ATE116371T1 - Verfahren zur herstellung von castanosperminestern. - Google Patents

Verfahren zur herstellung von castanosperminestern.

Info

Publication number: ATE116371T1
Authority: AT; Austria
Prior art keywords: esters; producing; castanospermine; castanospermine esters; give
Prior art date: 1989-08-08

Application number

AT90115107T

Other languages

English (en)

Inventor

Alexey L Margolin

Deborah L Delinck

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-08

Filing date

1990-08-06

Publication date

1995-01-15

1990-08-06 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1995-01-15 Application granted granted Critical

1995-01-15 Publication of ATE116371T1 publication Critical patent/ATE116371T1/de

Links

JDVVGAQPNNXQDW-TVNFTVLESA-N Castinospermine Chemical class C1[C@H](O)[C@@H](O)[C@H](O)[C@H]2[C@@H](O)CCN21 JDVVGAQPNNXQDW-TVNFTVLESA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
150000002148 esters Chemical class 0.000 abstract 2
JDVVGAQPNNXQDW-WCMLQCRESA-N Castanospermine Natural products O[C@H]1[C@@H](O)[C@H]2[C@@H](O)CCN2C[C@H]1O JDVVGAQPNNXQDW-WCMLQCRESA-N 0.000 abstract 1
108090000787 Subtilisin Proteins 0.000 abstract 1
150000005690 diesters Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Wood Science & Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Steroid Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT90115107T 1989-08-08 1990-08-06 Verfahren zur herstellung von castanosperminestern. ATE116371T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/390,794 US4970317A (en)	1989-08-08	1989-08-08	Process for the preparation of castanospermine esters

Publications (1)

Publication Number	Publication Date
ATE116371T1 true ATE116371T1 (de)	1995-01-15

Family

ID=23543967

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90115107T ATE116371T1 (de)	1989-08-08	1990-08-06	Verfahren zur herstellung von castanosperminestern.

Country Status (15)

Country	Link
US (1)	US4970317A (de)
EP (1)	EP0412487B1 (de)
JP (1)	JP3019263B2 (de)
KR (1)	KR0167764B1 (de)
AT (1)	ATE116371T1 (de)
AU (1)	AU624013B2 (de)
CA (1)	CA2022576C (de)
DE (1)	DE69015499T2 (de)
DK (1)	DK0412487T3 (de)
ES (1)	ES2068957T3 (de)
GR (1)	GR3015396T3 (de)
HU (1)	HU209671B (de)
IE (1)	IE64971B1 (de)
IL (1)	IL95300A (de)
ZA (1)	ZA906098B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5066807A (en) *	1990-03-12	1991-11-19	Merrell Dow Pharmaceuticals Inc.	Process for the preparation of castanospermine
US5844102A (en) *	1994-07-07	1998-12-01	University Of Maryland Baltimore County	Glycohydrolase inhibitors, their preparation and use thereof
GB0110832D0 (en) *	2001-05-03	2001-06-27	Virogen Ltd	Antiviral compounds
US20060093577A1 (en) *	2004-10-06	2006-05-04	Migenix Inc.	Combination anti-viral compositions and methods of use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4952585A (en) *	1988-12-15	1990-08-28	Merrell Dow Pharmaceuticals Inc.	Castanospermine esters in the inhibition of tumor metastasis

1989
- 1989-08-08 US US07/390,794 patent/US4970317A/en not_active Expired - Lifetime
1990
- 1990-08-02 ZA ZA906098A patent/ZA906098B/xx unknown
- 1990-08-02 CA CA002022576A patent/CA2022576C/en not_active Expired - Lifetime
- 1990-08-03 AU AU60145/90A patent/AU624013B2/en not_active Expired
- 1990-08-06 DK DK90115107.6T patent/DK0412487T3/da active
- 1990-08-06 AT AT90115107T patent/ATE116371T1/de not_active IP Right Cessation
- 1990-08-06 EP EP90115107A patent/EP0412487B1/de not_active Expired - Lifetime
- 1990-08-06 IL IL9530090A patent/IL95300A/en unknown
- 1990-08-06 DE DE69015499T patent/DE69015499T2/de not_active Expired - Lifetime
- 1990-08-06 ES ES90115107T patent/ES2068957T3/es not_active Expired - Lifetime
- 1990-08-07 KR KR1019900012069A patent/KR0167764B1/ko not_active Expired - Lifetime
- 1990-08-07 HU HU904925A patent/HU209671B/hu unknown
- 1990-08-07 IE IE285390A patent/IE64971B1/en not_active IP Right Cessation
- 1990-08-07 JP JP2207714A patent/JP3019263B2/ja not_active Expired - Lifetime
1995
- 1995-03-13 GR GR950400549T patent/GR3015396T3/el unknown

Also Published As

Publication number	Publication date
HUT57271A (en)	1991-11-28
IE64971B1 (en)	1995-09-20
IE902853A1 (en)	1991-02-27
IL95300A0 (en)	1991-06-30
IL95300A (en)	1994-10-21
AU624013B2 (en)	1992-05-28
EP0412487B1 (de)	1994-12-28
JPH0377883A (ja)	1991-04-03
DE69015499D1 (de)	1995-02-09
KR0167764B1 (en)	1999-01-15
EP0412487A2 (de)	1991-02-13
HU904925D0 (en)	1991-01-28
CA2022576C (en)	2001-05-01
AU6014590A (en)	1991-02-14
CA2022576A1 (en)	1991-02-09
GR3015396T3 (en)	1995-06-30
DK0412487T3 (da)	1995-02-20
KR910004618A (ko)	1991-03-29
ZA906098B (en)	1991-05-29
HU209671B (en)	1994-10-28
DE69015499T2 (de)	1995-05-11
JP3019263B2 (ja)	2000-03-13
ES2068957T3 (es)	1995-05-01
US4970317A (en)	1990-11-13
EP0412487A3 (en)	1991-05-29

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Legal Events

Date	Code	Title	Description
1995-07-15	UEP	Publication of translation of european patent specification
2010-05-15	REN	Ceased due to non-payment of the annual fee