ATE115402T1 - Verfahren und zusammensetzung zur verzögerten freigabe von biologisch wirksamen wirkstoffen. - Google Patents

Verfahren und zusammensetzung zur verzögerten freigabe von biologisch wirksamen wirkstoffen.

Info

Publication number
ATE115402T1
ATE115402T1 AT91901710T AT91901710T ATE115402T1 AT E115402 T1 ATE115402 T1 AT E115402T1 AT 91901710 T AT91901710 T AT 91901710T AT 91901710 T AT91901710 T AT 91901710T AT E115402 T1 ATE115402 T1 AT E115402T1
Authority
AT
Austria
Prior art keywords
crystalline phase
liquid crystalline
composition
delayed release
biological agents
Prior art date
Application number
AT91901710T
Other languages
English (en)
Inventor
Pia Lading
Yvonne Lundsholm
Tomas Norling
Original Assignee
Dumex Ltd As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dumex Ltd As filed Critical Dumex Ltd As
Application granted granted Critical
Publication of ATE115402T1 publication Critical patent/ATE115402T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT91901710T 1990-11-21 1990-11-21 Verfahren und zusammensetzung zur verzögerten freigabe von biologisch wirksamen wirkstoffen. ATE115402T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002095354A CA2095354C (en) 1990-11-21 1990-11-21 Method and composition for controlled delivery of biologically active agents
PCT/DK1990/000299 WO1992009272A1 (en) 1990-11-21 1990-11-21 Method and composition for controlled delivery of biologically active agents

Publications (1)

Publication Number Publication Date
ATE115402T1 true ATE115402T1 (de) 1994-12-15

Family

ID=25676134

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91901710T ATE115402T1 (de) 1990-11-21 1990-11-21 Verfahren und zusammensetzung zur verzögerten freigabe von biologisch wirksamen wirkstoffen.

Country Status (15)

Country Link
US (1) US5143934A (de)
EP (1) EP0558475B1 (de)
JP (1) JPH03135925A (de)
KR (1) KR0180750B1 (de)
AT (1) ATE115402T1 (de)
AU (1) AU647768B2 (de)
CA (1) CA2095354C (de)
DE (1) DE69015212T2 (de)
DK (1) DK0558475T3 (de)
ES (1) ES2065670T3 (de)
FI (1) FI109452B (de)
GR (1) GR3015329T3 (de)
HU (1) HU220216B (de)
NO (1) NO305931B1 (de)
WO (1) WO1992009272A1 (de)

