ATE112318T1 - Protease, reverse transcriptase und endonuklease von retroviren und verfahren zur herstellung dieser enzyme. - Google Patents

Protease, reverse transcriptase und endonuklease von retroviren und verfahren zur herstellung dieser enzyme.

Info

Publication number
ATE112318T1
ATE112318T1 AT89312662T AT89312662T ATE112318T1 AT E112318 T1 ATE112318 T1 AT E112318T1 AT 89312662 T AT89312662 T AT 89312662T AT 89312662 T AT89312662 T AT 89312662T AT E112318 T1 ATE112318 T1 AT E112318T1
Authority
AT
Austria
Prior art keywords
retroviral
protease
proteins
endonuclease
reverse transcriptase
Prior art date
Application number
AT89312662T
Other languages
English (en)
Inventor
Atsusi Saito
Hideo Shinagawa
Atsuo Nakata
Original Assignee
Univ Osaka Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1088411A external-priority patent/JP2852431B2/ja
Application filed by Univ Osaka Res Found filed Critical Univ Osaka Res Found
Application granted granted Critical
Publication of ATE112318T1 publication Critical patent/ATE112318T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
    • C12N2740/14022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT89312662T 1988-12-07 1989-12-05 Protease, reverse transcriptase und endonuklease von retroviren und verfahren zur herstellung dieser enzyme. ATE112318T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP30942788 1988-12-07
JP1088411A JP2852431B2 (ja) 1988-12-07 1989-04-06 レトロウイルスのプロテアーゼ、逆転写酵素及びエンドヌクレアーゼ、並びにこれ等の酵素の製法

Publications (1)

Publication Number Publication Date
ATE112318T1 true ATE112318T1 (de) 1994-10-15

Family

ID=26429797

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89312662T ATE112318T1 (de) 1988-12-07 1989-12-05 Protease, reverse transcriptase und endonuklease von retroviren und verfahren zur herstellung dieser enzyme.

Country Status (9)

Country Link
EP (1) EP0372904B1 (de)
AT (1) ATE112318T1 (de)
AU (1) AU643942B2 (de)
CA (1) CA2004646C (de)
DE (1) DE68918563T2 (de)
DK (1) DK612889A (de)
HU (1) HU209835B (de)
MY (1) MY104975A (de)
NZ (1) NZ231593A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT62654A (en) * 1990-05-28 1993-05-28 Univ Osaka Res Found Process for producing plasmid capable of expressing retrovirus gene and processing it after translation, as well its expression products
WO1992011028A1 (en) * 1990-12-19 1992-07-09 Epitope, Inc. Hiv reverse transcriptase vaccine
EP0555797A1 (de) * 1992-02-10 1993-08-18 Becton, Dickinson and Company Universalpufferlösung für Restriktionsendonukleasen
DE69604051T2 (de) * 1995-01-27 1999-12-16 The Government Of The United States Of America, As Represented By The Secretary Verfahren zum sensitiven nachweis von reverser transcriptase
US6242187B1 (en) 1996-01-29 2001-06-05 Virologic, Inc. Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening
EP0852626B1 (de) * 1996-01-29 2002-04-03 Virologic, Inc. Verfahren und zusammensetzungen zur bestimmung der empfindlichkeit und resistenz gegen antivirale wirkstoffe und screening für antivirale wirkstoffe

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7512287A (en) * 1986-05-20 1987-12-22 Dana-Farber Cancer Institute Expression of human t-cell lymphotropic virus (htlv-iii)reve rse transcriptase and uses thereof

Also Published As

Publication number Publication date
MY104975A (en) 1994-07-30
AU643942B2 (en) 1993-12-02
HUT54412A (en) 1991-02-28
DK612889D0 (da) 1989-12-05
AU4590889A (en) 1990-08-02
EP0372904A3 (de) 1991-09-25
NZ231593A (en) 1992-07-28
DE68918563D1 (de) 1994-11-03
HU896176D0 (en) 1990-02-28
EP0372904A2 (de) 1990-06-13
DE68918563T2 (de) 1995-02-23
EP0372904B1 (de) 1994-09-28
DK612889A (da) 1990-06-08
CA2004646C (en) 1999-10-05
CA2004646A1 (en) 1990-06-07
HU209835B (en) 1994-11-28

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