromultimers
KR20150030744A (ko) 2012-06-27 2015-03-20 에프. 호프만-라 로슈 아게 표적에 특이적으로 결합하는 하나 이상의 결합 단위를 포함하는 항체 Ｆｃ－영역 접합체의 제조 방법 및 그의 용도
RU2639287C2 (ru) 2012-06-27 2017-12-20 Ф. Хоффманн-Ля Рош Аг Способ отбора и получения высокоселективных и мультиспецифичных нацеливающих групп с заданными свойствами, включающих по меньшей мере две различные связывающие группировки, и их применения
EP3227332B1 (de) 2014-12-03 2019-11-06 F.Hoffmann-La Roche Ag Multispezifische antikörper

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3628910A (en) * 1966-05-02 1971-12-21 American Cyanamid Co Compositions for the deformation of keratin
FR1574239A (de) * 1967-07-12 1969-07-11
US3754035A (en) * 1970-01-29 1973-08-21 American Cyanamid Co Tertiary organophosphines
US3970532A (en) * 1975-01-16 1976-07-20 Borg-Warner Corporation 2-Hydroxyethylphosphines

Also Published As

Publication number Publication date
DE68918323T2 (de) 1995-05-18
EP0339217B1 (de) 1994-09-21
CA1330800C (en) 1994-07-19
DE68918323D1 (de) 1994-10-27
JPH0215092A (ja) 1990-01-18
ES2064374T3 (es) 1995-02-01
EP0339217A3 (en) 1990-01-03
EP0339217A2 (de) 1989-11-02

Similar Documents

Publication Publication Date Title
NL300118I1 (nl) Voor Factor VIIIC coderende DNA-sequenties en verwante DNA-constructen.
ATE105867T1 (de) Immunaffinitäts-reinigungssystem.
ATE111918T1 (de) Spezifische spaltung von peptidbindungen durch organische tertiäre phosphine mit nukleophilen seitenketten.
DK0700998T3 (da) Rekombinant mersacidin samt en fremgangsmåde til fremstilling deraf
DE3650676D1 (de) Verfahren und mittel zur sortierung und bestimmung biologischer informationen
DE3881023D1 (de) Proteine, expressionsvektoren, die fuer solche proteine kodierende dna enthalten und zellen, die solche expressionsvektoren enthalten.
DE68925043D1 (de) Synthetische Peptide und deren Mischungen für den Nachweis von HIV-Antikörpern
DE3481386D1 (de) Bestimmung von fibrin mit fibrin-spezifischen antikoerpern.
DE69318559D1 (de) Peptide brauchbar als microsequezierungsstandard und verfahren zu ihrer anwendung
DE3873273D1 (de) Verfahren zur selektiven spaltung von fusionsproteinen.
ATE97494T1 (de) Geraete und verfahren zur bestimmung der sequenz von aminosaeuren.
ATE188483T1 (de) Verzweigte peptide zum nachweis von antikörpern
NO904129D0 (no) Antistoffer mot hoeykonserverte aminosyresekvenser fra immunogene forbindelser, fremgangsmaate for fremstilling av antistoffer samt anvendelse derav i immunoanalyser.
DE69534738D1 (de) Leukocyten-aktivierender Faktor
DE69613086D1 (de) Antigenen Peptide mit Glycinsubstitution
DE69831584T2 (de) Polypeptide mit wasserkanalaktivität und dna sequenzen
WO1990000179A3 (fr) Nouvelles proteins, adn les codant et leur usage
DK0572088T3 (da) Modificerede signalsekvenser
SE8803986D0 (sv) Method for sequencing peptides or proteins
ES2114004T3 (es) Procedimiento de preparacion de peptidos con un residuo prolina amidado en la posicion c-terminal.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee