ATE115121T1 - 1-phenylalkyl-phenylharnstoff-derivate. - Google Patents
1-phenylalkyl-phenylharnstoff-derivate.Info
- Publication number
- ATE115121T1 ATE115121T1 AT90114966T AT90114966T ATE115121T1 AT E115121 T1 ATE115121 T1 AT E115121T1 AT 90114966 T AT90114966 T AT 90114966T AT 90114966 T AT90114966 T AT 90114966T AT E115121 T1 ATE115121 T1 AT E115121T1
- Authority
- AT
- Austria
- Prior art keywords
- carbon atoms
- phenylalkyl
- alkyl group
- phenylurea derivatives
- phenylurea
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000005577 familial hyperlipidemia Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
- C07C273/1827—X being H
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20242289 | 1989-08-04 | ||
| JP5006590 | 1990-03-01 | ||
| JP18584590A JPH03294256A (ja) | 1989-08-04 | 1990-07-13 | １―フェニルアルキル―３―フェニル尿素誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE115121T1 true ATE115121T1 (de) | 1994-12-15 |
Family
ID=27293825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90114966T ATE115121T1 (de) | 1989-08-04 | 1990-08-03 | 1-phenylalkyl-phenylharnstoff-derivate. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5126483A (de) |
| EP (1) | EP0415123B1 (de) |
| AT (1) | ATE115121T1 (de) |
| AU (1) | AU629376B2 (de) |
| CA (1) | CA2022346A1 (de) |
| DE (1) | DE69014775T2 (de) |
| DK (1) | DK0415123T3 (de) |
| ES (1) | ES2064557T3 (de) |
| GR (1) | GR3015275T3 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05310678A (ja) * | 1990-01-22 | 1993-11-22 | Mitsubishi Kasei Corp | １−フェニルアルキル−３−フェニル尿素誘導体 |
| IL100915A (en) * | 1991-02-19 | 1996-03-31 | Erba Carlo Spa | Disubstituted ureas and thioureas their preparation and pharmaceutical compositions containing them |
| FR2678938B1 (fr) * | 1991-07-10 | 1993-10-08 | Rhone Poulenc Rorer Sa | Derives de pyrrolidine, leur preparation et les medicaments les contenant. |
| DE4126662A1 (de) * | 1991-08-13 | 1993-02-18 | Boehringer Mannheim Gmbh | Neue 3,5-di-tert.butyl-4-hydroxyphenyl-derivate, verfahren zu ihrer herstellung und arzneimittel |
| WO1993024458A1 (en) * | 1992-05-28 | 1993-12-09 | Pfizer Inc. | New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a:cholesterol acyl transferase (acat) |
| CA2107196A1 (en) * | 1992-09-29 | 1994-03-30 | Mitsubishi Chemical Corporation | Carboxamide derivatives |
| US5441984A (en) * | 1994-01-06 | 1995-08-15 | Eli Lilly And Company | Urea, thiourea and guanidine derivatives |
| US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| HUP9602538A3 (en) | 1995-09-18 | 1997-08-28 | Sankyo Co | New urea and amide derivatives having acat inhibitory activity, their preparation and their use |
| EE200200429A (et) | 2000-02-02 | 2003-12-15 | Warner-Lambert Company | Kolesteroolestri ja vahaestri sünteesi duaalsed inhibiitorid rasunäärme häirete jaoks |
| JP5118120B2 (ja) * | 2009-12-16 | 2013-01-16 | エンパイア テクノロジー ディベロップメント エルエルシー | コンデンサ |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1471681A (de) * | 1965-03-25 | 1967-05-25 | ||
| US4623662A (en) * | 1985-05-23 | 1986-11-18 | American Cyanamid Company | Antiatherosclerotic ureas and thioureas |
| IE61716B1 (en) * | 1987-06-02 | 1994-11-30 | Warner Lambert Co | Antihyperlipidemic and antiatherosclerotic urea compounds |
| EP0297610B1 (de) * | 1987-07-02 | 1991-03-13 | Warner-Lambert Company | N-[(2,6-disubstituierte)-Phenyl]-Harnstoff und -Carbamat-Inhibitoren der Acyl-Coenzym A:Cholesterol-Acyltransferase |
| ATE98223T1 (de) * | 1988-03-30 | 1993-12-15 | Warner Lambert Co | N-(((2,6-disubstituierte)phenyl>n'- arylalkyl> harnstoffe als antihypercholesterolemische und antiatherosclerotische mittel. |
| US5116848A (en) * | 1988-03-30 | 1992-05-26 | Warner-Lambert Company | N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents |
| US4868210A (en) * | 1988-03-30 | 1989-09-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
-
1990
- 1990-07-31 CA CA002022346A patent/CA2022346A1/en not_active Abandoned
- 1990-07-31 AU AU60013/90A patent/AU629376B2/en not_active Ceased
- 1990-08-03 AT AT90114966T patent/ATE115121T1/de not_active IP Right Cessation
- 1990-08-03 US US07/562,337 patent/US5126483A/en not_active Expired - Fee Related
- 1990-08-03 DE DE69014775T patent/DE69014775T2/de not_active Expired - Fee Related
- 1990-08-03 EP EP90114966A patent/EP0415123B1/de not_active Expired - Lifetime
- 1990-08-03 DK DK90114966.6T patent/DK0415123T3/da active
- 1990-08-03 ES ES90114966T patent/ES2064557T3/es not_active Expired - Lifetime
-
1995
- 1995-03-03 GR GR940404117T patent/GR3015275T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0415123T3 (da) | 1995-02-13 |
| AU629376B2 (en) | 1992-10-01 |
| CA2022346A1 (en) | 1991-02-05 |
| US5126483A (en) | 1992-06-30 |
| DE69014775D1 (de) | 1995-01-19 |
| EP0415123B1 (de) | 1994-12-07 |
| AU6001390A (en) | 1991-02-07 |
| EP0415123A2 (de) | 1991-03-06 |
| ES2064557T3 (es) | 1995-02-01 |
| GR3015275T3 (en) | 1995-06-30 |
| DE69014775T2 (de) | 1995-05-18 |
| EP0415123A3 (en) | 1992-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEFA | Change of the company name | ||
| REN | Ceased due to non-payment of the annual fee |