ES2067460T3 - Mevalonolactonas de tipo quinolina. - Google Patents

Mevalonolactonas de tipo quinolina.

Info

Publication number
ES2067460T3
ES2067460T3 ES88113448T ES88113448T ES2067460T3 ES 2067460 T3 ES2067460 T3 ES 2067460T3 ES 88113448 T ES88113448 T ES 88113448T ES 88113448 T ES88113448 T ES 88113448T ES 2067460 T3 ES2067460 T3 ES 2067460T3
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
phenyl
chem
together form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88113448T
Other languages
English (en)
Inventor
Yoshihiro Nissan Fujikawa
Mikio Nissan Suzuki
Hiroshi Nissan Iwasaki
Mitsuaki Nissan Chem Sakashita
Masaki Nissan Chemica Kitahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Original Assignee
Nissan Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP63193606A external-priority patent/JP2569746B2/ja
Application filed by Nissan Chemical Corp filed Critical Nissan Chemical Corp
Application granted granted Critical
Publication of ES2067460T3 publication Critical patent/ES2067460T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN COMPUESTO DE FORMULA(I), EN LA QUE R1, R2, R3, R4 Y R6 SON INDEPENDIENTEMENTE HIDROGENO, O DIVERSOS GRUPOS ALQUILICOS O ALCOXI, GRUPOS FLUORADOS, HALOGENOS, GRUPOS AROMATICOS, ALQUILSILOXI, GRUPOS FLUORADOS, HALOGENOS, GRUPOS AROMATICOS, ALQUILSILOXI, ETC O TIENEN DIVERSAS RELACIONES ENTRE ELLOS; Y ES UN GRUPO - CH2 -, - CH2CH2 -, - CH = CH -, - CH2 - CH = CH - O - CH = CH - CH2 -; Z ES - Q - CH2WCH2CO2R12, O LOS GRUPOS (II), (III) O (IV) (INDICANDOSE LOS SIGNIFICADOS POSIBLES DE Q, R11, R12, R13 Y R17); Y R5 ES HIDROGENO, ALQUILO DE 1 A 6 C, ALQUENILO DE 2 A 3 C, CICLOALQUILO DE 3 A 6 C, EL GRUPO(V), (DONDE R9 ES HIDROGENO, ALQUILO DE 1 A 4 C, ALCOXI DE 1 A 3 C, FLUOR, CLORO, BROMO O TRIFLUORMETILO), FENIL - (CH2)M - (SIENDO M 1, 2 O3), - (CH2)NCH(CH3) - FENILO O FENIL - (CH2)NCH(CH3) (DONDE N ES 1 O 2).
ES88113448T 1987-08-20 1988-08-18 Mevalonolactonas de tipo quinolina. Expired - Lifetime ES2067460T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP20722487 1987-08-20
JP1558588 1988-01-26
JP63193606A JP2569746B2 (ja) 1987-08-20 1988-08-03 キノリン系メバロノラクトン類

Publications (1)

Publication Number Publication Date
ES2067460T3 true ES2067460T3 (es) 1995-04-01

Family

ID=27281072

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88113448T Expired - Lifetime ES2067460T3 (es) 1987-08-20 1988-08-18 Mevalonolactonas de tipo quinolina.

Country Status (7)

Country Link
EP (1) EP0304063B1 (es)
AT (1) ATE114645T1 (es)
CA (1) CA1336714C (es)
DE (1) DE3852243T2 (es)
ES (1) ES2067460T3 (es)
GR (1) GR3015186T3 (es)
HU (1) HU211700A9 (es)

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JP3130342B2 (ja) * 1991-10-04 2001-01-31 日産化学工業株式会社 動脈硬化性血管内膜肥厚抑制薬
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US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
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US5475003A (en) * 1994-03-03 1995-12-12 Syntex (U.S.A.) Inc. 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
DE19528418A1 (de) * 1995-08-02 1997-02-06 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
DE69625046T2 (de) * 1995-12-22 2003-04-10 Kowa Co., Ltd. Pharmazeutische zusammensetzung stabilisiert mit einem basischen medium
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DE19709125A1 (de) * 1997-03-06 1998-09-10 Bayer Ag Substituierte Chinoline
DE19741051A1 (de) * 1997-09-18 1999-03-25 Bayer Ag Hetero-Tetrahydrochinoline
US7939105B2 (en) 1998-11-20 2011-05-10 Jagotec Ag Process for preparing a rapidly dispersing solid drug dosage form
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CN101219992B (zh) 2003-02-12 2011-08-31 日产化学工业株式会社 匹伐他汀钙的晶形
EP1510208A1 (en) 2003-08-22 2005-03-02 Fournier Laboratories Ireland Limited Pharmaceutical composition comprising a combination of metformin and statin
TWI343914B (en) 2003-10-03 2011-06-21 Nissan Chemical Ind Ltd Process for producing high purity 3,5-dihydroxy-6-heptenoic acid derivative
PE20050676A1 (es) * 2003-12-12 2005-11-02 Wyeth Corp Quinolinas referidas a enfermedades cardiovasculares
JP4711952B2 (ja) * 2004-02-25 2011-06-29 興和株式会社 Ｒａｃタンパク質の核内移行促進剤及びそのスクリーニング方法
EP1719525B1 (en) * 2004-02-25 2014-12-10 Kowa Company, Ltd. Nuclear transfer promoter for cdc42 protein and method of screening the same
GB0427491D0 (en) * 2004-12-16 2005-01-19 Avecia Ltd Process and compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US8455640B2 (en) 2006-05-03 2013-06-04 Msn Laboratories Limited Process for statins and its pharmaceutically acceptable salts thereof
ES2378281T3 (es) 2006-07-05 2012-04-10 Nycomed Gmbh Combinación de atorvastatina con un inhibidor de fosfodiesterasa 4 para el tratamiento de neumopatías inflamatorias
US8404841B2 (en) 2006-10-09 2013-03-26 Msn Laboratories Limited Process for the preparation of statins and their pharmaceutically acceptable salts thereof
ES2425969T3 (es) 2007-04-27 2013-10-18 Kyushu University, National University Corporation Agente para el tratamiento de enfermedades pulmonares
EP2387561A4 (en) 2009-01-19 2012-07-25 Msn Lab Ltd IMPROVED METHOD FOR THE PRODUCTION OF HIGH-PURITY (3R, 5S) -7- [2-CYCLOPROPYL-4- (4-FLUORPHENYL) CHINOLIN-3-YL] -3,5-DIHYDROXY-6 (E) -HEPTENIC ACID AND PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
WO2011086584A2 (en) 2010-01-18 2011-07-21 Msn Laboratories Limited Improved process for the preparation of amide intermediates and their use thereof
US20120022102A1 (en) 2010-01-20 2012-01-26 Cadila Healthcare Limited Method for preparation of pitavastatin and its pharmaceutical acceptable salts thereof
US8372877B2 (en) 2010-04-16 2013-02-12 Cumberland Pharmaceuticals Stabilized statin formulations
TWI516264B (zh) * 2010-05-06 2016-01-11 臺北醫學大學 芳香醯喹啉化合物
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CN105153010B (zh) 2010-07-01 2018-06-08 柳韩洋行 HMG-CoA还原酶抑制剂及其中间体的制备方法
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JPWO2012046772A1 (ja) 2010-10-06 2014-02-24 国立大学法人 東京大学 リンパ浮腫予防治療剤
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CN104066846B (zh) 2011-11-28 2018-09-25 迈兰实验室有限公司 采用南极假丝酵母脂肪酶b制备手性他汀侧链中间体的方法
CN103204807B (zh) * 2013-04-08 2015-12-23 黄河三角洲京博化工研究院有限公司 一种2-环丙基-4-（4-氟-苯基）-3-喹啉甲醛的合成方法
SG11201507496UA (en) 2013-04-17 2015-11-27 Pfizer N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2014203045A1 (en) 2013-06-20 2014-12-24 Lupin Limited A novel, green and cost effective process for synthesis of tert-butyl (3r,5s)-6-oxo-3,5-dihydroxy-3,5-o-isopropylidene-hexanoate
CN103483252B (zh) * 2013-09-04 2015-07-22 黄河三角洲京博化工研究院有限公司 一种2-环丙基-4-(4-氟苯基)-3-喹啉甲醇的合成方法
CN103508948A (zh) * 2013-10-17 2014-01-15 凯莱英医药集团（天津）股份有限公司 一种匹伐他汀钙的制备方法
CN103694228B (zh) * 2013-12-18 2018-08-28 北京华禧联合科技发展有限公司 一种制备匹伐他汀钙关键中间体的方法
US9969691B2 (en) 2014-07-09 2018-05-15 Lupin Limited Polymorphic forms of pitavastatin sodium
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
US11248001B2 (en) 2019-01-18 2022-02-15 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof
ES3066472T3 (en) 2023-12-07 2026-05-13 Krka D D Novo Mesto Solid pharmaceutical dosage form comprising ezetimibe and pitavastatin
TW202545529A (zh) 2024-02-05 2025-12-01 瑞典商阿斯特捷利康公司 組合療法
TW202539678A (zh) 2024-03-20 2025-10-16 瑞典商阿斯特捷利康公司 Ｐｃｓｋ９抑制劑及其使用方法
TW202602866A (zh) 2024-03-20 2026-01-16 瑞典商阿斯特捷利康公司 Ｐｃｓｋ９抑制劑及其使用方法
TW202602886A (zh) 2024-03-20 2026-01-16 瑞典商阿斯特捷利康公司 Ｐｃｓｋ９抑制劑及其使用方法
WO2025238159A1 (en) 2024-05-16 2025-11-20 Astrazeneca Ab Combination therapy comprising azd0780 and ezetimibe

Family Cites Families (4)

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Also Published As

Publication number Publication date
ATE114645T1 (de) 1994-12-15
HU211700A9 (en) 1995-12-28
GR3015186T3 (en) 1995-05-31
DE3852243T2 (de) 1995-06-14
EP0304063B1 (en) 1994-11-30
EP0304063A3 (en) 1990-10-03
CA1336714C (en) 1995-08-15
EP0304063A2 (en) 1989-02-22
DE3852243D1 (de) 1995-01-12

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