ATE115587T1 - 11-keto- oder hydroxy-3,5-diensteroiden als inhibitoren der steroid-5-alpha-reduktase. - Google Patents
11-keto- oder hydroxy-3,5-diensteroiden als inhibitoren der steroid-5-alpha-reduktase.Info
- Publication number
- ATE115587T1 ATE115587T1 AT90311807T AT90311807T ATE115587T1 AT E115587 T1 ATE115587 T1 AT E115587T1 AT 90311807 T AT90311807 T AT 90311807T AT 90311807 T AT90311807 T AT 90311807T AT E115587 T1 ATE115587 T1 AT E115587T1
- Authority
- AT
- Austria
- Prior art keywords
- alpha
- keto
- steroids
- steroid
- hydroxy
- Prior art date
Links
- 239000002677 5-alpha reductase inhibitor Substances 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 3
- 229930194542 Keto Natural products 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000468 ketone group Chemical group 0.000 abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/002—Expansion of ring A by one atom, e.g. A homo steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0095—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 carbon in position 21 is part of carboxylic group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/430,152 US5041433A (en) | 1987-04-29 | 1989-11-01 | 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-α-reductase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE115587T1 true ATE115587T1 (de) | 1994-12-15 |
Family
ID=23706275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90311807T ATE115587T1 (de) | 1989-11-01 | 1990-10-29 | 11-keto- oder hydroxy-3,5-diensteroiden als inhibitoren der steroid-5-alpha-reduktase. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5041433A (de) |
| EP (1) | EP0427434B1 (de) |
| JP (1) | JPH03169890A (de) |
| KR (1) | KR100187945B1 (de) |
| AT (1) | ATE115587T1 (de) |
| AU (1) | AU641701B2 (de) |
| CA (1) | CA2028622A1 (de) |
| DE (1) | DE69015129T2 (de) |
| DK (1) | DK0427434T3 (de) |
| ES (1) | ES2064661T3 (de) |
| GR (1) | GR3015372T3 (de) |
| IE (1) | IE65562B1 (de) |
| NZ (1) | NZ235871A (de) |
| PT (1) | PT95750A (de) |
| ZA (1) | ZA908730B (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5516768A (en) * | 1990-03-16 | 1996-05-14 | Smithkline Beecham Corporation | Uncompetitive inhibition of steroid and 5α-reductose |
| US5300294A (en) * | 1990-06-27 | 1994-04-05 | Smithkline Beecham Corporation | Method of treating prostatic adenocarcinoma |
| IT1259419B (it) * | 1991-05-24 | 1996-03-18 | Erba Carlo Spa | Steroidi 3-carbossi 17b - sostituiti insaturi utili come inibitori della testosterone 5 a reduttasi |
| NZ245504A (en) * | 1991-12-20 | 1995-08-28 | Hoechst Ag | Bile acid derivatives containing an ethylenically unsaturated grouping |
| US5215894A (en) * | 1992-02-25 | 1993-06-01 | Merck & Co., Inc. | Biological process for producing 17β-N-monosubstituted carbamoyl-11-oxo-4-aza-5-α-androst-3-one testosterone-5-α reductase inhibitors |
| HUT71514A (en) * | 1992-05-21 | 1995-12-28 | Endorecherche Inc | Inhibitors of testosterone 5 alfa-reductase activity and pharmaceutical compositions containing the same |
| US5641765A (en) * | 1992-11-18 | 1997-06-24 | Smithkline Beecham Corporation | 17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase |
| US5683995A (en) * | 1992-11-18 | 1997-11-04 | Smithkline Beecham Corporation | 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors |
| AP9300589A0 (en) * | 1992-11-18 | 1994-01-31 | Smithkline Beecham Corp | Novel 17a and 17b substituted acyl-3-carboxy 3,5-diene steroidal compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-a-reductase. |
| TW369521B (en) * | 1993-09-17 | 1999-09-11 | Smithkline Beecham Corp | Androstenone derivative |
| US5637310A (en) * | 1993-12-20 | 1997-06-10 | Smithkline Beecham Corporation | Method of treating prostatic adenocarcinoma |
| WO1995028413A1 (en) * | 1994-04-15 | 1995-10-26 | Smithkline Beecham Corporation | 17β-SUBSTITUTED 3-CARBOXY STEROIDS THAT INHIBIT 5-α-REDUCTASE |
