ATE115571T1 - Verfahren zur herstellung von 1-(3'-(chloro)- phenyl>-4-(methyl>-7,8-di-(methoxy>-5h-2,3- benzodiazepin hoher reinheit. - Google Patents

Verfahren zur herstellung von 1-(3'-(chloro)- phenyl>-4-(methyl>-7,8-di-(methoxy>-5h-2,3- benzodiazepin hoher reinheit.

Info

Publication number: ATE115571T1
Authority: AT; Austria
Prior art keywords: formula; chloro; methoxy; benzodiazepine; phenyl
Prior art date: 1991-05-03

Application number

AT92107402T

Other languages

English (en)

Inventor

Gyoergy Somogyi

Peter Botka

Tamas Dr Hamori

Jeno Dr Koeroesi

Csilla Kiss

Nee Igloi Maria Dr Bidlo

Tibor Dr Balogh

Gyula Dr Horvath

Antal Dr Simay

Rozsa Dr Gyenge

Imre Moravcsik

Ernoe Dr Orban

Nee Dievald Emilia Dr Uskert

Original Assignee

Egyt Gyogyszervegyeszeti Gyar

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-03

Filing date

1992-05-04

Publication date

1994-12-15

1992-05-04 Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar

1994-12-15 Application granted granted Critical

1994-12-15 Publication of ATE115571T1 publication Critical patent/ATE115571T1/de

Links

238000000034 method Methods 0.000 title abstract 2
VQYLGVVODFDFNK-UHFFFAOYSA-N girisopam Chemical compound C1=2C=C(OC)C(OC)=CC=2CC(C)=NN=C1C1=CC=CC(Cl)=C1 VQYLGVVODFDFNK-UHFFFAOYSA-N 0.000 abstract 3
239000003513 alkali Substances 0.000 abstract 2
239000003960 organic solvent Substances 0.000 abstract 2
NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 abstract 1
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
JRILKXNWJMAVMT-UHFFFAOYSA-N 1-[2-(3-chlorobenzoyl)-4,5-dimethoxyphenyl]propan-2-one Chemical compound C1=C(OC)C(OC)=CC(CC(C)=O)=C1C(=O)C1=CC=CC(Cl)=C1 JRILKXNWJMAVMT-UHFFFAOYSA-N 0.000 abstract 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
229910001854 alkali hydroxide Inorganic materials 0.000 abstract 1
150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000011109 contamination Methods 0.000 abstract 1
239000012043 crude product Substances 0.000 abstract 1
IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT92107402T 1991-05-03 1992-05-04 Verfahren zur herstellung von 1-(3'-(chloro)- phenyl>-4-(methyl>-7,8-di-(methoxy>-5h-2,3- benzodiazepin hoher reinheit. ATE115571T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU911482A HU208429B (en)	1991-05-03	1991-05-03	Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity

Publications (1)

Publication Number	Publication Date
ATE115571T1 true ATE115571T1 (de)	1994-12-15

Family

ID=10954672

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92107402T ATE115571T1 (de)	1991-05-03	1992-05-04	Verfahren zur herstellung von 1-(3'-(chloro)- phenyl>-4-(methyl>-7,8-di-(methoxy>-5h-2,3- benzodiazepin hoher reinheit.

Country Status (11)

Country	Link
US (1)	US5288863A (de)
EP (1)	EP0512419B1 (de)
JP (1)	JPH0656800A (de)
KR (1)	KR920021519A (de)
CN (1)	CN1067652A (de)
AT (1)	ATE115571T1 (de)
DE (1)	DE69200889T2 (de)
GB (1)	GB2255338B (de)
HU (1)	HU208429B (de)
RU (1)	RU2065852C1 (de)
YU (1)	YU44992A (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19604920A1 (de) *	1996-02-01	1997-08-07	Schering Ag	Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
HU9600871D0 (en) *	1996-04-04	1996-05-28	Gyogyszerkutato Intezet	New 2,3-benzodiazepine derivatives
ZA972746B (en) *	1996-04-04	1998-10-09	Egyt Gyogyszervegyeszeti Gyar	Novel 2,3-benzodiazepine derivatives
WO2004069155A2 (en) *	2002-12-03	2004-08-19	Vela Pharmaceuticals, Inc.	Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof
US7745431B2 (en) *	2002-12-03	2010-06-29	Vela Acquisition Corporation	Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5H-2,3-benzodiazepine and uses thereof
US6864251B2 (en) *	2002-12-03	2005-03-08	Vela Pharmaceuticals, Inc.	Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US6638928B1 (en)	2002-12-03	2003-10-28	Vela Pharmaceuticals, Inc.	Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US7022700B2 (en) *	2002-12-03	2006-04-04	Vela Pharmaceuticals, Inc.	Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US20040162284A1 (en) *	2003-02-19	2004-08-19	Harris Herbert W.	Method of lowering body temperature with (S) tofisopam
US20040224943A1 (en) *	2003-02-19	2004-11-11	Leventer Steven M.	Method of lowering body temperature with (R) - 2,3-benzodiazepines
TW200732314A (en) *	2005-10-26	2007-09-01	Smithkline Beecham Corp	Substituted thiazoles and their use
EP2885286B1 (de)	2012-08-16	2017-03-22	Bayer Pharma Aktiengesellschaft	2,3-benzodiazepine
SG11201505979UA (en)	2013-02-19	2015-09-29	Bayer Pharma AG	Bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines
CN110128270B (zh) *	2018-11-09	2022-05-24	郑州手性药物研究院有限公司	2,2-二苯基环丙基类化合物及其合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU179018B (en) *	1978-10-19	1982-08-28	Gyogyszerkutato Intezet	Process for producing new 5h-2,3-benzodiazepine derivatives
HU191702B (en) *	1984-06-27	1987-03-30	Gyogyszerkutato Intezet	New process for preparing 1-aryl-5 h-2,3-benzodiazepines

1991
- 1991-05-03 HU HU911482A patent/HU208429B/hu not_active IP Right Cessation
1992
- 1992-04-24 YU YU44992A patent/YU44992A/sh unknown
- 1992-04-30 RU SU925011607A patent/RU2065852C1/ru active
- 1992-04-30 JP JP4135665A patent/JPH0656800A/ja active Pending
- 1992-05-01 GB GB9209433A patent/GB2255338B/en not_active Expired - Fee Related
- 1992-05-04 DE DE69200889T patent/DE69200889T2/de not_active Expired - Lifetime
- 1992-05-04 AT AT92107402T patent/ATE115571T1/de not_active IP Right Cessation
- 1992-05-04 US US07/878,379 patent/US5288863A/en not_active Expired - Fee Related
- 1992-05-04 KR KR1019920007570A patent/KR920021519A/ko not_active Withdrawn
- 1992-05-04 CN CN92104382A patent/CN1067652A/zh active Pending
- 1992-05-04 EP EP92107402A patent/EP0512419B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69200889T2 (de)	1995-05-18
HUT61005A (en)	1992-11-30
JPH0656800A (ja)	1994-03-01
HU911482D0 (en)	1991-11-28
US5288863A (en)	1994-02-22
CN1067652A (zh)	1993-01-06
HU208429B (en)	1993-10-28
EP0512419B1 (de)	1994-12-14
EP0512419A1 (de)	1992-11-11
KR920021519A (ko)	1992-12-18
GB2255338A (en)	1992-11-04
GB9209433D0 (en)	1992-06-17
DE69200889D1 (de)	1995-01-26
RU2065852C1 (ru)	1996-08-27
GB2255338B (en)	1995-01-18
YU44992A (sh)	1994-11-15

Legal Events

Date	Code	Title	Description
1995-06-15	UEP	Publication of translation of european patent specification
1999-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE115571T1 (de)	1994-12-15	Verfahren zur herstellung von 1-(3'-(chloro)- phenyl>-4-(methyl>-7,8-di-(methoxy>-5h-2,3- benzodiazepin hoher reinheit.
US6177575B1 (en)	2001-01-23	Process for manufacture of imidazoles
EP0172413B1 (de)	1993-06-16	Verfahren zur Herstellung von Piperidinderivaten
HU209723B (en)	1994-10-28	Process for producing of piperazine derivatives
KR920014787A (ko)	1992-08-25	2-(2',4'-디하이드록시페닐)-4,6-디아릴-s-트리아진의 제조방법
EP1982983B1 (de)	2011-08-17	Verbessertes Verfahren zur Herstellung von Moxonidin
EP0729947A1 (de)	1996-09-04	Verfahren zur Methylierung von 2,2,6,6-Tetramethylpiperidin-4-on
US4754045A (en)	1988-06-28	Method for producing hydroxyphenylpropionic acid ester
EP0872463B1 (de)	2002-01-09	Chlorierung von sustituierten Alkenen mittels Trichlorisocyanursäure
US3047573A (en)	1962-07-31	N-alkylamido substituted
JP2889838B2 (ja)	1999-05-10	ハロゲン化エーテルの製造方法
EP0133322A1 (de)	1985-02-20	Fluorierte Benzodiazepine
US6160160A (en)	2000-12-12	Process for preparing benzyl carbazates
US5663365A (en)	1997-09-02	Process for the preparation of pyrazolones
HU204803B (en)	1992-02-28	Process for producing isothiazolones
EP1873152B1 (de)	2008-10-15	Reinigungsverfahren von Moxonidine
CA1137482A (en)	1982-12-14	Process for the production of 5-aminoisoxazoles
JPH02149550A (ja)	1990-06-08	Ｎ―（２―カルボキシ―３’，４’―ジメトキシ―シンナモイル）―アンスラニル酸及びその製造方法
JPH05339248A (ja)	1993-12-21	２−ヒドロキシ−４，６−ジアリール−１，３，５−トリアジンの製造方法
CA1220205A (en)	1987-04-07	Preparation of biphenylylsulfonylureas and intermediates therefor
AU680989B2 (en)	1997-08-14	Method of preparing 6-aryloxymethyl-1-hydroxy-4-methyl-2-pyridones
HU202813B (en)	1991-04-29	Process for producing dialkyl-acetals containing keto-groups
JPH03169877A (ja)	1991-07-23	１―メトキシピリミジニル―１ｈ―１，２，４―トリアゾール―３―スルホン酸ニトロアニリド、その製造方法、該化合物を含有する除草剤および該除草剤の製造方法
CA1289558C (en)	1991-09-24	Purification of 1-(alkylamino)-alkyl-2-keto-1,4- diazacycloalkanes
HU210673B (en)	1995-06-28	Method for producing of sulfonyl-urea-derivatives