ATE117697T1 - Supersulfatierte heparine. - Google Patents

Supersulfatierte heparine.

Info

Publication number: ATE117697T1
Authority: AT; Austria
Prior art keywords: heparins; supersulfated; heparin; supersulfated heparins; supersulfation
Prior art date: 1989-11-24

Application number

AT90122309T

Other languages

English (en)

Inventor

Renato Conti

Paolo Casati

Maria Beatrice Gorini

Antonio Maggi

Original Assignee

Iketon Farmaceutici Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-24

Filing date

1990-11-22

Publication date

1995-02-15

1990-11-22 Application filed by Iketon Farmaceutici Srl filed Critical Iketon Farmaceutici Srl

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE117697T1 publication Critical patent/ATE117697T1/de

Links

229960002897 heparin Drugs 0.000 title abstract 5
229920000669 heparin Polymers 0.000 title abstract 5
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
230000002785 anti-thrombosis Effects 0.000 abstract 1
230000019635 sulfation Effects 0.000 abstract 1
238000005670 sulfation reaction Methods 0.000 abstract 1
AKEJUJNQAAGONA-UHFFFAOYSA-N sulfur trioxide Inorganic materials O=S(=O)=O AKEJUJNQAAGONA-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Public Health (AREA)
Materials Engineering (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Polymers & Plastics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT90122309T 1989-11-24 1990-11-22 Supersulfatierte heparine. ATE117697T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT02250489A IT1237518B (it)	1989-11-24	1989-11-24	Eparine supersolfatate

Publications (1)

Publication Number	Publication Date
ATE117697T1 true ATE117697T1 (de)	1995-02-15

Family

ID=11197161

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90122309T ATE117697T1 (de)	1989-11-24	1990-11-22	Supersulfatierte heparine.

Country Status (9)

Country	Link
US (1)	US5164378A (de)
EP (1)	EP0432537B1 (de)
JP (1)	JPH03210302A (de)
AT (1)	ATE117697T1 (de)
DE (1)	DE69016383T2 (de)
ES (1)	ES2068969T3 (de)
IE (1)	IE904225A1 (de)
IT (1)	IT1237518B (de)
PT (1)	PT95961B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1244373B (it) *	1991-01-18	1994-07-08	Sclavo Spa	Composizioni farmaceutiche per uso orale contenenti eparina a basso peso molecolare, loro preparazione ed uso
SE9101155D0 (sv) *	1991-04-18	1991-04-18	Kabi Pharmacia Ab	Novel heparin derivatives
US5514665A (en) *	1993-12-30	1996-05-07	University Of British Columbia	Method of preventing or reducing the risk of infection by bacterial pathogens utilizing simple and conjugated dextrans
US5783568A (en) *	1994-06-10	1998-07-21	Sugen, Inc.	Methods for treating cancer and other cell proliferative diseases
WO1997016556A1 (en)	1995-10-30	1997-05-09	Massachusetts Institute Of Technology	Rationally designed polysaccharide lyases derived from heparinase i
IT1285546B1 (it) *	1996-01-16	1998-06-18	Alfa Wassermann Spa	Uso del dermatano solfato a basso peso molecolare e delle specialita' medicinali che lo contengono nella terapia e nella prevenzione della
IT1290814B1 (it) *	1997-03-24	1998-12-11	Istituto Scient Di Chimica E B	Glicosaminoglicani aventi elevata attivita' antitrombotica
US7056504B1 (en)	1998-08-27	2006-06-06	Massachusetts Institute Of Technology	Rationally designed heparinases derived from heparinase I and II
EP1109919A2 (de)	1998-08-27	2001-06-27	Massachusetts Institute Of Technology	Von heparinase i und ii abgeleitete heparinasen
WO2000065521A2 (en) *	1999-04-23	2000-11-02	Massachusetts Institute Of Technology	System and method for polymer notation
AU2001243512C1 (en)	2000-03-08	2008-04-17	Massachusetts Institute Of Technology	Heparinase III and uses thereof
DK1319183T3 (da)	2000-09-12	2009-05-18	Massachusetts Inst Technology	Fremgangsmåder og produkter relateret til heparin med lav molekylvægt
EP1328260A2 (de)	2000-10-18	2003-07-23	Massachusetts Institute Of Technology	Verfahren und produkte zur pulmonalen verabreichung von polysacchariden
EP1238670A1 (de) *	2001-03-07	2002-09-11	Bruce Daniels	Zusammensetzungen zur Behandlung und Verhütung von Gefässerkrankungen und Hypertonie
JP4828795B2 (ja)	2002-03-11	2011-11-30	モメンタファーマシューティカルズインコーポレイテッド	硫酸化多糖類の分析
CA2483271A1 (en) *	2002-04-25	2003-11-06	Momenta Pharmaceuticals, Inc.	Methods and products for mucosal delivery
GB0306615D0 (en) *	2003-03-22	2003-04-30	Astrazeneca Ab	New use
WO2007019554A2 (en) *	2005-08-08	2007-02-15	Momenta Pharmaceuticals, Inc.	Polysaccharides for delivery of active agents
US9139876B1 (en)	2007-05-03	2015-09-22	Momenta Pharmacueticals, Inc.	Method of analyzing a preparation of a low molecular weight heparin
US8435795B2 (en) *	2010-01-19	2013-05-07	Momenta Pharmaceuticals, Inc.	Evaluating heparin preparations
WO2012115952A1 (en)	2011-02-21	2012-08-30	Momenta Pharmaceuticals, Inc.	Evaluating heparin preparations
EP3398971A4 (de) *	2015-12-30	2019-09-25	Shenzhen Hepalink Pharmaceutical Group Co., Ltd.	Sulfatiertes heparinoligosaccharid und herstellungsverfahren und anwendung davon

