ATE112779T1 - Verfahren zur herstellung von 6-(d(-)-alpha-(4- äthyl-2,3-dioxo-1-piperazin-carboxamido)- phenylacetamido>penicillansäure. - Google Patents

Verfahren zur herstellung von 6-(d(-)-alpha-(4- äthyl-2,3-dioxo-1-piperazin-carboxamido)- phenylacetamido>penicillansäure.

Info

Publication number: ATE112779T1
Authority: AT; Austria
Prior art keywords: dioxo; alpha; ethyl; formula; chem
Prior art date: 1987-06-11

Application number

AT88109147T

Other languages

English (en)

Inventor

Pavel Zupet

Natalija Vitezic

Original Assignee

Krka Tovarna Zdravil

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-11

Filing date

1988-06-08

Publication date

1994-10-15

1988-06-08 Application filed by Krka Tovarna Zdravil filed Critical Krka Tovarna Zdravil

1994-10-15 Application granted granted Critical

1994-10-15 Publication of ATE112779T1 publication Critical patent/ATE112779T1/de

Links

239000002253 acid Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
XEMQZDXXLWKXEQ-UHFFFAOYSA-N 4-ethyl-2,3-dioxopiperazine-1-carboxylic acid Chemical compound CCN1CCN(C(O)=O)C(=O)C1=O XEMQZDXXLWKXEQ-UHFFFAOYSA-N 0.000 abstract 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
-1 alkali metal salts Chemical class 0.000 abstract 1
YXIWHUQXZSMYRE-UHFFFAOYSA-N benzothiazolyl mercaptan Natural products C1=CC=C2SC(S)=NC2=C1 YXIWHUQXZSMYRE-UHFFFAOYSA-N 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
RBKMMJSQKNKNEV-RITPCOANSA-N penicillanic acid Chemical compound OC(=O)[C@H]1C(C)(C)S[C@@H]2CC(=O)N21 RBKMMJSQKNKNEV-RITPCOANSA-N 0.000 abstract 1
IVBHGBMCVLDMKU-GXNBUGAJSA-N piperacillin Chemical compound O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 IVBHGBMCVLDMKU-GXNBUGAJSA-N 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
125000004436 sodium atom Chemical group 0.000 abstract 1
150000007970 thio esters Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT88109147T 1987-06-11 1988-06-08 Verfahren zur herstellung von 6-(d(-)-alpha-(4- äthyl-2,3-dioxo-1-piperazin-carboxamido)- phenylacetamido>penicillansäure. ATE112779T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
YU1089/87A YU44630B (en)	1987-06-11	1987-06-11	Process for preparing 6-/d(-)-alpha(4-ethyl-2,3-dioxo-1-piperazincarboxamido)-phenylacetamido/phenicilanic acid

Publications (1)

Publication Number	Publication Date
ATE112779T1 true ATE112779T1 (de)	1994-10-15

Family

ID=25552720

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88109147T ATE112779T1 (de)	1987-06-11	1988-06-08	Verfahren zur herstellung von 6-(d(-)-alpha-(4- äthyl-2,3-dioxo-1-piperazin-carboxamido)- phenylacetamido>penicillansäure.

Country Status (7)

Country	Link
EP (1)	EP0294789B1 (de)
JP (1)	JPS6479187A (de)
AT (1)	ATE112779T1 (de)
DE (1)	DE3851783T2 (de)
HU (1)	HU199849B (de)
SI (1)	SI8711089A8 (de)
YU (1)	YU44630B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2714148B2 (ja) *	1989-06-28	1998-02-16	三洋電機株式会社	自動販売機の商品搬出装置
ITMI20011718A1 (it)	2001-08-03	2003-02-03	Istituto Biochimico Italiano	Processo per la preparazione del sale sodico dell'acido-6(d-(-)-alpha-(4-etil-2,3-diosso-1-piperazinocarbonilammino)fenilacetammido)penicill
MX2009008124A (es) *	2007-01-31	2009-10-08	Toyama Chemical Co Ltd	Cristal nuevo de piperacilina sodica.
CN105859746A (zh) *	2016-03-22	2016-08-17	江西富祥药业股份有限公司	一种合成阿扑西林的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0037380B1 (de) *	1980-03-28	1984-09-12	BIOCHEMIE Gesellschaft m.b.H.	Verfahren zum Herstellen von Cephalosporin-Antibiotika und Zwischenprodukte zur Verwendung in diesem Verfahren und ihre Herstellung
US4316024A (en) *	1980-09-15	1982-02-16	Bristol-Myers Company	Dioxo piperazine compounds
EP0096297B1 (de) *	1982-06-03	1988-06-15	F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft	Verfahren zur Herstellung von 1-Sulfo-2-oxoazetidinderivaten
EP0115770B2 (de) *	1983-01-07	1996-06-19	Takeda Chemical Industries, Ltd.	Thiazolderivate
DE3585154D1 (de) *	1984-11-15	1992-02-20	Hoffmann La Roche	Verfahren zur herstellung von cephalosporinestern.

1987
- 1987-06-11 SI SI8711089A patent/SI8711089A8/sl unknown
- 1987-06-11 YU YU1089/87A patent/YU44630B/xx unknown
1988
- 1988-06-08 AT AT88109147T patent/ATE112779T1/de active
- 1988-06-08 DE DE3851783T patent/DE3851783T2/de not_active Expired - Fee Related
- 1988-06-08 EP EP88109147A patent/EP0294789B1/de not_active Expired - Lifetime
- 1988-06-10 HU HU883021A patent/HU199849B/hu not_active IP Right Cessation
- 1988-06-10 JP JP63141937A patent/JPS6479187A/ja active Pending

Also Published As

Publication number	Publication date
DE3851783T2 (de)	1995-02-16
YU108987A (en)	1988-12-31
HU199849B (en)	1990-03-28
SI8711089A8 (en)	1996-08-31
JPS6479187A (en)	1989-03-24
EP0294789A1 (de)	1988-12-14
HUT48260A (en)	1989-05-29
EP0294789B1 (de)	1994-10-12
YU44630B (en)	1990-10-31
DE3851783D1 (de)	1994-11-17

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