ATE114654T1 - 2-(heterocyclylthio)carbapenemderivate, deren herstellung und deren verwendung als antibiotika. - Google Patents
2-(heterocyclylthio)carbapenemderivate, deren herstellung und deren verwendung als antibiotika.Info
- Publication number
- ATE114654T1 ATE114654T1 AT89303216T AT89303216T ATE114654T1 AT E114654 T1 ATE114654 T1 AT E114654T1 AT 89303216 T AT89303216 T AT 89303216T AT 89303216 T AT89303216 T AT 89303216T AT E114654 T1 ATE114654 T1 AT E114654T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen
- carboxy
- formula
- alkyl
- alkanoyl
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 229940088710 antibiotic agent Drugs 0.000 title abstract 2
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical class C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001589 carboacyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001768 cations Chemical class 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8097488 | 1988-04-01 | ||
| JP11164088 | 1988-05-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE114654T1 true ATE114654T1 (de) | 1994-12-15 |
Family
ID=26421941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89303216T ATE114654T1 (de) | 1988-04-01 | 1989-03-31 | 2-(heterocyclylthio)carbapenemderivate, deren herstellung und deren verwendung als antibiotika. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5104867A (de) |
| EP (2) | EP0337637B1 (de) |
| KR (2) | KR0133071B1 (de) |
| AT (1) | ATE114654T1 (de) |
| AU (1) | AU615729B2 (de) |
| CA (1) | CA1336092C (de) |
| DE (1) | DE68919508T2 (de) |
| DK (2) | DK175029B1 (de) |
| ES (1) | ES2067534T3 (de) |
| FI (1) | FI91258C (de) |
| GR (1) | GR3015128T3 (de) |
| HK (1) | HK1005733A1 (de) |
| HU (2) | HU204275B (de) |
| IE (2) | IE66711B1 (de) |
| NO (1) | NO168304C (de) |
| NZ (1) | NZ228589A (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6425779A (en) * | 1987-04-11 | 1989-01-27 | Lederle Japan Ltd | (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative |
| US5227376A (en) * | 1990-02-14 | 1993-07-13 | Sumitomo Pharmaceuticals Co., Ltd. | β-lactam compounds and their production |
| CA2050255C (en) * | 1990-09-07 | 1997-02-04 | Tameo Iwasaki | 1-methylcarbapenem derivatives and process for preparation thereof |
| US5208348A (en) * | 1990-09-07 | 1993-05-04 | Tanabe Seiyaku Co., Ltd. | Mercaptan compound |
| GB9122988D0 (en) * | 1991-10-30 | 1991-12-18 | Ici Plc | Heterocyclic compounds |
| GB9127279D0 (en) * | 1991-12-23 | 1992-02-19 | Ici Plc | Heterocyclic derivatives |
| EP0596058A1 (de) * | 1992-04-10 | 1994-05-11 | Zeneca Limited | Biphenylylchinuclidine Derivate als squalen synthase Inhibitoren. |
| GB9211796D0 (en) * | 1992-06-04 | 1992-07-15 | Ici Plc | Heterocyclic derivatives |
| GB9216721D0 (en) * | 1992-08-06 | 1992-09-23 | Ici Plc | Therapeutic heterocyclic derivatives |
| JP2696807B2 (ja) * | 1992-08-06 | 1998-01-14 | 田辺製薬株式会社 | カルバペネム誘導体の製法 |
| GB9218334D0 (en) * | 1992-08-28 | 1992-10-14 | Ici Plc | Heterocyclic compounds |
| US5631363A (en) * | 1992-11-13 | 1997-05-20 | Tanabe Seiyaku Co., Ltd. | Azetidinone compound and process for preparation thereof |