| US5541322A (en) * | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
| CA2330611A1 (en) | 1998-05-22 | 1999-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
| US20060148725A1 (en) * | 2001-12-21 | 2006-07-06 | The Miriam Hospital | Selective 11beta HSD inhibitors and methods of use thereof |
| WO2003059267A2 (en) * | 2001-12-21 | 2003-07-24 | Rhode Island Hospital | SELECTIVE 11β-HSD INHIBITORS AND METHODS FOR USE THEREOF |
| US20050020550A1 (en) * | 2003-04-29 | 2005-01-27 | Morris David J. | Selective testicular 11beta-HSD inhibitors and methods of use thereof |
| SI1889198T1 (sl) | 2005-04-28 | 2015-02-27 | Proteus Digital Health, Inc. | Farma-informacijski sistem |
| WO2007035716A2 (en) | 2005-09-16 | 2007-03-29 | Raptor Pharmaceutical Inc. | Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof |
| DK2398500T3 (da) | 2009-02-20 | 2019-05-13 | 2 Bbb Medicines B V | Glutathion-baseret lægemiddelafgivelsessystem |
| SG175896A1 (en) | 2009-05-06 | 2011-12-29 | Lab Skin Care Inc | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
| CN116606340A (zh) * | 2022-10-14 | 2023-08-18 | 上海醇健实业发展有限公司 | 一种甾体化合物及其制备方法、其用途和其药物组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4191759A (en) * | 1978-04-13 | 1980-03-04 | Merck & Co., Inc. | N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors |
| US4377584A (en) * | 1978-04-13 | 1983-03-22 | Merck & Co., Inc. | 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors |
| US4317817A (en) * | 1979-08-27 | 1982-03-02 | Richardson-Merrell Inc. | Novel steroid 5α-reductase inhibitors |
| DK465481A (da) * | 1980-11-21 | 1982-05-22 | Hoffmann La Roche | Fremgangsmaade til fremstilling af d-homostemoider |
| US4814324A (en) * | 1987-03-06 | 1989-03-21 | Merck & Co., Inc. | Sterol inhibitors of testosterone 5α-reductase |
| US4910226A (en) * | 1987-04-29 | 1990-03-20 | Smithkline Beckman Corporation | Steroid 5-alpha-reductase inhibitors |
-
1989
- 1989-11-01 US US07/430,152 patent/US5041433A/en not_active Expired - Lifetime
-
1990
- 1990-10-26 CA CA002028622A patent/CA2028622A1/en not_active Abandoned
- 1990-10-26 AU AU65511/90A patent/AU641701B2/en not_active Ceased
- 1990-10-29 ES ES90311807T patent/ES2064661T3/es not_active Expired - Lifetime
- 1990-10-29 DE DE69015129T patent/DE69015129T2/de not_active Expired - Fee Related
- 1990-10-29 EP EP90311807A patent/EP0427434B1/de not_active Expired - Lifetime
- 1990-10-29 NZ NZ235871A patent/NZ235871A/en unknown
- 1990-10-29 AT AT90311807T patent/ATE115587T1/de not_active IP Right Cessation
- 1990-10-29 DK DK90311807.3T patent/DK0427434T3/da active
- 1990-10-31 PT PT95750A patent/PT95750A/pt not_active Application Discontinuation
- 1990-10-31 JP JP2297020A patent/JPH03169890A/ja active Pending
- 1990-10-31 ZA ZA908730A patent/ZA908730B/xx unknown
- 1990-10-31 IE IE392090A patent/IE65562B1/en unknown
- 1990-11-01 KR KR1019900017704A patent/KR100187945B1/ko not_active Expired - Fee Related
-
1995
- 1995-03-13 GR GR940403878T patent/GR3015372T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR100187945B1 (ko) | 1999-06-01 |
| KR910009725A (ko) | 1991-06-28 |
| NZ235871A (en) | 1991-12-23 |
| DK0427434T3 (da) | 1995-05-08 |
| US5041433A (en) | 1991-08-20 |
| JPH03169890A (ja) | 1991-07-23 |
| AU6551190A (en) | 1991-07-18 |
| DE69015129D1 (de) | 1995-01-26 |
| IE65562B1 (en) | 1995-11-01 |
| EP0427434B1 (de) | 1994-12-14 |
| EP0427434A2 (de) | 1991-05-15 |
| AU641701B2 (en) | 1993-09-30 |
| ES2064661T3 (es) | 1995-02-01 |
| PT95750A (pt) | 1991-09-13 |
| EP0427434A3 (en) | 1992-03-04 |
| CA2028622A1 (en) | 1991-05-02 |
| ZA908730B (en) | 1991-11-27 |
| GR3015372T3 (en) | 1995-06-30 |
| DE69015129T2 (de) | 1995-05-04 |
| IE903920A1 (en) | 1991-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |