ATE116000T1 - Lichtaktivierte acylenzyme. - Google Patents
Lichtaktivierte acylenzyme.Info
- Publication number
- ATE116000T1 ATE116000T1 AT90913585T AT90913585T ATE116000T1 AT E116000 T1 ATE116000 T1 AT E116000T1 AT 90913585 T AT90913585 T AT 90913585T AT 90913585 T AT90913585 T AT 90913585T AT E116000 T1 ATE116000 T1 AT E116000T1
- Authority
- AT
- Austria
- Prior art keywords
- unconjugated
- acyl
- enzymes
- alkyl
- acylene
- Prior art date
Links
- 229940088598 enzyme Drugs 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 229960004072 thrombin Drugs 0.000 abstract 2
- -1 4-(aminoiminomethyl)phenyl ester Chemical class 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012038 nucleophile Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
- C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/43—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/44—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/400,507 US5114851A (en) | 1989-08-29 | 1989-08-29 | Light activated acyl-enzymes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE116000T1 true ATE116000T1 (de) | 1995-01-15 |
Family
ID=23583888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90913585T ATE116000T1 (de) | 1989-08-29 | 1990-08-27 | Lichtaktivierte acylenzyme. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5114851A (de) |
| EP (1) | EP0489836B1 (de) |
| JP (1) | JP2839371B2 (de) |
| KR (1) | KR100192004B1 (de) |
| AT (1) | ATE116000T1 (de) |
| AU (1) | AU636269B2 (de) |
| CA (1) | CA2065008C (de) |
| DE (1) | DE69015361T2 (de) |
| DK (1) | DK0489836T3 (de) |
| ES (1) | ES2067044T3 (de) |
| WO (1) | WO1991003549A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5583107A (en) * | 1990-09-04 | 1996-12-10 | Cor Therapeutics, Inc. | Agents affecting thrombosis and hemostasis |
| SG93823A1 (en) * | 1998-02-13 | 2003-01-21 | Givaudan Roure Int | Aryl-acrylic acid esters |
| US6229020B1 (en) | 1999-01-12 | 2001-05-08 | Laboratory Of Molecular Biophotonics | Reagents for preparation of caged compounds, and method for preparation of the caged compounds |
| US6329546B1 (en) | 1999-01-12 | 2001-12-11 | Laboratory Of Molecular Biophotonics | Caged amino acids |
| US6774116B2 (en) * | 2001-04-17 | 2004-08-10 | Cryolife, Inc. | Prodrugs via acylation with cinnamate |
| US7157458B2 (en) * | 2001-04-17 | 2007-01-02 | Cryolife, Inc. | Bifunctional energy-reversible acyl-compositions |
| AU2002257325A1 (en) | 2001-05-29 | 2002-12-09 | Vanderbilt University | Cleavable surfactants and methods of use thereof |
| AU2002337954C1 (en) | 2001-10-22 | 2008-10-23 | The Scripps Research Institute | Integrin targeting compounds |
| KR20040058229A (ko) | 2001-10-22 | 2004-07-03 | 더 스크립스 리서치 인스티튜트 | 항체 표적화 화합물 |
| WO2007048127A2 (en) * | 2005-10-20 | 2007-04-26 | The Scripps Research Institute | Fc labeling for immunostaining and immunotargeting |
| TWI311679B (en) * | 2006-04-28 | 2009-07-01 | Primax Electronics Ltd | A method of evaluating minimum sampling steps of auto focus |
| JP5008578B2 (ja) | 2008-01-28 | 2012-08-22 | 株式会社リコー | 画像処理方法、画像処理装置及び画像撮像装置 |
| US20100068254A1 (en) * | 2008-09-16 | 2010-03-18 | Mahalaxmi Gita Bangera | Modifying a medicament availability state of a final dosage form |
| US20100068235A1 (en) * | 2008-09-16 | 2010-03-18 | Searete LLC, a limited liability corporation of Deleware | Individualizable dosage form |
| US20100068275A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Personalizable dosage form |
| US20100069821A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo modifiable medicament release-sites final dosage form |
| US20100068266A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo-modifiable multiple-release state final dosage form |
| US20100068152A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo modifiable particle or polymeric based final dosage form |
| US20100068233A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Modifiable dosage form |
| US20100068153A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo activatable final dosage form |
-
1989
- 1989-08-29 US US07/400,507 patent/US5114851A/en not_active Expired - Lifetime
-
1990
- 1990-08-27 EP EP90913585A patent/EP0489836B1/de not_active Expired - Lifetime
- 1990-08-27 JP JP2512544A patent/JP2839371B2/ja not_active Expired - Fee Related
- 1990-08-27 CA CA002065008A patent/CA2065008C/en not_active Expired - Fee Related
- 1990-08-27 DE DE69015361T patent/DE69015361T2/de not_active Expired - Fee Related
- 1990-08-27 DK DK90913585.7T patent/DK0489836T3/da active
- 1990-08-27 WO PCT/US1990/004872 patent/WO1991003549A1/en not_active Ceased
- 1990-08-27 KR KR1019920700467A patent/KR100192004B1/ko not_active Expired - Fee Related
- 1990-08-27 AT AT90913585T patent/ATE116000T1/de not_active IP Right Cessation
- 1990-08-27 AU AU63319/90A patent/AU636269B2/en not_active Ceased
- 1990-08-27 ES ES90913585T patent/ES2067044T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK0489836T3 (da) | 1995-06-06 |
| KR927003805A (ko) | 1992-12-18 |
| EP0489836B1 (de) | 1994-12-21 |
| DE69015361T2 (de) | 1995-06-22 |
| WO1991003549A1 (en) | 1991-03-21 |
| EP0489836A1 (de) | 1992-06-17 |
| KR100192004B1 (ko) | 1999-06-15 |
| JP2839371B2 (ja) | 1998-12-16 |
| AU6331990A (en) | 1991-04-08 |
| CA2065008A1 (en) | 1991-03-01 |
| AU636269B2 (en) | 1993-04-22 |
| CA2065008C (en) | 1995-08-01 |
| US5114851A (en) | 1992-05-19 |
| EP0489836A4 (en) | 1993-05-26 |
| DE69015361D1 (de) | 1995-02-02 |
| ES2067044T3 (es) | 1995-03-16 |
| JPH05500004A (ja) | 1993-01-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0489836T3 (da) | Lysaktiverede acyl-enzymer | |
| AR038429A2 (es) | Compuestos 15-alquil-16-hidroxilo de marcfortina | |
| DK0519327T3 (da) | N-Acyl-S-(2-hydroxyalkyl) -cysteiner, deres fremstilling samt deres anvendelse som mellemprodukter til fremstilling af synt | |
| SE8404019D0 (sv) | Oftalmiskt medel | |
| ES2133430T3 (es) | Derivados de n-heteroaril-n-fenilurea, su preparacion y utilizacion. | |
| DK0776324T3 (da) | Endothelin-antagonister | |
| DK307289D0 (da) | Pyrimidinderivater | |
| ES2158284T3 (es) | Metil-fenil-oxazolidinonas quirales. | |
| DK0532515T3 (da) | Fremstilling af substituerede piperidiner | |
| ES2058173T3 (es) | Dioxialquilenaril-dihidropiridinas, productos intermedios para su fabricacion, procedimientos para su fabricacion y su utilizacion. | |
| FI972384A0 (fi) | Uudet dipeptidiset p-amidinobentsyyliamidit, jotka sisältävät N-terminaalisia sulfonyyli- tai amidinosulfonyyliryhmiä | |
| EA200000094A1 (ru) | Способ получения замещенного пергидроизоиндола | |
| ATE51617T1 (de) | Verfahren zur herstellung von 4-phenyl-pyrrolderivaten. | |
| DK0565558T3 (da) | Fremgangsmåde og mellemprodukter til fremstilling af azabicyclo(2.2.2)octan-3-iminer | |
| ES2039272T3 (es) | Sales opticamente activas a base de un tiazolidin-4-carboxilato sustituido y 3-cloro-2-hidroxipropiltrimetilamonio, su preparacion y empleo. | |
| ES2139744T3 (es) | Sintesis estereoselectiva de analogos de nucleosidos empleando un intermediario biciclico. | |
| DE59010545D1 (de) | Phosphinesterhaltige N-Acyl-2-aminosäureamide, Verfahren zu ihrer Herstellung und N-Acyl-2-aminosäurenitrile als Vorprodukte | |
| FI970449A0 (fi) | N-substituoituja atsabisykloheptaanijohdannaisia, jotka ovat käyttökelpoisia neuroleptisinä aineina | |
| DK1205476T3 (da) | Fremgangsmåde til syntese af N-(mercaptoacyl)-aminosyrederivater ud fra alfa-substituerede acrylsyrer | |
| EA199900888A1 (ru) | Противоревматические средства | |
| ES2039364T3 (es) | Derivados de n - ariltetrahidroftalimida y sus productos previos. | |
| DK0779895T3 (da) | Forbedret fremgangsmåde til fremstilling af sidekædederivater af cyclohexapeptidyl-lipopeptider | |
| CZ281393B6 (cs) | Způsob výroby 6-(substituovaných amino)-propionyl derivátů forskolinu | |
| TR200001122T2 (tr) | Farmasötikler olarak bifenil türevleri. | |
| ES2186127T3 (es) | Sintesis de derivados de nucleosidos aciclicos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |