ES2069589T3 - Derivados de milbemicina 13-sustituidos, su preparacion y uso. - Google Patents

Derivados de milbemicina 13-sustituidos, su preparacion y uso.

Info

Publication number
ES2069589T3
ES2069589T3 ES89308900T ES89308900T ES2069589T3 ES 2069589 T3 ES2069589 T3 ES 2069589T3 ES 89308900 T ES89308900 T ES 89308900T ES 89308900 T ES89308900 T ES 89308900T ES 2069589 T3 ES2069589 T3 ES 2069589T3
Authority
ES
Spain
Prior art keywords
nnr
alkyl
sec
substituted
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89308900T
Other languages
English (en)
Inventor
Yasuhiro C O Sankyo C Morisawa
Akio C O Sankyo Company Saito
Toshimitsu C O Sankyo C Toyama
Susumu C O Sankyo Compa Kaneko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2069589T3 publication Critical patent/ES2069589T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

COMPUESTOS DE FORMULA (I). EN LA QUE R1 Y R2 SON H, HALOGENO, CINAO, NITRO, ALQUILO, ALQUILO SUSTITUIDO, ALCOXI, ALCOXIALQUILO, -(CH2)NNHR9, DONDE N ES 0, 1 O 2 Y R2 ES H O ALQUILO, -(CH2)NNR9C(=O)R6, DONDE R6 ES H, ALQUILO, ALQUILO SUSTITUIDO, ALQUENILO, ALQUINILO, CICLOALQUILO, CICLOALQUILO SUSTITUIDO, ARILO O HETEROCICLO, -(CH2)NNR9COCOR6, -(CH2)NNR9COCOOR7, DONDE R7 ES ALQUILO, CICLOALQUILO O ARALQUILO, -(CH2)NNR9CHR6NHCOR6, -(CH2)NNR9NHCOCONHR6, -(CH2)NNR9CHR6NHCOOR7, -(CH2)NNR9C(=Y)YR6, DONDE CADA Y ES O O S, -(CH2)NNR9C(=Y)NR6''R6'', DONDE CADA R6'' ES R6 O LOS DOS Y EL N FORMAN UN GRUPO HETEROCICLICO, -(CH2)NNR9C(=Y)NR6"R6", DONDE CADA R6" ES R6, O CUALESQUIERA DOS R6" Y SU ATOMO DE N FORMA UN GRUPO HETEROCICLICO, -(CH2)NNR9C(=Y)NR6NHZ, DONDE Z ES -COOR7, -COR6 O -SO2R6, -(CH2)NNR9C(=NR10)NHR10, DONDE CADA R10 ES R6, CIANO, NITRO, -COOR7 O -COR6, -(CH2)NNR9C(-NR10)R6, -(CH2)NNR9SOMR6, DONDE M ES 1 O 2, -CONHR6, O -COOR7; R3 Y R4 SON CADA UNO H, ALQUILO O ALCOXI; R5 ES METILO, ETILO, ISOPROPILO O SEC-BUTILO; Y X ES HIDROXI, ALCANOILOXI, ALCANOILOXI SUSTITUIDO O HIDROXIIMINO, Y SUS SALES TIENEN ACTIVIDADSE ACARICIDAS, INSECTICIDAS Y ANTIHELMINTICAS VALIOSAS.
ES89308900T 1988-09-02 1989-09-01 Derivados de milbemicina 13-sustituidos, su preparacion y uso. Expired - Lifetime ES2069589T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22023588 1988-09-02

Publications (1)

Publication Number Publication Date
ES2069589T3 true ES2069589T3 (es) 1995-05-16

Family

ID=16748008

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89308900T Expired - Lifetime ES2069589T3 (es) 1988-09-02 1989-09-01 Derivados de milbemicina 13-sustituidos, su preparacion y uso.

Country Status (11)

Country Link
EP (1) EP0357460B1 (es)
KR (1) KR960006391B1 (es)
AT (1) ATE117305T1 (es)
AU (1) AU613521B2 (es)
CA (1) CA1339129C (es)
DE (1) DE68920673T2 (es)
ES (1) ES2069589T3 (es)
GR (1) GR3015691T3 (es)
HU (1) HU211838A9 (es)
NZ (1) NZ230516A (es)
ZA (1) ZA896705B (es)

Families Citing this family (170)

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JPH085894B2 (ja) * 1990-03-01 1996-01-24 三共株式会社 ミルベマイシンエーテル誘導体
US5229416A (en) * 1992-04-29 1993-07-20 Merck & Co., Inc. Avermectin difluoro derivatives
US5461168A (en) * 1992-09-01 1995-10-24 Sankyo Company, Limited Processes for the production of 13-ether derivatives of milbemycins, and intermediates therefor
US5614470A (en) * 1994-04-01 1997-03-25 Sankyo Company, Limited 13-substituted milbemycin derivatives, their preparation and their use
US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
US6136838A (en) * 1998-03-19 2000-10-24 Merck & Co., Inc. Sulfurpentafluorophenylpyrazoles for controlling ectoparasitic infestations
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ATE117305T1 (de) 1995-02-15
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DE68920673T2 (de) 1995-08-31
EP0357460A2 (en) 1990-03-07
ZA896705B (en) 1991-06-26
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CA1339129C (en) 1997-07-29
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