ATE116321T1 - NEW METHOD FOR ISOLATION OF CASTANOSPERMINE. - Google Patents

NEW METHOD FOR ISOLATION OF CASTANOSPERMINE.

Info

Publication number
ATE116321T1
ATE116321T1 AT92115805T AT92115805T ATE116321T1 AT E116321 T1 ATE116321 T1 AT E116321T1 AT 92115805 T AT92115805 T AT 92115805T AT 92115805 T AT92115805 T AT 92115805T AT E116321 T1 ATE116321 T1 AT E116321T1
Authority
AT
Austria
Prior art keywords
castanospermine
isolation
new method
tetrc
enydroxyindolizidine
Prior art date
Application number
AT92115805T
Other languages
German (de)
Inventor
Paul S Liu
Barry L Rhinehart
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of ATE116321T1 publication Critical patent/ATE116321T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Compsn. comprises castanozpermine (ie. IS, 6S, 7R. 8R, (aR - 1, 6, 7, 8-tetrc enydroxyindolizidine) of formula (I).
AT92115805T 1985-05-24 1986-05-21 NEW METHOD FOR ISOLATION OF CASTANOSPERMINE. ATE116321T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73812785A 1985-05-24 1985-05-24

Publications (1)

Publication Number Publication Date
ATE116321T1 true ATE116321T1 (en) 1995-01-15

Family

ID=24966697

Family Applications (2)

Application Number Title Priority Date Filing Date
AT86106863T ATE92318T1 (en) 1985-05-24 1986-05-21 ISOLATION OF CASTANOSPERMINE AND ITS USE AS AN ANTIDABETIC REMEDY.
AT92115805T ATE116321T1 (en) 1985-05-24 1986-05-21 NEW METHOD FOR ISOLATION OF CASTANOSPERMINE.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT86106863T ATE92318T1 (en) 1985-05-24 1986-05-21 ISOLATION OF CASTANOSPERMINE AND ITS USE AS AN ANTIDABETIC REMEDY.

Country Status (5)

Country Link
EP (2) EP0202661B1 (en)
JP (2) JPH0729923B2 (en)
AT (2) ATE92318T1 (en)
CA (1) CA1327970C (en)
DE (2) DE3650190T2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3650377T2 (en) * 1985-12-23 1996-02-22 Hutchinson Fred Cancer Res REGULATION OF RETROVIRAL REPLICATION, INFECTION AND PATHOGENESIS.
GB8827701D0 (en) * 1987-12-09 1988-12-29 Nippon Shinyaku Co Ltd Thrombolytic &c compositions
US5192772A (en) * 1987-12-09 1993-03-09 Nippon Shinyaku Co. Ltd. Therapeutic agents
JPH04500959A (en) * 1988-08-10 1992-02-20 ジ オーストラリアン ナショナル ユニバーシティー Use of castanospermine as an anti-inflammatory and immunosuppressant
AU618838B2 (en) * 1988-08-10 1992-01-09 Praxis Pharmaceuticals, Inc. Use of castanospermine as an anti-inflammatory and immunosuppressant agent
GB8924292D0 (en) * 1989-10-27 1989-12-13 Novalal Ltd The production of a novel dimer chemical product"novo dimers"by the polymersation of indolizidine alkaloids using cyclo dextrin glucosyl transferase
US5844102A (en) * 1994-07-07 1998-12-01 University Of Maryland Baltimore County Glycohydrolase inhibitors, their preparation and use thereof
BR112018072298A2 (en) 2016-05-02 2019-02-12 Florida State University Research Foundation, Inc. treatment of Zika virus infections using alpha-glucosidase inhibitors
US11518762B2 (en) * 2020-06-04 2022-12-06 Florida State University Research Foundation, Inc. Large scale purification of castanospermine

Also Published As

Publication number Publication date
DE3650190D1 (en) 1995-02-09
CA1327970C (en) 1994-03-22
DE3688807D1 (en) 1993-09-09
EP0202661A3 (en) 1990-07-25
DE3688807T2 (en) 1994-02-10
JPS61271220A (en) 1986-12-01
JPH07252151A (en) 1995-10-03
EP0522599A1 (en) 1993-01-13
JPH0729923B2 (en) 1995-04-05
JP2528083B2 (en) 1996-08-28
EP0202661A2 (en) 1986-11-26
DE3650190T2 (en) 1995-05-11
EP0522599B1 (en) 1994-12-28
ATE92318T1 (en) 1993-08-15
EP0202661B1 (en) 1993-08-04

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee