ATE113654T1 - Follistatin und verfahren zur reinigung desselben. - Google Patents

Follistatin und verfahren zur reinigung desselben.

Info

Publication number
ATE113654T1
ATE113654T1 AT88908558T AT88908558T ATE113654T1 AT E113654 T1 ATE113654 T1 AT E113654T1 AT 88908558 T AT88908558 T AT 88908558T AT 88908558 T AT88908558 T AT 88908558T AT E113654 T1 ATE113654 T1 AT E113654T1
Authority
AT
Austria
Prior art keywords
porcine
rat
protein
residues
gln
Prior art date
Application number
AT88908558T
Other languages
English (en)
Inventor
Nicholas Chai-Kwan Ling
Naoto Assistant Professor Ueno
Of Tsukuba University
Shunichi Shimasaki
Frederick Steven Esch
Shao-Yao Ying
Roger Charles Louis Guillemin
Original Assignee
Salk Inst For Biological Studi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi
Application granted granted Critical
Publication of ATE113654T1 publication Critical patent/ATE113654T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT88908558T 1987-08-28 1988-08-26 Follistatin und verfahren zur reinigung desselben. ATE113654T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9063587A 1987-08-28 1987-08-28
US07/224,432 US5041538A (en) 1987-08-28 1988-07-26 Mammalian follistatin

Publications (1)

Publication Number Publication Date
ATE113654T1 true ATE113654T1 (de) 1994-11-15

Family

ID=26782471

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88908558T ATE113654T1 (de) 1987-08-28 1988-08-26 Follistatin und verfahren zur reinigung desselben.

Country Status (8)

Country Link
US (1) US5041538A (de)
EP (1) EP0377659B1 (de)
JP (1) JP2709113B2 (de)
AT (1) ATE113654T1 (de)
AU (1) AU620346B2 (de)
CA (1) CA1340972C (de)
DE (1) DE3852033T2 (de)
WO (1) WO1989001945A1 (de)

Families Citing this family (39)

