ATE117305T1 - 13-substituierte milbemycinderivate, ihre herstellung und verwendung. - Google Patents

13-substituierte milbemycinderivate, ihre herstellung und verwendung.

Info

Publication number: ATE117305T1
Authority: AT; Austria
Prior art keywords: nnr; alkyl; sec; hydrogen; substituted
Prior art date: 1988-09-02

Application number

AT89308900T

Other languages

English (en)

Inventor

Yasuhiro C O Sankyo C Morisawa

Hiromachi

Akio C O Sankyo Company Saito

Toshimitsu C O Sankyo C Toyama

Susumu C O Sankyo Compa Kaneko

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-02

Filing date

1989-09-01

Publication date

1995-02-15

1989-09-01 Application filed by Sankyo Co filed Critical Sankyo Co

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE117305T1 publication Critical patent/ATE117305T1/de

Links

FXWHFKOXMBTCMP-WMEDONTMSA-N milbemycin Natural products COC1C2OCC3=C/C=C/C(C)CC(=CCC4CC(CC5(O4)OC(C)C(C)C(OC(=O)C(C)CC(C)C)C5O)OC(=O)C(C=C1C)C23O)C FXWHFKOXMBTCMP-WMEDONTMSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
125000000623 heterocyclic group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
125000004423 acyloxy group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
125000000547 substituted alkyl group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
230000000895 acaricidal effect Effects 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
230000000507 anthelmentic effect Effects 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000000749 insecticidal effect Effects 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Environmental Sciences (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Plant Pathology (AREA)
Pest Control & Pesticides (AREA)
Agronomy & Crop Science (AREA)
Dentistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT89308900T 1988-09-02 1989-09-01 13-substituierte milbemycinderivate, ihre herstellung und verwendung. ATE117305T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP22023588		1988-09-02

Publications (1)

Publication Number	Publication Date
ATE117305T1 true ATE117305T1 (de)	1995-02-15

Family

ID=16748008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89308900T ATE117305T1 (de)	1988-09-02	1989-09-01	13-substituierte milbemycinderivate, ihre herstellung und verwendung.

Country Status (11)

Country	Link
EP (1)	EP0357460B1 (de)
KR (1)	KR960006391B1 (de)
AT (1)	ATE117305T1 (de)
AU (1)	AU613521B2 (de)
CA (1)	CA1339129C (de)
DE (1)	DE68920673T2 (de)
ES (1)	ES2069589T3 (de)
GR (1)	GR3015691T3 (de)
HU (1)	HU211838A9 (de)
NZ (1)	NZ230516A (de)
ZA (1)	ZA896705B (de)

Families Citing this family (170)

* Cited by examiner, † Cited by third party
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US5428034A (en) *	1988-09-02	1995-06-27	Sankyo Co., Ltd.	Milbemycin derivatives, their preparation and their use
TW202452B (de) *	1989-12-01	1993-03-21	Ciba Geigy Ag
JPH085894B2 (ja) *	1990-03-01	1996-01-24	三共株式会社	ミルベマイシンエーテル誘導体
JP2622197B2 (ja) *	1990-03-01	1997-06-18	三共株式会社	１３−エーテル置換ミルベマイシン誘導体
US5229416A (en) *	1992-04-29	1993-07-20	Merck & Co., Inc.	Avermectin difluoro derivatives
AU666750B2 (en) *	1992-09-01	1996-02-22	Novartis Animal Health K.K.	Novel processes for the production of 13-ether derivatives of milbemycins, and novel intermediates therefor
US5614470A (en) *	1994-04-01	1997-03-25	Sankyo Company, Limited	13-substituted milbemycin derivatives, their preparation and their use
US6221894B1 (en)	1995-03-20	2001-04-24	Merck & Co., Inc.	Nodulisporic acid derivatives
US6136838A (en) *	1998-03-19	2000-10-24	Merck & Co., Inc.	Sulfurpentafluorophenylpyrazoles for controlling ectoparasitic infestations
CA2560510C (en)	2004-03-18	2009-10-13	Pfizer Inc.	N-(1-arylpyrazol-4yl) sulfonamides and their use as parasiticides
US7919522B2 (en)	2007-05-03	2011-04-05	Merial Limited	Compositions comprising C-13 alkoxyether macrolide compounds and phenylpyrazole compounds
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1989
- 1989-08-30 AU AU40924/89A patent/AU613521B2/en not_active Ceased
- 1989-08-31 NZ NZ230516A patent/NZ230516A/en unknown
- 1989-09-01 ES ES89308900T patent/ES2069589T3/es not_active Expired - Lifetime
- 1989-09-01 AT AT89308900T patent/ATE117305T1/de not_active IP Right Cessation
- 1989-09-01 DE DE68920673T patent/DE68920673T2/de not_active Expired - Fee Related
- 1989-09-01 ZA ZA896705A patent/ZA896705B/xx unknown
- 1989-09-01 EP EP89308900A patent/EP0357460B1/de not_active Expired - Lifetime
- 1989-09-01 CA CA000610224A patent/CA1339129C/en not_active Expired - Fee Related
- 1989-09-02 KR KR1019890012702A patent/KR960006391B1/ko not_active Expired - Fee Related
1995
- 1995-04-04 GR GR950400838T patent/GR3015691T3/el unknown
- 1995-06-29 HU HU95P/P00569P patent/HU211838A9/hu unknown

Also Published As

Publication number	Publication date
ES2069589T3 (es)	1995-05-16
KR960006391B1 (ko)	1996-05-15
KR900004744A (ko)	1990-04-12
HU211838A9 (en)	1995-12-28
ZA896705B (en)	1991-06-26
GR3015691T3 (en)	1995-07-31
EP0357460A2 (de)	1990-03-07
AU613521B2 (en)	1991-08-01
EP0357460A3 (de)	1991-01-09
AU4092489A (en)	1990-03-08
DE68920673D1 (de)	1995-03-02
NZ230516A (en)	1991-03-26
DE68920673T2 (de)	1995-08-31
CA1339129C (en)	1997-07-29
EP0357460B1 (de)	1995-01-18

Legal Events

Date	Code	Title	Description
1995-08-15	UEP	Publication of translation of european patent specification
2002-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE68920673D1 (de)	1995-03-02	13-Substituierte Milbemycinderivate, ihre Herstellung und Verwendung.
DE69104746D1 (de)	1994-12-01	Milbemycinderivate, ihre Herstellung und ihre Verwendung als Anthelmintika.
ATE160341T1 (de)	1997-12-15	Benzolsulfonamid-derivate und verfahren zur herstellung
NO900306D0 (no)	1990-01-22	Fremgangsmaate for fremstilling av nye pyrazolopyridin-forbindelser.
PT92437A (pt)	1990-05-31	Processo de preparacao de derivados da quinazolinona, dos seus intermediarios e de composicoes farmaceuticas que os contem
DE19675020I2 (de)	2002-11-07	Morpholinoethylester von Mycophenolsaeure und ihre Derivate ihre Herstellung und Verwendung in pharmazeutische Zusammensetzungen
FI92399B (fi)	1994-07-29	Menetelmä lääkeaineena käyttökelpoisen tiatsolidinonin johdannaisen valmistamiseksi
FI894045A0 (fi)	1989-08-29	Menetelmä terapeuttisesti aktiivisen 10-atsaspiro-9-fluori-2,3-dihydro-3-metyyli-7-okso-7H-pyrido/1,2,3-de//1,4/bentsoksatsiini-6-karboksyylihappojohdannaisen valmistamiseksi
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AU6586196A (en)	1997-04-10	13-substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests
DE69701298D1 (de)	2000-03-23	Hydroxypyridin-Derivate, ihre Herstellung und ihre pharmazeutische Verwendung
FI880748A0 (fi)	1988-02-17	Foerfarande foer framstaellning av naftalen-derivat anvaendbara saosom antiallergiska och antiinflammatoriska medel.
IT1224405B (it)	1990-10-04	Composti attivi sul sistema cardiovascolare
DE3650297D1 (de)	1995-05-18	Griseolsäurederivate, ihre Herstellung und ihre Verwendung.
DE3675277D1 (de)	1990-12-06	Catechinamide, verfahren zu ihrer herstellung, zwischenprodukte und pharmazeutische zubereitung.
ES2036539T3 (es)	1993-06-01	Un procedimiento para preparar derivados de ergolina.
IT1199339B (it)	1988-12-30	N-alchil derivati della 2-ammino-6,7-dimetossi tetralina,procedimenti per la loro preparazione e composizioni farmaceutiche ad attivita'an tiipertensiva che li contengono
ES2006165A6 (es)	1989-04-16	Procedimiento para la preparacion de derivados de 1,4-dihidropiridina y sus sales de adicion farmaceuticamente aceptables
ES2045335T3 (es)	1994-01-16	Un procedimiento para la preparacion de nuevas s-difluorometilhomocisteinas.
ES2039270T3 (es)	1993-09-16	Derivados de gamma-l-glutamil-4-nitroanilida y procedimiento para determinar actividad de gamma-gtp utilizandolos.