ES2063901T3 - Compuestos inmunogenos y su uso en la preparacion de vacunas sinteticas geneticamente no restringidas y en la determinacion inmunoenzimatica de anticuerpos antiesporozoito de plasmodium malariae. - Google Patents
Compuestos inmunogenos y su uso en la preparacion de vacunas sinteticas geneticamente no restringidas y en la determinacion inmunoenzimatica de anticuerpos antiesporozoito de plasmodium malariae.Info
- Publication number
- ES2063901T3 ES2063901T3 ES90201244T ES90201244T ES2063901T3 ES 2063901 T3 ES2063901 T3 ES 2063901T3 ES 90201244 T ES90201244 T ES 90201244T ES 90201244 T ES90201244 T ES 90201244T ES 2063901 T3 ES2063901 T3 ES 2063901T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- plasmodium malariae
- preparation
- lysine
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 241000223821 Plasmodium malariae Species 0.000 title abstract 3
- 229940118768 plasmodium malariae Drugs 0.000 title abstract 3
- 229940126577 synthetic vaccine Drugs 0.000 title 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 239000002699 waste material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
- A61K2039/645—Dendrimers; Multiple antigen peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE DESCRIBE UNA NUEVA CLASE DE COMPUESTOS INMUNOGENICOS, DEFINIBLES POR LA FORMULA (I): FIG DONDE: D ES L-LISINA O POLI(L-LISINA) RAMIFICADA, CON UN NUMERO N DE RESIDUOS DE ACIDO AMINO L-LISINA DE ENLACES AMIDO ALFA Y EPSILON.; N ES UN NUMERO ENTERO IMPAR DEL 1 AL 15; M ES UN NUMERO ENTERO DEL 3 AL 40; R1 ES LA CADENA LATERAL DE UN RESIDUO DE AMINOACIDO, ELEGIDO DE ENTRE L-ASP, L-HIS, L-CIS, L-GLN, L-THR, L-ALA, L-LEU, L-MET, L-PHE, L-GLU, L-ARG, L-TYR, L-ASN, L-SER, L-GLY, L-VAL, L-ILEU, L-PRO, Y L-TRP; R2 ES OH O NH2; R ES HIDROGENO O UN RADICAL ACIL; Y LAS CORRESPONDIENTES SALES FARMACEUTICAMENTE ACEPTABLES DE ADICION ACIDA O BASE. LOS COMPUESTOS DE LA FORMULA (I) SON PARTICULARMENTE APTOS PARA LA PREPARACION DE UNA VACUNA ANTIESPORAS PARA EL PLASMODIUM MALARIAE Y, EN LA DIAGNOSIS, PARA LA DETERMINACION DE ANTICUERPOS ANTIESPORAS DEL PLASMODIUM MALARIAE EN LA SANGRE HUMANA, EN MUESTRAS DE SUERO O DE SANGRE, MEDIANTE UNA PRUEBA INMUNOENZIMATICA. LOS COMPUESTOS DE LA FORMULA (I) TAMBIEN SON ADECUADOS COMO MOLECULAS PORTADORAS, PARA MEJORAR LA CAPACIDAD INMUNOGENICA
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8920553A IT1229765B (it) | 1989-05-19 | 1989-05-19 | Nuovo costrutto antigenico sintetico e suo impiego in diagnostica. |
| IT19800A IT1241081B (it) | 1990-03-23 | 1990-03-23 | Composti immunogenici e loro impiego per la preparazione di vaccini sintetici geneticamente non ristretti per la determinazione immunoenzimatica di anticorpi anti-sporozoita di plasmodium malariae |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2063901T3 true ES2063901T3 (es) | 1995-01-16 |
Family
ID=26327309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90201244T Expired - Lifetime ES2063901T3 (es) | 1989-05-19 | 1990-05-16 | Compuestos inmunogenos y su uso en la preparacion de vacunas sinteticas geneticamente no restringidas y en la determinacion inmunoenzimatica de anticuerpos antiesporozoito de plasmodium malariae. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0398443B1 (es) |
| AT (1) | ATE114158T1 (es) |
| DE (1) | DE69014150T2 (es) |
| DK (1) | DK0398443T3 (es) |
| ES (1) | ES2063901T3 (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1198225B (it) * | 1986-12-04 | 1988-12-21 | Eniricerche Spa | Polipeptidi immunologicamente attivi utili per la preparazione di vaccini antimalaria e di kits diagnostici per la determinazione di anticorpi antisporozoita |
| IT1198233B (it) * | 1986-12-23 | 1988-12-21 | Eniricerche Spa | Metodo per la determinazione di anticorpi antisporozoita di p. falciparum nel sangue umano |
-
1990
- 1990-05-16 AT AT90201244T patent/ATE114158T1/de not_active IP Right Cessation
- 1990-05-16 EP EP90201244A patent/EP0398443B1/en not_active Expired - Lifetime
- 1990-05-16 DK DK90201244.2T patent/DK0398443T3/da active
- 1990-05-16 DE DE69014150T patent/DE69014150T2/de not_active Expired - Fee Related
- 1990-05-16 ES ES90201244T patent/ES2063901T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69014150D1 (de) | 1994-12-22 |
| EP0398443B1 (en) | 1994-11-17 |
| EP0398443A1 (en) | 1990-11-22 |
| DE69014150T2 (de) | 1995-05-11 |
| DK0398443T3 (da) | 1995-04-03 |
| ATE114158T1 (de) | 1994-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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