ATE115577T1 - Tri- und tetrasubstituierte oxetane und tetrahydrofurane und deren zwischenprodukte. - Google Patents

Tri- und tetrasubstituierte oxetane und tetrahydrofurane und deren zwischenprodukte.

Info

Publication number: ATE115577T1
Authority: AT; Austria
Prior art keywords: tetra; tri; substituted; tetrahydrofuranes; cis
Prior art date: 1987-11-20

Application number

AT88310904T

Other languages

English (en)

Inventor

Anil K Saksena

Ashit K Ganguly

Viyyoor M Girijavallabhan

Dinanath F Rane

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-20

Filing date

1988-11-18

Publication date

1994-12-15

1988-11-18 Application filed by Schering Corp filed Critical Schering Corp

1994-12-15 Application granted granted Critical

1994-12-15 Publication of ATE115577T1 publication Critical patent/ATE115577T1/de

Links

239000013067 intermediate product Substances 0.000 title 1
150000002921 oxetanes Chemical class 0.000 title 1
150000007984 tetrahydrofuranes Chemical class 0.000 title 1
-1 4-(4-isopropylpiperazin-1-yl)phenoxy Chemical group 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000003626 1,2,4-triazol-1-yl group Chemical group [*]N1N=C([H])N=C1[H] 0.000 abstract 1
206010017533 Fungal infection Diseases 0.000 abstract 1
241000282412 Homo Species 0.000 abstract 1
206010020751 Hypersensitivity Diseases 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
208000031888 Mycoses Diseases 0.000 abstract 1
230000003266 anti-allergic effect Effects 0.000 abstract 1
230000000843 anti-fungal effect Effects 0.000 abstract 1
229940121375 antifungal agent Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
AHHWIHXENZJRFG-UHFFFAOYSA-N oxetane Chemical compound C1COC1 AHHWIHXENZJRFG-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
IWELDVXSEVIIGI-UHFFFAOYSA-N piperazin-2-one Chemical class O=C1CNCCN1 IWELDVXSEVIIGI-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)

AT88310904T 1987-11-20 1988-11-18 Tri- und tetrasubstituierte oxetane und tetrahydrofurane und deren zwischenprodukte. ATE115577T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US12350087A	1987-11-20	1987-11-20

Publications (1)

Publication Number	Publication Date
ATE115577T1 true ATE115577T1 (de)	1994-12-15

Family

ID=22409034

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88310904T ATE115577T1 (de)	1987-11-20	1988-11-18	Tri- und tetrasubstituierte oxetane und tetrahydrofurane und deren zwischenprodukte.

Country Status (9)

Country	Link
EP (2)	EP0386143A1 (de)
JP (2)	JPH0717634B2 (de)
AT (1)	ATE115577T1 (de)
AU (1)	AU2811689A (de)
DE (1)	DE3852477T2 (de)
ES (1)	ES2065340T3 (de)
GR (1)	GR3015217T3 (de)
HK (1)	HK186296A (de)
WO (1)	WO1989004829A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5134152A (en) *	1989-12-07	1992-07-28	Sankyo Company, Limited	Oxetane derivatives and their use as anti-fungal or fungicidal agents
IL103558A0 (en)	1991-10-30	1993-03-15	Schering Corp	Tri-substituted tetrahydrofuran antifungals
US5403937A (en) *	1993-04-30	1995-04-04	Schering Corporation	Process for preparing intermediates for the synthesis of antifungal agents
US5349099A (en) *	1993-12-13	1994-09-20	Schering Corporation	Process for preparing intermediates for the synthesis of antifungal agents
US5710154A (en) *	1993-12-21	1998-01-20	Schering Corporation	Tetrahydrofuran antifungals
ZA9410142B (en) *	1993-12-21	1996-05-02	Schering Corp	Tetrahydrofuran antifungals
US5693626A (en) *	1993-12-21	1997-12-02	Schering Corporation	Tetrahydrofuran antifungals
US5703236A (en) *	1993-12-21	1997-12-30	Schering Corporation	Tetrahydrofuran antifungals
US5714490A (en) *	1993-12-21	1998-02-03	Schering Corporation	Tetrahydrofuran antifungals
US5661151A (en) *	1993-12-21	1997-08-26	Schering Corporation	Tetrahydrofuran antifungals
US5703079A (en) *	1993-12-21	1997-12-30	Schering Corporation	Tetrahydrofuran antifungals
US5442093A (en) *	1994-05-09	1995-08-15	Schering Corporation	Process for preparing intermediates for the synthesis of antifungal agents
US5486625A (en) *	1994-07-08	1996-01-23	Schering Corporation	Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents
US5625064A (en) *	1995-04-19	1997-04-29	Schering Corporation	Process for the preparation of triazolones
US5616777A (en) *	1995-04-19	1997-04-01	Schering Corporation	Chiral hydrazine derivatives
US5698557A (en) *	1995-06-19	1997-12-16	Schering Corporation	Hydroxy-substituted antifungals
US5834472A (en) *	1996-05-24	1998-11-10	Schering Corporation	Antifungal composition with enhanced bioavailability
US5846971A (en) *	1996-06-28	1998-12-08	Schering Corporation	Oral antifungal composition
KR100342383B1 (ko) *	1999-06-17	2002-12-06	한국화학연구원	이소옥사졸리딘 유도체, 그의 제조 방법 및 그를 포함하는 살균제 조성물
KR101415742B1 (ko) *	2011-12-21	2014-07-04	영남대학교 산학협력단	6―아미노피리딘―3―올 유도체 또는 이의 약제학적 허용가능한 염 및 이를 유효성분으로 함유하는 혈관신생으로 인한 질환의 예방 또는 치료용 약학조성물
CN107001343B (zh)	2014-12-05	2020-12-11	普尔莫赛德有限公司	抗真菌的化合物
WO2016185225A1 (en)	2015-05-21	2016-11-24	Pulmocide Limited	Antifungal 4-(4-(4-(((3r,5r)-5-((1 h -1,2,4-triazol-1 -yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)- 3-methylphenyl)piperazin-1 -yl )-n -(2-h yd roxycyc lo h exyl) b e nzam i d e, or a pharmaceutically acceptable salt thereof.
CN105949278B (zh) *	2016-03-30	2019-12-06	南京曼杰生物科技有限公司	一种取代的四氢呋喃水溶性衍生物及其应用
EP3886854A4 (de)	2018-11-30	2022-07-06	Nuvation Bio Inc.	Pyrrol- und pyrazolverbindungen und verfahren zu deren verwendung
GB201917867D0 (en)	2019-12-06	2020-01-22	Pulmocide Ltd	Polymorphs
CN115322182B (zh) *	2022-08-23	2025-03-14	广西医科大学	一种氮唑类抗真菌化合物及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS55125405A (en) *	1979-03-22	1980-09-27	Funakubo Hiroyasu	Posture discriminating system
FR2458838A1 (fr) *	1979-06-06	1981-01-02	Thomson Csf	Dispositif de mesure de l'orientation relative de deux corps et systeme de reperage de direction correspondant
US4456605A (en)	1981-05-07	1984-06-26	Janssen Pharmaceutica N.V.	Heterocyclic derivatives of [4-(piperazin-1-yl-phenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles
GB2099818A (en)	1981-06-06	1982-12-15	Pfizer Ltd	Triazoles
EP0089100B1 (de)	1982-02-09	1989-05-31	Imperial Chemical Industries Plc	Fungizide Azolylderivate
DE3370798D1 (en)	1982-06-14	1987-05-14	Ici Plc	Fungicidal or plant growth regulating triazolyl ethanols
US4482558A (en) *	1982-06-18	1984-11-13	Pfizer Inc.	Antifungal amide and urea derivatives of (3-amino-2-aryl-2-hydroxyprop-1-yl)-1H-1,2,4-triazoles
EP0106515B1 (de) *	1982-09-30	1988-12-28	Pfizer Limited	Triazol-Derivate als Antifungale Mittel
GB8306512D0 (en) *	1983-03-09	1983-04-13	Ici Plc	Heterocyclic compounds
DE3402166A1 (de) *	1984-01-23	1985-07-25	Hoechst Ag, 6230 Frankfurt	Azolyl-aryl-alkanol-derivate, verfahren zu ihrer herstellung und ihre verwendung
FR2597868B1 (fr) *	1986-04-23	1988-09-02	Rhone Poulenc Agrochimie	Composes a groupements triazole ou imidazole et tetrahydrofuranne, utilisation de ceux-ci a titre de fongicides et procedes de preparation
FR2558834B1 (fr) *	1984-01-26	1988-01-08	Rhone Poulenc Agrochimie	Fongicides a groupes triazole et oligoether
DK354185A (da)	1984-08-31	1986-03-01	Hoffmann La Roche	1,3-dioxolanderivater
FR2611714A2 (fr) *	1986-04-23	1988-09-09	Rhone Poulenc Agrochimie	Composes a groupements triazole ou imidazole et tetrahydrofuran, utilisation de ceux-ci a titre de fongicides et procedes de preparation
FR2603039B1 (fr) *	1986-08-22	1990-01-05	Rhone Poulenc Agrochimie	Derives de 2,5-dihydrofuranne a groupe triazole ou imidazole, procede de preparation, utilisation comme fongicide
FR2603036B1 (fr) *	1986-08-22	1988-11-25	Rhone Poulenc Agrochimie	Derives de 2,3-dihydrofuranne, leur procede de preparation, leur utilisation comme intermediaire pour la preparation de tetrahydrofuranne
FR2603038B1 (fr) *	1986-08-22	1988-11-25	Rhone Poulenc Agrochimie	Procede de preparation de composes a groupes triazole et tetrahydrofuranne, nouveaux composes utilisables pour la preparation desdits composes

1988
- 1988-11-18 AT AT88310904T patent/ATE115577T1/de not_active IP Right Cessation
- 1988-11-18 AU AU28116/89A patent/AU2811689A/en not_active Abandoned
- 1988-11-18 EP EP89900481A patent/EP0386143A1/de active Pending
- 1988-11-18 WO PCT/US1988/003987 patent/WO1989004829A1/en not_active Ceased
- 1988-11-18 DE DE3852477T patent/DE3852477T2/de not_active Expired - Fee Related
- 1988-11-18 ES ES88310904T patent/ES2065340T3/es not_active Expired - Lifetime
- 1988-11-18 EP EP88310904A patent/EP0318214B1/de not_active Expired - Lifetime
- 1988-11-18 JP JP1500271A patent/JPH0717634B2/ja not_active Expired - Lifetime
1994
- 1994-08-09 JP JP6217792A patent/JPH07196506A/ja active Pending
1995
- 1995-02-28 GR GR950400421T patent/GR3015217T3/el unknown
1996
- 1996-10-03 HK HK186296A patent/HK186296A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH02504033A (ja)	1990-11-22
WO1989004829A1 (en)	1989-06-01
JPH07196506A (ja)	1995-08-01
GR3015217T3 (en)	1995-05-31
DE3852477D1 (de)	1995-01-26
AU2811689A (en)	1989-06-14
JPH0717634B2 (ja)	1995-03-01
HK186296A (en)	1996-10-11
EP0318214B1 (de)	1994-12-14
EP0386143A1 (de)	1990-09-12
EP0318214A1 (de)	1989-05-31
DE3852477T2 (de)	1995-05-04
ES2065340T3 (es)	1995-02-16

Legal Events

Date	Code	Title	Description
2003-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE115577T1 (de)	1994-12-15	Tri- und tetrasubstituierte oxetane und tetrahydrofurane und deren zwischenprodukte.
NZ218553A (en)	1990-06-26	((4-(4-(4-phenyl-1-piperazinyl)-phenoxy methyl)-1,3-dioxolan-2-yl)-methyl)-1h-imidazole and -1h-1,2,4 triazole derivatives as pharmaceuticals
NZ237565A (en)	1993-02-25	Substituted thiazolidinones, oxazolidinones or imidazolidinones and antiinflammatory pharmaceutical compositions thereof
BR8306240A (pt)	1984-06-19	Processo para a preparacao de derivados de hidroxialquil-azolilo heterociclicamente substituidos,composicao fungicida,processos para o combate de fungos,para a protecao de plantas e para a preparacao de composicoes
ATE80626T1 (de)	1992-10-15	4-(4-(4-(4-((2-(2,4-difluorophenyl)-2-(1hazolylmethyl)-1,3-dioxolan-4-yl>-methoxy>phenyl - 1-piperazinyl>phenyl>triazolone.
NO903640L (no)	1991-02-19	Fremgangsmaate for fremstilling av 2-(rs)-substituerte 2,3-dihydro-5-oksy-4,6,7-trimetylbenzofuraner.
ATE136305T1 (de)	1996-04-15	4-(4-(4-(4-((2-(2,4-difluorphenyl)-2-(1h- azolylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl> 1-piperazinyl>phenyl>triazolone und imidazolone zur bekämpfung von pilzen
EP0801065A4 (de)	1998-02-25	1,4-dihydropyridinverbindungen und sie enthaltende medizinische zusammensetzungen
BR8401701A (pt)	1984-11-20	Processo para a preparacao de derivados de 1-azolil-3-pirazolil-2-propanol,composicoes fungicidas e processo para o combate de fungos e para a preparacao de composicoes
MX9205186A (es)	1993-03-01	Derivados de 4-[4-[4-(4-hidroxifenil)-1-piperazinil]-fenil]-5-metil-3h-1,2,4-triazo l-3-ona
EP0171724A3 (de)	1988-08-31	Phenoxypropionsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide
DE69523447D1 (de)	2001-11-29	Kristallformen von 1-[5-methansulfonamidoindolyl-2-carbonyl]-4-[3-[1-methylethylamino]-2-pyridinyl] piperazin
DE3878186D1 (de)	1993-03-18	Azolverbindungen.
ATE1709T1 (de)	1982-11-15	Heterocyclische (4-(piperazin-1-ylphenyloxymethyl)-1.3-dioxolan-2-ylmethyl) -1himidazol- und 1h-1.2.4-triazol-derivate, ihre herstellung und verwendung als fungizide und bakterizide.