ATE116638T1 - N-substituierte lactame als cholecystokinin- antagonisten. - Google Patents
N-substituierte lactame als cholecystokinin- antagonisten.Info
- Publication number
- ATE116638T1 ATE116638T1 AT92901239T AT92901239T ATE116638T1 AT E116638 T1 ATE116638 T1 AT E116638T1 AT 92901239 T AT92901239 T AT 92901239T AT 92901239 T AT92901239 T AT 92901239T AT E116638 T1 ATE116638 T1 AT E116638T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- lactames
- cholecystokinin antagonists
- cholecystokinin
- antagonists
- Prior art date
Links
- 102100025841 Cholecystokinin Human genes 0.000 title abstract 3
- 101800001982 Cholecystokinin Proteins 0.000 title abstract 3
- 229940107137 cholecystokinin Drugs 0.000 title abstract 3
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000036528 appetite Effects 0.000 abstract 1
- 235000019789 appetite Nutrition 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 150000003951 lactams Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/626,590 US5202344A (en) | 1990-12-11 | 1990-12-11 | N-substituted lactams useful as cholecystokinin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE116638T1 true ATE116638T1 (de) | 1995-01-15 |
Family
ID=24511043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92901239T ATE116638T1 (de) | 1990-12-11 | 1991-11-25 | N-substituierte lactame als cholecystokinin- antagonisten. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5202344A (de) |
| EP (1) | EP0561941B1 (de) |
| JP (1) | JPH06503827A (de) |
| AT (1) | ATE116638T1 (de) |
| AU (1) | AU9057191A (de) |
| CA (1) | CA2097517A1 (de) |
| DE (1) | DE69106532T2 (de) |
| DK (1) | DK0561941T3 (de) |
| ES (1) | ES2067322T3 (de) |
| IE (1) | IE62703B1 (de) |
| PT (1) | PT99739A (de) |
| WO (1) | WO1992010476A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE912285A1 (en) * | 1990-07-12 | 1992-01-15 | Black James Foundation | Amino acid derivatives |
| DE4127404A1 (de) * | 1991-08-19 | 1993-02-25 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| WO1995007886A1 (en) * | 1993-09-17 | 1995-03-23 | Pfizer Inc. | 3-amino-5-carboxy-substituted piperidines and 3-amino-4-carboxy-substituted pyrrolidines as tachykinin antagonists |
| US6083943A (en) * | 1993-09-17 | 2000-07-04 | Pfizer Inc | Substituted azaheterocyclecarboxylic acid |
| US5719296A (en) * | 1995-10-30 | 1998-02-17 | Merck & Co., Inc. | Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins |
| AU6659298A (en) | 1997-02-18 | 1998-09-08 | Thomas Jefferson University | Compositions that bind to pancreatic cancer cells and methods of using the same |
| ATE299499T1 (de) | 1998-11-09 | 2005-07-15 | Black James Foundation | Gastrin und cholecystokinin rezeptor ligande |
| US6207638B1 (en) | 2000-02-23 | 2001-03-27 | Pacifichealth Laboratories, Inc. | Nutritional intervention composition for enhancing and extending satiety |
| GB0011095D0 (en) | 2000-05-08 | 2000-06-28 | Black James Foundation | astrin and cholecystokinin receptor ligands (III) |
| US6429190B1 (en) | 2000-12-15 | 2002-08-06 | Pacifichealth Laboratories, Inc. | Method for extending the satiety of food by adding a nutritional composition designed to stimulate cholecystokinin(CCK) |
| AU2002232575A1 (en) | 2000-12-15 | 2002-06-24 | Pacifichealth Laboratories, Inc. | Nutritional composition for improving the efficacy of a lipase inhibitor |
| KR20040048936A (ko) * | 2001-10-03 | 2004-06-10 | 유씨비 소시에떼아노님 | 피롤리디논 유도체 |
| GB0130705D0 (en) * | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | Chemical compounds |
| WO2004022536A1 (en) * | 2002-09-04 | 2004-03-18 | Glenmark Pharmaceuticals Limited | New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
| EA010408B1 (ru) | 2002-10-23 | 2008-08-29 | Гленмарк Фармасьютикалс Лтд. | Трициклические соединения для лечения воспалительных и аллергических нарушений, способы их приготовления и содержащие их фармацевтические составы |
| OA13154A (en) | 2003-04-11 | 2006-12-13 | Glenmark Pharmaceuticals Sa | Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them. |
| GB0314299D0 (en) | 2003-06-19 | 2003-07-23 | Glaxo Group Ltd | Chemical compounds |
| JP2006527732A (ja) | 2003-06-19 | 2006-12-07 | グラクソ グループ リミテッド | Ｘａ因子の阻害剤としての３−スルホニルアミノ−ピロリジン−２−オン誘導体 |
| GB0314373D0 (en) | 2003-06-19 | 2003-07-23 | Glaxo Group Ltd | Chemical compounds |
| MX2007004400A (es) | 2004-10-13 | 2007-06-19 | Glenmark Pharmaceuticals Sa | Procedimiento para la preparacion de n-(3,5-dicloropirid-a-il)-4- ifluorometoxi-8-metanosulfonamido-dibenzo [b,d] difuran-1-carboxamida. |
| US7943634B2 (en) | 2004-12-17 | 2011-05-17 | Glenmark Pharmaceuticals S.A. | Substituted benzo[4,5]furo[3,2-c]pyridine derivatives as PDE 4 inhibitors |
| BRPI0517211B8 (pt) | 2004-12-17 | 2021-05-25 | Glenmark Pharmaceuticals Sa | composto, composição farmacêutica e seu uso. |
| FR2913888B1 (fr) * | 2007-03-21 | 2010-01-01 | Jean Pierre Breda | Procede et dispositif d'irradiation par rayonnement d'energie photonique modulee |
| GB0910003D0 (en) * | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| JP6162799B2 (ja) * | 2012-07-02 | 2017-07-12 | ピーエヌビー ヴェスパー ライフ サイエンス ピーヴィティー リミテッドＰｎｂ Ｖｅｓｐｅｒ Ｌｉｆｅ Ｓｃｉｅｎｃｅ Ｐｖｔ Ｌｉｍｉｔｅｄ | 新規なコレシストキニン受容体リガンド |
| ES2752733T3 (es) * | 2013-11-28 | 2020-04-06 | Kyorin Seiyaku Kk | Derivados de urea deuterados o marcados isotópicamente o sales farmacológicamente aceptables de los mismos útiles como agonistas de FPRL-1 |
| US10676431B2 (en) | 2018-03-05 | 2020-06-09 | Bristol-Myers Squibb Company | Phenylpyrrolidinone formyl peptide 2 receptor agonists |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3474093A (en) * | 1966-05-03 | 1969-10-21 | American Home Prod | Enamine adducts of n-acyloxy-n-acylaminoacetanilide |
| US4200572A (en) * | 1975-09-03 | 1980-04-29 | Smithkline Corporation | Substituted azetidinones |
| US4085100A (en) * | 1976-11-01 | 1978-04-18 | Smithkline Corporation | Intermediate for dephthaloylation of azetidinone compounds |
| US4260743A (en) * | 1979-12-31 | 1981-04-07 | Gist-Brocades N.V. | Preparation of β-lactams and intermediates therefor |
| US4757068A (en) * | 1984-06-26 | 1988-07-12 | Merck & Co., Inc. | Lactams and bicyclic lactams useful as cholecystokinin antagonists |
-
1990
- 1990-12-11 US US07/626,590 patent/US5202344A/en not_active Expired - Lifetime
-
1991
- 1991-11-25 JP JP4502321A patent/JPH06503827A/ja active Pending
- 1991-11-25 EP EP92901239A patent/EP0561941B1/de not_active Expired - Lifetime
- 1991-11-25 WO PCT/US1991/008648 patent/WO1992010476A1/en not_active Ceased
- 1991-11-25 CA CA002097517A patent/CA2097517A1/en not_active Abandoned
- 1991-11-25 AU AU90571/91A patent/AU9057191A/en not_active Abandoned
- 1991-11-25 DE DE69106532T patent/DE69106532T2/de not_active Expired - Fee Related
- 1991-11-25 AT AT92901239T patent/ATE116638T1/de not_active IP Right Cessation
- 1991-11-25 DK DK92901239.1T patent/DK0561941T3/da active
- 1991-11-25 ES ES92901239T patent/ES2067322T3/es not_active Expired - Lifetime
- 1991-12-10 IE IE429391A patent/IE62703B1/en not_active IP Right Cessation
- 1991-12-10 PT PT99739A patent/PT99739A/pt not_active Application Discontinuation
-
1992
- 1992-10-29 US US07/968,617 patent/US5314886A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5202344A (en) | 1993-04-13 |
| WO1992010476A1 (en) | 1992-06-25 |
| CA2097517A1 (en) | 1992-06-12 |
| US5314886A (en) | 1994-05-24 |
| IE914293A1 (en) | 1992-06-17 |
| ES2067322T3 (es) | 1995-03-16 |
| AU9057191A (en) | 1992-07-08 |
| DE69106532D1 (de) | 1995-02-16 |
| IE62703B1 (en) | 1995-02-22 |
| PT99739A (pt) | 1992-11-30 |
| JPH06503827A (ja) | 1994-04-28 |
| EP0561941A1 (de) | 1993-09-29 |
| EP0561941B1 (de) | 1995-01-04 |
| DK0561941T3 (da) | 1995-03-06 |
| DE69106532T2 (de) | 1995-06-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE116638T1 (de) | N-substituierte lactame als cholecystokinin- antagonisten. | |
| DK0607164T3 (da) | Kondenserede tricykliske nitrogenholdige heterocykliske forbindelser som substans P-receptorantagonister | |
| MX9203053A (es) | Derivados de aza nor bornano. | |
| EA200000592A1 (ru) | Азаполициклические соединения, конденсированные с арилом | |
| BR9206161A (pt) | Derivados fluoroalcoxibenzilamino de heterociclos contendo nitrogénio | |
| BG102999A (bg) | Нови 2,3 дизаместени-4(3н)-хиназолинони | |
| DE69331190D1 (de) | Überbrückte azabicyclische derivate als substanz p antagonisten | |
| BR9408450A (pt) | Antagonistas da neuroquinina diazabiciclicos | |
| MX9206499A (es) | Derivados de etilendiamina aciclica | |
| DE69626981D1 (de) | N-(2-oxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3-yl)-3-amide | |
| DK0711283T3 (da) | Tetrahydro-1H-benzazepinoner og hexahydroazepinoner som selektive cholecystokinin-B-receptorantagonister | |
| DE69610628D1 (de) | N-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3-yl)-3-amide | |
| ATE168103T1 (de) | Cholecystokininantagoniste | |
| ATE236888T1 (de) | N-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5- benzodiazepin-3-yl)-3-amide | |
| BG101163A (bg) | 8-флуоро-антрациклини, процеси за тяхното получаване и фармацевтични състави съдържащи ги | |
| ES2106683A1 (es) | Derivados de 1,3-dioxoperhidropirido (1,2-c) pirimidinas como antagonistas de colecistoquinina. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |