ATE115126T1 - Muscarin-rezeptor-antagonisten. - Google Patents

Muscarin-rezeptor-antagonisten.

Info

Publication number: ATE115126T1
Authority: AT; Austria
Prior art keywords: alkyl; pct; receptor antagonists; date jun; sec
Prior art date: 1989-12-12

Application number

AT90917056T

Other languages

English (en)

Inventor

Alexander Roderick Mackenzie

Peter Edward Pfizer Cent Cross

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-12

Filing date

1990-11-28

Publication date

1994-12-15

1990-11-28 Application filed by Pfizer filed Critical Pfizer

1994-12-15 Application granted granted Critical

1994-12-15 Publication of ATE115126T1 publication Critical patent/ATE115126T1/de

Links

UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 8
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
-1 -(CH2)nOH Chemical group 0.000 abstract 1
229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

AT90917056T 1989-12-12 1990-11-28 Muscarin-rezeptor-antagonisten. ATE115126T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898928042A GB8928042D0 (en)	1989-12-12	1989-12-12	Muscarinic receptor antagonists

Publications (1)

Publication Number	Publication Date
ATE115126T1 true ATE115126T1 (de)	1994-12-15

Family

ID=10667813

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90917056T ATE115126T1 (de)	1989-12-12	1990-11-28	Muscarin-rezeptor-antagonisten.

Country Status (14)

Country	Link
US (1)	US5340831A (de)
EP (1)	EP0505376B1 (de)
JP (1)	JPH0678303B2 (de)
AT (1)	ATE115126T1 (de)
CA (1)	CA2069910C (de)
DE (1)	DE69014901T2 (de)
DK (1)	DK0505376T3 (de)
ES (1)	ES2064771T3 (de)
FI (1)	FI95027C (de)
GB (1)	GB8928042D0 (de)
GR (1)	GR3014907T3 (de)
IE (1)	IE64205B1 (de)
PT (1)	PT96144A (de)
WO (1)	WO1991009013A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6017931A (en) *	1994-03-01	2000-01-25	Fmc Corporation	Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US5569664A (en) *	1995-02-16	1996-10-29	Fmc Corporation	Insecticidal n-(substituted arylmethyl)-4-[bis(substituted phenyl) methyl]pi
US5639763A (en) *	1994-03-01	1997-06-17	Fmc Corporation	Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
JP4167302B2 (ja) *	1996-12-02	2008-10-15	杏林製薬株式会社	新規ｎ―置換ピロリジン誘導体及びその製造法
US6693202B1 (en) *	1999-02-16	2004-02-17	Theravance, Inc.	Muscarinic receptor antagonists
AU2002345266B2 (en)	2002-07-08	2009-07-02	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
HK1079787A1 (zh)	2002-07-31	2006-04-13	Ranbaxy Laboratories Limited	用作毒蕈碱受体拮抗剂的3，6-二取代的氮杂双环[3．1．0]己烷衍生物
WO2004014363A1 (en)	2002-08-09	2004-02-19	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonist
EP1534675B1 (de)	2002-08-23	2009-02-25	Ranbaxy Laboratories, Ltd.	Fluor- und sulfonylaminohaltige, 3,6-disubstituierte azabicyclo¬3.1.0 hexanderivate als muscarinrezeptorantagonisten
TWI295669B (en) *	2002-10-30	2008-04-11	Theravance Inc	Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
ATE400553T1 (de)	2002-12-10	2008-07-15	Ranbaxy Lab Ltd	3,6-disubstituierte azabicyclo 3.1.0 - hexanderivative als antagonisten des muscarinrezeptors
AU2002347552A1 (en)	2002-12-23	2004-07-14	Ranbaxy Laboratories Limited	1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
DE60225195T2 (de)	2002-12-23	2009-02-26	Ranbaxy Laboratories, Ltd.	Flavaxat-derivate als muscarin-rezeptor antagonisten
US7488748B2 (en)	2003-01-28	2009-02-10	Ranbaxy Laboratories Limited	3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
JP4767842B2 (ja)	2003-04-01	2011-09-07	セラヴァンス，インコーポレーテッド	β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物
EP1618091A1 (de)	2003-04-09	2006-01-25	Ranbaxy Laboratories, Ltd.	Substituierte azabicyclohexanderivate als antagonisten von muscarinrezeptoren
EA009059B1 (ru)	2003-04-10	2007-10-26	Рэнбакси Лабораториз Лимитед	Замещенные производные азабициклогексана в качестве антагонистов мускаринового рецептора
AU2003223010A1 (en)	2003-04-10	2004-11-01	Ranbaxy Laboratories Limited	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
JP2006522787A (ja)	2003-04-11	2006-10-05	ランバクシーラボラトリーズリミテッド	ムスカリン様受容体アンタゴニストとしてのアザビシクロ誘導体
TW200510298A (en)	2003-06-13	2005-03-16	Theravance Inc	Substituted pyrrolidine and related compounds
WO2005007645A1 (en)	2003-07-11	2005-01-27	Theravance, Inc.	Substituted 4-amino-1-benzylpiperidine compounds
EP1725525A1 (de) *	2004-03-11	2006-11-29	Theravance, Inc.	Als muscarinrezeptorantagonisten geeignete diphenylmethylverbindungen
JP2007528418A (ja) *	2004-03-11	2007-10-11	セラヴァンス，インコーポレーテッド	ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物
EP1926709A4 (de)	2005-08-25	2009-06-24	Rstech Corp	Verfahren zur herstellung einer chiralen 3-hydroxypyrrolidinverbindung und derivaten davon mit hoher optischer reinheit
AU2006305619A1 (en)	2005-10-19	2007-04-26	Ranbaxy Laboratories Limited	Pharmaceutical compositions of muscarinic receptor antagonists
US20070203221A1 (en) *	2005-12-27	2007-08-30	Valeriano Merli	Processes for preparing darifenacin hydrobromide
CA2675942C (en) *	2007-02-23	2016-04-12	Theravance, Inc.	Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists
US8202891B2 (en) *	2007-04-24	2012-06-19	Theravance, Inc.	Quaternary ammonium compounds useful as muscarinic receptor antagonists
US8445700B2 (en)	2008-11-24	2013-05-21	Council Of Scientific & Industrial Research	Process for the preparation of optically active N-benzyl-3 hydroxypyrrolidines

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL76583A (en) *	1984-10-19	1988-08-31	Robins Co Inc A H	1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them
US4810713A (en) *	1985-12-20	1989-03-07	A. H. Robins Company, Incorporated	Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
EP0228893A3 (de) *	1985-12-20	1990-01-03	A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation)	Durch Aryloxyalkyl-Gruppen N-substituierte Arylalkyl heterozyklische Amine in Allergieheilverfahren
IL78939A (en) *	1986-01-17	1990-04-29	Robins Co Inc A H	Pharmaceutical compositions containing n-substituted arylalkyl-and arylalkylene-piperidines and tetrahydropyridines and certain such novel compounds
GB8906166D0 (en) *	1989-03-17	1989-05-04	Pfizer Ltd	Therapeutic agents
US5233053A (en) *	1989-03-17	1993-08-03	Pfizer Inc.	Pyrrolidine derivatives

1989
- 1989-12-12 GB GB898928042A patent/GB8928042D0/en active Pending
1990
- 1990-11-28 EP EP90917056A patent/EP0505376B1/de not_active Expired - Lifetime
- 1990-11-28 DK DK90917056.5T patent/DK0505376T3/da active
- 1990-11-28 AT AT90917056T patent/ATE115126T1/de not_active IP Right Cessation
- 1990-11-28 CA CA002069910A patent/CA2069910C/en not_active Expired - Fee Related
- 1990-11-28 WO PCT/EP1990/002043 patent/WO1991009013A1/en not_active Ceased
- 1990-11-28 DE DE69014901T patent/DE69014901T2/de not_active Expired - Fee Related
- 1990-11-28 ES ES90917056T patent/ES2064771T3/es not_active Expired - Lifetime
- 1990-11-28 JP JP2515786A patent/JPH0678303B2/ja not_active Expired - Fee Related
- 1990-11-29 US US07/859,471 patent/US5340831A/en not_active Expired - Lifetime
- 1990-12-10 PT PT96144A patent/PT96144A/pt unknown
- 1990-12-11 IE IE446390A patent/IE64205B1/en not_active IP Right Cessation
1992
- 1992-05-22 FI FI922345A patent/FI95027C/fi not_active IP Right Cessation
1995
- 1995-02-01 GR GR940404057T patent/GR3014907T3/el unknown

Also Published As

Publication number	Publication date
IE904463A1 (en)	1991-06-19
EP0505376A1 (de)	1992-09-30
FI922345A0 (fi)	1992-05-22
GR3014907T3 (en)	1995-05-31
DK0505376T3 (da)	1995-02-13
FI95027C (fi)	1995-12-11
JPH04505927A (ja)	1992-10-15
FI95027B (fi)	1995-08-31
CA2069910A1 (en)	1991-06-13
GB8928042D0 (en)	1990-02-14
DE69014901D1 (de)	1995-01-19
CA2069910C (en)	1996-11-12
PT96144A (pt)	1991-09-30
EP0505376B1 (de)	1994-12-07
WO1991009013A1 (en)	1991-06-27
IE64205B1 (en)	1995-07-12
ES2064771T3 (es)	1995-02-01
JPH0678303B2 (ja)	1994-10-05
FI922345L (fi)	1992-05-22
DE69014901T2 (de)	1995-04-27
US5340831A (en)	1994-08-23

Legal Events

Date	Code	Title	Description
1995-06-15	UEP	Publication of translation of european patent specification
2009-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69014901D1 (de)	1995-01-19	Muscarin-rezeptor-antagonisten.
ES2082013T3 (es)	1996-03-16	Antagonistas de receptores muscarinicos.
DK0510003T3 (da)	1996-01-29	Piperidin-og pyrrolidinderivater
ATE102183T1 (de)	1994-03-15	Muscarin-rezeptor-antagonisten.
DK581486A (da)	1987-06-05	Antihypertensivt kombinationspraeparat
ATE64373T1 (de)	1991-06-15	Muscarin-rezeptor-antagonisten.
DE69010917D1 (de)	1994-08-25	Muscarin-rezeptor-antagonisten.
ES2087917T3 (es)	1996-08-01	Derivados de 1,2-dihidro-2-oxo-quinoxalinas, su preparacion y su aplicacion en terapeutica.
CA2069931A1 (en)	1991-07-07	Muscarinic receptor antagonists