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Publication number Priority date Publication date Assignee Title
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
WO1988005789A1 (en) * 1987-01-29 1988-08-11 Biotechnology Australia Pty. Ltd. Isolation of single chain proteins with fsh suppressing activity from follicular fluid
US5942220A (en) * 1990-03-16 1999-08-24 Chiron Corporation Inhibitor of cytokine activity and applications thereof
KR100259827B1 (ko) 1991-11-04 2000-06-15 브루스 엠. 에이센, 토마스 제이 데스로저 재조합 골형태 형성 단백질 헤테로다이머, 그 조성물 및 사용방법
EP0698094B1 (de) * 1993-05-12 2004-02-04 Genetics Institute, LLC Bmp-11 zusammensetzungen
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US6686198B1 (en) 1993-10-14 2004-02-03 President And Fellows Of Harvard College Method of inducing and maintaining neuronal cells
DE69434934D1 (de) * 1993-10-14 2007-04-12 Harvard College Verfahren zur induzierung und zur erhaltung neuronalen zellen
EP0733109B9 (de) 1993-12-07 2006-07-05 Genetics Institute, LLC Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
US5658876A (en) * 1994-04-28 1997-08-19 The General Hospital Corporation Activin antagonists as novel contraceptives
AU5902398A (en) 1996-12-31 1998-07-31 Human Genome Sciences, Inc. Cortistatin polypeptides
US5942420A (en) 1997-11-17 1999-08-24 Millennium Biotherapeutics, Inc. Molecules of the follistatin-related protein family and uses therefor
US6004937A (en) 1998-03-09 1999-12-21 Genetics Institute, Inc. Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11]
US6087168A (en) 1999-01-20 2000-07-11 Cedars Sinai Medical Center Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
WO2001009368A1 (en) * 1999-07-30 2001-02-08 The General Hospital Corporation Follistatin antagonists
EP1223990B1 (de) 1999-10-15 2004-07-28 Genetics Institute, LLC Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine
TWI329129B (en) * 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
ATE476654T1 (de) * 2001-03-02 2010-08-15 Activx Biosciences Inc Plattform für protein-profiling
US7226587B2 (en) 2001-06-01 2007-06-05 Wyeth Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
EP1399177A1 (de) * 2001-06-08 2004-03-24 Smith & Nephew PLC Bmp bindende proteine zur verwendung in knochen- oder knorpelregeneration
AUPR638101A0 (en) 2001-07-13 2001-08-09 Bioa Pty Limited Composition and method for treatment of disease
CN1966725A (zh) * 2001-10-31 2007-05-23 爱尔康公司 骨形态生发蛋白(bmp)、bmp受体和bmp结合蛋白及它们在诊断和治疗青光眼中的用途
TW200518767A (en) 2003-09-12 2005-06-16 Wyeth Corp Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
WO2005032578A1 (en) * 2003-10-06 2005-04-14 Monash University Therapeutic method
WO2008067480A2 (en) 2006-11-29 2008-06-05 Nationwide Children's Hospital Myostatin inhibition for enhancing muscle and/or improving muscle function
EP2315602A4 (de) 2008-06-26 2011-11-02 Acceleron Pharma Inc Verfahren zur dosierung eines actriib-antagonisten und überwachung von behandelten patienten
CA2816883A1 (en) 2010-11-23 2012-05-31 Presage Biosciences, Inc. Therapeutic methods and compositions for solid delivery
CN104302408B (zh) 2012-02-27 2016-12-14 阿穆尼克斯运营公司 Xten缀合组合物和制造其的方法
EP2674033A1 (de) * 2012-06-11 2013-12-18 Deutsches Institut für Lebensmitteltechnik e.V. Prozess zur Herstellung einer Zusammensetzung mit aktivem Follistatin
PL2883461T3 (pl) * 2013-12-11 2018-04-30 Deutsches Institut Für Lebensmitteltechnik E.V. Sposób wytwarzania aktywnej folistatyny
US10010498B2 (en) 2014-06-04 2018-07-03 Acceleron Pharma Inc. Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins
JP6568110B2 (ja) 2014-06-04 2019-08-28 アクセルロン ファーマ， インコーポレイテッド フォリスタチンポリペプチドによる障害の処置のための方法および組成物
CA2980757A1 (en) 2015-03-26 2016-09-29 Acceleron Pharma Inc. Follistatin-related fusion proteins and uses thereof
EP4077687A1 (de) 2019-12-20 2022-10-26 Research Institute at Nationwide Children's Hospital Optimierte gentherapie zum targeting von muskeln bei muskelerkrankungen
KR102971166B1 (ko) * 2022-12-09 2026-06-01 (주)케어젠 연골 재생용 펩타이드 및 이의 용도
JP2026516715A (ja) 2023-04-18 2026-05-26 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル 肢帯型筋ジストロフィーｒ９及び先天性筋ジストロフィー１ｃを治療するための遺伝子療法
WO2025188993A2 (en) 2024-03-07 2025-09-12 Research Institute At Nationwide Children's Hospital Gene therapy for treating gne-related disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4624944A (en) * 1985-06-14 1986-11-25 The Regents Of The University Of California Human seminal alpha-inhibins

Also Published As

Publication number Publication date
EP0377659A1 (de) 1990-07-18
JP2709113B2 (ja) 1998-02-04
DE3852033D1 (de) 1994-12-08
JPH04504105A (ja) 1992-07-23
WO1989001945A1 (en) 1989-03-09
DE3852033T2 (de) 1995-04-27
AU2420088A (en) 1989-03-31
EP0377659A4 (en) 1990-12-27
AU620346B2 (en) 1992-02-20
CA1340972C (en) 2000-04-25
EP0377659B1 (de) 1994-11-02
US5041538A (en) 1991-08-20

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