ATE117207T1 - Stabile azelastinhydrochlorid-zubereitung. - Google Patents

Stabile azelastinhydrochlorid-zubereitung.

Info

Publication number: ATE117207T1
Authority: AT; Austria
Prior art keywords: stable; azelastine hydrochloride; carbon atoms; hydrochloride preparation; fatty acid
Prior art date: 1992-07-20

Application number

AT93111334T

Other languages

English (en)

Inventor

Yutaka Morita

Noritosi Koyama

Sigemitu Ohsawa

Original Assignee

Asta Medica Ag

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-20

Filing date

1993-07-15

Publication date

1995-02-15

1993-07-15 Application filed by Asta Medica Ag, Eisai Co Ltd filed Critical Asta Medica Ag

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE117207T1 publication Critical patent/ATE117207T1/de

Links

238000002360 preparation method Methods 0.000 title abstract 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 1
229960004335 azelastine hydrochloride Drugs 0.000 abstract 3
YEJAJYAHJQIWNU-UHFFFAOYSA-N azelastine hydrochloride Chemical compound Cl.C1CN(C)CCCC1N1C(=O)C2=CC=CC=C2C(CC=2C=CC(Cl)=CC=2)=N1 YEJAJYAHJQIWNU-UHFFFAOYSA-N 0.000 abstract 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
235000014113 dietary fatty acids Nutrition 0.000 abstract 2
229930195729 fatty acid Natural products 0.000 abstract 2
239000000194 fatty acid Substances 0.000 abstract 2
150000004665 fatty acids Chemical class 0.000 abstract 2
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
239000004615 ingredient Substances 0.000 abstract 1
229940067606 lecithin Drugs 0.000 abstract 1
235000010445 lecithin Nutrition 0.000 abstract 1
239000000787 lecithin Substances 0.000 abstract 1
150000005846 sugar alcohols Polymers 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Immunology (AREA)
Otolaryngology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT93111334T 1992-07-20 1993-07-15 Stabile azelastinhydrochlorid-zubereitung. ATE117207T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP21324392A JP3190441B2 (ja)	1992-07-20	1992-07-20	塩酸アゼラスチンを含有する安定な製剤

Publications (1)

Publication Number	Publication Date
ATE117207T1 true ATE117207T1 (de)	1995-02-15

Family

ID=16635891

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93111334T ATE117207T1 (de)	1992-07-20	1993-07-15	Stabile azelastinhydrochlorid-zubereitung.

Country Status (8)

Country	Link
US (1)	US6117864A (de)
EP (1)	EP0580074B1 (de)
JP (1)	JP3190441B2 (de)
AT (1)	ATE117207T1 (de)
DE (1)	DE69300054T2 (de)
DK (1)	DK0580074T3 (de)
ES (1)	ES2068725T3 (de)
GR (1)	GR3015822T3 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5800807A (en) *	1997-01-29	1998-09-01	Bausch & Lomb Incorporated	Ophthalmic compositions including glycerin and propylene glycol
JP4138910B2 (ja) *	1997-07-02	2008-08-27	帝國製薬株式会社	経皮吸収性が良好で且つ皮膚刺激性の少ない塩酸アゼラスチン含有経皮製剤
BE1011899A6 (fr) *	1998-04-30	2000-02-01	Ucb Sa	Compositions pharmaceutiques gelifiables utilisables.
US8119159B2 (en)	1999-02-22	2012-02-21	Merrion Research Iii Limited	Solid oral dosage form containing an enhancer
US7658938B2 (en)	1999-02-22	2010-02-09	Merrion Reasearch III Limited	Solid oral dosage form containing an enhancer
WO2000053226A1 (fr) *	1999-03-11	2000-09-14	Saitama Daiichi Pharmaceutical Co., Ltd.	Compositions facilitant l'absorption cutanee
EP1170004B1 (de) *	1999-04-13	2010-10-27	Hisamitsu Pharmaceutical Co., Inc.	Zubereitungen zur perkutanen absorption
US7029694B2 (en) *	2000-04-26	2006-04-18	Watson Laboratories, Inc.	Compositions and methods for transdermal oxybutynin therapy
US7179483B2 (en) *	2000-04-26	2007-02-20	Watson Pharmaceuticals, Inc.	Compositions and methods for transdermal oxybutynin therapy
US6387383B1 (en) *	2000-08-03	2002-05-14	Dow Pharmaceutical Sciences	Topical low-viscosity gel composition
ATE547095T1 (de)	2001-05-11	2012-03-15	Isis Pharmaceuticals Inc	Antisense-permeationsverstärker
EP1390024A4 (de) *	2001-05-11	2010-02-17	Merrion Res Iii Ltd	Isostearinsäuresalze als permeationsverbesserer
US7858115B2 (en) *	2004-06-24	2010-12-28	Idexx Laboratories	Phospholipid gel compositions for drug delivery and methods of treating conditions using same
PL2486942T3 (pl) *	2004-11-24	2019-05-31	Meda Pharmaceuticals Inc	Kompozycje zawierające azelastynę oraz sposoby ich stosowania
BRPI0710503A2 (pt)	2006-04-07	2011-08-16	Merrion Res Iii Ltd	uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral
US20090280169A1 (en)	2008-05-07	2009-11-12	Merrion Research Iii Limited	Compositions of peptides and processes of preparation thereof
US9089484B2 (en)	2010-03-26	2015-07-28	Merrion Research Iii Limited	Pharmaceutical compositions of selective factor Xa inhibitors for oral administration
WO2012057220A1 (ja) *	2010-10-28	2012-05-03	久光製薬株式会社	経皮吸収型製剤
KR101261230B1 (ko) *	2010-11-29	2013-05-07	한림제약(주)	모메타손 푸로에이트 및 아젤라스틴 염산염을 포함하는 비내 투여용 약학 조성물
EP2661273A4 (de)	2011-01-07	2014-06-04	Merrion Res Iii Ltd	Pharmazeutische zusammensetzungen aus eisen zur oralen verabreichung
EP2968323A4 (de)	2013-03-13	2016-12-14	Flatley Discovery Lab	Pyridazinonverbindungen und verfahren zur behandlung von zystischer fibrose
JP7211704B2 (ja)	2015-01-29	2023-01-24	ノヴォノルディスクアー／エス	Ｇｌｐ－１アゴニスト及び腸溶コーティングを含む錠剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0720866B2 (ja) *	1987-05-15	1995-03-08	三生製薬株式会社	エペリゾン又はトルペリゾン或いはそれらの塩類含有経皮適用製剤
US4879297A (en) *	1987-06-01	1989-11-07	Warner-Lambert Company	Fatty acids and their small chain esters as penetration enhancers in aqueous systems
CA2002299A1 (en) *	1988-11-10	1990-05-10	Eugene G. Drust	Compositions for the transdermal delivery of buprenorphine salts
US5110814A (en) *	1989-01-11	1992-05-05	Asta Pharma Ag	Azelastine and its salts used to combat psoriasis
US5219877A (en) *	1989-09-25	1993-06-15	Bristol-Myers Squibb Company	Lauryl alcohol as skin penetration enhancer for topical imidazole agents
ES2083437T3 (es) *	1989-11-14	1996-04-16	Beta Pharm Co	Composiciones anti-inflamatorias para uso externo.

1992
- 1992-07-20 JP JP21324392A patent/JP3190441B2/ja not_active Expired - Lifetime
1993
- 1993-07-15 AT AT93111334T patent/ATE117207T1/de active
- 1993-07-15 EP EP93111334A patent/EP0580074B1/de not_active Expired - Lifetime
- 1993-07-15 DE DE69300054T patent/DE69300054T2/de not_active Expired - Lifetime
- 1993-07-15 ES ES93111334T patent/ES2068725T3/es not_active Expired - Lifetime
- 1993-07-15 DK DK93111334.4T patent/DK0580074T3/da active
1995
- 1995-04-17 GR GR950400952T patent/GR3015822T3/el unknown
1997
- 1997-07-08 US US08/889,807 patent/US6117864A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69300054D1 (de)	1995-03-02
EP0580074B1 (de)	1995-01-18
DK0580074T3 (da)	1995-04-10
EP0580074A1 (de)	1994-01-26
JPH0640949A (ja)	1994-02-15
DE69300054T2 (de)	1996-05-30
ES2068725T3 (es)	1995-04-16
GR3015822T3 (en)	1995-07-31
JP3190441B2 (ja)	2001-07-23
US6117864A (en)	2000-09-12

Legal Events

Date	Code	Title	Description
1995-06-15	UEP	Publication of translation of european patent specification
2002-09-15	EEIH	Change in the person of patent owner

Publication	Publication Date	Title
DE69300054D1 (de)	1995-03-02	Stabile Azelastinhydrochlorid-Zubereitung.
TW341514B (en)	1998-10-01	Aqueous topical pharmaceutical compositions useful for exfoliation and prevention or treatment of acne
GB2308546B (en)	1999-06-02	Topical macrolide compositions
MX9302843A (es)	1994-02-28	Composiciones de glicosido de alquilo con propiedades humectantes mejoradas.
ES456287A1 (es)	1978-06-01	Procedimiento para la preparacion de derivados de ladano po-lioxigenados.
NO308792B1 (no)	2000-10-30	Derivater av valproinsyre og 2-valproensyreamider, farmasøytisk sammensetning derav og deres anvendelse for fremstilling av et farmasøytisk preparat
HU895609D0 (en)	1990-01-28	Process for the preparation of novel 1,4-diazepine derivatives and pharmaceutical compositions containing such compounds
AU669122B2 (en)	1996-05-30	New pyrazine derivatives, their preparation and their use
ATE76066T1 (de)	1992-05-15	1,2,5,6-tetrahydropyridin-3carboxaldehydoximderivate, verfahren zur herstellung, sie enthaltende zusammensetzungen und deren anwendung als heilmittel.
DK0564350T3 (da)	1997-12-15	3, 5-di-tert-butyl-4-hydroxyflavoner, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger med antioxidant- og anti-vasokonstriktorisk virkning
CA2433464A1 (en)	2002-05-16	Fuel composition
JPS6413017A (en)	1989-01-17	Skin-beautifying cosmetic
WO2002007677A3 (en)	2002-05-30	Use of derivatives of valproic acid and 2-valproenic acid amides for the treatment of mania in bipolar disorder
EP0450527A3 (de)	1991-10-30	N-tris(hydroxymethyl)methylfettsäureamiden und diese enthaltende kosmetische Zusammensetzungen
ES8106289A1 (es)	1981-02-16	Procedimiento de preparacion de nuevos derivados del a-fe- nil-2-pirrolidin-metanol
ES8500269A1 (es)	1984-10-01	Procedimiento para la fabricacion de un derivado de azolcarboxamida n,n-subsitutida.
FR2687154B1 (fr)	1995-05-12	Nouveau derive de l'isoindolinone, sa preparation et les compositions pharmaceutiques qui le contiennent.
GB1521181A (en)	1978-08-16	Ketolactones and their manufacture
AP1518A (en)	2005-12-12	Novel octahydro-6, 10-dioxo-6h-pyridazino/1,2-a/ /1,2/diazepin-1-carboxylic acid derivatives, preparation method and use for preparing therapeutically active compounds.
DE69501183D1 (de)	1998-01-22	Feste orale pharmazeutische Zubereitung mit Gemfibrozil als aktiver Inhaltsstoff und Verfahren zur Herstellung
KR910016313A (ko)	1991-11-05	멜라닌 생성억제 외용제
NZ323980A (en)	2000-01-28	Antiseptic composition containing a quaternary ammonium compound, a chelating agent and a polyol
GB2175584A (en)	1986-12-03	Kojic acid derivatives and whitening cosmetics containing same
AU5170285A (en)	1986-06-26	Dihydrodithiazine derivatives
KR860001088A (ko)	1986-02-22	r-피론인산 에스테르 유도체