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2599172A (en) *	1948-11-29	1952-06-03	Searle & Co	Sulfuric acid esters of hyaluronic acid and processes for the production thereof
FR1714M (fr) *	1960-12-29	1963-02-25	Chugai Pharmaceutical Co Ltd	Sulfates de polysaccharides faiblement polymérisés.
DE1418844A1 (de) *	1961-05-24	1969-05-08	Hoechst Ag	Verfahren zur Herstellung von gegebenenfalls Phosphatgruppen enthaltenden Polysacchariden
US3454560A (en) *	1966-03-01	1969-07-08	Seikagaku Kogyo Co Ltd	Process for the production of chondroitin polysulfate
US3506642A (en) *	1967-07-03	1970-04-14	Canada Packers Ltd	Stable orally active heparinoid complexes
IT1083903B (it) *	1977-08-09	1985-05-25	Lobo Srl	Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche
SE7811306L (sv) *	1978-11-01	1980-05-02	Rothman Gunnvor	Antikoagulationsmedel samt sett for dess framstellning
JPS57134419A (en) *	1981-02-12	1982-08-19	Eisai Co Ltd	Stable anticoagulant of blood
DE3244214A1 (de) *	1982-11-30	1984-05-30	B. Braun Melsungen Ag, 3508 Melsungen	Verfahren zur reinigung und fraktionierung von heparin
CA1218986A (en) *	1982-12-28	1987-03-10	Annamaria Naggi	Process for the depolymerisation and sulfatation of polysaccharides
US4948881A (en) *	1982-12-28	1990-08-14	Sanofi	Process for the depolymerization and sulfation of polysaccharides
FR2538404B1 (de) *	1982-12-28	1985-08-23	Anic Spa
FR2548672A1 (fr) *	1983-07-04	1985-01-11	Pharmuka Lab	Oligosaccharides sulfates et leur utilisation comme medicaments
JPS6049001A (ja) *	1983-08-30	1985-03-18	Eisai Co Ltd	アンチトロンビン３低親和性ヘパリン
FR2584728B1 (fr) *	1985-07-12	1987-11-20	Choay Sa	Procede de sulfatation de glycosaminoglycanes et de leurs fragments
FR2614026B1 (fr) *	1987-04-16	1992-04-17	Sanofi Sa	Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
DE3734815A1 (de) *	1987-10-14	1989-04-27	Luitpold Werk Chem Pharm	Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel
DE3744119A1 (de) *	1987-12-24	1989-07-06	Basf Ag	Verwendung von polysulfatierten heparinen
WO1989012070A1 (en) *	1988-06-03	1989-12-14	Italfarmaco S.P.A.	Glycosaminoglycan salts, processes for the preparation thereof and pharmaceutical compositions containing them

1989
- 1989-11-24 IT IT02250489A patent/IT1237518B/it active IP Right Grant
1990
- 1990-11-22 AT AT90122309T patent/ATE117697T1/de active
- 1990-11-22 JP JP2315683A patent/JPH03210302A/ja active Pending
- 1990-11-22 IE IE422590A patent/IE904225A1/en unknown
- 1990-11-22 PT PT95961A patent/PT95961B/pt not_active IP Right Cessation
- 1990-11-22 DE DE69016383T patent/DE69016383T2/de not_active Expired - Fee Related
- 1990-11-22 ES ES90122309T patent/ES2068969T3/es not_active Expired - Lifetime
- 1990-11-22 EP EP90122309A patent/EP0432537B1/de not_active Expired - Lifetime
- 1990-11-26 US US07/618,051 patent/US5164378A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IE904225A1 (en)	1991-06-05
EP0432537A2 (de)	1991-06-19
JPH03210302A (ja)	1991-09-13
DE69016383D1 (de)	1995-03-09
ES2068969T3 (es)	1995-05-01
PT95961A (pt)	1991-09-13
IT8922504A1 (it)	1991-05-24
PT95961B (pt)	1996-12-31
DE69016383T2 (de)	1995-07-13
IT8922504A0 (it)	1989-11-24
EP0432537B1 (de)	1995-01-25
US5164378A (en)	1992-11-17
EP0432537A3 (en)	1991-11-13
IT1237518B (it)	1993-06-08

Publication	Publication Date	Title
ATE117697T1 (de)	1995-02-15	Supersulfatierte heparine.
GB2068011B (en)	1983-07-27	Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties and product so obtained
FR2596765B1 (fr)	1993-10-08	Procede de preparation de polymeres acryliques de poids moleculaire eleve
DE69022595D1 (de)	1995-10-26	Herstellung von kohlefaser-halbfabrikaten.
FR2503714B1 (fr)	1986-11-21	Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
BE891018A (fr)	1982-05-06	Procede de purification de polymeres de sulfures d'arylene
PT92531A (pt)	1990-06-29	Processo de preparacao de polimeros de metacrilato substituido
BR9002231A (pt)	1991-08-13	Polimero de enxerto de oximetileno e processo de obtencao de polimero de enxerto de oximetileno
RO83549A (ro)	1984-04-12	Suspensie stabila de polimerihidrosolubili si procedeu pentru obtinerea acesteia
ATE117937T1 (de)	1995-02-15	Herstellungsverfahren von zellkunststoff.
FR2618451B1 (fr)	1991-05-31	Procede et installation de vinification et utilisations s'y rapportant
FR2614047B1 (fr)	1989-07-28	Procede de greffage assurant l'impermeabilisation d'un materiau polymerique par un monomere fluore et materiau ainsi obtenu
BE894713A (fr)	1983-01-31	Polymeres greffes d'ammonium quaternaire
NO173355C (no)	1993-12-01	Fremgangsm}te og selektiv bestemmelse av en h!ymolekylvekts hyaluronsyre og reagenssett for utf!relse av fremgangsm}ten
BE873692A (fr)	1979-07-24	Procede de polymerisation de l'ethylene en plusieurs stades
ZA829463B (en)	1983-10-26	Process for manufacturing low molecular weight heparins by depolymerization of normal heparin
FR2558166B1 (fr)	1987-08-14	Procede de preparation d'un polymere hydrosoluble de haut poids moleculaire
BR8804651A (pt)	1990-05-01	Processo para a producao de um polimero de adicao via radical livre de anidridomaleico e no minimo um 1-alceno;e polimero de adicao
ES8100364A1 (es)	1980-11-01	Un procedimiento de hilatura de filamentos de polimeros de acrilonitrilo
EP0452986A3 (en)	1991-12-18	Photosensitive amphiphilic high molecular weight polymers and process for their production
FR2643371B1 (fr)	1993-11-05	Nouveaux derives de l'acide 2-amino pentanedioique, leur procede de preparation et leur application comme medicaments
FR2604625B1 (fr)	1989-09-01	Procede pour la fabrication de compositions cosmetiques a base d'acide alginique et compositions cosmetiques obtenues
PT89491A (pt)	1989-10-04	Processo de preparacao de polimeros de organoborossilazanos
PT84376B (pt)	1989-10-04	Processo de imortalizacao de celulas primarias e linhas de celulas assim preparadas
ES2070364T3 (es)	1995-06-01	Mezclas polimeras homogeneas de polimeros de polimetacrilimida.