ATE113660T1 - Phenylglycidat-stereoisomere, umsetzungsprodukte mit 2-nitrothiophenol und herstellung von diltiazen. - Google Patents

Phenylglycidat-stereoisomere, umsetzungsprodukte mit 2-nitrothiophenol und herstellung von diltiazen.

Info

Publication number
ATE113660T1
ATE113660T1 AT89201236T AT89201236T ATE113660T1 AT E113660 T1 ATE113660 T1 AT E113660T1 AT 89201236 T AT89201236 T AT 89201236T AT 89201236 T AT89201236 T AT 89201236T AT E113660 T1 ATE113660 T1 AT E113660T1
Authority
AT
Austria
Prior art keywords
stereoisomers
diltiazen
nitrothiophenol
production
reaction products
Prior art date
Application number
AT89201236T
Other languages
English (en)
Inventor
Lumbertus Albregt Hulshof
Jan Hendrik Roskam
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Application granted granted Critical
Publication of ATE113660T1 publication Critical patent/ATE113660T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT89201236T 1988-05-20 1989-05-17 Phenylglycidat-stereoisomere, umsetzungsprodukte mit 2-nitrothiophenol und herstellung von diltiazen. ATE113660T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8801311A NL8801311A (nl) 1988-05-20 1988-05-20 Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem.

Publications (1)

Publication Number Publication Date
ATE113660T1 true ATE113660T1 (de) 1994-11-15

Family

ID=19852333

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89201236T ATE113660T1 (de) 1988-05-20 1989-05-17 Phenylglycidat-stereoisomere, umsetzungsprodukte mit 2-nitrothiophenol und herstellung von diltiazen.

Country Status (6)

Country Link
EP (1) EP0343714B1 (de)
JP (1) JPH07121231B2 (de)
AT (1) ATE113660T1 (de)
DE (1) DE68919125T2 (de)
ES (1) ES2064423T3 (de)
NL (1) NL8801311A (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5274300A (en) 1988-10-26 1993-12-28 Sepracor, Inc. Enzymatic hydrolysis of glycidate esters in the presence of bisulfite anion
US6521445B1 (en) * 1988-10-26 2003-02-18 Sepracor, Inc. Process for preparing optically active glycidate esters
JPH02207799A (ja) * 1989-02-03 1990-08-17 Tanabe Seiyaku Co Ltd 光学活性３―フェニルグリシッド酸エステル類化合物の単離方法
US5244803A (en) * 1989-09-13 1993-09-14 Tanabe Seiyaku Co., Ltd. Process for preparing optically active 3-phenylglycidic acid esters
JPH0779706B2 (ja) * 1990-03-22 1995-08-30 田辺製薬株式会社 ２―クロロ―３―ヒドロキシ―３―フエニルプロピオン酸エステル類の製法
US5130252A (en) * 1990-05-14 1992-07-14 Synthetech, Inc. Resolution of furopyridine enantiomers and synthetic precursors thereof
IT1240651B (it) * 1990-05-17 1993-12-17 Zambon Spa Processo per la risoluzione di derivati glicidici
IT1249777B (it) 1990-05-17 1995-03-18 Zambon Spa Processo per la preparazione di intermedi per la sintesi del diltiazem
JP3027442B2 (ja) * 1990-10-30 2000-04-04 日東電工株式会社 光学活性エポキシアルコールの製法
FR2672600B1 (fr) * 1991-02-08 1994-10-14 Synthelabo Procede de preparation du (-)-(2r,3s)-2,3-epoxy-3-(4-methoxyphenyl) propionate de methyle.
JP2687789B2 (ja) * 1991-08-13 1997-12-08 田辺製薬株式会社 光学活性３−フェニルグリシッド酸エステル類化合物の製法
FI93833C (fi) * 1992-05-14 1995-06-12 Orion Yhtymae Oy Menetelmä propionihappojohdosten valmistamiseksi
US6020174A (en) * 1992-07-27 2000-02-01 The Board Of Governors For Higher Education Chemoenzymatic synthesis of the taxol C-13 side chain N-benzolyl- (2R,3S)-Phenylisoserine
NL9202208A (nl) * 1992-12-18 1994-07-18 Dsm Nv Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters.
US5529929A (en) * 1995-06-07 1996-06-25 Seprachem, Inc. Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens
US5658796A (en) * 1995-06-07 1997-08-19 Seprachem, Inc. Optical resolution of alkyl chroman-2-carboxylates
IL123352A0 (en) 1997-02-27 1998-09-24 Tanabe Seiyaku Co Process for preparing an optically active trans-3-substituted glycidic acid ester
KR20010013668A (ko) * 1997-06-11 2001-02-26 찌바따 이찌로 광학 활성 페닐옥시란 화합물의 제조방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562257A (en) 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
JPS4936221A (de) 1972-08-03 1974-04-04
EP0059335B1 (de) 1981-02-27 1985-05-15 Tanabe Seiyaku Co., Ltd. Verfahren zur Herstellung von threo-2-Hydroxy-3-(-methoxyphenyl)-3-(2-nitrophenylthio)-propionsäureestern
IT1152721B (it) 1982-10-15 1987-01-07 Luso Farmaco Inst Risoluzione ottica dell'acido dl-alfa-2-idrossi-3-(4-metossifenil)-3-(2-amminofeniltio)propionico
US4552695A (en) 1983-04-21 1985-11-12 Shionogi & Co., Ltd. Process for production of diltiazem hydrochloride
US4585768A (en) * 1984-04-10 1986-04-29 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and processes for preparing the same
IT1189069B (it) * 1986-03-14 1988-01-28 Donegani Guido Ist Processo per la preparazione biotecnologica della l(-)-carnitina cloruro
EP0264457B1 (de) * 1986-04-16 1993-03-31 Sumitomo Chemical Company, Limited Herstellung optisch aktiver cyclopropancarbonsäuren
US4908469A (en) * 1988-05-18 1990-03-13 Marion Laboratories, Inc. 2-Hydroxy-propanoic acid acyclic alkyl esters for benzothiazepines
US4885375A (en) * 1988-05-18 1989-12-05 Marion Laboratories, Inc. Resolution of 3-(4-methoxyphenyl)glycidic acid with in situ conversion to alkyl esters
EP0342904A3 (de) * 1988-05-18 1991-01-30 MARION LABORATORIES, INC. (a Delaware corporation) 2-Hydroxy-3-(4-methoxyphenyl)-3-(2-aminophenylthio)propionsäure-8'-phenylmenthylester, insbesondere für Diltiazem
JPH0678B2 (ja) * 1988-09-02 1994-01-05 田辺製薬株式会社 光学活性３―フェニルグリシッド酸エステル類化合物の製法
US6521445B1 (en) * 1988-10-26 2003-02-18 Sepracor, Inc. Process for preparing optically active glycidate esters

Also Published As

Publication number Publication date
JPH02109995A (ja) 1990-04-23
DE68919125D1 (de) 1994-12-08
EP0343714B1 (de) 1994-11-02
DE68919125T2 (de) 1995-06-01
JPH07121231B2 (ja) 1995-12-25
ES2064423T3 (es) 1995-02-01
NL8801311A (nl) 1989-12-18
EP0343714A1 (de) 1989-11-29

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee