ATE117207T1 - Stabile azelastinhydrochlorid-zubereitung. - Google Patents

Stabile azelastinhydrochlorid-zubereitung.

Info

Publication number: ATE117207T1
Authority: AT; Austria
Prior art keywords: stable; azelastine hydrochloride; carbon atoms; hydrochloride preparation; fatty acid
Prior art date: 1992-07-20

Application number

AT93111334T

Other languages

English (en)

Inventor

Yutaka Morita

Noritosi Koyama

Sigemitu Ohsawa

Original Assignee

Asta Medica Ag

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-20

Filing date

1993-07-15

Publication date

1995-02-15

1993-07-15 Application filed by Asta Medica Ag, Eisai Co Ltd filed Critical Asta Medica Ag

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE117207T1 publication Critical patent/ATE117207T1/de

Links

238000002360 preparation method Methods 0.000 title abstract 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 1
229960004335 azelastine hydrochloride Drugs 0.000 abstract 3
YEJAJYAHJQIWNU-UHFFFAOYSA-N azelastine hydrochloride Chemical compound Cl.C1CN(C)CCCC1N1C(=O)C2=CC=CC=C2C(CC=2C=CC(Cl)=CC=2)=N1 YEJAJYAHJQIWNU-UHFFFAOYSA-N 0.000 abstract 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
235000014113 dietary fatty acids Nutrition 0.000 abstract 2
229930195729 fatty acid Natural products 0.000 abstract 2
239000000194 fatty acid Substances 0.000 abstract 2
150000004665 fatty acids Chemical class 0.000 abstract 2
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
239000004615 ingredient Substances 0.000 abstract 1
229940067606 lecithin Drugs 0.000 abstract 1
235000010445 lecithin Nutrition 0.000 abstract 1
239000000787 lecithin Substances 0.000 abstract 1
150000005846 sugar alcohols Polymers 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Otolaryngology (AREA)
Immunology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT93111334T 1992-07-20 1993-07-15 Stabile azelastinhydrochlorid-zubereitung. ATE117207T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP21324392A JP3190441B2 (ja)	1992-07-20	1992-07-20	塩酸アゼラスチンを含有する安定な製剤

Publications (1)

Publication Number	Publication Date
ATE117207T1 true ATE117207T1 (de)	1995-02-15

Family

ID=16635891

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93111334T ATE117207T1 (de)	1992-07-20	1993-07-15	Stabile azelastinhydrochlorid-zubereitung.

Country Status (8)

