ATE116995T1 - Enzyminhibitoren. - Google Patents

Enzyminhibitoren.

Info

Publication number: ATE116995T1
Authority: AT; Austria
Prior art keywords: amino acid; derivatives; hydroxy; peptide; hydrogen
Prior art date: 1989-06-06

Application number

AT90110322T

Other languages

English (en)

Inventor

Paul Cates Anderson

Yvan Guindon

Christiane Yoakim

Original Assignee

Bio Mega Boehringer Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-06

Filing date

1990-05-31

Publication date

1995-01-15

1990-05-31 Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim

1995-01-15 Application granted granted Critical

1995-01-15 Publication of ATE116995T1 publication Critical patent/ATE116995T1/de

Links

125000000217 alkyl group Chemical group 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
241000725303 Human immunodeficiency virus Species 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
208000031886 HIV Infections Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
NNOPDLNHPOLRRE-UHFFFAOYSA-N Nequinate Chemical group CCCCC1=CC(C(C(C(=O)OC)=CN2)=O)=C2C=C1OCC1=CC=CC=C1 NNOPDLNHPOLRRE-UHFFFAOYSA-N 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
108090000783 Renin Proteins 0.000 abstract 1
102100028255 Renin Human genes 0.000 abstract 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Crystallography & Structural Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT90110322T 1989-06-06 1990-05-31 Enzyminhibitoren. ATE116995T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/362,171 US5212157A (en)	1989-06-06	1989-06-06	Enzyme inhibitors

Publications (1)

Publication Number	Publication Date
ATE116995T1 true ATE116995T1 (de)	1995-01-15

Family

ID=23424961

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90110322T ATE116995T1 (de)	1989-06-06	1990-05-31	Enzyminhibitoren.

Country Status (7)

Country	Link
US (1)	US5212157A (de)
EP (1)	EP0401676B1 (de)
JP (1)	JPH0347196A (de)
AT (1)	ATE116995T1 (de)
AU (1)	AU646806B2 (de)
CA (1)	CA2016656C (de)
DE (1)	DE69015885T2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5516784A (en) *	1991-08-13	1996-05-14	Schering Corporation	Anti-HIV (AIDS) agents
DE69333270T2 (de)	1992-03-11	2004-08-05	Narhex Ltd.	Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US6071895A (en) *	1992-03-11	2000-06-06	Narhex Limited	Polar-substituted hydrocarbons
US5888992A (en) *	1992-03-11	1999-03-30	Narhex Limited	Polar substituted hydrocarbons
BR9306058A (pt) *	1992-03-11	1997-11-18	Narhex Ltd	Derivados de amina de hidrocarbonetos oxo- e hidroxi- substituidos
US5559256A (en) *	1992-07-20	1996-09-24	E. R. Squibb & Sons, Inc.	Aminediol protease inhibitors
US5236934A (en) *	1992-08-26	1993-08-17	E. I. Du Pont De Nemours And Company	1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders
US5693815A (en) *	1993-01-17	1997-12-02	Schering Corporation	Peptides
IL110898A0 (en) *	1993-09-10	1994-11-28	Narhex Australia Pty Ltd	Polar-substituted hydrocarbons
US6222043B1 (en)	1995-06-30	2001-04-24	Japan Energy Corporation	Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof
US5932550A (en) *	1995-06-30	1999-08-03	Japan Energy Corporation	Dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof
US5849691A (en) *	1996-02-20	1998-12-15	The United States Of America As Represented By The Department Of Health And Human Services	Peptidomimetic inhibitors of cathepsin D and plasmepsins I and II
EP0900566A4 (de)	1996-12-27	2001-04-25	Japan Energy Corp	Neuartige tripeptidvebindungen und arzneimittel gegen aids
US6783947B1 (en)	1999-09-09	2004-08-31	Dade Behring Marburg Gmbh	Protecting groups for biological labeling
EP1499306A4 (de)	2002-04-12	2007-03-28	Merck & Co Inc	Bicyclische amide
AR091490A1 (es)	2012-06-19	2015-02-11	Bristol Myers Squibb Co	Antagonistas de iap

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1258748A (en) *	1981-10-08	1989-08-22	Daniel F. Veber	Renin inhibitory peptides
US4680284A (en) *	1985-01-23	1987-07-14	Abbott Laboratories	Modified phenylalanine peptidylaminodiols
DE3538749A1 (de) *	1985-10-31	1987-05-07	Merck Patent Gmbh	Peptide
WO1987002986A1 (en) *	1985-11-15	1987-05-21	The Upjohn Company	Novel renin inhibiting polypeptide analogs containing s-aryl-d- or l- or dl-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
US4894437A (en) *	1985-11-15	1990-01-16	The Upjohn Company	Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
DE3627877A1 (de) *	1986-07-30	1988-02-04	Hoechst Ag	Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
HU204285B (en) *	1986-10-31	1991-12-30	Pfizer	Process for producing renin-inhibiting polypeptides of small molecule mass and pharmaceutical compositions containing them
FR2614533A1 (fr) *	1987-04-23	1988-11-04	Sandoz Sa	Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments
US5342922A (en) *	1989-03-08	1994-08-30	Washington University	Inhibitors of retroviral protease

1989
- 1989-06-06 US US07/362,171 patent/US5212157A/en not_active Expired - Lifetime
1990
- 1990-05-14 CA CA002016656A patent/CA2016656C/en not_active Expired - Fee Related
- 1990-05-31 EP EP90110322A patent/EP0401676B1/de not_active Expired - Lifetime
- 1990-05-31 AT AT90110322T patent/ATE116995T1/de active
- 1990-05-31 DE DE69015885T patent/DE69015885T2/de not_active Expired - Fee Related
- 1990-06-05 JP JP2147159A patent/JPH0347196A/ja active Pending
- 1990-06-05 AU AU56289/90A patent/AU646806B2/en not_active Ceased

Also Published As

Publication number	Publication date
JPH0347196A (ja)	1991-02-28
CA2016656C (en)	2000-04-11
AU646806B2 (en)	1994-03-10
EP0401676A1 (de)	1990-12-12
AU5628990A (en)	1990-12-13
US5212157A (en)	1993-05-18
CA2016656A1 (en)	1990-12-06
EP0401676B1 (de)	1995-01-11
DE69015885D1 (de)	1995-02-23
DE69015885T2 (de)	1995-06-08

Publication	Publication Date	Title
DE69015885D1 (de)	1995-02-23	Enzyminhibitoren.
AU653972B2 (en)	1994-10-20	HIV protease inhibitors
DE69321845D1 (en)	1998-12-03	Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
DE69015451D1 (de)	1995-02-09	Enzym-inhibierende Peptid-Derivate.
ES2139195T3 (es)	2000-02-01	Derivados de sulfonamidas como inhibidores de la aspartil-proteasa.
EP0291917A3 (en)	1990-12-05	Novel oxetanocins
ATE123275T1 (de)	1995-06-15	Substituierte pyrrolidinderivate als hiv-protease-hemmer.
AU5646280A (en)	1980-09-18	Peptides
FI871445A0 (fi)	1987-04-02	Foerfarande foer framstaellning av nya spergualinderivat.
AU643448B2 (en)	1993-11-18	Antiviral peptides having a 2-Oxoalkyl amino acid side chain
DK0399556T3 (da)	1995-05-29	Aminosubstituerede heterocycliske forbindelser som renininhibitorer
FI944187A0 (fi)	1994-09-12	Isosteeriset antiherpespeptidijohdannaiset
ATE106386T1 (de)	1994-06-15	Gem-diamino-derivate und ihre verwendung bei der herstellung von retro-inverso-peptiden.
EP0406931A3 (en)	1991-07-17	New analogues of all-bond retroinverted thymopentin, the method for the synthesis of the same and their employment for the preparation of pharmaceutical compositions
ES2099081T3 (es)	1997-05-16	Derivados de pradimicina.
KR950011464A (ko)	1995-05-15	비가역적 에이치아이브이(hiv) 프로테아제 억제제
IT1229658B (it)	1991-09-06	Analoghi della timopentina retro-inversi ad uno o piu' legami, il metodo per la loro sintesi ed il loro impiego per la preparazione di composizioni farmaceutiche.
CA2019005A1 (en)	1991-12-14	Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain
KR950011431A (ko)	1995-05-15	비가역적 에이치아이브이(hiv) 프로테아제 억제제의 중간체
TH14688A (th)	1994-09-30	กรรมวิธีสำหรับเตรียมอนุพันธ์ต่างๆของ (สูตร)-ซับ?สทิทิวเทดเบนซีนมีเธนแอมีน