ES2065670T3 - Metodo y composicion para el aporte controlado de agentes biologicamente activos. - Google Patents

Metodo y composicion para el aporte controlado de agentes biologicamente activos.

Info

Publication number
ES2065670T3
ES2065670T3 ES91901710T ES91901710T ES2065670T3 ES 2065670 T3 ES2065670 T3 ES 2065670T3 ES 91901710 T ES91901710 T ES 91901710T ES 91901710 T ES91901710 T ES 91901710T ES 2065670 T3 ES2065670 T3 ES 2065670T3
Authority
ES
Spain
Prior art keywords
inmate
biologically active
active agents
composition
controlled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91901710T
Other languages
English (en)
Inventor
Pia Lading
Yvonne Lundsholm
Tomas Norling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xellia Pharmaceuticals ApS
Original Assignee
Dumex AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dumex AS filed Critical Dumex AS
Application granted granted Critical
Publication of ES2065670T3 publication Critical patent/ES2065670T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA DISTRIBUCION CONTROLADA DE AGENTES BIOLOGICAMENTE ACTIVOS COMO PRODUCTOS FARMACEUTICOS A SITIOS DEL CUERPO SE EJECUTA POR LA COMBINACION DE UN MONOGLICERIDO Y UN ACEITE VEGETAL. AL CONTACTO CON UN LIQUIDO ACUOSO, LA COMPOSICION FORMA UNA MATRIZ DE FASE CRISTALINA LIQUIDA HEXAGONAL INVERTIDA QUE LIBERA EL AGENTE ACTIVO DE MANERA CONTROLADA. EL METODO DE DISTRIBUCION ES PARTICULARMENTE UTIL PARA EL TRATAMIENTO DE ENFERMEDAD PERIODONTAL MEDIANTE LA INSERCION DE LA COMPOSICION DE PRECURSOR DE FASE CRISTALINA LIQUIDA DIRECTAMENTE EN LA CAVIDAD PERIODONTAL, EN DONDE AGUA DEL FLUIDO GENGIVAL INDUCE LA FORMACION ESPONTANEA IN SITU DE LA MATRIZ DE FASE CRISTALINA LIQUIDA HEXAGONAL.
ES91901710T 1990-11-21 1990-11-21 Metodo y composicion para el aporte controlado de agentes biologicamente activos. Expired - Lifetime ES2065670T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/DK1990/000299 WO1992009272A1 (en) 1990-11-21 1990-11-21 Method and composition for controlled delivery of biologically active agents
CA002095354A CA2095354C (en) 1990-11-21 1990-11-21 Method and composition for controlled delivery of biologically active agents

Publications (1)

Publication Number Publication Date
ES2065670T3 true ES2065670T3 (es) 1995-02-16

Family

ID=25676134

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91901710T Expired - Lifetime ES2065670T3 (es) 1990-11-21 1990-11-21 Metodo y composicion para el aporte controlado de agentes biologicamente activos.

Country Status (15)

Country Link
US (1) US5143934A (es)
EP (1) EP0558475B1 (es)
JP (1) JPH03135925A (es)
KR (1) KR0180750B1 (es)
AT (1) ATE115402T1 (es)
AU (1) AU647768B2 (es)
CA (1) CA2095354C (es)
DE (1) DE69015212T2 (es)
DK (1) DK0558475T3 (es)
ES (1) ES2065670T3 (es)
FI (1) FI109452B (es)
GR (1) GR3015329T3 (es)
HU (1) HU220216B (es)
NO (1) NO305931B1 (es)
WO (1) WO1992009272A1 (es)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8206744D0 (sv) * 1982-11-26 1982-11-26 Fluidcarbon International Ab Preparat for kontrollerad avgivning av substanser
US5371109A (en) * 1986-07-01 1994-12-06 Drilletten Ab Controlled release composition for a biologically active material dissolved or dispersed in an L2-phase
US5262164A (en) * 1989-11-17 1993-11-16 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5620700A (en) * 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
BR9206593A (pt) * 1991-10-04 1995-11-28 Gs Biochem Ab Partículas especialmente partículas coloidais processo de prepará-las a partir de uma fase cristalina líquida homogênea ou fase L3 composição farmacêutica e uso destas partículas
US5447725A (en) * 1993-06-11 1995-09-05 The Procter & Gamble Company Methods for aiding periodontal tissue regeneration
US5538954A (en) * 1994-06-24 1996-07-23 A/S Dumex (Dumex Ltd.) Salts of tetracyclines
JPH09507233A (ja) * 1993-12-29 1997-07-22 マトリクス ファーマスーティカル，インコーポレイティド 細胞増殖性疾患に罹る宿主の治療方法及び治療のための組成物
EP0788346B9 (en) * 1994-03-18 2007-02-14 Supernus Pharmaceuticals, Inc. Emulsified drug delivery systems
JPH10500687A (ja) * 1994-05-20 1998-01-20 ノババックス インコーポレイテッド 抗菌性水中油エマルジョン
SE518578C2 (sv) * 1994-06-15 2002-10-29 Gs Dev Ab Lipidbaserad komposition
FR2726762B1 (fr) * 1994-11-10 1997-01-17 Oreal Composition cosmetique ou dermatologique sous forme d'une dispersion d'une phase huileuse dans une phase aqueuse stabilisee a l'aide de particules de gel cubique et son procede d'obtention
US5824638A (en) * 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
US5744062A (en) * 1996-08-29 1998-04-28 R.I.T.A. Corporation Balanced emulsifier blends for oil-in-water emulsions
CN1108149C (zh) 1997-03-18 2003-05-14 新时代株式会社 固体微粒形成用组合物
PT942780E (pt) 1997-09-09 2003-11-28 Lyotropic Therapeutics Inc Particulas revestidas processos de obtencao e uso
US6638621B2 (en) * 2000-08-16 2003-10-28 Lyotropic Therapeutics, Inc. Coated particles, methods of making and using
US6017516A (en) * 1997-10-31 2000-01-25 Lekar Pharma Limited Pharmaceutical dental formulation for topical application of metronidazole benzoate and chlorhexidine gluconate
GB9827034D0 (en) * 1998-12-10 1999-02-03 Univ Manchester Delivery formulation
GB0001449D0 (en) * 2000-01-21 2000-03-08 Cortendo Ab Compositions
US6423707B1 (en) 2000-08-28 2002-07-23 California Pacific Medical Center Nitroimidazole ester analogues and therapeutic applications
JP2003171301A (ja) * 2001-11-09 2003-06-20 Mahidol Univ 歯周炎治療における補助剤としてのカルメグゲル
US20040156816A1 (en) * 2002-08-06 2004-08-12 David Anderson Lipid-drug complexes in reversed liquid and liquid crystalline phases
CA2496864C (en) 2002-08-26 2009-04-28 S.L.A. Pharma Ag A pharmaceutical composition
US20060233724A1 (en) * 2002-08-29 2006-10-19 Toray Industries, Inc. Medicinal composition for peridontal pocket administration containing bisphosphonic acid derivative or its salt as the active ingredient
DE60233507D1 (de) * 2002-11-01 2009-10-08 Univ Mahidol Gel, einen antimikrobiellen Extrakt enthaltend als Zusatzmittel in der Therapie von Periodontitis
DE10332680A1 (de) * 2003-07-18 2005-02-17 Biomet Deutschland Gmbh Verwendung von antiseptischen Wirkstoffen in PMMA-Knochenzementen
AU2004274000B2 (en) * 2003-09-19 2009-07-30 Drugtech Corporation Pharmaceutical delivery system
US20060140990A1 (en) * 2003-09-19 2006-06-29 Drugtech Corporation Composition for topical treatment of mixed vaginal infections
US7846903B2 (en) * 2004-10-19 2010-12-07 National Institute Of Advanced Industrial Science And Technology Type II cubic liquid crystal composition
US20060127437A1 (en) * 2004-12-13 2006-06-15 Misty Anderson Kennedy Semisolid system and combination semisolid, multiparticulate system for sealing tissues and/or controlling biological fluids
AR048742A1 (es) * 2004-12-22 2006-05-24 Gador Sa Sistema de aplicacion de medicamentos intra-oral
US7125954B2 (en) * 2005-01-27 2006-10-24 General Electric Company Method for producing polyether polymers
CA2601064C (en) * 2005-03-18 2012-03-06 Lg Household & Health Care Ltd. Tooth whitener
MX2007013631A (es) * 2005-05-09 2008-01-24 Drugtech Corp Composiciones farmaceuticas de liberacion modificada.
US20080219935A1 (en) * 2005-07-08 2008-09-11 Sang-Hoon Kwak Phase Transitive Breath Care Products
EA200870153A1 (ru) * 2006-01-05 2008-12-30 Драгтек Корпорейшн Композиция и способ ее использования
KR20080083190A (ko) * 2006-01-05 2008-09-16 드러그테크 코포레이션 외음질 표면에 생체접착을 위한 약물 전달 시스템
US20100105750A1 (en) * 2008-10-23 2010-04-29 Nycomed Us Inc. Stable metronidazole gel formulations
EP2498754B1 (en) * 2009-06-25 2018-06-06 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Reverse hexagonal mesophases (h ii) and uses thereof
US20120100192A1 (en) 2009-07-01 2012-04-26 Dexcel Pharma Technologies Ltd. Local therapeutic release device
US8865198B2 (en) 2010-10-25 2014-10-21 Dexcel Pharma Technologies Ltd. Method for treating a periodontal disease
US11730709B2 (en) 2010-10-29 2023-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US9504664B2 (en) 2010-10-29 2016-11-29 Infirst Healthcare Limited Compositions and methods for treating severe pain
US10695431B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US9308213B2 (en) 2010-10-29 2016-04-12 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US9737500B2 (en) 2010-10-29 2017-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US10695432B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US9744132B2 (en) 2010-10-29 2017-08-29 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US9271950B2 (en) 2010-10-29 2016-03-01 Infirst Healthcare Limited Compositions for treating chronic inflammation and inflammatory diseases
US8895537B2 (en) 2010-10-29 2014-11-25 Infirst Healthcare Ltd. Compositions and methods for treating cardiovascular diseases
US11224659B2 (en) 2010-10-29 2022-01-18 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US11202831B2 (en) 2010-10-29 2021-12-21 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
RU2508101C1 (ru) * 2012-10-16 2014-02-27 Открытое акционерное общество "Биосинтез" Мягкая лекарственная форма комбинированного действия для локального лечения заболеваний пародонта
KR102235264B1 (ko) * 2013-01-14 2021-04-02 인퍼스트 헬스케어 리미티드 고용체 조성물들 및 심각한 통증에서의 이들의 용도
EP2943183A1 (en) * 2013-01-14 2015-11-18 InFirst Healthcare Limited Compositions and methods for treating severe pain
CA2898017A1 (en) * 2013-02-04 2014-08-07 Infirst Healthcare Limited Compositions and methods for treating chronic inflammation and inflammatory diseases
HK1224175A1 (zh) * 2013-04-26 2017-08-18 贝欧格兰公司 用於减少痂形成并促进癒合的组合物
US20220226627A1 (en) * 2021-01-15 2022-07-21 Covidien Lp Surgical stapling device with therapeutic suppository

