ATE114674T1 - Oligosaccharide von heparin mit einer affinität für faktoren von zellwachstum. - Google Patents

Oligosaccharide von heparin mit einer affinität für faktoren von zellwachstum.

Info

Publication number: ATE114674T1
Authority: AT; Austria
Prior art keywords: cell growth; affinity; growth factors; possessing; heparin oligosaccharides
Prior art date: 1986-04-17

Application number

AT87400884T

Other languages

English (en)

Inventor

Jean-Claude Lormeau

Maurice Petitou

Jean Choay

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-17

Filing date

1987-04-16

Publication date

1994-12-15

1987-04-16 Application filed by Sanofi Sa filed Critical Sanofi Sa

1994-12-15 Application granted granted Critical

1994-12-15 Publication of ATE114674T1 publication Critical patent/ATE114674T1/de

Links

230000010261 cell growth Effects 0.000 title abstract 2
239000003102 growth factor Substances 0.000 title abstract 2
229960002897 heparin Drugs 0.000 title abstract 2
229920000669 heparin Polymers 0.000 title abstract 2
229920001542 oligosaccharide Polymers 0.000 title abstract 2
-1 HEPARIN OLIGOSACCHARIDES Chemical class 0.000 title 1
125000000129 anionic group Chemical group 0.000 abstract 2
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
125000002091 cationic group Chemical group 0.000 abstract 1
238000000655 nuclear magnetic resonance spectrum Methods 0.000 abstract 1
150000002482 oligosaccharides Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Materials Engineering (AREA)
Polymers & Plastics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT87400884T 1986-04-17 1987-04-16 Oligosaccharide von heparin mit einer affinität für faktoren von zellwachstum. ATE114674T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8605546A FR2597484B1 (fr)	1986-04-17	1986-04-17	Glycosaminoglycanes de type heparine ou heparane-sulfate dotes d'une activite sur la division et la differentiation cellulaires, leur preparation et leurs applications therapeutiques.

Publications (1)

Publication Number	Publication Date
ATE114674T1 true ATE114674T1 (de)	1994-12-15

Family

ID=9334346

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87400884T ATE114674T1 (de)	1986-04-17	1987-04-16	Oligosaccharide von heparin mit einer affinität für faktoren von zellwachstum.

Country Status (8)

Country	Link
US (1)	US5034520A (de)
EP (1)	EP0244298B1 (de)
JP (1)	JPS6366192A (de)
AT (1)	ATE114674T1 (de)
CA (1)	CA1339925C (de)
DE (1)	DE3750785T2 (de)
FR (1)	FR2597484B1 (de)
PT (1)	PT84719B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5273900A (en) *	1987-04-28	1993-12-28	The Regents Of The University Of California	Method and apparatus for preparing composite skin replacement
PT93847A (pt) *	1989-04-24	1990-11-20	Harvard College	Processo para a preparacao de oligossacaridos de baixo peso molecular derivados de heparina ou de sulfato de heparano despolimerizados e de composicoes farmaceuticas que os contem
FI921689L (fi) *	1991-04-16	1992-10-17	Seikagagu Kogyo Kabushiki Kais	Oligosackarid med affinitet foer fibroblasttillvaextfaktor och foerfarande foer framstaellning av denna
US5145956A (en) *	1991-12-11	1992-09-08	Glycomed Incorporated	Method for separation of anionic oligosaccharides
GB9206291D0 (en) *	1992-03-23	1992-05-06	Cancer Res Campaign Tech	Oligosaccharides having growth factor binding affinity
GB2266239B (en) *	1992-03-25	1996-03-06	Jevco Ltd	Wound healing compositions containing chondroitin sulphate oligosaccharides
US6750207B1 (en)	1992-05-01	2004-06-15	Yeda Research And Development Co. Ltd.	Compositions for the regulation of cytokine activity
US5861382A (en) *	1992-05-01	1999-01-19	Yeda Research And Development Co. Ltd.	Methods for regulation of active TNF-α
FR2691066B1 (fr) *	1992-05-15	1995-06-09	Sanofi Elf	Utilisation de glycosaminoglycanes exogenes, de leurs analogues ainsi que de leurs fragments, fractions et derives, pour la preparation de medicaments destines au traitement de thrombopenies.
HUT70945A (en) *	1992-11-10	1995-11-28	Yeda Res & Dev	Compositions for the regulation of cytokine activity contg. oligosaccharides and process to prepare them
GB9306255D0 (en) *	1993-03-25	1993-05-19	Cancer Res Campaign Tech	Heparan sulphate oligosaccharides having hepatocyte growth factor binding affinity
US5583121A (en) *	1994-01-12	1996-12-10	Michigan State University	Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
US6127347A (en) *	1994-01-12	2000-10-03	Univ Michigan	Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
WO1996023003A1 (en) *	1995-01-27	1996-08-01	Amrad Operations Pty. Ltd.	A therapeutic molecule
AUPN261895A0 (en) *	1995-04-28	1995-05-18	Australian National University, The	Preparation and use of sulfated oligosaccharides
AU702500B2 (en) *	1995-04-28	1999-02-25	Australian National University, The	Preparation and use of sulfated oligosaccharides
US5646130A (en) *	1995-06-30	1997-07-08	Ocean University Of Oingdao	Low molecular weight sulfated polysaccharides and uses thereof
WO1999004801A1 (en) *	1997-07-28	1999-02-04	Rijks Universiteit Leiden	Use of sulfated glycosaminoglycans for treating of retinopathy
DE19747195A1 (de) *	1997-10-24	1999-04-29	Knoll Ag	Verwendung von Glykosaminoglykanen zur Herstellung von pharmazeutischen Zubereitungen zur Behandlung von mit Diabetes assoziierten Augenkrankheiten
JP4633232B2 (ja) *	2000-06-22	2011-02-16	生化学工業株式会社	成長因子誘導剤
AU2002236477A1 (en) *	2000-11-21	2002-06-03	The Texas A & M University System	Fgf-affinity chromatography
US7285536B2 (en) *	2001-12-05	2007-10-23	Yeda Research And Development Co., Ltd.	Anti-cancer therapeutic compounds
US20040171819A1 (en)	2002-10-10	2004-09-02	Aventis Pharma S.A.	Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
WO2005079817A1 (en) *	2004-02-18	2005-09-01	The Texas A & M University System	Affinity purified heparin/heparan sulfate for controlling the biological activity of the fgf receptor
US20060293275A1 (en) *	2004-03-29	2006-12-28	Toshikazu Nakamura	Hgf production accelerator containing heparin-like oligosaccharide
US20060183712A1 (en) *	2005-02-17	2006-08-17	The Texas A&M University System	Affinity purified heparin/heparan sulfate for controlling the biological activity of the FGF receptor
JP2006291028A (ja) *	2005-04-11	2006-10-26	Q P Corp	低分子ヘパリンまたはその塩、ならびにその製造方法
EP2356128A1 (de) *	2008-09-15	2011-08-17	Endotis Pharma	Oligosaccharidverbindungen zur verwendung bei der mobilisierung von stammzellen
FR2949115B1 (fr) *	2009-08-14	2012-11-02	Sanofi Aventis	OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL61201A (en) *	1979-10-05	1984-09-30	Choay Sa	Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
EP0114589B1 (de) *	1982-12-20	1987-09-23	The President And Fellows Of Harvard College	Hemmung der Gefässneubildung
FR2553287B1 (fr) *	1983-10-18	1986-09-12	Choay Sa	Compositions a base de mucopolysaccharides ou d'oligosaccharides, notamment a base de fractions ou fragments d'heparine, appropriees au traitement de desordres de la proliferation cellulaire
US4847338A (en) *	1985-03-28	1989-07-11	University Of Iowa Research Foundation	Low molecular weight heparin fragments as inhibitors of complement activation

1986
- 1986-04-17 FR FR8605546A patent/FR2597484B1/fr not_active Expired
1987
- 1987-04-16 PT PT84719A patent/PT84719B/pt not_active IP Right Cessation
- 1987-04-16 DE DE3750785T patent/DE3750785T2/de not_active Expired - Fee Related
- 1987-04-16 EP EP87400884A patent/EP0244298B1/de not_active Expired - Lifetime
- 1987-04-16 AT AT87400884T patent/ATE114674T1/de active
- 1987-04-16 JP JP62092122A patent/JPS6366192A/ja active Pending
- 1987-04-16 CA CA000535040A patent/CA1339925C/fr not_active Expired - Fee Related
- 1987-04-16 US US07/039,471 patent/US5034520A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT84719B (pt)	1989-12-29
US5034520A (en)	1991-07-23
EP0244298A2 (de)	1987-11-04
DE3750785D1 (de)	1995-01-12
EP0244298B1 (de)	1994-11-30
EP0244298A3 (en)	1988-09-21
DE3750785T2 (de)	1995-06-22
PT84719A (fr)	1987-05-01
FR2597484A1 (fr)	1987-10-23
FR2597484B1 (fr)	1988-12-23
CA1339925C (fr)	1998-06-23
JPS6366192A (ja)	1988-03-24

Publication	Publication Date	Title
DE3750785D1 (de)	1995-01-12	Oligosaccharide von Heparin mit einer Affinität für Faktoren von Zellwachstum.
DE68912249D1 (de)	1994-02-24	Einrichtung für Wartungsarbeiten, insbesondere für das Waschen von Isolatorketten an Hochspannungsleitungen.
DE3775359D1 (de)	1992-01-30	Pruefung von photodioden mit elektronenstrahlen.
NO910996D0 (no)	1991-03-13	Blekepreparat, samt fremgangsmaate for bleking.
FI873719L (fi)	1988-02-29	Alkoxisilanterminala, i fukt haerdande polyuretaner, samt deras anvaendning i lim- och taetningsmassor.
ES513896A0 (es)	1983-05-01	"un procedimiento para preparar hidrogeles que retienen la forma a base de colageno solubilizado, utiles por ejemplo para fines medicos y cosmeticos".
DE58906319D1 (de)	1994-01-13	Neigungskompensator für schnellfahrende fahrzeuge, insbesondere schienenfahrzeuge.
DE3767905D1 (de)	1991-03-14	Abnehmbahrer zapfen, insbesondere fuer das hebelwerk von textilmaschinen.
DE58907577D1 (de)	1994-06-01	Gleitlack für Elastomerteile.
DE59009718D1 (de)	1995-11-02	Rotor für Drucksortierer zum Sortieren von Fasersuspensionen.
DE69009380D1 (de)	1994-07-07	Chloroprenpolymerisat.
FI843498A0 (fi)	1984-09-06	Med polyisocyanatblandningar limmade papperprodukter.
ATE86490T1 (de)	1993-03-15	Tracheobronchodilatator.
DE69000546D1 (de)	1993-01-21	Dampferzeuger mit vorwaermung.
DE3854006D1 (de)	1995-07-27	Generator von periodischen Signalen, insbesondere für Schaltnetzteile.
ES2093458T3 (es)	1996-12-16	Procedimiento para la obtencion de 1,1,1,3,3-pentafluorpropano.
DE69017775D1 (de)	1995-04-20	Wasserstoffprüfgerät.
DE68916969D1 (de)	1994-08-25	Prüfung von elektrischen kreisen.
DE3870557D1 (de)	1992-06-04	Drehzylinder mit stiften fuer eine textilmaschine, einen oeffner, zerfaserungs-, reiss-maschine oder aehnliches.
DE68922304D1 (de)	1995-05-24	Scharnierverschluss für behälter.
DE69017227D1 (de)	1995-03-30	Zusatzschiene für boote.
PT93300A (pt)	1990-11-07	Processo para a sintese de proteinas utilizando vectores de expressao na levedura de cisao schizosaccharomyces pombe
FI891049L (fi)	1990-09-07	En eller flera lockfoersedda oeppningar i arbetspaln, i synnerhet diskbaenk i koek.
DE59006823D1 (de)	1994-09-22	Elektronenstrahlerzeuger für eine Elektronenstrahlkanone.
DE59009200D1 (de)	1995-07-13	Elektronenstrahlerzeuger, insbesondere für eine Elektronenstrahlkanone.