ATE114158T1 - Immunogen-verbindungen und deren benutzung in der herstellung von genetisch unbeschränkten synthetischen impfstoffen und bei der immunoenzymatischer bestimmung von antisporozoiden antikörpern von plasmodium malariae. - Google Patents

Immunogen-verbindungen und deren benutzung in der herstellung von genetisch unbeschränkten synthetischen impfstoffen und bei der immunoenzymatischer bestimmung von antisporozoiden antikörpern von plasmodium malariae.

Info

Publication number: ATE114158T1
Authority: AT; Austria
Prior art keywords: compounds; plasmodium malariae; formula; lysine; antibodies
Prior art date: 1989-05-19

Application number

AT90201244T

Other languages

English (en)

Inventor

Antonello Pessi

Fabio Bonelli

Lorella Chiappinelli

Elisabetta Bianchi

Giudice Giuseppe Del

Original Assignee

Eniricerche Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-19

Filing date

1990-05-16

Publication date

1994-12-15

1989-05-19 Priority claimed from IT8920553A external-priority patent/IT1229765B/it

1990-03-23 Priority claimed from IT19800A external-priority patent/IT1241081B/it

1990-05-16 Application filed by Eniricerche Spa filed Critical Eniricerche Spa

1994-12-15 Application granted granted Critical

1994-12-15 Publication of ATE114158T1 publication Critical patent/ATE114158T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 4
241000223821 Plasmodium malariae Species 0.000 title abstract 3
229940118768 plasmodium malariae Drugs 0.000 title abstract 3
230000002163 immunogen Effects 0.000 title abstract 2
229940126577 synthetic vaccine Drugs 0.000 title 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 3
-1 poly(L-lysine) Polymers 0.000 abstract 3
235000019766 L-Lysine Nutrition 0.000 abstract 2
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
239000004472 Lysine Substances 0.000 abstract 2
239000008280 blood Substances 0.000 abstract 2
210000004369 blood Anatomy 0.000 abstract 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 1
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000005847 immunogenicity Effects 0.000 abstract 1
229940124280 l-arginine Drugs 0.000 abstract 1
229920000729 poly(L-lysine) polymer Polymers 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
210000002966 serum Anatomy 0.000 abstract 1
229960005486 vaccine Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
- A61K2039/645—Dendrimers; Multiple antigen peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Tropical Medicine & Parasitology (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Mycology (AREA)
Microbiology (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)

AT90201244T 1989-05-19 1990-05-16 Immunogen-verbindungen und deren benutzung in der herstellung von genetisch unbeschränkten synthetischen impfstoffen und bei der immunoenzymatischer bestimmung von antisporozoiden antikörpern von plasmodium malariae. ATE114158T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT8920553A IT1229765B (it)	1989-05-19	1989-05-19	Nuovo costrutto antigenico sintetico e suo impiego in diagnostica.
IT19800A IT1241081B (it)	1990-03-23	1990-03-23	Composti immunogenici e loro impiego per la preparazione di vaccini sintetici geneticamente non ristretti per la determinazione immunoenzimatica di anticorpi anti-sporozoita di plasmodium malariae

Publications (1)

Publication Number	Publication Date
ATE114158T1 true ATE114158T1 (de)	1994-12-15

Family

ID=26327309

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90201244T ATE114158T1 (de)	1989-05-19	1990-05-16	Immunogen-verbindungen und deren benutzung in der herstellung von genetisch unbeschränkten synthetischen impfstoffen und bei der immunoenzymatischer bestimmung von antisporozoiden antikörpern von plasmodium malariae.

Country Status (5)

Country	Link
EP (1)	EP0398443B1 (de)
AT (1)	ATE114158T1 (de)
DE (1)	DE69014150T2 (de)
DK (1)	DK0398443T3 (de)
ES (1)	ES2063901T3 (de)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1198225B (it) *	1986-12-04	1988-12-21	Eniricerche Spa	Polipeptidi immunologicamente attivi utili per la preparazione di vaccini antimalaria e di kits diagnostici per la determinazione di anticorpi antisporozoita
IT1198233B (it) *	1986-12-23	1988-12-21	Eniricerche Spa	Metodo per la determinazione di anticorpi antisporozoita di p. falciparum nel sangue umano

1990
- 1990-05-16 AT AT90201244T patent/ATE114158T1/de not_active IP Right Cessation
- 1990-05-16 EP EP90201244A patent/EP0398443B1/de not_active Expired - Lifetime
- 1990-05-16 DK DK90201244.2T patent/DK0398443T3/da active
- 1990-05-16 DE DE69014150T patent/DE69014150T2/de not_active Expired - Fee Related
- 1990-05-16 ES ES90201244T patent/ES2063901T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2063901T3 (es)	1995-01-16
DE69014150D1 (de)	1994-12-22
EP0398443B1 (de)	1994-11-17
EP0398443A1 (de)	1990-11-22
DE69014150T2 (de)	1995-05-11
DK0398443T3 (da)	1995-04-03

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Legal Events

Date	Code	Title	Description
1995-04-15	UEP	Publication of translation of european patent specification
1999-02-15	REN	Ceased due to non-payment of the annual fee