ATE112279T1 - Cc-1065 analoge. - Google Patents

Cc-1065 analoge.

Info

Publication number: ATE112279T1
Authority: AT; Austria
Prior art keywords: formula; compounds; useful; analogue; spirocyclopropylpyrroloindole
Prior art date: 1986-12-19

Application number

AT88901185T

Other languages

English (en)

Inventor

Robert C Kelly

David G Martin

Paul A Aristoff

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-19

Filing date

1987-12-11

Publication date

1994-10-15

1987-12-11 Application filed by Upjohn Co filed Critical Upjohn Co

1994-10-15 Application granted granted Critical

1994-10-15 Publication of ATE112279T1 publication Critical patent/ATE112279T1/de

Links

KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000000126 substance Substances 0.000 abstract 2
241001465754 Metazoa Species 0.000 abstract 1
239000006096 absorbing agent Substances 0.000 abstract 1
238000010171 animal model Methods 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
150000002475 indoles Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biochemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Fire Alarms (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)
Silicon Polymers (AREA)
Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
Reduction Or Emphasis Of Bandwidth Of Signals (AREA)
Forms Removed On Construction Sites Or Auxiliary Members Thereof (AREA)
Control Of Driving Devices And Active Controlling Of Vehicle (AREA)
Plural Heterocyclic Compounds (AREA)
Design And Manufacture Of Integrated Circuits (AREA)
Emergency Protection Circuit Devices (AREA)

AT88901185T 1986-12-19 1987-12-11 Cc-1065 analoge. ATE112279T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US94463386A	1986-12-19	1986-12-19

Publications (1)

Publication Number	Publication Date
ATE112279T1 true ATE112279T1 (de)	1994-10-15

Family

ID=25481770

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88901185T ATE112279T1 (de)	1986-12-19	1987-12-11	Cc-1065 analoge.

Country Status (8)

Country	Link
EP (1)	EP0340243B1 (de)
JP (1)	JP2598819B2 (de)
KR (1)	KR960009264B1 (de)
AT (1)	ATE112279T1 (de)
AU (1)	AU617304B2 (de)
DE (1)	DE3750612T2 (de)
MX (1)	MX9203200A (de)
WO (1)	WO1988004659A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0684377B2 (ja) *	1986-04-17	1994-10-26	協和醗酵工業株式会社	新規化合物ｄｃ―８８ａ及びｄｃ―８９ａ１
JP2562935B2 (ja) *	1988-04-28	1996-12-11	明治製菓株式会社	抗腫瘍性物質ｓｆ２５８２誘導体
US4994578A (en) *	1987-11-27	1991-02-19	Meiji Seika Kaisha, Ltd.	Certain anti-tumor duocarmycin antibiotics from streptomyces
JP2642165B2 (ja) *	1988-07-22	1997-08-20	協和醗酵工業株式会社	新規ｄｃ−８９化合物およびその製造法
US5084468A (en) *	1988-08-11	1992-01-28	Kyowa Hakko Kogyo Co., Ltd.	Dc-88a derivatives
US5541339A (en) *	1988-09-12	1996-07-30	The Upjohn Company	CC-1065 analogs having two CPI subunits
US5008271A (en) *	1988-10-21	1991-04-16	Kyowa Hakko Kogyo Co., Ltd.	DC-88A derivatives
US5187186A (en) *	1989-07-03	1993-02-16	Kyowa Hakko Kogyo Co., Ltd.	Pyrroloindole derivatives
JP2510335B2 (ja) *	1989-07-03	1996-06-26	協和醗酵工業株式会社	Ｄｃ―８８ａ誘導体
CA2078118C (en) *	1990-04-25	1999-11-16	Paul A. Aristoff	Cc-1065 analogs
US5214065A (en) *	1990-06-11	1993-05-25	Kyowa Hakko Kogyo Co., Ltd.	Dc-89 derivatives
US5248692A (en) *	1990-06-11	1993-09-28	Kyowa Hakko Kogyo Co., Ltd.	DC-89 derivatives as anti-tumor agents
US5258383A (en) *	1991-06-28	1993-11-02	Kyowa Hakko Kogyo Co., Ltd.	DC-89 derivatives
EP0563475B1 (de) *	1992-03-25	2000-05-31	Immunogen Inc	Konjugaten von Zell-bindender Mittel und Derivaten von CC-1065
US5248691A (en) *	1992-09-03	1993-09-28	Eli Lilly And Company	Furanoindolines
AU689566B2 (en) *	1994-04-01	1998-04-02	Kyowa Hakko Kogyo Co. Ltd.	DC-89 derivatives
US5641780A (en) *	1994-04-22	1997-06-24	Kyowa Hakko Kogyo Co., Ltd.	Pyrrolo-indole derivatives
CN1051552C (zh) *	1994-11-29	2000-04-19	杏林制药株式会社	丙烯酰胺衍生物及其制造方法
GB9516943D0 (en) *	1995-08-18	1995-10-18	Cancer Soc Auckland Div Nz Inc	Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs
US6130237A (en) *	1996-09-12	2000-10-10	Cancer Research Campaign Technology Limited	Condensed N-aclyindoles as antitumor agents
AU721037B2 (en) *	1996-09-12	2000-06-22	Auckland Uniservices Limited	Condensed N-acylindoles as antitumor agents
GB9818730D0 (en)	1998-08-27	1998-10-21	Univ Portsmouth	Collections of compounds
DE69925133T2 (de)	1998-08-27	2006-01-19	Spirogen Ltd., Ryde	Pyrrolobenzodiazepine
US6909006B1 (en)	1999-08-27	2005-06-21	Spirogen Limited	Cyclopropylindole derivatives
US6989452B2 (en) *	2001-05-31	2006-01-24	Medarex, Inc.	Disulfide prodrugs and linkers and stabilizers useful therefor
GB0226593D0 (en)	2002-11-14	2002-12-24	Consultants Ltd	Compounds
GB0321295D0 (en)	2003-09-11	2003-10-15	Spirogen Ltd	Synthesis of protected pyrrolobenzodiazepines
JP4806680B2 (ja)	2004-05-19	2011-11-02	メダレックスインコーポレイテッド	自己犠牲リンカー及び薬剤複合体
AR065404A1 (es)	2007-02-21	2009-06-03	Medarex Inc	Conjugados farmaco-ligando, los que se unen a citotoxinas potentes, composicion farmaceutica que los contienen y su uso para retardar o detener el crecimiento de un tumor en un mamifero
US9901567B2 (en)	2007-08-01	2018-02-27	Syntarga B.V.	Substituted CC-1065 analogs and their conjugates
ES2647317T3 (es)	2008-11-03	2017-12-20	Syntarga B.V.	Análogos de CC-1065 y sus conjugados
PT3056203T (pt)	2010-04-21	2018-02-15	Syntarga Bv	Conjugados de análogos de cc-1065 e ligantes bifuncionais
RU2680404C2 (ru)	2014-01-10	2019-02-21	Синтон Байофармасьютикалс Б. В.	Способ очистки cys-связанных конъюгатов антитело-лекарственное средство

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1238907A (en) *	1984-02-21	1988-07-05	Robert C. Kelly	1,2,8,8a-tetrahydrocyclopropa¬c\|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds

1987
- 1987-12-11 DE DE3750612T patent/DE3750612T2/de not_active Expired - Fee Related
- 1987-12-11 MX MX9203200A patent/MX9203200A/es unknown
- 1987-12-11 JP JP63501400A patent/JP2598819B2/ja not_active Expired - Lifetime
- 1987-12-11 WO PCT/US1987/003227 patent/WO1988004659A2/en not_active Ceased
- 1987-12-11 AU AU12290/88A patent/AU617304B2/en not_active Ceased
- 1987-12-11 EP EP88901185A patent/EP0340243B1/de not_active Expired - Lifetime
- 1987-12-11 AT AT88901185T patent/ATE112279T1/de not_active IP Right Cessation
1988
- 1988-08-19 KR KR88701019A patent/KR960009264B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HK1000510A1 (en)	1998-04-03
JPH02502005A (ja)	1990-07-05
MX9203200A (es)	1992-09-01
WO1988004659A2 (en)	1988-06-30
JP2598819B2 (ja)	1997-04-09
EP0340243B1 (de)	1994-09-28
AU1229088A (en)	1988-07-15
KR960009264B1 (en)	1996-07-16
WO1988004659A3 (en)	1988-08-11
DE3750612T2 (de)	1995-03-02
EP0340243A1 (de)	1989-11-08
AU617304B2 (en)	1991-11-28
DE3750612D1 (de)	1994-11-03
KR890700127A (ko)	1989-03-02

Similar Documents

Publication	Publication Date	Title
ATE112279T1 (de)	1994-10-15	Cc-1065 analoge.
FI853625L (fi)	1986-03-23	Tetralinderivat, deras framstaellning och anvaendning.
FI852974L (fi)	1986-02-04	Nya n-hydroxylgruppen skyddande grupper och framstaellningsfoerfarande foer 3-acylamino-1-hydroxi-2-azetidinoner.
MX9102582A (es)	1993-01-01	Derivados de indol 3,7-disubstituidos, procedimiento para su preparacion y composicion farmaceutica que los contiene.
FI103668B1 (fi)	1999-08-13	Menetelmä farmakologisesti aktiivisten pyrrolo[3,2-e]indol-4(5H)-onidimeerien valmistamiseksi
NO20004978L (no)	2000-12-05	Semi-syntetiske ecteinascidiner
SE9904129D0 (sv)	1999-11-15	Novel compounds
MX9200396A (es)	1992-08-01	Derivados de benciloxifenilo, procedimiento para su preparacion y composicion farmaceutica que los contiene.
FR2392989A1 (fr)	1978-12-29	Nouveaux phenyl-benzimidazolyl-furannes, leur procede de preparation et leur utilisation comme azurants optiques des matieres organiques
SE8302751D0 (sv)	1983-05-16	2(1h)-pyridinon-derivate, ihre herstellung und sie enthaltende pharmazeutische zubereitungen
FI925745A0 (fi)	1992-12-17	Interleukin-6-kompositioner och foerfarande foer deras framstaellning
FR2483948B1 (fr)	1985-06-07	Production de l-proline par fermentation
ATE93846T1 (de)	1993-09-15	S-substituierte beta-thioacrylamide und deren verwendung als mikrobizide.
FR2389631A1 (de)	1978-12-01
NO872574L (no)	1987-12-22	Fremgangsmte for fremstilling av terapeutisk aktive tetrahydro-benzotiazoler.
AU587661B2 (en)	1989-08-24	Phenylacetaldehydes substituted by basic groups, their preparation and drugs containing these compounds
BR8108862A (pt)	1983-05-31	Hidroximidato e tiol-hidroximidatos heterobiciclicos e seus derivados ester -carbamato com atividade biologica
FR2630104B1 (fr)	1990-07-13	Procede de preparation de disulfures organiques
ES517874A0 (es)	1983-12-01	Procedimiento de preparacion de derivados de diaza-3,7a-cicloherta-(j,k)-fluorenos.
DE3785368D1 (de)	1993-05-19	Neues glucopyranosid.
ES2039270T3 (es)	1993-09-16	Derivados de gamma-l-glutamil-4-nitroanilida y procedimiento para determinar actividad de gamma-gtp utilizandolos.
EP0264951A3 (en)	1988-09-14	Procaterol-derivatives
ATE124402T1 (de)	1995-07-15	1,4-bis(alkylamino)-2,3-diaza-anthracen-9,10- dione.
JPS5398183A (en)	1978-08-28	Baseless colored lamp
IT8024758A0 (it)	1980-09-19	N-mercaptoacil derivati di tripeptidi e di composti affini utili come antiipertensivi e processi per la loro preparazione.

Legal Events

Date	Code	Title	Description
2003-09-15	REN	Ceased due to non-payment of the annual fee