ES2065670T3 - Metodo y composicion para el aporte controlado de agentes biologicamente activos. - Google Patents

Metodo y composicion para el aporte controlado de agentes biologicamente activos.

Info

Publication number
ES2065670T3
ES2065670T3 ES91901710T ES91901710T ES2065670T3 ES 2065670 T3 ES2065670 T3 ES 2065670T3 ES 91901710 T ES91901710 T ES 91901710T ES 91901710 T ES91901710 T ES 91901710T ES 2065670 T3 ES2065670 T3 ES 2065670T3
Authority
ES
Spain
Prior art keywords
inmate
biologically active
active agents
composition
controlled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91901710T
Other languages
English (en)
Inventor
Pia Lading
Yvonne Lundsholm
Tomas Norling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xellia Pharmaceuticals ApS
Original Assignee
Dumex AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dumex AS filed Critical Dumex AS
Application granted granted Critical
Publication of ES2065670T3 publication Critical patent/ES2065670T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA DISTRIBUCION CONTROLADA DE AGENTES BIOLOGICAMENTE ACTIVOS COMO PRODUCTOS FARMACEUTICOS A SITIOS DEL CUERPO SE EJECUTA POR LA COMBINACION DE UN MONOGLICERIDO Y UN ACEITE VEGETAL. AL CONTACTO CON UN LIQUIDO ACUOSO, LA COMPOSICION FORMA UNA MATRIZ DE FASE CRISTALINA LIQUIDA HEXAGONAL INVERTIDA QUE LIBERA EL AGENTE ACTIVO DE MANERA CONTROLADA. EL METODO DE DISTRIBUCION ES PARTICULARMENTE UTIL PARA EL TRATAMIENTO DE ENFERMEDAD PERIODONTAL MEDIANTE LA INSERCION DE LA COMPOSICION DE PRECURSOR DE FASE CRISTALINA LIQUIDA DIRECTAMENTE EN LA CAVIDAD PERIODONTAL, EN DONDE AGUA DEL FLUIDO GENGIVAL INDUCE LA FORMACION ESPONTANEA IN SITU DE LA MATRIZ DE FASE CRISTALINA LIQUIDA HEXAGONAL.
ES91901710T 1990-11-21 1990-11-21 Metodo y composicion para el aporte controlado de agentes biologicamente activos. Expired - Lifetime ES2065670T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002095354A CA2095354C (en) 1990-11-21 1990-11-21 Method and composition for controlled delivery of biologically active agents
PCT/DK1990/000299 WO1992009272A1 (en) 1990-11-21 1990-11-21 Method and composition for controlled delivery of biologically active agents

Publications (1)

Publication Number Publication Date
ES2065670T3 true ES2065670T3 (es) 1995-02-16

Family

ID=25676134

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91901710T Expired - Lifetime ES2065670T3 (es) 1990-11-21 1990-11-21 Metodo y composicion para el aporte controlado de agentes biologicamente activos.

Country Status (15)

Country Link
US (1) US5143934A (es)
EP (1) EP0558475B1 (es)
JP (1) JPH03135925A (es)
KR (1) KR0180750B1 (es)
AT (1) ATE115402T1 (es)
AU (1) AU647768B2 (es)
CA (1) CA2095354C (es)
DE (1) DE69015212T2 (es)
DK (1) DK0558475T3 (es)
ES (1) ES2065670T3 (es)
FI (1) FI109452B (es)
GR (1) GR3015329T3 (es)
HU (1) HU220216B (es)
NO (1) NO305931B1 (es)
WO (1) WO1992009272A1 (es)

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US5447725A (en) * 1993-06-11 1995-09-05 The Procter & Gamble Company Methods for aiding periodontal tissue regeneration
US5538954A (en) * 1994-06-24 1996-07-23 A/S Dumex (Dumex Ltd.) Salts of tetracyclines
DE69431071T2 (de) * 1993-12-29 2003-03-20 Matrix Pharma Zusammensetzung für lokale freigabe von zytostatika
DE69535127T2 (de) * 1994-03-18 2007-02-15 Supernus Pharmaceuticals, Inc. Emulgierte arzneistoffabgabesysteme
AU687562B2 (en) * 1994-05-20 1998-02-26 Novavax, Inc. Antimicrobial oil-in-water emulsions
SE518578C2 (sv) * 1994-06-15 2002-10-29 Gs Dev Ab Lipidbaserad komposition
FR2726762B1 (fr) * 1994-11-10 1997-01-17 Oreal Composition cosmetique ou dermatologique sous forme d'une dispersion d'une phase huileuse dans une phase aqueuse stabilisee a l'aide de particules de gel cubique et son procede d'obtention
US5824638A (en) * 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
US5744062A (en) * 1996-08-29 1998-04-28 R.I.T.A. Corporation Balanced emulsifier blends for oil-in-water emulsions
EP1033127A4 (en) 1997-03-18 2006-07-26 Sunstar Inc COMPOSITIONS FOR THE FORMATION OF SOLID-PARTICULAR PARTICLES
TR199901008T1 (xx) 1997-09-09 2000-02-21 Select Release, L.C. Kaplanm�� partik�ller, yap�m� ve kullan�m y�ntemleri.
US6638621B2 (en) * 2000-08-16 2003-10-28 Lyotropic Therapeutics, Inc. Coated particles, methods of making and using
US6017516A (en) * 1997-10-31 2000-01-25 Lekar Pharma Limited Pharmaceutical dental formulation for topical application of metronidazole benzoate and chlorhexidine gluconate
GB9827034D0 (en) * 1998-12-10 1999-02-03 Univ Manchester Delivery formulation
GB0001449D0 (en) * 2000-01-21 2000-03-08 Cortendo Ab Compositions
US6423707B1 (en) 2000-08-28 2002-07-23 California Pacific Medical Center Nitroimidazole ester analogues and therapeutic applications
JP2003171301A (ja) * 2001-11-09 2003-06-20 Mahidol Univ 歯周炎治療における補助剤としてのカルメグゲル
AU2003258075A1 (en) * 2002-08-06 2004-02-23 Lyotropic Therapeutics, Inc. Lipid-drug complexes in reversed liquid and liquid crystalline phases
CN101843614B (zh) 2002-08-26 2013-05-22 S.L.A.制药有限公司 甲硝哒唑或其药学上可接受的衍生物的用途
KR20050059095A (ko) * 2002-08-29 2005-06-17 도레이 가부시끼가이샤 비스포스폰산 유도체 또는 그 염을 유효성분으로 하는 치주포켓 투여용 의약조성물
DK1415646T3 (da) * 2002-11-01 2009-12-21 Univ Mahidol Gel omfattende et antimikrobielt ekstrakt som tilsætningsmiddel i behandlingen af periodontitis
DE10332680A1 (de) * 2003-07-18 2005-02-17 Biomet Deutschland Gmbh Verwendung von antiseptischen Wirkstoffen in PMMA-Knochenzementen
WO2005027807A1 (en) 2003-09-19 2005-03-31 Drugtech Corporation Pharmaceutical delivery system
US20060140990A1 (en) * 2003-09-19 2006-06-29 Drugtech Corporation Composition for topical treatment of mixed vaginal infections
WO2006043705A1 (ja) * 2004-10-19 2006-04-27 National Institute Of Advanced Industrial Scienceand Technology Ｉｉ型キュービック液晶組成物
US20060127437A1 (en) * 2004-12-13 2006-06-15 Misty Anderson Kennedy Semisolid system and combination semisolid, multiparticulate system for sealing tissues and/or controlling biological fluids
AR048742A1 (es) * 2004-12-22 2006-05-24 Gador Sa Sistema de aplicacion de medicamentos intra-oral
US7125954B2 (en) * 2005-01-27 2006-10-24 General Electric Company Method for producing polyether polymers
JP4677029B2 (ja) * 2005-03-18 2011-04-27 エル・ジー ハウスホールド アンド ヘルスケア リミティッド 歯牙美白剤
CA2605341A1 (en) * 2005-05-09 2006-11-16 Drugtech Corporation Modified-release pharmaceutical compositions
US20080219935A1 (en) * 2005-07-08 2008-09-11 Sang-Hoon Kwak Phase Transitive Breath Care Products
WO2007079389A2 (en) * 2006-01-05 2007-07-12 Drugtech Corporation Composition and method of use thereof
KR20080083190A (ko) * 2006-01-05 2008-09-16 드러그테크 코포레이션 외음질 표면에 생체접착을 위한 약물 전달 시스템
US20100105750A1 (en) * 2008-10-23 2010-04-29 Nycomed Us Inc. Stable metronidazole gel formulations
EP2498754B1 (en) * 2009-06-25 2018-06-06 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Reverse hexagonal mesophases (h ii) and uses thereof
US20120100192A1 (en) 2009-07-01 2012-04-26 Dexcel Pharma Technologies Ltd. Local therapeutic release device
US8865198B2 (en) 2010-10-25 2014-10-21 Dexcel Pharma Technologies Ltd. Method for treating a periodontal disease
US11224659B2 (en) 2010-10-29 2022-01-18 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US9308213B2 (en) 2010-10-29 2016-04-12 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US9504664B2 (en) 2010-10-29 2016-11-29 Infirst Healthcare Limited Compositions and methods for treating severe pain
US8895537B2 (en) 2010-10-29 2014-11-25 Infirst Healthcare Ltd. Compositions and methods for treating cardiovascular diseases
US11202831B2 (en) 2010-10-29 2021-12-21 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US9744132B2 (en) 2010-10-29 2017-08-29 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US9271950B2 (en) 2010-10-29 2016-03-01 Infirst Healthcare Limited Compositions for treating chronic inflammation and inflammatory diseases
US11730709B2 (en) 2010-10-29 2023-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US9737500B2 (en) 2010-10-29 2017-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US10695432B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US10695431B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
RU2508101C1 (ru) * 2012-10-16 2014-02-27 Открытое акционерное общество "Биосинтез" Мягкая лекарственная форма комбинированного действия для локального лечения заболеваний пародонта
MX377877B (es) * 2013-01-14 2025-03-11 Infirst Healthcare Ltd Composiciones de solución sólida y su uso en el tratamiento del dolor intenso.
JP6474732B2 (ja) * 2013-01-14 2019-02-27 インファースト ヘルスケア リミテッド 激痛治療用組成物と方法
CN105120900A (zh) * 2013-02-04 2015-12-02 因佛斯特医疗有限公司 用于治疗慢性炎症和炎性疾病的组合物及方法
CA2910114A1 (en) * 2013-04-26 2014-10-30 Bioglan Ab Composition for use in reducing scab formation and promoting healing
US20220226627A1 (en) * 2021-01-15 2022-07-21 Covidien Lp Surgical stapling device with therapeutic suppository

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US2196322A (en) * 1937-12-04 1940-04-09 Squibb & Sons Inc Pharmaceutical
DK116528A (es) * 1966-09-30
US4568535A (en) * 1982-08-06 1986-02-04 Loesche Walter J Composition for periodontal administration
US4698359A (en) * 1982-08-24 1987-10-06 Cilag, Ag Medicated suppository
SE8206744D0 (sv) * 1982-11-26 1982-11-26 Fluidcarbon International Ab Preparat for kontrollerad avgivning av substanser
US4780320A (en) * 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
EP1169958A1 (en) * 2000-06-28 2002-01-09 Tege Patents Aktiengesellschaft Vending machine cooking unit

Also Published As

Publication number Publication date
EP0558475A1 (en) 1993-09-08
AU647768B2 (en) 1994-03-31
FI932278A0 (fi) 1993-05-19
FI932278L (fi) 1993-05-19
GR3015329T3 (en) 1995-06-30
HU220216B (hu) 2001-11-28
NO931832D0 (no) 1993-05-19
WO1992009272A1 (en) 1992-06-11
JPH03135925A (ja) 1991-06-10
DK0558475T3 (da) 1995-04-24
CA2095354A1 (en) 1992-05-22
NO931832L (no) 1993-07-19
AU7049991A (en) 1992-06-25
EP0558475B1 (en) 1994-12-14
NO305931B1 (no) 1999-08-23
DE69015212T2 (de) 1995-05-04
HU9301346D0 (en) 1993-09-28
KR0180750B1 (ko) 1999-03-20
FI109452B (fi) 2002-08-15
ATE115402T1 (de) 1994-12-15
US5143934A (en) 1992-09-01
DE69015212D1 (de) 1995-01-26
HUT75453A (en) 1997-05-28
CA2095354C (en) 2001-10-09

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