| US5442055A (en) * | 1992-11-13 | 1995-08-15 | Tanabe Seiyaku Co., Ltd. | Azetidinone compound and process for preparation thereof |
| US6011150A (en) * | 1992-11-13 | 2000-01-04 | Tanabe Seiyaku Co., Ltd. | Azetidinone compound and process for preparation thereof |
| EP0599512B1 (de) * | 1992-11-17 | 1999-03-24 | Sankyo Company Limited | Krystallines Carbapenemderivat |
| GB9226573D0 (en) * | 1992-12-21 | 1993-02-17 | Ici Plc | Heterocyclic compounds |
| JP2701685B2 (ja) * | 1992-12-28 | 1998-01-21 | 田辺製薬株式会社 | 光学活性４−メルカプト−２−ピロリドン誘導体及びその合成中間体の製法 |
| US5495012A (en) * | 1992-12-28 | 1996-02-27 | Tanabe Seiyaku Co., Ltd. | Process for preparing optically active 4-mercapto-2-pyrrolidone derivative and intermediate therefor |
| IL109451A0 (en) * | 1993-04-29 | 1994-07-31 | Zeneca Ltd | Heterocyclic derivatives |
| AU4912393A (en) * | 1993-06-15 | 1994-12-22 | Dong Kook Pharmaceutical Co., Ltd. | 1-beta-methyl-2-thiolic carbapenem derivatives |
| US5550229A (en) * | 1993-06-23 | 1996-08-27 | Tanabe Seiyaku Co., Ltd. | Alkylation process for preparing azetidinone compound and starting compound therefor |
| JP2969616B2 (ja) * | 1994-11-24 | 1999-11-02 | 田辺製薬株式会社 | ４−メルカプトピロリジン化合物の製法 |
| JPH09143156A (ja) | 1995-11-17 | 1997-06-03 | Tanabe Seiyaku Co Ltd | アセトキシアゼチジノン誘導体の製法及びその合成中間体 |
| TW420681B (en) * | 1995-12-08 | 2001-02-01 | Lederle Japan Ltd | Carbapenem-3-carboxylic acid ester derivatives |
| CA2252723A1 (en) * | 1996-04-26 | 1997-11-06 | Sankyo Company, Limited | 1-methylcarbapenem derivatives |
| JPH1077285A (ja) | 1996-09-04 | 1998-03-24 | Sumitomo Pharmaceut Co Ltd | 新規なβ−ラクタム化合物およびその製造法 |
| RU2222540C2 (ru) | 1998-05-01 | 2004-01-27 | Киото Фармасьютикал Индастриз, Лтд. | Производные карбапенема, их применение и промежуточные соединения для их получения |
| US6599895B1 (en) | 1998-05-08 | 2003-07-29 | Sumitomo Pharmaceuticals Company, Limited | β-lactam compounds and process for producing the same |
| WO2000042041A1 (en) * | 1999-01-13 | 2000-07-20 | Sankyo Company, Limited | Carbapenem ester compounds |
| EP1204657A1 (de) * | 1999-08-18 | 2002-05-15 | Schering Aktiengesellschaft | Piperidine- und pyrrolidinederivate mit neuronaler wirkung |
| NZ530170A (en) * | 2001-05-21 | 2005-09-30 | Kyoto Pharma Ind | Carbapenem compound |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| WO2004089954A1 (ja) * | 2003-04-08 | 2004-10-21 | Sumitomo Pharmaceuticals Co., Ltd. | 新規なカルバペネム化合物 |
| WO2006025475A1 (ja) * | 2004-09-03 | 2006-03-09 | Dainippon Sumitomo Pharma Co., Ltd. | 新規なカルバペネム化合物 |
| US7932381B2 (en) * | 2005-02-15 | 2011-04-26 | Shionogi & Co., Ltd. | Process for producing carbapenem derivative and intermediate crystal therefor |
| WO2006103999A1 (ja) * | 2005-03-25 | 2006-10-05 | Dainippon Sumitomo Pharma Co., Ltd. | 新規なカルバペネム化合物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0017992A1 (de) * | 1979-04-19 | 1980-10-29 | Merck & Co. Inc. | 2-Substituierte-6-substituierte-1-Carbadethiapen-2-em-3-carbonsäuren, Verfahren zu ihrer Herstellung, sie enthaltende antibiotische pharmazeutische Zusammensetzungen und Verfahren zur Herstellung von Zwischenprodukten |
| FR2508440B1 (fr) * | 1981-06-25 | 1985-11-08 | Saint Gobain Isover | Procede de preparation d'alcools orthohydroxybenzyliques |
| JPS58198486A (ja) * | 1982-05-14 | 1983-11-18 | Sankyo Co Ltd | ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法 |
| US4552873A (en) * | 1981-08-19 | 1985-11-12 | Sankyo Company Limited | Carbapenem compounds, and compositions containing them |
| US4665170A (en) * | 1982-06-18 | 1987-05-12 | Bristol-Myers Company | Carbapenem antibiotics |
| US4640799A (en) * | 1982-06-18 | 1987-02-03 | Bristol-Myers Company | Carbapenem antibiotics |
| CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
| JPS60202886A (ja) * | 1984-03-27 | 1985-10-14 | Sankyo Co Ltd | １―置換カルバペネム―３―カルボン酸誘導体 |
| CA1273011A (en) * | 1984-07-02 | 1990-08-21 | Susan M. Schmitt | Carbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkylthio substituent |
| CA1272719A (en) * | 1986-03-06 | 1990-08-14 | Pierre Dextraze | Carbapenem antibiotics |
-
1989
- 1989-03-31 AT AT89303216T patent/ATE114654T1/de not_active IP Right Cessation
- 1989-03-31 EP EP89303216A patent/EP0337637B1/de not_active Expired - Lifetime
- 1989-03-31 NO NO891364A patent/NO168304C/no not_active IP Right Cessation
- 1989-03-31 EP EP94100573A patent/EP0597821A1/de not_active Ceased
- 1989-03-31 IE IE103589A patent/IE66711B1/en not_active IP Right Cessation
- 1989-03-31 FI FI891572A patent/FI91258C/fi not_active IP Right Cessation
- 1989-03-31 IE IE950607A patent/IE950607L/xx not_active IP Right Cessation
- 1989-03-31 DE DE68919508T patent/DE68919508T2/de not_active Expired - Fee Related
- 1989-03-31 DK DK198901580A patent/DK175029B1/da not_active IP Right Cessation
- 1989-03-31 ES ES89303216T patent/ES2067534T3/es not_active Expired - Lifetime
- 1989-04-01 KR KR1019890004321A patent/KR0133071B1/ko not_active Expired - Fee Related
- 1989-04-01 HU HU891629A patent/HU204275B/hu not_active IP Right Cessation
- 1989-04-03 AU AU32386/89A patent/AU615729B2/en not_active Ceased
- 1989-04-03 CA CA000595556A patent/CA1336092C/en not_active Expired - Fee Related
- 1989-04-03 NZ NZ228589A patent/NZ228589A/en unknown
-
1990
- 1990-06-20 US US07/540,878 patent/US5104867A/en not_active Expired - Lifetime
-
1995
- 1995-02-22 GR GR950400348T patent/GR3015128T3/el unknown
- 1995-06-29 HU HU95P/P00545P patent/HU211836A9/hu unknown
-
1997
- 1997-08-16 KR KR1019970039082A patent/KR0132907B1/ko not_active Expired - Fee Related
-
1998
- 1998-06-03 HK HK98104834A patent/HK1005733A1/en not_active IP Right Cessation
- 1998-11-30 DK DK199801576A patent/DK199801576A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0337637B1 (de) | 1994-11-30 |
| HUT50178A (en) | 1989-12-28 |
| NO168304C (no) | 1992-02-05 |
| NO891364L (no) | 1990-02-08 |
| HU204275B (en) | 1991-12-30 |
| HU211836A9 (en) | 1995-12-28 |
| ES2067534T3 (es) | 1995-04-01 |
| EP0337637A1 (de) | 1989-10-18 |
| IE66711B1 (en) | 1996-01-24 |
| FI891572A7 (fi) | 1989-10-02 |
| DE68919508D1 (de) | 1995-01-12 |
| CA1336092C (en) | 1995-06-27 |
| DE68919508T2 (de) | 1995-07-20 |
| DK158089A (da) | 1989-10-02 |
| NO891364D0 (no) | 1989-03-31 |
| DK199801576A (da) | 1998-11-30 |
| FI891572A0 (fi) | 1989-03-31 |
| KR0133071B1 (ko) | 1998-04-17 |
| DK158089D0 (da) | 1989-03-31 |
| IE950607L (en) | 1989-10-01 |
| NZ228589A (en) | 1991-06-25 |
| AU3238689A (en) | 1989-10-05 |
| HK1005733A1 (en) | 1999-01-22 |
| FI91258C (fi) | 1994-06-10 |
| DK175029B1 (da) | 2004-05-03 |
| FI91258B (fi) | 1994-02-28 |
| AU615729B2 (en) | 1991-10-10 |
| KR890016045A (ko) | 1989-11-28 |
| US5104867A (en) | 1992-04-14 |
| EP0597821A1 (de) | 1994-05-18 |
| NO168304B (no) | 1991-10-28 |
| IE891035L (en) | 1989-10-01 |
| KR0132907B1 (ko) | 1998-04-17 |
| GR3015128T3 (en) | 1995-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE114654T1 (de) | 2-(heterocyclylthio)carbapenemderivate, deren herstellung und deren verwendung als antibiotika. | |
| FI885594A0 (fi) | Tiazolidindioner anvaendbara foer saenkande av blodsockerhalten samt atherosklerosis hindrande medel. | |
| ATE42952T1 (de) | Carbapenem-derivate, deren herstellung und sie enthaltende zusammensetzungen. | |
| AU6601294A (en) | Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses | |
| PL309874A1 (en) | Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives | |
| AU626740B2 (en) | Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments | |
| AU3181789A (en) | 4-amino-3-acylquinoline derivatives and their use as inhibitors of gastric secretion | |
| PT92524A (pt) | Processo para a preparacao de derivados de indole | |
| AU1507888A (en) | New bicyclic compounds, processes for preparation thereof and pharmaceutical composition comprising the same | |
| DE69416191D1 (de) | Spiropyran-Derivate mit photochromischen Eigenschaften | |
| AU4889496A (en) | Pyrrolocarbazole derivatives | |
| ATE218562T1 (de) | Substituierte aminochinazolinon (thion) derivate und deren sälze, deren zwischenprodukten und pestkontrollemittel und deren verwendungsmittel | |
| HUT51597A (en) | Process for production of derivatives of n,n-disubstituated diaryl-alcane-carbonic acid amid and medical compositions containing them as active substances | |
| AU686104B2 (en) | Substituted amidinonaphthyl ester derivatives | |
| AU7424394A (en) | 3- or 4-glycosyloxybenzopyran derivatives and antiallergic agents containing the derivatives as active ingredients | |
| FI103885B1 (fi) | Menetelmä terapeuttisesti aktiivisten 1-bentsyyli-4-fenyylipiperatsiinijohdannaisten valmistamiseksi ja välituotteina käyttökelpoisia yhdisteitä | |
| DE3661197D1 (en) | Oxadiazolylimidazobenzodiazepines, process for their preparation and pharmaceutical compositions | |
| AU657423B2 (en) | Novel piperidine derivatives and process for preparation thereof | |
| FI933928A0 (fi) | Heteroarenylpiperaziner, foerfarande foer framstaellning av dessa och anvaendning som laekemedel | |
| HUT51895A (en) | Process for production of antiflammation medical compositions containing derivatives of imidasole | |
| JO1681B1 (en) | Therapeutic agents |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |