ATE115126T1 - Muscarin-rezeptor-antagonisten. - Google Patents
Muscarin-rezeptor-antagonisten.Info
- Publication number
- ATE115126T1 ATE115126T1 AT90917056T AT90917056T ATE115126T1 AT E115126 T1 ATE115126 T1 AT E115126T1 AT 90917056 T AT90917056 T AT 90917056T AT 90917056 T AT90917056 T AT 90917056T AT E115126 T1 ATE115126 T1 AT E115126T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- pct
- receptor antagonists
- date jun
- sec
- Prior art date
Links
- UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 8
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- -1 -(CH2)nOH Chemical group 0.000 abstract 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898928042A GB8928042D0 (en) | 1989-12-12 | 1989-12-12 | Muscarinic receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE115126T1 true ATE115126T1 (de) | 1994-12-15 |
Family
ID=10667813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90917056T ATE115126T1 (de) | 1989-12-12 | 1990-11-28 | Muscarin-rezeptor-antagonisten. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5340831A (de) |
| EP (1) | EP0505376B1 (de) |
| JP (1) | JPH0678303B2 (de) |
| AT (1) | ATE115126T1 (de) |
| CA (1) | CA2069910C (de) |
| DE (1) | DE69014901T2 (de) |
| DK (1) | DK0505376T3 (de) |
| ES (1) | ES2064771T3 (de) |
| FI (1) | FI95027C (de) |
| GB (1) | GB8928042D0 (de) |
| GR (1) | GR3014907T3 (de) |
| IE (1) | IE64205B1 (de) |
| PT (1) | PT96144A (de) |
| WO (1) | WO1991009013A1 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639763A (en) * | 1994-03-01 | 1997-06-17 | Fmc Corporation | Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines |
| US5569664A (en) * | 1995-02-16 | 1996-10-29 | Fmc Corporation | Insecticidal n-(substituted arylmethyl)-4-[bis(substituted phenyl) methyl]pi |
| US6017931A (en) * | 1994-03-01 | 2000-01-25 | Fmc Corporation | Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines |
| WO1998024431A1 (en) * | 1996-12-02 | 1998-06-11 | Kyorin Pharmaceutical Co., Ltd. | Novel n-substituted pyrrolidine derivatives and process for preparing the same |
| US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| NZ537584A (en) | 2002-07-08 | 2006-07-28 | Ranbaxy Lab Ltd | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
| WO2004014853A1 (en) | 2002-07-31 | 2004-02-19 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
| AU2002321711A1 (en) | 2002-08-09 | 2004-02-25 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives useful as muscarinic receptor antagonist |
| JP2006501236A (ja) | 2002-08-23 | 2006-01-12 | ランバクシー ラボラトリーズ リミテッド | ムスカリン性レセプター拮抗薬としてのフルオロおよびスルホニルアミノ含有３，６−二置換アザビシクロ（３．１．０）ヘキサン誘導体 |
| TW200800953A (en) * | 2002-10-30 | 2008-01-01 | Theravance Inc | Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine |
| US7232835B2 (en) | 2002-12-10 | 2007-06-19 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo derivatives as muscarinic receptor antagonists |
| AU2002347552A1 (en) | 2002-12-23 | 2004-07-14 | Ranbaxy Laboratories Limited | 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists |
| AU2002347553A1 (en) | 2002-12-23 | 2004-07-14 | Ranbaxy Laboratories Limited | Flavaxate derivatives as muscarinic receptor antagonists |
| US7488748B2 (en) | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| WO2004089892A2 (en) | 2003-04-01 | 2004-10-21 | Theravance, Inc. | Diarylmethyl and related compounds having beta2 andrenergic receptor agonist and muscarinic receptor antagonist activity |
| WO2004089898A1 (en) | 2003-04-09 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| AU2003223010A1 (en) | 2003-04-10 | 2004-11-01 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| CA2521788A1 (en) | 2003-04-10 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| BRPI0409302A (pt) | 2003-04-11 | 2006-04-11 | Ranbaxy Lab Ltd | derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos |
| TW200510298A (en) | 2003-06-13 | 2005-03-16 | Theravance Inc | Substituted pyrrolidine and related compounds |
| JP2007524641A (ja) | 2003-07-11 | 2007-08-30 | セラヴァンス， インコーポレーテッド | 置換４−アミノ−１−ベンジルピペリジン化合物 |
| US7071224B2 (en) * | 2004-03-11 | 2006-07-04 | Theravance, Inc. | Diphenylmethyl compounds useful as muscarinic receptor antagonists |
| WO2005087763A1 (en) * | 2004-03-11 | 2005-09-22 | Theravance, Inc. | Diphenylmethyl compounds useful as muscarinic receptor antagonists |
| WO2007024113A1 (en) | 2005-08-25 | 2007-03-01 | Rstech Corporation | Process for the preparation of chiral 3-hydroxy pyrrolidine compound and derivatives thereof having high optical purity |
| WO2007045979A1 (en) | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of muscarinic receptor antagonists |
| WO2007076159A2 (en) * | 2005-12-27 | 2007-07-05 | Teva Pharmaceutical Industries Ltd. | Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof |
| CA2675942C (en) * | 2007-02-23 | 2016-04-12 | Theravance, Inc. | Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists |
| WO2008133900A1 (en) | 2007-04-24 | 2008-11-06 | Theravance, Inc. | Quaternary ammonium compounds useful as muscarinic receptor antagonists |
| JP5779100B2 (ja) | 2008-11-24 | 2015-09-16 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | 光学的に活性なｎ−ベンジル−３−ヒドロキシピロリジンの製造方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL76583A (en) * | 1984-10-19 | 1988-08-31 | Robins Co Inc A H | 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them |
| US4810713A (en) * | 1985-12-20 | 1989-03-07 | A. H. Robins Company, Incorporated | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment |
| EP0235463A3 (de) * | 1985-12-20 | 1990-01-17 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | N-substituierte Arylalkyl- und Arylalkylen-Piperidine und Anwendung als kardiovaskulär antihistaminische und antisekretorische Mittel |
| IN163948B (de) * | 1986-01-17 | 1988-12-10 | Robins Co Inc A H | |
| GB8906166D0 (en) * | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
| US5233053A (en) * | 1989-03-17 | 1993-08-03 | Pfizer Inc. | Pyrrolidine derivatives |
-
1989
- 1989-12-12 GB GB898928042A patent/GB8928042D0/en active Pending
-
1990
- 1990-11-28 AT AT90917056T patent/ATE115126T1/de not_active IP Right Cessation
- 1990-11-28 DE DE69014901T patent/DE69014901T2/de not_active Expired - Fee Related
- 1990-11-28 EP EP90917056A patent/EP0505376B1/de not_active Expired - Lifetime
- 1990-11-28 WO PCT/EP1990/002043 patent/WO1991009013A1/en not_active Ceased
- 1990-11-28 JP JP2515786A patent/JPH0678303B2/ja not_active Expired - Fee Related
- 1990-11-28 ES ES90917056T patent/ES2064771T3/es not_active Expired - Lifetime
- 1990-11-28 CA CA002069910A patent/CA2069910C/en not_active Expired - Fee Related
- 1990-11-28 DK DK90917056.5T patent/DK0505376T3/da active
- 1990-11-29 US US07/859,471 patent/US5340831A/en not_active Expired - Lifetime
- 1990-12-10 PT PT96144A patent/PT96144A/pt unknown
- 1990-12-11 IE IE446390A patent/IE64205B1/en not_active IP Right Cessation
-
1992
- 1992-05-22 FI FI922345A patent/FI95027C/fi not_active IP Right Cessation
-
1995
- 1995-02-01 GR GR940404057T patent/GR3014907T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI922345L (fi) | 1992-05-22 |
| WO1991009013A1 (en) | 1991-06-27 |
| FI922345A0 (fi) | 1992-05-22 |
| DK0505376T3 (da) | 1995-02-13 |
| IE64205B1 (en) | 1995-07-12 |
| US5340831A (en) | 1994-08-23 |
| PT96144A (pt) | 1991-09-30 |
| GB8928042D0 (en) | 1990-02-14 |
| EP0505376B1 (de) | 1994-12-07 |
| DE69014901T2 (de) | 1995-04-27 |
| GR3014907T3 (en) | 1995-05-31 |
| DE69014901D1 (de) | 1995-01-19 |
| EP0505376A1 (de) | 1992-09-30 |
| JPH04505927A (ja) | 1992-10-15 |
| CA2069910A1 (en) | 1991-06-13 |
| CA2069910C (en) | 1996-11-12 |
| JPH0678303B2 (ja) | 1994-10-05 |
| IE904463A1 (en) | 1991-06-19 |
| FI95027C (fi) | 1995-12-11 |
| ES2064771T3 (es) | 1995-02-01 |
| FI95027B (fi) | 1995-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |