ATE117303T1 - Imidazo(1,2-c>chinazolinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen. - Google Patents

Imidazo(1,2-c>chinazolinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.

Info

Publication number: ATE117303T1
Authority: AT; Austria
Prior art keywords: optionally substituted; imidazo; amino; hydrogen; production
Prior art date: 1990-03-09

Application number

AT91400645T

Other languages

English (en)

Inventor

Jean-Jacques Bourguignon

Camille-Georges Wermuth

De La Faverie Jean-Fran Renaud

Catherine Thollon

Alain Lombet

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-09

Filing date

1991-03-08

Publication date

1995-02-15

1991-03-08 Application filed by Adir filed Critical Adir

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE117303T1 publication Critical patent/ATE117303T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
230000004064 dysfunction Effects 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
HKJZDEUEWZSNFY-UHFFFAOYSA-N imidazo[1,2-c]quinazoline Chemical class C1=CC=C2C3=NC=CN3C=NC2=C1 HKJZDEUEWZSNFY-UHFFFAOYSA-N 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
210000002460 smooth muscle Anatomy 0.000 abstract 1
239000000050 smooth muscle relaxant Substances 0.000 abstract 1
229910052717 sulfur Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT91400645T 1990-03-09 1991-03-08 Imidazo(1,2-c>chinazolinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen. ATE117303T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9003003A FR2659329B1 (fr)	1990-03-09	1990-03-09	Nouveaux derives d'imidazo [1,2-c] quinazoline, leur procede de preparation et les compositions pharmaceutiques les renfermant.

Publications (1)

Publication Number	Publication Date
ATE117303T1 true ATE117303T1 (de)	1995-02-15

Family

ID=9394556

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91400645T ATE117303T1 (de)	1990-03-09	1991-03-08	Imidazo(1,2-c>chinazolinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.

Country Status (16)

Country	Link
US (1)	US5128338A (de)
EP (1)	EP0446141B1 (de)
JP (1)	JPH07103122B2 (de)
AT (1)	ATE117303T1 (de)
AU (1)	AU633408B2 (de)
CA (1)	CA2037812A1 (de)
DE (1)	DE69106746T2 (de)
DK (1)	DK0446141T3 (de)
ES (1)	ES2069841T3 (de)
FR (1)	FR2659329B1 (de)
GR (1)	GR3015514T3 (de)
IE (1)	IE66181B1 (de)
NZ (1)	NZ237363A (de)
OA (1)	OA09488A (de)
PT (1)	PT96982A (de)
ZA (1)	ZA911726B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK588389D0 (da) *	1989-11-22	1989-11-22	Ferrosan As	Heterocykliske forbindelser, deres fremstilling og anvendelse
DK588489D0 (da) *	1989-11-22	1989-11-22	Ferrosan As	Heterocykliske forbindelser, deres fremstilling og anvendelse
US5512677A (en) *	1991-08-13	1996-04-30	National Science Council	3-substituted methyl-2,3-dihydroimidazo 1,2-c!quinazoline derivatives, the preparation and use thereof
US5158953A (en) *	1991-08-13	1992-10-27	National Science Council	2-substituted methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-ones (thiones), the preparation and use thereof
US5212310A (en) *	1991-12-19	1993-05-18	Neurogen Corporation	Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands
US5792766A (en) *	1996-03-13	1998-08-11	Neurogen Corporation	Imidazo 1,5-c! quinazolines; a new class of GABA brain receptor ligands
AU727482B2 (en)	1996-10-01	2000-12-14	Daiichi Pharmaceutical Co., Ltd.	Mitochondrial membrane stabilizer
FR2778564B1 (fr) *	1998-05-13	2001-07-13	Sanofi Sa	Utilisation de composes reduisant l'apoptose
WO1999058117A1 (fr) *	1998-05-13	1999-11-18	Sanofi-Synthelabo	Utilisation de composes reduisant l'apoptose
ATE300947T1 (de)	1998-12-18	2005-08-15	Scios Inc	Behandlung von erkrankungen mit zystenbildung
EP1607744A3 (de) *	1998-12-18	2009-09-30	Scios Inc.	Behandlung von zystenbildenden Erkrankungen mit Kombinationen enthaltend PTBR-Agonisten
US6342495B1 (en)	1998-12-18	2002-01-29	Scios, Inc.	Agonists and antagonists of peripheral-type benzodiazepine receptors
JPWO2003030937A1 (ja) *	2001-10-05	2005-01-20	小野薬品工業株式会社	ミトコンドリアルベンゾジアゼピン受容体アンタゴニストからなるストレス疾患の治療剤
US8053762B2 (en) *	2005-12-13	2011-11-08	Lg Chem, Ltd.	Imidazoquinazoline derivative, process for preparing the same, and organic electronic device using the same
MX357320B (es) *	2012-06-18	2018-07-04	Dart Neuroscience Cayman Ltd	Compuestos de la azolopirimidina-5-(6h)-ona de piridina sustituida.
JP6420400B2 (ja) *	2017-04-12	2018-11-07	ダート・ニューロサイエンス・（ケイマン）・リミテッド	置換ピリジンアゾロピリミジン−５−（６ｈ）−オン化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4129653A (en) *	1977-01-05	1978-12-12	Ortho Pharmaceutical Corporation	Substituted pyrrolo [1,2-c] quinazolines and pharmaceutical compositions and methods employing them
US4110452A (en) *	1977-10-17	1978-08-29	E. R. Squibb & Sons, Inc.	Pyrazolo (1,5-c) quinazoline derivatives and related compounds
DE3046366A1 (de) *	1980-12-09	1982-07-08	Bayer Ag, 5090 Leverkusen	Tricyclische cytosinderivate zur verwendung in arzneimitteln und verfahren zu ihrer herstellung
US4713383A (en) *	1984-10-01	1987-12-15	Ciba-Geigy Corporation	Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
DK155524C (da) *	1987-03-18	1989-09-11	Ferrosan As	Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse

1990
- 1990-03-09 FR FR9003003A patent/FR2659329B1/fr not_active Expired - Fee Related
1991
- 1991-03-08 PT PT96982A patent/PT96982A/pt not_active Application Discontinuation
- 1991-03-08 DK DK91400645.7T patent/DK0446141T3/da active
- 1991-03-08 AU AU72745/91A patent/AU633408B2/en not_active Ceased
- 1991-03-08 ZA ZA911726A patent/ZA911726B/xx unknown
- 1991-03-08 CA CA002037812A patent/CA2037812A1/fr not_active Abandoned
- 1991-03-08 DE DE69106746T patent/DE69106746T2/de not_active Expired - Fee Related
- 1991-03-08 EP EP91400645A patent/EP0446141B1/de not_active Expired - Lifetime
- 1991-03-08 OA OA59972A patent/OA09488A/xx unknown
- 1991-03-08 US US07/666,802 patent/US5128338A/en not_active Expired - Fee Related
- 1991-03-08 ES ES91400645T patent/ES2069841T3/es not_active Expired - Lifetime
- 1991-03-08 AT AT91400645T patent/ATE117303T1/de not_active IP Right Cessation
- 1991-03-08 JP JP3043610A patent/JPH07103122B2/ja not_active Expired - Lifetime
- 1991-03-08 NZ NZ237363A patent/NZ237363A/en unknown
- 1991-03-08 IE IE77091A patent/IE66181B1/en not_active IP Right Cessation
1995
- 1995-03-21 GR GR950400646T patent/GR3015514T3/el unknown

Also Published As

Publication number	Publication date
FR2659329A1 (fr)	1991-09-13
PT96982A (pt)	1991-10-31
OA09488A (fr)	1992-11-15
ES2069841T3 (es)	1995-05-16
IE910770A1 (en)	1991-09-11
CA2037812A1 (fr)	1991-09-10
EP0446141A1 (de)	1991-09-11
US5128338A (en)	1992-07-07
EP0446141B1 (de)	1995-01-18
DE69106746D1 (de)	1995-03-02
NZ237363A (en)	1992-12-23
JPH07103122B2 (ja)	1995-11-08
AU7274591A (en)	1991-09-12
IE66181B1 (en)	1995-12-13
FR2659329B1 (fr)	1994-06-03
DK0446141T3 (da)	1995-05-15
GR3015514T3 (en)	1995-06-30
AU633408B2 (en)	1993-01-28
JPH04217682A (ja)	1992-08-07
DE69106746T2 (de)	1995-08-31
ZA911726B (en)	1991-12-24

Legal Events

Date	Code	Title	Description
1995-06-15	UEP	Publication of translation of european patent specification
1997-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE117303T1 (de)	1995-02-15	Imidazo(1,2-c>chinazolinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
ATE9793T1 (de)	1984-10-15	5-oxo- und 5-thioxoproline, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
DK0649418T3 (da)	1999-07-12	7-(2-aminoethyl)benzothiazolon
DE3762860D1 (de)	1990-06-28	2-thiazolylimidazo(1,2-a)pyrimidine und ihre salze, verfahren zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende zubereitungen.
ATE116647T1 (de)	1995-01-15	Thiophenderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
DE3574471D1 (de)	1990-01-04	1,6-naphthyridin-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel.
ATE13885T1 (de)	1985-07-15	Phenylpiperazinderivate von hetarylphenolen und hetarylanilinen, ihre herstellung und diese enthaltende therapeutische mittel.
ATE70827T1 (de)	1992-01-15	Benzhydryloxyaethyl-piperidine-derivate, verfahren zur herstellung und pharmazeutische zusammenstellungen, die diese enthalten.
DE58909420D1 (de)	1995-10-19	3,4-Disubstituierte Phenyl-Heterocyclen und deren Verwendung.
ATA226688A (de)	1990-03-15	Neue thienyloxy-alkylamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ATE101610T1 (de)	1994-03-15	Indol-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
DE3688161D1 (de)	1993-05-06	Gegebenenfalls etherifizierte oder esterifizierte in stellung 2 substituierte 4-oh-chinolincarbonsaeurederivate, verfahren und zwischenprodukte zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende zubereitungen.
DE3770117D1 (de)	1991-06-20	Neue 1-/ 3-(2-dialkylaminoaethoxy)-2-thienyl/-3-phenyl-1-propanone und ihre saeureadditionssalze und verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
DE69101740D1 (de)	1994-05-26	(1-Phenylpyrrolidin-2-yl)methylpiperazinderivate, Verfahren zur Herstellung und therapeutische Anwendung.
DE3778152D1 (de)	1992-05-14	Derivate von 5-(2-(1-pyrrolidinyl)-aethoxy)-p-cymen, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel.
IT1267173B1 (it)	1997-01-28	Poliamidi cicliche dell'acido glutammico ed aspartico ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso