ATE115402T1 - Verfahren und zusammensetzung zur verzögerten freigabe von biologisch wirksamen wirkstoffen. - Google Patents

Verfahren und zusammensetzung zur verzögerten freigabe von biologisch wirksamen wirkstoffen.

Info

Publication number
ATE115402T1
ATE115402T1 AT91901710T AT91901710T ATE115402T1 AT E115402 T1 ATE115402 T1 AT E115402T1 AT 91901710 T AT91901710 T AT 91901710T AT 91901710 T AT91901710 T AT 91901710T AT E115402 T1 ATE115402 T1 AT E115402T1
Authority
AT
Austria
Prior art keywords
crystalline phase
liquid crystalline
composition
delayed release
biological agents
Prior art date
Application number
AT91901710T
Other languages
English (en)
Inventor
Pia Lading
Yvonne Lundsholm
Tomas Norling
Original Assignee
Dumex Ltd As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dumex Ltd As filed Critical Dumex Ltd As
Application granted granted Critical
Publication of ATE115402T1 publication Critical patent/ATE115402T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
AT91901710T 1990-11-21 1990-11-21 Verfahren und zusammensetzung zur verzögerten freigabe von biologisch wirksamen wirkstoffen. ATE115402T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/DK1990/000299 WO1992009272A1 (en) 1990-11-21 1990-11-21 Method and composition for controlled delivery of biologically active agents
CA002095354A CA2095354C (en) 1990-11-21 1990-11-21 Method and composition for controlled delivery of biologically active agents

Publications (1)

Publication Number Publication Date
ATE115402T1 true ATE115402T1 (de) 1994-12-15

Family

ID=25676134

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91901710T ATE115402T1 (de) 1990-11-21 1990-11-21 Verfahren und zusammensetzung zur verzögerten freigabe von biologisch wirksamen wirkstoffen.

Country Status (15)