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US5538954A (en) * 1994-06-24 1996-07-23 A/S Dumex (Dumex Ltd.) Salts of tetracyclines
DE69431071T2 (de) * 1993-12-29 2003-03-20 Matrix Pharma Zusammensetzung für lokale freigabe von zytostatika
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SE518578C2 (sv) * 1994-06-15 2002-10-29 Gs Dev Ab Lipidbaserad komposition
FR2726762B1 (fr) * 1994-11-10 1997-01-17 Oreal Composition cosmetique ou dermatologique sous forme d'une dispersion d'une phase huileuse dans une phase aqueuse stabilisee a l'aide de particules de gel cubique et son procede d'obtention
US5824638A (en) * 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
US5744062A (en) * 1996-08-29 1998-04-28 R.I.T.A. Corporation Balanced emulsifier blends for oil-in-water emulsions
EP1033127A4 (de) 1997-03-18 2006-07-26 Sunstar Inc Zusammensetzungen zur bildung von festkörperpartikeln
TR199901008T1 (xx) 1997-09-09 2000-02-21 Select Release, L.C. Kaplanm�� partik�ller, yap�m� ve kullan�m y�ntemleri.
US6638621B2 (en) * 2000-08-16 2003-10-28 Lyotropic Therapeutics, Inc. Coated particles, methods of making and using
US6017516A (en) * 1997-10-31 2000-01-25 Lekar Pharma Limited Pharmaceutical dental formulation for topical application of metronidazole benzoate and chlorhexidine gluconate
GB9827034D0 (en) * 1998-12-10 1999-02-03 Univ Manchester Delivery formulation
GB0001449D0 (en) * 2000-01-21 2000-03-08 Cortendo Ab Compositions
US6423707B1 (en) 2000-08-28 2002-07-23 California Pacific Medical Center Nitroimidazole ester analogues and therapeutic applications
JP2003171301A (ja) * 2001-11-09 2003-06-20 Mahidol Univ 歯周炎治療における補助剤としてのカルメグゲル
AU2003258075A1 (en) * 2002-08-06 2004-02-23 Lyotropic Therapeutics, Inc. Lipid-drug complexes in reversed liquid and liquid crystalline phases
CN101843614B (zh) 2002-08-26 2013-05-22 S.L.A.制药有限公司 甲硝哒唑或其药学上可接受的衍生物的用途
KR20050059095A (ko) * 2002-08-29 2005-06-17 도레이 가부시끼가이샤 비스포스폰산 유도체 또는 그 염을 유효성분으로 하는 치주포켓 투여용 의약조성물
DK1415646T3 (da) * 2002-11-01 2009-12-21 Univ Mahidol Gel omfattende et antimikrobielt ekstrakt som tilsætningsmiddel i behandlingen af periodontitis
DE10332680A1 (de) * 2003-07-18 2005-02-17 Biomet Deutschland Gmbh Verwendung von antiseptischen Wirkstoffen in PMMA-Knochenzementen
WO2005027807A1 (en) 2003-09-19 2005-03-31 Drugtech Corporation Pharmaceutical delivery system
US20060140990A1 (en) * 2003-09-19 2006-06-29 Drugtech Corporation Composition for topical treatment of mixed vaginal infections
WO2006043705A1 (ja) * 2004-10-19 2006-04-27 National Institute Of Advanced Industrial Scienceand Technology Ｉｉ型キュービック液晶組成物
US20060127437A1 (en) * 2004-12-13 2006-06-15 Misty Anderson Kennedy Semisolid system and combination semisolid, multiparticulate system for sealing tissues and/or controlling biological fluids
AR048742A1 (es) * 2004-12-22 2006-05-24 Gador Sa Sistema de aplicacion de medicamentos intra-oral
US7125954B2 (en) * 2005-01-27 2006-10-24 General Electric Company Method for producing polyether polymers
JP4677029B2 (ja) * 2005-03-18 2011-04-27 エル・ジー ハウスホールド アンド ヘルスケア リミティッド 歯牙美白剤
CA2605341A1 (en) * 2005-05-09 2006-11-16 Drugtech Corporation Modified-release pharmaceutical compositions
US20080219935A1 (en) * 2005-07-08 2008-09-11 Sang-Hoon Kwak Phase Transitive Breath Care Products
WO2007079389A2 (en) * 2006-01-05 2007-07-12 Drugtech Corporation Composition and method of use thereof
KR20080083190A (ko) * 2006-01-05 2008-09-16 드러그테크 코포레이션 외음질 표면에 생체접착을 위한 약물 전달 시스템
US20100105750A1 (en) * 2008-10-23 2010-04-29 Nycomed Us Inc. Stable metronidazole gel formulations
EP2498754B1 (de) * 2009-06-25 2018-06-06 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Reverse hexagonale mesophasen (h ii) und ihre verwendung
US20120100192A1 (en) 2009-07-01 2012-04-26 Dexcel Pharma Technologies Ltd. Local therapeutic release device
US8865198B2 (en) 2010-10-25 2014-10-21 Dexcel Pharma Technologies Ltd. Method for treating a periodontal disease
US11224659B2 (en) 2010-10-29 2022-01-18 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US9308213B2 (en) 2010-10-29 2016-04-12 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US9504664B2 (en) 2010-10-29 2016-11-29 Infirst Healthcare Limited Compositions and methods for treating severe pain
US8895537B2 (en) 2010-10-29 2014-11-25 Infirst Healthcare Ltd. Compositions and methods for treating cardiovascular diseases
US11202831B2 (en) 2010-10-29 2021-12-21 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US9744132B2 (en) 2010-10-29 2017-08-29 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US9271950B2 (en) 2010-10-29 2016-03-01 Infirst Healthcare Limited Compositions for treating chronic inflammation and inflammatory diseases
US11730709B2 (en) 2010-10-29 2023-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US9737500B2 (en) 2010-10-29 2017-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US10695432B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US10695431B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
RU2508101C1 (ru) * 2012-10-16 2014-02-27 Открытое акционерное общество "Биосинтез" Мягкая лекарственная форма комбинированного действия для локального лечения заболеваний пародонта
MX377877B (es) * 2013-01-14 2025-03-11 Infirst Healthcare Ltd Composiciones de solución sólida y su uso en el tratamiento del dolor intenso.
JP6474732B2 (ja) * 2013-01-14 2019-02-27 インファースト ヘルスケア リミテッド 激痛治療用組成物と方法
CN105120900A (zh) * 2013-02-04 2015-12-02 因佛斯特医疗有限公司 用于治疗慢性炎症和炎性疾病的组合物及方法
CA2910114A1 (en) * 2013-04-26 2014-10-30 Bioglan Ab Composition for use in reducing scab formation and promoting healing
US20220226627A1 (en) * 2021-01-15 2022-07-21 Covidien Lp Surgical stapling device with therapeutic suppository

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US2196322A (en) * 1937-12-04 1940-04-09 Squibb & Sons Inc Pharmaceutical
DK116528A (de) * 1966-09-30
US4568535A (en) * 1982-08-06 1986-02-04 Loesche Walter J Composition for periodontal administration
US4698359A (en) * 1982-08-24 1987-10-06 Cilag, Ag Medicated suppository
SE8206744D0 (sv) * 1982-11-26 1982-11-26 Fluidcarbon International Ab Preparat for kontrollerad avgivning av substanser
US4780320A (en) * 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
EP1169958A1 (de) * 2000-06-28 2002-01-09 Tege Patents Aktiengesellschaft Kocheinheit für einen Verkaufsautomaten

Also Published As

Publication number Publication date
EP0558475A1 (de) 1993-09-08
AU647768B2 (en) 1994-03-31
FI932278A0 (fi) 1993-05-19
FI932278L (fi) 1993-05-19
GR3015329T3 (en) 1995-06-30
HU220216B (hu) 2001-11-28
NO931832D0 (no) 1993-05-19
WO1992009272A1 (en) 1992-06-11
JPH03135925A (ja) 1991-06-10
DK0558475T3 (da) 1995-04-24
CA2095354A1 (en) 1992-05-22
NO931832L (no) 1993-07-19
AU7049991A (en) 1992-06-25
EP0558475B1 (de) 1994-12-14
NO305931B1 (no) 1999-08-23
DE69015212T2 (de) 1995-05-04
HU9301346D0 (en) 1993-09-28
KR0180750B1 (ko) 1999-03-20
FI109452B (fi) 2002-08-15
US5143934A (en) 1992-09-01
DE69015212D1 (de) 1995-01-26
HUT75453A (en) 1997-05-28
CA2095354C (en) 2001-10-09
ES2065670T3 (es) 1995-02-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee