ATE114645T1 - Mevalonolaktone vom chinolin-typ. - Google Patents
Mevalonolaktone vom chinolin-typ.Info
- Publication number
- ATE114645T1 ATE114645T1 AT88113448T AT88113448T ATE114645T1 AT E114645 T1 ATE114645 T1 AT E114645T1 AT 88113448 T AT88113448 T AT 88113448T AT 88113448 T AT88113448 T AT 88113448T AT E114645 T1 ATE114645 T1 AT E114645T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- hydrogen
- phenyl
- chem
- together form
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 150000003973 alkyl amines Chemical class 0.000 abstract 3
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- -1 trifluoromethoxy, difluoromethoxy, fluoro, chloro, bromo, phenyl Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006592 (C2-C3) alkenyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical group N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 229910003202 NH4 Inorganic materials 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 239000011591 potassium Chemical group 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 125000005920 sec-butoxy group Chemical group 0.000 abstract 1
- 239000011734 sodium Chemical group 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20722487 | 1987-08-20 | ||
| JP1558588 | 1988-01-26 | ||
| JP63193606A JP2569746B2 (ja) | 1987-08-20 | 1988-08-03 | キノリン系メバロノラクトン類 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE114645T1 true ATE114645T1 (de) | 1994-12-15 |
Family
ID=27281072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88113448T ATE114645T1 (de) | 1987-08-20 | 1988-08-18 | Mevalonolaktone vom chinolin-typ. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0304063B1 (de) |
| AT (1) | ATE114645T1 (de) |
| CA (1) | CA1336714C (de) |
| DE (1) | DE3852243T2 (de) |
| ES (1) | ES2067460T3 (de) |
| GR (1) | GR3015186T3 (de) |
| HU (1) | HU211700A9 (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5506219A (en) * | 1988-08-29 | 1996-04-09 | E. R. Squibb & Sons, Inc. | Pyridine anchors for HMG-CoA reductase inhibitors |
| NZ230121A (en) * | 1988-08-29 | 1993-08-26 | Squibb & Sons Inc | Pyridine and quinoline terminal groups for hmg-coenzyme a reductase inhibitors and pharmaceutical compositions for lowering blood serum cholesterol levels |
| US5753675A (en) * | 1989-03-03 | 1998-05-19 | Novartis Pharmaceuticals Corporation | Quinoline analogs of mevalonolactone and derivatives thereof |
| JP3528186B2 (ja) * | 1991-06-24 | 2004-05-17 | 日産化学工業株式会社 | 光学活性キノリンメバロン酸のジアステレオマー塩 |
| JP3130342B2 (ja) * | 1991-10-04 | 2001-01-31 | 日産化学工業株式会社 | 動脈硬化性血管内膜肥厚抑制薬 |
| TW232013B (de) * | 1992-04-24 | 1994-10-11 | Takeda Pharm Industry Co Ltd | |
| US5455252A (en) * | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
| DE69422450T2 (de) * | 1993-06-29 | 2000-06-08 | Takeda Chemical Industries, Ltd. | Chinoline oder Chinazolin-Derivate und deren Verwendung zur Herstellung eines Medikaments für die Behandlung von Osteoporose |
| US5475003A (en) * | 1994-03-03 | 1995-12-12 | Syntex (U.S.A.) Inc. | 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives |
| DE19528418A1 (de) * | 1995-08-02 | 1997-02-06 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
| ES2183023T3 (es) * | 1995-12-22 | 2003-03-16 | Kowa Co | Composicion farmaceutica estabilizada con un agente basico. |
| HRP970330B1 (en) * | 1996-07-08 | 2004-06-30 | Bayer Ag | Cycloalkano pyridines |
| DE19709125A1 (de) * | 1997-03-06 | 1998-09-10 | Bayer Ag | Substituierte Chinoline |
| DE19741051A1 (de) * | 1997-09-18 | 1999-03-25 | Bayer Ag | Hetero-Tetrahydrochinoline |
| IL143197A0 (en) | 1998-11-20 | 2002-04-21 | Rtp Pharma Inc | Dispersible phospholipid stabilized microparticles |
| SK8512001A3 (en) | 1999-01-14 | 2001-12-03 | Nissan Chemical Ind Ltd | Process for producing quinolinecarbaldehyde |
| WO2001060800A1 (en) | 2000-02-21 | 2001-08-23 | Kuraray Co., Ltd. | Processes for preparing quinoline derivatives and intermediates thereof |
| CN1329520C (zh) | 2001-02-02 | 2007-08-01 | 三菱化学株式会社 | 制备(3r,5s)－(e)－7－[2－环丙基－4－(4－氟苯基)－喹啉－3－基]－3,5－二羟基庚－6－烯酸酯的方法 |
| TWI309644B (de) * | 2001-02-14 | 2009-05-11 | Nissan Chemical Ind Ltd | |
| IL158151A0 (en) * | 2001-04-05 | 2004-03-28 | Nissan Chemical Ind Ltd | Method for preparing 7-quinolinyl-3, 5-dihydroxyhept-6-enoate |
| PT1386608E (pt) | 2001-04-19 | 2011-07-26 | Kowa Co | Agente terapêutico para doença glomerular |
| CN1261415C (zh) | 2001-05-30 | 2006-06-28 | 大赛璐化学工业株式会社 | 喹啉甲醛的制造方法 |
| BR0307303A (pt) | 2002-01-31 | 2005-01-11 | Novartis Ag | Processo para a fabricação de inibidores da hmg-coa redutase |
| GB0204129D0 (en) | 2002-02-21 | 2002-04-10 | Novartis Ag | Process for the manufacture of organic compounds |
| TW200305645A (en) | 2002-03-19 | 2003-11-01 | Mitsubishi Chem Corp | Novel carbonyl reductase, gene encoding the same and process for producing optically active alcohols using the same |
| KR20050072798A (ko) * | 2002-11-06 | 2005-07-12 | 닛산 가가쿠 고교 가부시키 가이샤 | 퀴놀린카르발데히드류의 제조 방법 |
| EP1592668A1 (de) | 2003-02-12 | 2005-11-09 | Ciba SC Holding AG | Kristalline formen von pitavastatin-calcium |
| EP1510208A1 (de) | 2003-08-22 | 2005-03-02 | Fournier Laboratories Ireland Limited | Metformin-Statin-Kombination enthaltende pharmazeutische Zusammensetzungen |
| TWI343914B (en) | 2003-10-03 | 2011-06-21 | Nissan Chemical Ind Ltd | Process for producing high purity 3,5-dihydroxy-6-heptenoic acid derivative |
| EP2284157A1 (de) | 2003-12-12 | 2011-02-16 | Wyeth | Quinolinen zur behandlung von cardiovascular krankheiten |
| US8309574B2 (en) | 2004-02-25 | 2012-11-13 | Kowa Company, Ltd. | Nuclear transfer promoter for Rac protein and method of screening the same |
| WO2005079847A1 (ja) * | 2004-02-25 | 2005-09-01 | Kowa Company, Ltd. | Cdc42タンパク質の核内移行促進剤及びそのスクリーニング方法 |
| GB0427491D0 (en) * | 2004-12-16 | 2005-01-19 | Avecia Ltd | Process and compounds |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| WO2007125547A2 (en) | 2006-05-03 | 2007-11-08 | Manne Satyanarayana Reddy | Novel process for statins and its pharmaceutically acceptable salts thereof |
| RS53084B (sr) | 2006-07-05 | 2014-06-30 | Takeda Gmbh | Kombinacija inhibitora hmg-coa reduktaze rosuvastatina sa inhibitorom fosfodiesteraze 4, kao što je roflumilast, roflumilast-n-oksid za lečenje inflamatornih plućnih obolenja |
| US8404841B2 (en) | 2006-10-09 | 2013-03-26 | Msn Laboratories Limited | Process for the preparation of statins and their pharmaceutically acceptable salts thereof |
| US20100086615A1 (en) | 2007-04-27 | 2010-04-08 | Kyushu University, National University Corporation | Agent for treatment of pulmonary disease |
| US8487105B2 (en) | 2009-01-19 | 2013-07-16 | Msn Laboratories Limited | Process for preparing pitavastatin, intermediates and pharmaceuctically acceptable salts thereof |
| US8987444B2 (en) | 2010-01-18 | 2015-03-24 | Msn Laboratories Private Limited | Process for the preparation of amide intermediates and their use thereof |
| JP2013516459A (ja) | 2010-01-20 | 2013-05-13 | カディラ・ヘルスケア・リミテッド | ピタバスタチン及び医薬として許容可能なそれらの塩の製造方法 |
| US8372877B2 (en) | 2010-04-16 | 2013-02-12 | Cumberland Pharmaceuticals | Stabilized statin formulations |
| TWI516264B (zh) * | 2010-05-06 | 2016-01-11 | 臺北醫學大學 | 芳香醯喹啉化合物 |
| WO2011141934A1 (en) | 2010-05-13 | 2011-11-17 | Matrix Laboratories Ltd. | An improved process for the preparation of an intermediate of hmg-coa reductase inhibitors |
| WO2012002741A2 (en) | 2010-07-01 | 2012-01-05 | Yuhan Corporation | Process for the preparation of hmg-coa reductase inhibitors and intermediates thereof |
| JP2013536219A (ja) | 2010-08-25 | 2013-09-19 | カディラ・ヘルスケア・リミテッド | ピタバスタチンカルシウムおよびその調製方法 |
| TW201219037A (en) | 2010-10-06 | 2012-05-16 | Univ Tokyo | Prophylactic and/or therapeutic agent against lymphedema |
| EP2751081B1 (de) | 2011-09-12 | 2017-01-04 | Farma GRS, d.o.o. | Polymorphe form von pitavastatin kalzium |
| JP6181063B2 (ja) | 2011-11-28 | 2017-08-16 | マイラン ラボラトリーズ リミテッドＭｙｌａｎ Ｌａｂｏｒａｔｏｒｉｅｓ Ｌｉｍｉｔｅｄ | ＨＭＧ−ＣｏＡレダクターゼ阻害剤の中間体の新規な製造方法 |
| CN103204807B (zh) * | 2013-04-08 | 2015-12-23 | 黄河三角洲京博化工研究院有限公司 | 一种2-环丙基-4-（4-氟-苯基）-3-喹啉甲醛的合成方法 |
| BR112015026513A2 (pt) | 2013-04-17 | 2017-07-25 | Pfizer | derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares |
| WO2014203045A1 (en) | 2013-06-20 | 2014-12-24 | Lupin Limited | A novel, green and cost effective process for synthesis of tert-butyl (3r,5s)-6-oxo-3,5-dihydroxy-3,5-o-isopropylidene-hexanoate |
| CN103483252B (zh) * | 2013-09-04 | 2015-07-22 | 黄河三角洲京博化工研究院有限公司 | 一种2-环丙基-4-(4-氟苯基)-3-喹啉甲醇的合成方法 |
| CN103508948A (zh) * | 2013-10-17 | 2014-01-15 | 凯莱英医药集团（天津）股份有限公司 | 一种匹伐他汀钙的制备方法 |
| CN103694228B (zh) * | 2013-12-18 | 2018-08-28 | 北京华禧联合科技发展有限公司 | 一种制备匹伐他汀钙关键中间体的方法 |
| AU2015287284A1 (en) | 2014-07-09 | 2017-02-02 | Lupin Limited | Polymorphic forms of pitavastatin sodium |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| RS66416B1 (sr) | 2019-01-18 | 2025-02-28 | Astrazeneca Ab | 6'-[[(1s,3s)-3-[[5-(difluorometoksi)-2-pirimidinil]amino]ciklopentil]amino][1(2h),3'-bipiridin]-2-on kao inhibitor pcsk9 i metode njegove primene |
| EP4566591B1 (de) | 2023-12-07 | 2025-12-31 | KRKA, d.d., Novo mesto | Feste pharmazeutische darreichungsform mit ezetimibe und pitavastatin |
| TW202545529A (zh) | 2024-02-05 | 2025-12-01 | 瑞典商阿斯特捷利康公司 | 組合療法 |
| WO2025196153A1 (en) | 2024-03-20 | 2025-09-25 | Astrazeneca Ab | Pcsk9 inhibitors and methods of use thereof |
| WO2025196155A1 (en) | 2024-03-20 | 2025-09-25 | Astrazeneca Ab | Pcsk9 inhibitors and methods of use thereof |
| TW202539678A (zh) | 2024-03-20 | 2025-10-16 | 瑞典商阿斯特捷利康公司 | Ｐｃｓｋ９抑制劑及其使用方法 |
| WO2025238159A1 (en) | 2024-05-16 | 2025-11-20 | Astrazeneca Ab | Combination therapy comprising azd0780 and ezetimibe |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU570021B2 (en) * | 1982-11-22 | 1988-03-03 | Novartis Ag | Analogs of mevalolactone |
| FI860755A0 (fi) * | 1984-06-22 | 1986-02-20 | Sandoz Ag | Pyrazolanaloger av mevolonolakton och deras derivat, foerfaranden foer deras framstaellning samt deras andvaendning. |
| US4647576A (en) * | 1984-09-24 | 1987-03-03 | Warner-Lambert Company | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis |
| US4761419A (en) * | 1987-12-07 | 1988-08-02 | Warner-Lambert Company | 6-(((substituted)quinolinyl)ethyl)-and ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
-
1988
- 1988-08-17 CA CA000574999A patent/CA1336714C/en not_active Expired - Lifetime
- 1988-08-18 ES ES88113448T patent/ES2067460T3/es not_active Expired - Lifetime
- 1988-08-18 DE DE3852243T patent/DE3852243T2/de not_active Expired - Lifetime
- 1988-08-18 EP EP88113448A patent/EP0304063B1/de not_active Expired - Lifetime
- 1988-08-18 AT AT88113448T patent/ATE114645T1/de not_active IP Right Cessation
-
1995
- 1995-02-27 GR GR950400396T patent/GR3015186T3/el unknown
- 1995-06-20 HU HU95P/P00280P patent/HU211700A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3015186T3 (en) | 1995-05-31 |
| DE3852243D1 (de) | 1995-01-12 |
| DE3852243T2 (de) | 1995-06-14 |
| EP0304063A3 (en) | 1990-10-03 |
| ES2067460T3 (es) | 1995-04-01 |
| EP0304063A2 (de) | 1989-02-22 |
| CA1336714C (en) | 1995-08-15 |
| HU211700A9 (en) | 1995-12-28 |
| EP0304063B1 (de) | 1994-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |