DK0414529T3 - Substituerede steroidderivater - Google Patents

Substituerede steroidderivater

Info

Publication number: DK0414529T3
Authority: DK; Denmark
Prior art keywords: alpha; 8alkyl; keto; beta; ring
Prior art date: 1989-08-24

Application number

DK90309220.3T

Other languages

English (en)

Inventor

Brian Walter Metcalf

Dennis Alan Holt

Mark Alan Levy

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-24

Filing date

1990-08-22

Publication date

1995-05-22

1990-08-22 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1995-05-22 Application granted granted Critical

1995-05-22 Publication of DK0414529T3 publication Critical patent/DK0414529T3/da

Links

150000003431 steroids Chemical class 0.000 title 1
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
229930194542 Keto Natural products 0.000 abstract 2
125000000468 ketone group Chemical group 0.000 abstract 2
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
210000002307 prostate Anatomy 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)

DK90309220.3T 1989-08-24 1990-08-22 Substituerede steroidderivater DK0414529T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/398,192 US5032586A (en)	1989-08-24	1989-08-24	7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase

Publications (1)

Publication Number	Publication Date
DK0414529T3 true DK0414529T3 (da)	1995-05-22

Family

ID=23574362

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90309220.3T DK0414529T3 (da)	1989-08-24	1990-08-22	Substituerede steroidderivater

Country Status (15)

Country	Link
US (1)	US5032586A (da)
EP (1)	EP0414529B1 (da)
JP (1)	JPH03118326A (da)
KR (1)	KR910004653A (da)
AT (1)	ATE116657T1 (da)
AU (1)	AU640396B2 (da)
CA (1)	CA2023609A1 (da)
DE (1)	DE69015736T2 (da)
DK (1)	DK0414529T3 (da)
ES (1)	ES2066140T3 (da)
GR (1)	GR3015461T3 (da)
IE (1)	IE903070A1 (da)
NZ (1)	NZ235000A (da)
PT (1)	PT95090A (da)
ZA (1)	ZA906710B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5516768A (en) *	1990-03-16	1996-05-14	Smithkline Beecham Corporation	Uncompetitive inhibition of steroid and 5α-reductose
US5300294A (en) *	1990-06-27	1994-04-05	Smithkline Beecham Corporation	Method of treating prostatic adenocarcinoma
IT1259419B (it) *	1991-05-24	1996-03-18	Erba Carlo Spa	Steroidi 3-carbossi 17b - sostituiti insaturi utili come inibitori della testosterone 5 a reduttasi
IL104601A0 (en) *	1992-02-07	1993-07-08	Smithkline Beecham Corp	Process for the preparation of steroidal dienes
US5215894A (en) *	1992-02-25	1993-06-01	Merck & Co., Inc.	Biological process for producing 17β-N-monosubstituted carbamoyl-11-oxo-4-aza-5-α-androst-3-one testosterone-5-α reductase inhibitors
DK0567271T3 (da) *	1992-04-20	1998-02-16	Sankyo Co	Steroidderivater til behandling af prostatahypertrofi, fremgangsmåde til fremstilling heraf og anvendelser heraf
WO1993023420A1 (en) *	1992-05-20	1993-11-25	Merck & Co., Inc.	NEW 7β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS
KR950701527A (ko) *	1992-05-21	1995-04-28	라브리 페르낭	테스토스테론 5α 환원효소 활성 저해제(INHIBITORS OF TESTOSTERONE 5α-REDUCTASE ACTIVITY)
US5641765A (en) *	1992-11-18	1997-06-24	Smithkline Beecham Corporation	17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
IL107611A0 (en) *	1992-11-18	1994-02-27	Smithkline Beecham Corp	Steroid compounds and pharmaceutical compositions containing them
US5683995A (en) *	1992-11-18	1997-11-04	Smithkline Beecham Corporation	17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5637310A (en) *	1993-12-20	1997-06-10	Smithkline Beecham Corporation	Method of treating prostatic adenocarcinoma
WO1995028413A1 (en) *	1994-04-15	1995-10-26	Smithkline Beecham Corporation	17β-SUBSTITUTED 3-CARBOXY STEROIDS THAT INHIBIT 5-α-REDUCTASE
EP0784627A4 (en) *	1994-10-05	1998-05-06	Smithkline Beecham Corp	PROCESS FOR THE PREPARATION OF ANDROSTA-3,5-DIENE-3-CARBOXYLIC ACIDS WITH 17 BETA SUBSTITUTION
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
US5887683A (en) *	1996-12-23	1999-03-30	Shimano Inc.	Brake adjusting device
US6372712B1 (en)	1998-05-22	2002-04-16	The Board Of Trustees Of The Leland Stanford Jr. University	Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
EP2671508B1 (en)	2005-04-28	2020-09-16	Proteus Digital Health, Inc.	Pharma-informatics system
US9062126B2 (en)	2005-09-16	2015-06-23	Raptor Pharmaceuticals Inc.	Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
ES2919563T3 (es)	2009-02-20	2022-07-27	Enhanx Biopharm Inc	Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko)	2009-05-06	2018-10-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4191759A (en) *	1978-04-13	1980-03-04	Merck & Co., Inc.	N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors
US4377584A (en) *	1978-04-13	1983-03-22	Merck & Co., Inc.	4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4317817A (en) *	1979-08-27	1982-03-02	Richardson-Merrell Inc.	Novel steroid 5α-reductase inhibitors
DK465481A (da) *	1980-11-21	1982-05-22	Hoffmann La Roche	Fremgangsmaade til fremstilling af d-homostemoider
US4814324A (en) *	1987-03-06	1989-03-21	Merck & Co., Inc.	Sterol inhibitors of testosterone 5α-reductase
US4910226A (en) *	1987-04-29	1990-03-20	Smithkline Beckman Corporation	Steroid 5-alpha-reductase inhibitors

1989
- 1989-08-24 US US07/398,192 patent/US5032586A/en not_active Expired - Fee Related
1990
- 1990-08-20 CA CA002023609A patent/CA2023609A1/en not_active Abandoned
- 1990-08-21 AU AU61152/90A patent/AU640396B2/en not_active Ceased
- 1990-08-21 NZ NZ235000A patent/NZ235000A/en unknown
- 1990-08-22 AT AT90309220T patent/ATE116657T1/de not_active IP Right Cessation
- 1990-08-22 ES ES90309220T patent/ES2066140T3/es not_active Expired - Lifetime
- 1990-08-22 DK DK90309220.3T patent/DK0414529T3/da active
- 1990-08-22 EP EP90309220A patent/EP0414529B1/en not_active Expired - Lifetime
- 1990-08-22 DE DE69015736T patent/DE69015736T2/de not_active Expired - Fee Related
- 1990-08-23 JP JP2224148A patent/JPH03118326A/ja active Pending
- 1990-08-23 IE IE307090A patent/IE903070A1/en unknown
- 1990-08-23 ZA ZA906710A patent/ZA906710B/xx unknown
- 1990-08-23 PT PT95090A patent/PT95090A/pt not_active Application Discontinuation
- 1990-08-24 KR KR1019900013108A patent/KR910004653A/ko not_active Withdrawn
1995
- 1995-03-20 GR GR950400592T patent/GR3015461T3/el unknown

Also Published As

Publication number	Publication date
ES2066140T3 (es)	1995-03-01
DE69015736D1 (de)	1995-02-16
JPH03118326A (ja)	1991-05-20
PT95090A (pt)	1991-04-18
DE69015736T2 (de)	1995-05-11
ZA906710B (en)	1991-09-25
EP0414529A2 (en)	1991-02-27
ATE116657T1 (de)	1995-01-15
US5032586A (en)	1991-07-16
CA2023609A1 (en)	1991-02-25
AU640396B2 (en)	1993-08-26
GR3015461T3 (en)	1995-06-30
AU6115290A (en)	1991-02-28
EP0414529A3 (en)	1991-07-24
IE903070A1 (en)	1991-02-27
KR910004653A (ko)	1991-03-29
EP0414529B1 (en)	1995-01-04
NZ235000A (en)	1992-03-26

Publication	Publication Date	Title
EP0414529A3 (en)	1991-07-24	Substituted steroid derivatives
ES8404993A1 (es)	1984-05-16	Procedimiento para preparar derivados de piridina
DE69512797D1 (en)	1999-11-18	Prostaglandin-synthase hemmer
HU9401415D0 (en)	1994-08-29	Enzofuranyl- and -thiophenyl-alkane-carboxylic acid derivatives, pharmaceutical compositions contaning them, and process for producing them
GR3004902T3 (da)	1993-04-28
ES8606306A1 (es)	1986-04-16	Un procedimiento para preparar nuevos derivados de benzo- triazol- y benzoxazolamina
NO902598L (no)	1990-08-07	Fremgangsmaate og fremstilling av 7-substituert hept-6-ensyre og heptansyre og derivater og mellomprodukter derav.
ES8800272A1 (es)	1987-10-16	Un procedimiento para la preparacion de polipeptidos.
ATE115587T1 (de)	1994-12-15	11-keto- oder hydroxy-3,5-diensteroiden als inhibitoren der steroid-5-alpha-reduktase.
ES8305298A1 (es)	1983-04-01	Un procedimiento para la preparacion de un isomero (25) del acido 2-(4-(2-hidroxiciclopentan-1-ilmetil)fenil)propionico.
ES8207180A1 (es)	1982-09-01	Procedimiento de fabricacion de derivados de tetrahidro-5,67,7a 4h-tieno (3,2-c) piridinona-2 .
ATE110736T1 (de)	1994-09-15	Phosphonsäure-derivate von steroiden als hemmstoffe der 5-alpha-reduktase.
ES8501763A1 (es)	1984-12-16	"procedimiento para la fabricacion de derivados de la tetrahidro-5.6.7.7. 4h-tieno (3, 2-c) piridinona-2
AU640161B2 (en)	1993-08-19	3-substituted nitro-steroid derivatives as 5-alpha-reductase inhibitors
MY110751A (en)	1999-02-27	Positive inotropic and lusitropic pyrroloquinolinone derivatives
EP0074130A3 (en)	1983-08-10	New imidazole compounds, process for the preparation thereof and pharmaceutical compositions containing them
DE3374005D1 (en)	1987-11-12	1-methyl-5-nitro-imidazoline derivatives and therapeutic compositions which contain them as active principle
ES8104222A1 (es)	1981-04-16	Un procedimiento para la preparacion de derivados del acido 7-oxo-1-aza-biciclo (3,2,0) hept-2-en-2-carboxilico
DE3461079D1 (en)	1986-12-04	Unsaturated compounds, their preparation and use
JPS5754175A (ja)	1982-03-31	Shinkina33aminoindazoorujudotai
JPS5261087A (en)	1977-05-20	Method of assembling handrail for human conveyor
JPS5711975A (en)	1982-01-21	Aminophenyltetrazole derivative and salt thereof
JPS5610173A (en)	1981-02-02	Analgesic
ES2048090A1 (es)	1994-03-01	Procedimiento para la obtencion de nuevos antitromboticos derivados de la cumarina.
TW353071B (en)	1999-02-21	Chromene compounds with neutroleptic activity, their preparation and pharmaceutical compositions