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2196322A (en) * 1937-12-04 1940-04-09 Squibb & Sons Inc Pharmaceutical
DK116528A (es) * 1966-09-30
US4568535A (en) * 1982-08-06 1986-02-04 Loesche Walter J Composition for periodontal administration
US4698359A (en) * 1982-08-24 1987-10-06 Cilag, Ag Medicated suppository
SE8206744D0 (sv) * 1982-11-26 1982-11-26 Fluidcarbon International Ab Preparat for kontrollerad avgivning av substanser
US4780320A (en) * 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
EP1169958A1 (en) * 2000-06-28 2002-01-09 Tege Patents Aktiengesellschaft Vending machine cooking unit

Also Published As

Publication number Publication date
NO931832L (no) 1993-07-19
CA2095354C (en) 2001-10-09
GR3015329T3 (en) 1995-06-30
CA2095354A1 (en) 1992-05-22
DE69015212D1 (de) 1995-01-26
US5143934A (en) 1992-09-01
NO305931B1 (no) 1999-08-23
HUT75453A (en) 1997-05-28
AU7049991A (en) 1992-06-25
WO1992009272A1 (en) 1992-06-11
KR0180750B1 (ko) 1999-03-20
EP0558475A1 (en) 1993-09-08
HU220216B (hu) 2001-11-28
AU647768B2 (en) 1994-03-31
FI109452B (fi) 2002-08-15
DK0558475T3 (da) 1995-04-24
EP0558475B1 (en) 1994-12-14
FI932278L (fi) 1993-05-19
DE69015212T2 (de) 1995-05-04
ATE115402T1 (de) 1994-12-15
FI932278A0 (fi) 1993-05-19
JPH03135925A (ja) 1991-06-10
HU9301346D0 (en) 1993-09-28
NO931832D0 (no) 1993-05-19

Similar Documents

Publication Publication Date Title
ES2065670T3 (es) Metodo y composicion para el aporte controlado de agentes biologicamente activos.
MX2010004169A (es) Suministro transdermico de farmaco empleando un osmolito y un agente vasoactivo.
ES2055677T3 (es) Composicion para el tratamiento de la disfuncion erectil.
AR079738A1 (es) Composicion antitranspirante/desodorante anhidra liquida. metodo.
AR062656A1 (es) Formulaciones de emulsiones de pickering
AR066335A1 (es) Uso de elastomeros para producir geles para tratar una luz de pozo
ES2171186T3 (es) Composiciones liquidas de difusion.
AR046844A1 (es) Composicion y forma de dosificacion que comprende una molecula anfifilica como vehiculo de suspension
PE20000522A1 (es) Activos donantes protonicos en articulos absorbentes
CR6656A (es) Forma de dosificacion de farmacos accionada por un hidrogel
ES2077530B1 (es) Procedimiento para la preparacion de productos farmaceuticos para curar enfermedades tumorales.
ES2094688B1 (es) Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
AR013024A1 (es) Articulo absorbente descartable que tiene una composicion para el cuidado de la piel que contiene a un inhibidor de enzima y metodo para reducir laactividad enzimatica.
AR005867A1 (es) Composiciones desinfectantes y procesos para desinfectar superficies
PE20000721A1 (es) Articulo absorbente que incluye un agente modificador de heces basado en calcio
CL2009000624A1 (es) Composicion farmaceutica oftalmica que comprende un vehiculo que incluye agua, un agente terapeutico que es una prostaglandina, un compuesto de amonio cuaternario polimerico y 0,01-04% p/v de un surfafactante que es aceite vegetal etoxilado y/o hidrogenado, libre de cloruro de benzxalconio; util para tratar glaucoma
CO5190668A1 (es) Composiciones de beta lactama especificamente cefuroxima- axetil en una forma no gelatinosaal contacto con un liquido acuoso, util para la produccion de composiciones farmaceuticas que comprende cefuroxina-axetil como un ingrediente activo
AR025269A1 (es) Un material activo antitranspirante particulado, una composicion antitranspirante que lo comprende, un procedimiento para tratar la superficie de dicho material, y metodo para controlar la transpiracion, excluyendo todo tratamiento terapeutico, mediante dicha composicion.
AR009589A1 (es) Dispositivo dispensador para fluidos, y aplicacion para el uso de dispositivo
PE20061077A1 (es) Composicion farmaceutica que comprende 7-terbutoxi-imino-metil-camptotecina
PE20080712A1 (es) Tratamiento de fibrosis cistica con antibioticos por via de suministro de un torbellinador
ES2184512T3 (es) Agente de limpieza encapsulado.
AR008538A1 (es) Emulsion del tipo aceite en agua
AR051411A1 (es) Suspensiones farmaceuticas exentas de colorantes y metodos relacionados
AR040306A1 (es) Capsula de liberacion controlada para la administracion de formulacion liquida

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 558475

Country of ref document: ES