ES2067534T3 - Derivados de 2-(heterocicliltio)carbapenemo, su preparacion y su aplicacion como antibioticos. - Google Patents

Derivados de 2-(heterocicliltio)carbapenemo, su preparacion y su aplicacion como antibioticos.

Info

Publication number
ES2067534T3
ES2067534T3 ES89303216T ES89303216T ES2067534T3 ES 2067534 T3 ES2067534 T3 ES 2067534T3 ES 89303216 T ES89303216 T ES 89303216T ES 89303216 T ES89303216 T ES 89303216T ES 2067534 T3 ES2067534 T3 ES 2067534T3
Authority
ES
Spain
Prior art keywords
alcoxy
alco
formula
alcanoyl
exp1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89303216T
Other languages
English (en)
Inventor
Isao Kawamoto
Teruo Tanaka
Rokuro Endo
Masao Miyauchi
Masayuki Iwata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2067534T3 publication Critical patent/ES2067534T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

COMPUESTOS DE FORMULA (I), EN LA QUE R EXP.A ES UN GRUPO DE FORMULA (II) O UN GRUPO DE FORMULA (III) (DONDE R EXP1 ES UN ENLACE QUE LO UNE CON EL RESTO DEL COMPUESTO, OTRO R EXP1 ES R (AL CUADRADO) Y LOS OTROS SON TODOS H), R EXP1 ES H O CH3, R (AL CUADRADO) ES H, ALQUILO OPCIONALMENTE SUSTITUIDO, HALOGENO, OH, ALCOXI, AMINO, ALCANOILAMINO, ALCANOILOXI, ALCANOILO, CARBOXI, ALCOXICARBONILO, CIANO, - S(O)JR EXP9 (DONDE J ES 0, 1 O 2 Y R EXP9 ES ALQUILO), O - CONR EXP6 R EXP7 (QUE ES CARBANOILO O HETEROCICLIL - CARBONILO OPCIONALMENTE SUSTITUIDO), R EXP2A ES H, ALQUILO O ALCANOILO, - NR EXP3 R EXP4 ESTA OPCIONALMENTE SUSTITUIDO CON AMINO O HETEROCICLICO, Y - COOR EXP5 ES CARBOXI, - COO EXP- , COOMX (SIENDO M UN CATION Y X LA RECIPROCA DE LA VALENCIA DEL CATION M) O CARBOXI PROTEGIDO. EL COMPUESTO DE FORMULA (I) TAMBIEN CONTIENE UN ANION; LAMBDA, M Y N SON INDEPENDIENTEMENTE 0, 1, 2 O 3, SUPUESTO QUE (M + N) ES UN ENTERO DE 2 A 6; P ES 0, 1 O 2; Y ES UN ENLACE SENCILLO, OXIGENO, AZUFRE O R EXP8 N < (DONDE R EXP8 ES H, ALQUILO O ALCANOILO). ESTOS COMPUESTOS Y SUS SALES Y ESTERES FARMACEUTICAMENTE ACEPTABLES SON ANTIBIOTICOS POTENCIALMENTE VALIOSOS.
ES89303216T 1988-04-01 1989-03-31 Derivados de 2-(heterocicliltio)carbapenemo, su preparacion y su aplicacion como antibioticos. Expired - Lifetime ES2067534T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8097488 1988-04-01
JP11164088 1988-05-10

Publications (1)

Publication Number Publication Date
ES2067534T3 true ES2067534T3 (es) 1995-04-01

Family

ID=26421941

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89303216T Expired - Lifetime ES2067534T3 (es) 1988-04-01 1989-03-31 Derivados de 2-(heterocicliltio)carbapenemo, su preparacion y su aplicacion como antibioticos.

Country Status (16)

Country Link
US (1) US5104867A (es)
EP (2) EP0597821A1 (es)
KR (2) KR0133071B1 (es)
AT (1) ATE114654T1 (es)
AU (1) AU615729B2 (es)
CA (1) CA1336092C (es)
DE (1) DE68919508T2 (es)
DK (2) DK175029B1 (es)
ES (1) ES2067534T3 (es)
FI (1) FI91258C (es)
GR (1) GR3015128T3 (es)
HK (1) HK1005733A1 (es)
HU (2) HU204275B (es)
IE (2) IE950607L (es)
NO (1) NO168304C (es)
NZ (1) NZ228589A (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6425779A (en) * 1987-04-11 1989-01-27 Lederle Japan Ltd (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative
US5227376A (en) * 1990-02-14 1993-07-13 Sumitomo Pharmaceuticals Co., Ltd. β-lactam compounds and their production
CA2050255C (en) * 1990-09-07 1997-02-04 Tameo Iwasaki 1-methylcarbapenem derivatives and process for preparation thereof
US5208348A (en) * 1990-09-07 1993-05-04 Tanabe Seiyaku Co., Ltd. Mercaptan compound
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
GB9127279D0 (en) * 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
AU3901393A (en) * 1992-04-10 1993-11-18 Zeneca Limited Biphenylylquinuclidine derivatives as squalene synthase inhibitors
GB9211796D0 (en) * 1992-06-04 1992-07-15 Ici Plc Heterocyclic derivatives
JP2696807B2 (ja) * 1992-08-06 1998-01-14 田辺製薬株式会社 カルバペネム誘導体の製法
GB9216721D0 (en) * 1992-08-06 1992-09-23 Ici Plc Therapeutic heterocyclic derivatives
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
US6011150A (en) * 1992-11-13 2000-01-04 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
US5442055A (en) * 1992-11-13 1995-08-15 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
US5631363A (en) * 1992-11-13 1997-05-20 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
ES2131560T3 (es) * 1992-11-17 1999-08-01 Sankyo Co Derivado de carbapenem cristalino.
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
JP2701685B2 (ja) * 1992-12-28 1998-01-21 田辺製薬株式会社 光学活性４−メルカプト−２−ピロリドン誘導体及びその合成中間体の製法
US5495012A (en) * 1992-12-28 1996-02-27 Tanabe Seiyaku Co., Ltd. Process for preparing optically active 4-mercapto-2-pyrrolidone derivative and intermediate therefor
IL109451A0 (en) * 1993-04-29 1994-07-31 Zeneca Ltd Heterocyclic derivatives
AU4912393A (en) * 1993-06-15 1994-12-22 Dong Kook Pharmaceutical Co., Ltd. 1-beta-methyl-2-thiolic carbapenem derivatives
US5550229A (en) * 1993-06-23 1996-08-27 Tanabe Seiyaku Co., Ltd. Alkylation process for preparing azetidinone compound and starting compound therefor
JP2969616B2 (ja) * 1994-11-24 1999-11-02 田辺製薬株式会社 ４−メルカプトピロリジン化合物の製法
JPH09143156A (ja) * 1995-11-17 1997-06-03 Tanabe Seiyaku Co Ltd アセトキシアゼチジノン誘導体の製法及びその合成中間体
TW420681B (en) * 1995-12-08 2001-02-01 Lederle Japan Ltd Carbapenem-3-carboxylic acid ester derivatives
RU2162088C2 (ru) * 1996-04-26 2001-01-20 Санкио Компани Лимитед 1-метилкарбапенем или его фармакологически приемлемые соли, композиция, способ предупреждения или лечения бактериальных инфекций
JPH1077285A (ja) 1996-09-04 1998-03-24 Sumitomo Pharmaceut Co Ltd 新規なβ−ラクタム化合物およびその製造法
NZ508493A (en) 1998-05-01 2002-06-28 Kyoto Pharma Ind Carbapenem derivatives, utilization thereof and intermediate compounds of the same
WO1999058536A1 (fr) 1998-05-08 1999-11-18 Sumitomo Pharmaceuticals Company, Limited NOUVEAUX COMPOSES β-LACTAM ET LEUR PROCEDE DE PREPARATION
AU2003000A (en) * 1999-01-13 2000-08-01 Sankyo Company Limited Carbapenem ester compounds
WO2001012622A1 (en) * 1999-08-18 2001-02-22 Schering Aktiengesellschaft Piperidine and pyrrolidine derivatives displaying neuronal activity
BR0209970A (pt) * 2001-05-21 2004-04-06 Kyoto Pharma Ind Composto de carbapenem
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
CA2519794A1 (en) * 2003-04-08 2004-10-21 Sumitomo Pharmaceuticals Co., Ltd. Novel carbapenem compounds
US20070265242A1 (en) * 2004-09-03 2007-11-15 Makoto Sunagawa Novel Carbapenem Compound
US7932381B2 (en) * 2005-02-15 2011-04-26 Shionogi & Co., Ltd. Process for producing carbapenem derivative and intermediate crystal therefor
WO2006103999A1 (ja) * 2005-03-25 2006-10-05 Dainippon Sumitomo Pharma Co., Ltd. 新規なカルバペネム化合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017992A1 (en) * 1979-04-19 1980-10-29 Merck & Co. Inc. 2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates
FR2508440B1 (fr) * 1981-06-25 1985-11-08 Saint Gobain Isover Procede de preparation d'alcools orthohydroxybenzyliques
JPS58198486A (ja) * 1982-05-14 1983-11-18 Sankyo Co Ltd ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
US4665170A (en) * 1982-06-18 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
US4640799A (en) * 1982-06-18 1987-02-03 Bristol-Myers Company Carbapenem antibiotics
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
CA1273011A (en) * 1984-07-02 1990-08-21 Susan M. Schmitt Carbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkylthio substituent
CA1272719A (en) * 1986-03-06 1990-08-14 Pierre Dextraze Carbapenem antibiotics

Also Published As

Publication number Publication date
DE68919508D1 (de) 1995-01-12
IE891035L (en) 1989-10-01
DK158089D0 (da) 1989-03-31
EP0337637B1 (en) 1994-11-30
FI891572A7 (fi) 1989-10-02
FI891572A0 (fi) 1989-03-31
KR890016045A (ko) 1989-11-28
US5104867A (en) 1992-04-14
AU615729B2 (en) 1991-10-10
CA1336092C (en) 1995-06-27
NZ228589A (en) 1991-06-25
EP0337637A1 (en) 1989-10-18
HUT50178A (en) 1989-12-28
KR0133071B1 (ko) 1998-04-17
NO168304B (no) 1991-10-28
HU204275B (en) 1991-12-30
HK1005733A1 (en) 1999-01-22
DE68919508T2 (de) 1995-07-20
NO891364D0 (no) 1989-03-31
DK158089A (da) 1989-10-02
NO168304C (no) 1992-02-05
FI91258C (fi) 1994-06-10
GR3015128T3 (en) 1995-05-31
ATE114654T1 (de) 1994-12-15
IE950607L (en) 1989-10-01
DK175029B1 (da) 2004-05-03
DK199801576A (da) 1998-11-30
HU211836A9 (en) 1995-12-28
EP0597821A1 (en) 1994-05-18
KR0132907B1 (ko) 1998-04-17
FI91258B (fi) 1994-02-28
NO891364L (no) 1990-02-08
AU3238689A (en) 1989-10-05
IE66711B1 (en) 1996-01-24

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