ATE114661T1 - Benzylphosphonsäure-tyrosinkinaseinhibitoren. - Google Patents

Benzylphosphonsäure-tyrosinkinaseinhibitoren.

Info

Publication number
ATE114661T1
ATE114661T1 AT91907740T AT91907740T ATE114661T1 AT E114661 T1 ATE114661 T1 AT E114661T1 AT 91907740 T AT91907740 T AT 91907740T AT 91907740 T AT91907740 T AT 91907740T AT E114661 T1 ATE114661 T1 AT E114661T1
Authority
AT
Austria
Prior art keywords
tyrosine kinase
pct
benzylphosphonic acid
kinase inhibitors
acid tyrosine
Prior art date
Application number
AT91907740T
Other languages
English (en)
Inventor
Robert Lee Dow
Steven Wayne Goldstein
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE114661T1 publication Critical patent/ATE114661T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3882—Arylalkanephosphonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
AT91907740T 1990-04-02 1991-03-14 Benzylphosphonsäure-tyrosinkinaseinhibitoren. ATE114661T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50318890A 1990-04-02 1990-04-02

Publications (1)

Publication Number Publication Date
ATE114661T1 true ATE114661T1 (de) 1994-12-15

Family

ID=24001079

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91907740T ATE114661T1 (de) 1990-04-02 1991-03-14 Benzylphosphonsäure-tyrosinkinaseinhibitoren.

Country Status (12)

Country Link
US (1) US5326905A (de)
EP (1) EP0526488B1 (de)
JP (1) JPH0662650B2 (de)
AT (1) ATE114661T1 (de)
CA (1) CA2078214C (de)
DE (1) DE69105495T2 (de)
DK (1) DK0526488T3 (de)
ES (1) ES2064101T3 (de)
FI (1) FI924427L (de)
IE (1) IE64067B1 (de)
PT (1) PT97214A (de)
WO (1) WO1991015495A1 (de)

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Also Published As

Publication number Publication date
JPH0662650B2 (ja) 1994-08-17
CA2078214C (en) 1995-03-28
DE69105495T2 (de) 1995-04-06
EP0526488B1 (de) 1994-11-30
JPH05502452A (ja) 1993-04-28
EP0526488A1 (de) 1993-02-10
PT97214A (pt) 1992-01-31
FI924427A0 (fi) 1992-10-01
DK0526488T3 (da) 1995-04-24
US5326905A (en) 1994-07-05
IE64067B1 (en) 1995-07-12
DE69105495D1 (en) 1995-01-12
IE911035A1 (en) 1991-10-09
FI924427A7 (fi) 1992-10-01
ES2064101T3 (es) 1995-01-16
FI924427L (fi) 1992-10-01
WO1991015495A1 (en) 1991-10-17

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