Country	Link
US (1)	US6117864A (de)
EP (1)	EP0580074B1 (de)
JP (1)	JP3190441B2 (de)
AT (1)	ATE117207T1 (de)
DE (1)	DE69300054T2 (de)
DK (1)	DK0580074T3 (de)
ES (1)	ES2068725T3 (de)
GR (1)	GR3015822T3 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5800807A (en) *	1997-01-29	1998-09-01	Bausch & Lomb Incorporated	Ophthalmic compositions including glycerin and propylene glycol
JP4138910B2 (ja) *	1997-07-02	2008-08-27	帝國製薬株式会社	経皮吸収性が良好で且つ皮膚刺激性の少ない塩酸アゼラスチン含有経皮製剤
BE1011899A6 (fr)	1998-04-30	2000-02-01	Ucb Sa	Compositions pharmaceutiques gelifiables utilisables.
US8119159B2 (en)	1999-02-22	2012-02-21	Merrion Research Iii Limited	Solid oral dosage form containing an enhancer
US7658938B2 (en)	1999-02-22	2010-02-09	Merrion Reasearch III Limited	Solid oral dosage form containing an enhancer
AU2940100A (en) *	1999-03-11	2000-09-28	Saitama Daiichi Pharmaceutical Co., Ltd.	Compositions for promoting percutaneous absorption
DE60045153D1 (de)	1999-04-13	2010-12-09	Hisamitsu Pharmaceutical Co	Zubereitungen zur perkutanen absorption
US7029694B2 (en) *	2000-04-26	2006-04-18	Watson Laboratories, Inc.	Compositions and methods for transdermal oxybutynin therapy
US7179483B2 (en)	2000-04-26	2007-02-20	Watson Pharmaceuticals, Inc.	Compositions and methods for transdermal oxybutynin therapy
US6387383B1 (en) *	2000-08-03	2002-05-14	Dow Pharmaceutical Sciences	Topical low-viscosity gel composition
WO2002092616A1 (en)	2001-05-11	2002-11-21	Orasense, Ltd.	Antisense permeation enhancers
WO2002092070A1 (en) *	2001-05-11	2002-11-21	Elan Corporation, Plc	Isostearic acid salts as permeation enhancers
US7858115B2 (en) *	2004-06-24	2010-12-28	Idexx Laboratories	Phospholipid gel compositions for drug delivery and methods of treating conditions using same
EP2522365B1 (de) *	2004-11-24	2016-10-26	Meda Pharmaceuticals Inc.	Zusammensetzungen aus Azelastin und Verwendungsverfahren dafür
ES2426445T3 (es)	2006-04-07	2013-10-23	Merrion Research Iii Limited	Forma de dosificación oral sólida que contiene un potenciador
WO2009137080A1 (en)	2008-05-07	2009-11-12	Merrion Research Iii Limited	Compositions of gnrh related compounds and processes of preparation
US9089484B2 (en)	2010-03-26	2015-07-28	Merrion Research Iii Limited	Pharmaceutical compositions of selective factor Xa inhibitors for oral administration
US9254325B2 (en)	2010-10-28	2016-02-09	Hisamitsu Pharmaceutical Co., Inc.	Percutaneously absorbed preparation
KR101261230B1 (ko) *	2010-11-29	2013-05-07	한림제약(주)	모메타손 푸로에이트 및 아젤라스틴 염산염을 포함하는 비내 투여용 약학 조성물
US8802114B2 (en)	2011-01-07	2014-08-12	Merrion Research Iii Limited	Pharmaceutical compositions of iron for oral administration
US9783529B2 (en)	2013-03-13	2017-10-10	Flatley Discovery Lab, Llc	Pyridazinone compounds and methods for the treatment of cystic fibrosis
JP7211704B2 (ja)	2015-01-29	2023-01-24	ノヴォノルディスクアー／エス	Ｇｌｐ－１アゴニスト及び腸溶コーティングを含む錠剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0720866B2 (ja) *	1987-05-15	1995-03-08	三生製薬株式会社	エペリゾン又はトルペリゾン或いはそれらの塩類含有経皮適用製剤
US4879297A (en) *	1987-06-01	1989-11-07	Warner-Lambert Company	Fatty acids and their small chain esters as penetration enhancers in aqueous systems
CA2002299A1 (en) *	1988-11-10	1990-05-10	Eugene G. Drust	Compositions for the transdermal delivery of buprenorphine salts
US5110814A (en) *	1989-01-11	1992-05-05	Asta Pharma Ag	Azelastine and its salts used to combat psoriasis
US5219877A (en) *	1989-09-25	1993-06-15	Bristol-Myers Squibb Company	Lauryl alcohol as skin penetration enhancer for topical imidazole agents
ES2083437T3 (es) *	1989-11-14	1996-04-16	Beta Pharm Co	Composiciones anti-inflamatorias para uso externo.

1992
- 1992-07-20 JP JP21324392A patent/JP3190441B2/ja not_active Expired - Lifetime
1993
- 1993-07-15 DK DK93111334.4T patent/DK0580074T3/da active
- 1993-07-15 AT AT93111334T patent/ATE117207T1/de active
- 1993-07-15 DE DE69300054T patent/DE69300054T2/de not_active Expired - Lifetime
- 1993-07-15 EP EP93111334A patent/EP0580074B1/de not_active Expired - Lifetime
- 1993-07-15 ES ES93111334T patent/ES2068725T3/es not_active Expired - Lifetime
1995
- 1995-04-17 GR GR950400952T patent/GR3015822T3/el unknown
1997
- 1997-07-08 US US08/889,807 patent/US6117864A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK0580074T3 (da)	1995-04-10
EP0580074B1 (de)	1995-01-18
US6117864A (en)	2000-09-12
JP3190441B2 (ja)	2001-07-23
DE69300054T2 (de)	1996-05-30
EP0580074A1 (de)	1994-01-26
GR3015822T3 (en)	1995-07-31
JPH0640949A (ja)	1994-02-15
ES2068725T3 (es)	1995-04-16
DE69300054D1 (de)	1995-03-02

Legal Events

Date	Code	Title	Description
1995-06-15	UEP	Publication of translation of european patent specification
2002-09-15	EEIH	Change in the person of patent owner

Publication	Publication Date	Title
ATE117207T1 (de)	1995-02-15	Stabile azelastinhydrochlorid-zubereitung.
TW341514B (en)	1998-10-01	Aqueous topical pharmaceutical compositions useful for exfoliation and prevention or treatment of acne
GB2308546B (en)	1999-06-02	Topical macrolide compositions
MX9302843A (es)	1994-02-28	Composiciones de glicosido de alquilo con propiedades humectantes mejoradas.
ES456287A1 (es)	1978-06-01	Procedimiento para la preparacion de derivados de ladano po-lioxigenados.
NO308792B1 (no)	2000-10-30	Derivater av valproinsyre og 2-valproensyreamider, farmasøytisk sammensetning derav og deres anvendelse for fremstilling av et farmasøytisk preparat
HU895609D0 (en)	1990-01-28	Process for the preparation of novel 1,4-diazepine derivatives and pharmaceutical compositions containing such compounds
ATE76066T1 (de)	1992-05-15	1,2,5,6-tetrahydropyridin-3carboxaldehydoximderivate, verfahren zur herstellung, sie enthaltende zusammensetzungen und deren anwendung als heilmittel.
SG46307A1 (en)	1998-02-20	New pyrazine derivatives the preparation and use thereof
DK0564350T3 (da)	1997-12-15	3, 5-di-tert-butyl-4-hydroxyflavoner, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger med antioxidant- og anti-vasokonstriktorisk virkning
CA2433464A1 (en)	2002-05-16	Fuel composition
JPS6413017A (en)	1989-01-17	Skin-beautifying cosmetic
MXPA03000547A (es)	2004-04-05	Uso de derivados de amidas de acido valproico y de acido 2-valproenico, para el tratamiento de manias en trastornos bipolares.
EP0450527A3 (de)	1991-10-30	N-tris(hydroxymethyl)methylfettsäureamiden und diese enthaltende kosmetische Zusammensetzungen
ES8500269A1 (es)	1984-10-01	Procedimiento para la fabricacion de un derivado de azolcarboxamida n,n-subsitutida.
FR2687154B1 (fr)	1995-05-12	Nouveau derive de l'isoindolinone, sa preparation et les compositions pharmaceutiques qui le contiennent.
GB1521181A (en)	1978-08-16	Ketolactones and their manufacture
JPS6413018A (en)	1989-01-17	Skin-beautifying cosmetic
ATE160938T1 (de)	1997-12-15	Feste orale pharmazeutische zubereitung mit gemfibrozil als aktiver inhaltsstoff und verfahren zur herstellung
EA200001107A1 (ru)	2001-04-23	ПРОИЗВОДНЫЕ ОКТАГИДРО-6,10-ДИОКСО-6H-ПИРИДАЗИНО [1,2-a] [1,2] ДИАЗЕПИН-1-КАРБОНОВОЙ КИСЛОТЫ, СПОСОБ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ ДЛЯ ПОЛУЧЕНИЯ ТЕРАПЕВТИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙ
KR910016313A (ko)	1991-11-05	멜라닌 생성억제 외용제
NZ323980A (en)	2000-01-28	Antiseptic composition containing a quaternary ammonium compound, a chelating agent and a polyol
JPS6450867A (en)	1989-02-27	Salts of thiamorpholinonecarboxylic acid and 2,4-diaminopyrimidine derivative and use for cosmetic and pharmaceutical composition
AU573062B2 (en)	1988-05-26	Dihydrodithiazine derivatives
YU60790A (sh)	1994-04-05	Postupak za dobijanje 5-fenilpirimidin jedinjenja i njihovih soli