ES2194102T3 - Nuevas n-(2,4-dioxo-2,3,4,5-tetrahidro-1h-1,5-benzodiazepin-3-il)-3-amidas. - Google Patents

Nuevas n-(2,4-dioxo-2,3,4,5-tetrahidro-1h-1,5-benzodiazepin-3-il)-3-amidas.

Info

Publication number
ES2194102T3
ES2194102T3 ES96916954T ES96916954T ES2194102T3 ES 2194102 T3 ES2194102 T3 ES 2194102T3 ES 96916954 T ES96916954 T ES 96916954T ES 96916954 T ES96916954 T ES 96916954T ES 2194102 T3 ES2194102 T3 ES 2194102T3
Authority
ES
Spain
Prior art keywords
tetrahidro
amidas
benzodiazepin
dioxo
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96916954T
Other languages
English (en)
Inventor
David A Claremon
Nigel Liverton
Harold G Selnick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2194102T3 publication Critical patent/ES2194102T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

ESTA INVENCION TRATA DE NUEVOS COMPUESTOS REPRESENTADOS POR LA FORMULA ESTRUCTURAL (I) QUE RESULTAN UTILES EN EL TRATAMIENTO DE LA ARRITMIA.
ES96916954T 1995-06-07 1996-06-03 Nuevas n-(2,4-dioxo-2,3,4,5-tetrahidro-1h-1,5-benzodiazepin-3-il)-3-amidas. Expired - Lifetime ES2194102T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/476,301 US5700797A (en) 1995-06-07 1995-06-07 N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides

Publications (1)

Publication Number Publication Date
ES2194102T3 true ES2194102T3 (es) 2003-11-16

Family

ID=23891302

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96916954T Expired - Lifetime ES2194102T3 (es) 1995-06-07 1996-06-03 Nuevas n-(2,4-dioxo-2,3,4,5-tetrahidro-1h-1,5-benzodiazepin-3-il)-3-amidas.

Country Status (9)

Country Link
US (1) US5700797A (es)
EP (1) EP0842156B1 (es)
JP (1) JPH11506746A (es)
AT (1) ATE236888T1 (es)
AU (1) AU703665B2 (es)
CA (1) CA2222472A1 (es)
DE (1) DE69627344T2 (es)
ES (1) ES2194102T3 (es)
WO (1) WO1996040654A1 (es)

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US6569851B1 (en) 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
PL2254873T3 (pl) 2008-02-22 2014-10-31 Otsuka Pharma Co Ltd Związek benzodiazepinowy i kompozycja farmaceutyczna
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
WO2011021676A1 (ja) * 2009-08-21 2011-02-24 大塚製薬株式会社 ベンゾ［ｂ］［１，４］ジアゼピン－２，４－ジオン化合物の製造方法
US9815850B2 (en) 2016-02-05 2017-11-14 Denali Therapeutics Inc. Compounds, compositions and methods
LT3552017T (lt) 2016-12-09 2022-05-10 Denali Therapeutics Inc. Junginiai, naudotini kaip ripk1 inhibitoriai
EP4463229A1 (en) 2022-01-12 2024-11-20 Denali Therapeutics Inc. Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide

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DE3134672A1 (de) * 1981-09-02 1983-03-17 Boehringer Ingelheim KG, 6507 Ingelheim Heterocyclische verbindungen, ihre herstellung und verwendung
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
DE3373469D1 (en) * 1982-09-30 1987-10-15 Merck & Co Inc 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
US4537885A (en) * 1983-02-10 1985-08-27 Ciba Geigy Corporation Certain benzazocinone and benzazoninone derivatives
US4470988A (en) * 1983-02-10 1984-09-11 Ciba-Geigy Corporation Benzazocinone and benzazoninone derivatives, and their pharmaceutical use
CS249146B2 (en) * 1984-01-19 1987-03-12 Hoffmann La Roche Method of new imidazodiazepine's derivatives production
US4600534A (en) * 1984-02-06 1986-07-15 Ciba-Geigy Corporation Process and intermediates for manufacture of 3-(5-amino-1-carboxypentylamino)-tetrahydro-1-benzazepin-2-one-1-acetic acid
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
US5004741A (en) * 1984-06-26 1991-04-02 Merck & Co., Inc. Methods of antagonizing CCK or gastrin with benzodiazepine analogs
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
US4847248A (en) * 1986-12-23 1989-07-11 Merck & Co., Inc. 1,4-Benzodiazepines with 5- and 6-membered heterocyclic rings and their use as cholecystokinins and gastrin antagonists
EP0348523A4 (en) * 1987-12-22 1991-10-09 Yoshitomi Pharmaceutical Industries, Ltd. Thienodiazepine compounds and their medicinal use
EP0322779A3 (en) * 1987-12-29 1991-05-08 Yoshitomi Pharmaceutical Industries, Ltd. Benzolactam compounds and pharmaceutical uses thereof
US5166151A (en) * 1988-03-25 1992-11-24 Merck & Co., Inc. 2-Benzazepines with 5- and 6-membered heterocyclic rings, compositions and medical methods of use thereof
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US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck
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GB9116113D0 (en) * 1991-07-25 1991-09-11 Merck Sharp & Dohme Therapeutic agents
DE4125457A1 (de) * 1991-08-01 1993-02-04 Bayer Ag Verfahren zur herstellung von n-substituierten lactamen
KR970002640B1 (ko) * 1991-09-30 1997-03-07 요시또미세이야꾸 가부시끼가이샤 티에노디아제핀 화합물 및 그의 용도
WO1993007131A1 (en) * 1991-10-10 1993-04-15 Merck Sharp & Dohme Limited Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors
EP0538945A1 (en) * 1991-10-24 1993-04-28 Glaxo Group Limited Benzodiazepine derivatives, and their use as antagonists of gastrin and/or cholecystokinin
WO1993008176A1 (en) * 1991-10-24 1993-04-29 Merck Sharp & Dohme Limited Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
DE69204040T2 (de) * 1991-12-20 1996-03-28 Merck Sharp & Dohme 3-Phenylureido-1,4-Benzodiazepinone und ihre Verwendung als Cholecystokinin- oder Gastrinantagonisten.
ZA93436B (en) * 1992-01-24 1993-08-25 Chugai Pharmaceutical Co Ltd Benzopyran derivatives
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IT1254558B (it) * 1992-03-26 1995-09-25 Mini Ricerca Scient Tecnolog Composti a base di 3,4-diaril-(5h)-furan-2-one ad attivita' fungicida 3
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Also Published As

Publication number Publication date
DE69627344T2 (de) 2003-12-04
JPH11506746A (ja) 1999-06-15
AU5966496A (en) 1996-12-30
AU703665B2 (en) 1999-04-01
EP0842156A4 (en) 1998-11-11
ATE236888T1 (de) 2003-04-15
EP0842156B1 (en) 2003-04-09
EP0842156A1 (en) 1998-05-20
DE69627344D1 (de) 2003-05-15
CA2222472A1 (en) 1996-12-19
US5700797A (en) 1997-12-23
WO1996040654A1 (en) 1996-12-19

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