Country Link
US (1) US5143934A (de)
EP (1) EP0558475B1 (de)
JP (1) JPH03135925A (de)
KR (1) KR0180750B1 (de)
AT (1) ATE115402T1 (de)
AU (1) AU647768B2 (de)
CA (1) CA2095354C (de)
DE (1) DE69015212T2 (de)
DK (1) DK0558475T3 (de)
ES (1) ES2065670T3 (de)
FI (1) FI109452B (de)
GR (1) GR3015329T3 (de)
HU (1) HU220216B (de)
NO (1) NO305931B1 (de)
WO (1) WO1992009272A1 (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8206744D0 (sv) * 1982-11-26 1982-11-26 Fluidcarbon International Ab Preparat for kontrollerad avgivning av substanser
US5371109A (en) * 1986-07-01 1994-12-06 Drilletten Ab Controlled release composition for a biologically active material dissolved or dispersed in an L2-phase
US5262164A (en) * 1989-11-17 1993-11-16 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5620700A (en) * 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
ATE182278T1 (de) * 1991-10-04 1999-08-15 Gs Dev Ab Teilchen, methode zur herstellung der teilchen und deren verwendung
US5447725A (en) * 1993-06-11 1995-09-05 The Procter & Gamble Company Methods for aiding periodontal tissue regeneration
US5538954A (en) * 1994-06-24 1996-07-23 A/S Dumex (Dumex Ltd.) Salts of tetracyclines
CA2180260A1 (en) * 1993-12-29 1995-07-06 Dennis M. Brown Methods and compositions for the treatment of a host with a cellular proliferative disease
DE69535127T2 (de) * 1994-03-18 2007-02-15 Supernus Pharmaceuticals, Inc. Emulgierte arzneistoffabgabesysteme
US5618840A (en) * 1994-05-20 1997-04-08 Novavax, Inc. Antibacterial oil-in-water emulsions
SE518578C2 (sv) * 1994-06-15 2002-10-29 Gs Dev Ab Lipidbaserad komposition
FR2726762B1 (fr) * 1994-11-10 1997-01-17 Oreal Composition cosmetique ou dermatologique sous forme d'une dispersion d'une phase huileuse dans une phase aqueuse stabilisee a l'aide de particules de gel cubique et son procede d'obtention
US5824638A (en) * 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
US5744062A (en) * 1996-08-29 1998-04-28 R.I.T.A. Corporation Balanced emulsifier blends for oil-in-water emulsions
CN1108149C (zh) 1997-03-18 2003-05-14 新时代株式会社 固体微粒形成用组合物
US6638621B2 (en) * 2000-08-16 2003-10-28 Lyotropic Therapeutics, Inc. Coated particles, methods of making and using
NZ335676A (en) 1997-09-09 2001-03-30 Select Release L Coated particles comprising an exterior coating and a matrix comprising a liquid phase or liquid crystalline phase which is nanostructured
US6017516A (en) * 1997-10-31 2000-01-25 Lekar Pharma Limited Pharmaceutical dental formulation for topical application of metronidazole benzoate and chlorhexidine gluconate
GB9827034D0 (en) * 1998-12-10 1999-02-03 Univ Manchester Delivery formulation
GB0001449D0 (en) * 2000-01-21 2000-03-08 Cortendo Ab Compositions
US6423707B1 (en) 2000-08-28 2002-07-23 California Pacific Medical Center Nitroimidazole ester analogues and therapeutic applications
JP2003171301A (ja) * 2001-11-09 2003-06-20 Mahidol Univ 歯周炎治療における補助剤としてのカルメグゲル
WO2004012680A2 (en) * 2002-08-06 2004-02-12 Lyotropic Therapeutics, Inc. Lipid-drug complexes in reversed liquid and liquid crystalline phases
CN1678309A (zh) 2002-08-26 2005-10-05 S.L.A.制药有限公司 白凡士林中包含至少5%甲硝哒唑的局部用配方及其在肛门与直肠区的用途
JPWO2004019957A1 (ja) * 2002-08-29 2005-12-15 東レ株式会社 ビスホスホン酸誘導体又はその塩を有効成分とする歯周ポケット投与用医薬組成物
EP1415646B1 (de) * 2002-11-01 2009-08-26 Mahidol University Gel, einen antimikrobiellen Extrakt enthaltend als Zusatzmittel in der Therapie von Periodontitis
DE10332680A1 (de) * 2003-07-18 2005-02-17 Biomet Deutschland Gmbh Verwendung von antiseptischen Wirkstoffen in PMMA-Knochenzementen
US20050095245A1 (en) * 2003-09-19 2005-05-05 Riley Thomas C. Pharmaceutical delivery system
US20060140990A1 (en) * 2003-09-19 2006-06-29 Drugtech Corporation Composition for topical treatment of mixed vaginal infections
CA2584560A1 (en) * 2004-10-19 2006-04-27 National Institute Of Advanced Industrial Science And Technology Type ii cubic liquid crystal composition
US20060127437A1 (en) * 2004-12-13 2006-06-15 Misty Anderson Kennedy Semisolid system and combination semisolid, multiparticulate system for sealing tissues and/or controlling biological fluids
AR048742A1 (es) * 2004-12-22 2006-05-24 Gador Sa Sistema de aplicacion de medicamentos intra-oral
US7125954B2 (en) * 2005-01-27 2006-10-24 General Electric Company Method for producing polyether polymers
US20080193392A1 (en) * 2005-03-18 2008-08-14 Lg Household & Health Care Ltd. Tooth Whitener
WO2006121979A2 (en) * 2005-05-09 2006-11-16 Drugtech Corporation Modified-release pharmaceutical compositions
US20080219935A1 (en) * 2005-07-08 2008-09-11 Sang-Hoon Kwak Phase Transitive Breath Care Products
WO2007079389A2 (en) * 2006-01-05 2007-07-12 Drugtech Corporation Composition and method of use thereof
BRPI0620907A2 (pt) * 2006-01-05 2011-11-29 Drugtech Corp composição farmacêutica, sistema de distribuição de droga vaginal e uso da composição farmacêutica
US20100105750A1 (en) * 2008-10-23 2010-04-29 Nycomed Us Inc. Stable metronidazole gel formulations
US10149824B2 (en) * 2009-06-25 2018-12-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Reverse hexagonal mesophases (HII) and uses thereof
SG177354A1 (en) 2009-07-01 2012-02-28 Dexcel Pharma Technologies Ltd Local therapeutic release device
US8865198B2 (en) 2010-10-25 2014-10-21 Dexcel Pharma Technologies Ltd. Method for treating a periodontal disease
US8895537B2 (en) 2010-10-29 2014-11-25 Infirst Healthcare Ltd. Compositions and methods for treating cardiovascular diseases
US9271950B2 (en) 2010-10-29 2016-03-01 Infirst Healthcare Limited Compositions for treating chronic inflammation and inflammatory diseases
US11224659B2 (en) 2010-10-29 2022-01-18 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US9744132B2 (en) 2010-10-29 2017-08-29 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US10695431B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US9737500B2 (en) 2010-10-29 2017-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US9308213B2 (en) 2010-10-29 2016-04-12 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US11202831B2 (en) 2010-10-29 2021-12-21 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US10695432B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US11730709B2 (en) 2010-10-29 2023-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US9504664B2 (en) 2010-10-29 2016-11-29 Infirst Healthcare Limited Compositions and methods for treating severe pain
RU2508101C1 (ru) * 2012-10-16 2014-02-27 Открытое акционерное общество "Биосинтез" Мягкая лекарственная форма комбинированного действия для локального лечения заболеваний пародонта
NZ709486A (en) * 2013-01-14 2020-05-29 Infirst Healthcare Ltd Solid solution compositions and use in chronic inflammation
HK1217650A1 (zh) * 2013-01-14 2017-01-20 Infirst Healthcare Limited 用於治疗剧痛的组合物及方法
CN105120900A (zh) * 2013-02-04 2015-12-02 因佛斯特医疗有限公司 用于治疗慢性炎症和炎性疾病的组合物及方法
PL2988731T3 (pl) * 2013-04-26 2021-08-02 Bioglan Ab Kompozycje do stosowania w ograniczaniu tworzenia się strupa i promujące gojenie
US20220226627A1 (en) * 2021-01-15 2022-07-21 Covidien Lp Surgical stapling device with therapeutic suppository

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2196322A (en) * 1937-12-04 1940-04-09 Squibb & Sons Inc Pharmaceutical
DK116528A (de) * 1966-09-30
US4568535A (en) * 1982-08-06 1986-02-04 Loesche Walter J Composition for periodontal administration
US4698359A (en) * 1982-08-24 1987-10-06 Cilag, Ag Medicated suppository
SE8206744D0 (sv) * 1982-11-26 1982-11-26 Fluidcarbon International Ab Preparat for kontrollerad avgivning av substanser
US4780320A (en) * 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
EP1169958A1 (de) * 2000-06-28 2002-01-09 Tege Patents Aktiengesellschaft Kocheinheit für einen Verkaufsautomaten

Also Published As

Publication number Publication date
FI932278L (fi) 1993-05-19
JPH03135925A (ja) 1991-06-10
AU647768B2 (en) 1994-03-31
GR3015329T3 (en) 1995-06-30
NO305931B1 (no) 1999-08-23
ES2065670T3 (es) 1995-02-16
HUT75453A (en) 1997-05-28
EP0558475A1 (de) 1993-09-08
AU7049991A (en) 1992-06-25
EP0558475B1 (de) 1994-12-14
HU220216B (hu) 2001-11-28
CA2095354C (en) 2001-10-09
KR0180750B1 (ko) 1999-03-20
US5143934A (en) 1992-09-01
DE69015212D1 (de) 1995-01-26
FI932278A0 (fi) 1993-05-19
DK0558475T3 (da) 1995-04-24
WO1992009272A1 (en) 1992-06-11
NO931832L (no) 1993-07-19
NO931832D0 (no) 1993-05-19
DE69015212T2 (de) 1995-05-04
HU9301346D0 (en) 1993-09-28
CA2095354A1 (en) 1992-05-22
FI109452B (fi) 2002-08-15

Similar Documents

Publication Publication Date Title
ATE115402T1 (de) Verfahren und zusammensetzung zur verzögerten freigabe von biologisch wirksamen wirkstoffen.
AR007715A1 (es) Formulacion acuosa estable de un peptido, un metodo para preparar la misma y su uso para tratamiento
ATE221774T1 (de) Feuchtigkeitsaktivierbares therapeutisches system
DE69126776D1 (de) Parasitizide zusammensetzung und verfahren zu ihrer herstellung und ihre verwendung
CA2547990A1 (en) Pharmaceutical compositions and methods for insulin treatment
CA2119554A1 (en) Method and compositions with aldehyde stabilizing solution
DE69800859D1 (de) Verwendung von Moxonidin zur Behandlung neuropathischer Schmerzen
DE3866682D1 (de) Chemische behandlung zur kontrolle des algenwachstums in offenen wassersystemen.
ATE202894T1 (de) Glutaraldehydzusammensetzung
JPS55152597A (en) Treatment of waste water containing organophoshoric compound
ES2113803A1 (es) Metodo para el tratamiento de plantas.
CA2248837A1 (en) Method and composition for enhancing biocidal activity
RU93034455A (ru) Композиция для контролируемой подачи биологически активных агентов, способ контролируемого высвобождения биологически активного агента, способ лечения периодонтальной болезни
RU2001124020A (ru) Состав для лечения ожогов
RU93032993A (ru) Состав для обработки скважины и/или призабойной зоны пласта и способ обработки скважины и/или призабойной зоны пласта
RU97120192A (ru) Способ микробиологической обработки нефтяного пласта
RU93016862A (ru) Водно-глицериновый комплекс (2,3-диоксипропил)-орто-титана-хлорид
ATE52994T1 (de) Fluessige, biologisch wirksame zusammensetzungen.
NO874155D0 (no) Fremgangsmaate for behandling av kvikksoelvforurensede innsjoeer.
KR20000062019A (ko) 한국에서 생산되는 견운모를 주성분으로 한 백토나 백토와 같은 종류의 토양물을 이용한 젓갈
RU97111543A (ru) Способ лечения неврологических нарушений, связанных с хронической формой врожденной вирусной инфекции
KR20000062015A (ko) 한국에서 생산되는 견운모를 주성분으로 한 백토나 백토와 같은 종류의 토양물을 이용 백토나 백토와 같은 종류의 토양물의 인체에 유익한 미네랄이 풍부한 것등의 성질이 들어간 인체에 유익한 어묵을 만든다
JPS55119495A (en) Treating method for waste water containing lignin
RU2003104260A (ru) Состав для покрытия зубов после препарирования
RU99107072A (ru) Способ немедикаментозного лечения, аниматерапия

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee