ES2064771T3 - Antagonistas de los receptores muscarinicos. - Google Patents

Antagonistas de los receptores muscarinicos.

Info

Publication number
ES2064771T3
ES2064771T3 ES90917056T ES90917056T ES2064771T3 ES 2064771 T3 ES2064771 T3 ES 2064771T3 ES 90917056 T ES90917056 T ES 90917056T ES 90917056 T ES90917056 T ES 90917056T ES 2064771 T3 ES2064771 T3 ES 2064771T3
Authority
ES
Spain
Prior art keywords
alkyl
antagonists
muscarinic receptors
independently
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90917056T
Other languages
English (en)
Inventor
Alexander Roderick Mackenzie
Peter Edward Pfizer Cent Cross
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2064771T3 publication Critical patent/ES2064771T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

ANTAGONISTAS RECEPTORES MUSCARINICOS. ANTAGONISTAS RECEPTORES MUSCARINICOS CON LA FORMULA Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, EN LA QUE Y ES -CH2-, -(CH2)2-, -CH2O-, -(CH2)2O GRUPO CON LA FORMULA, EN DONDE R2 Y R3 SON INDEPENDIENTEMENTE H, C1-C4 ALQUILO, C1-C4 ALCOXI, -(CH2)NOH, HALO, TRIFLUOROMETILO, CIANO, -(CH2)NNR4R5, -CO(C1-C4 ALQUILO), -OCO(C1-C4 ALQUILO), -CH(OH)(C1-C4 ALQUILO), -C(OH)(C1-C4 ALQUILO)2, -SO2NH2, -(CH2)NCONR6R7 O -(CH2)NCOO(C1-C4 ALQUILO); R4 ES H O C1-C4 ALQUILO; R5 ES H, C1-C4 ALQUILO O C1-C4 ALQUILSULFONILO; R6 Y R7 SON CADA UNO INDEPENDIENTEMENTE H O C1-C4 ALQUILO; Y N ES 0, 1 O 2. LOS COMPUESTOS SON PARTICULARMENTE UTILES EN EL TRATAMIENTO DEL SINDROME DE INTESTINO IRRITABLE.
ES90917056T 1989-12-12 1990-11-28 Antagonistas de los receptores muscarinicos. Expired - Lifetime ES2064771T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898928042A GB8928042D0 (en) 1989-12-12 1989-12-12 Muscarinic receptor antagonists

Publications (1)

Publication Number Publication Date
ES2064771T3 true ES2064771T3 (es) 1995-02-01

Family

ID=10667813

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90917056T Expired - Lifetime ES2064771T3 (es) 1989-12-12 1990-11-28 Antagonistas de los receptores muscarinicos.

Country Status (14)

Country Link
US (1) US5340831A (es)
EP (1) EP0505376B1 (es)
JP (1) JPH0678303B2 (es)
AT (1) ATE115126T1 (es)
CA (1) CA2069910C (es)
DE (1) DE69014901T2 (es)
DK (1) DK0505376T3 (es)
ES (1) ES2064771T3 (es)
FI (1) FI95027C (es)
GB (1) GB8928042D0 (es)
GR (1) GR3014907T3 (es)
IE (1) IE64205B1 (es)
PT (1) PT96144A (es)
WO (1) WO1991009013A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639763A (en) * 1994-03-01 1997-06-17 Fmc Corporation Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US5569664A (en) * 1995-02-16 1996-10-29 Fmc Corporation Insecticidal n-(substituted arylmethyl)-4-[bis(substituted phenyl) methyl]pi
US6017931A (en) * 1994-03-01 2000-01-25 Fmc Corporation Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
ATE235903T1 (de) * 1996-12-02 2003-04-15 Kyorin Seiyaku Kk Neue derivate von n-substituierten pyrrolidin derivaten und deren herstellungsverfahren
US6693202B1 (en) 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
AU2002345266B2 (en) 2002-07-08 2009-07-02 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
HK1079787A1 (zh) 2002-07-31 2006-04-13 Ranbaxy Laboratories Limited 用作毒蕈碱受体拮抗剂的3，6-二取代的氮杂双环[3．1．0]己烷衍生物
HK1079708A1 (zh) 2002-08-09 2006-04-13 Ranbaxy Laboratories, Ltd. 可用作毒蕈碱性受体拮抗剂的3，6-二取代氮杂二环[3．1．10]己烷衍生物
JP2006501236A (ja) 2002-08-23 2006-01-12 ランバクシー ラボラトリーズ リミテッド ムスカリン性レセプター拮抗薬としてのフルオロおよびスルホニルアミノ含有３，６−二置換アザビシクロ（３．１．０）ヘキサン誘導体
TW200800953A (en) * 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
US7232835B2 (en) 2002-12-10 2007-06-19 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo derivatives as muscarinic receptor antagonists
EP1581522B1 (en) 2002-12-23 2008-02-20 Ranbaxy Laboratories Limited Flavaxate derivatives as muscarinic receptor antagonists
AU2002347552A1 (en) 2002-12-23 2004-07-14 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
JP4767842B2 (ja) 2003-04-01 2011-09-07 セラヴァンス， インコーポレーテッド β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物
WO2004089898A1 (en) 2003-04-09 2004-10-21 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2003223010A1 (en) 2003-04-10 2004-11-01 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
DE60313898T2 (de) 2003-04-10 2008-01-17 Ranbaxy Laboratories, Ltd. Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten
EA009387B1 (ru) 2003-04-11 2007-12-28 Рэнбакси Лабораториз Лимитед Азабициклические производные в качестве антагонистов мускаринового рецептора
TW200510298A (en) 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
WO2005007645A1 (en) 2003-07-11 2005-01-27 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
EP1725525A1 (en) * 2004-03-11 2006-11-29 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
EP1723142A1 (en) * 2004-03-11 2006-11-22 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
WO2007024113A1 (en) 2005-08-25 2007-03-01 Rstech Corporation Process for the preparation of chiral 3-hydroxy pyrrolidine compound and derivatives thereof having high optical purity
RU2008119323A (ru) 2005-10-19 2009-11-27 Рэнбакси Лабораториз Лимитед (In) Фармацевтические композиции мускаринового рецептора
EP1966179A2 (en) * 2005-12-27 2008-09-10 Teva Pharmaceutical Industries Ltd Darifenacin hydrobromide composition substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof
ES2554646T3 (es) * 2007-02-23 2015-12-22 Theravance Biopharma R&D Ip, Llc Compuestos de difenilmetilo de amonio cuaternario, de utilidad como antagonistas de receptores muscarínicos
CA2682032A1 (en) 2007-04-24 2008-11-06 Theravance, Inc. Quaternary ammonium compounds useful as muscarinic receptor antagonists
US8445700B2 (en) 2008-11-24 2013-05-21 Council Of Scientific & Industrial Research Process for the preparation of optically active N-benzyl-3 hydroxypyrrolidines

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL76583A (en) * 1984-10-19 1988-08-31 Robins Co Inc A H 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them
EP0235463A3 (en) * 1985-12-20 1990-01-17 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
IL78939A (en) * 1986-01-17 1990-04-29 Robins Co Inc A H Pharmaceutical compositions containing n-substituted arylalkyl-and arylalkylene-piperidines and tetrahydropyridines and certain such novel compounds
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
US5233053A (en) * 1989-03-17 1993-08-03 Pfizer Inc. Pyrrolidine derivatives

Also Published As

Publication number Publication date
CA2069910A1 (en) 1991-06-13
DK0505376T3 (da) 1995-02-13
ATE115126T1 (de) 1994-12-15
GB8928042D0 (en) 1990-02-14
JPH04505927A (ja) 1992-10-15
PT96144A (pt) 1991-09-30
IE64205B1 (en) 1995-07-12
US5340831A (en) 1994-08-23
FI95027C (fi) 1995-12-11
IE904463A1 (en) 1991-06-19
GR3014907T3 (en) 1995-05-31
EP0505376A1 (en) 1992-09-30
FI95027B (fi) 1995-08-31
CA2069910C (en) 1996-11-12
FI922345L (fi) 1992-05-22
DE69014901D1 (de) 1995-01-19
DE69014901T2 (de) 1995-04-27
WO1991009013A1 (en) 1991-06-27
FI922345A0 (fi) 1992-05-22
EP0505376B1 (en) 1994-12-07
JPH0678303B2 (ja) 1994-10-05

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