ES2068969T3 - Heparinas supersulfatadas. - Google Patents

Heparinas supersulfatadas.

Info

Publication number
ES2068969T3
ES2068969T3 ES90122309T ES90122309T ES2068969T3 ES 2068969 T3 ES2068969 T3 ES 2068969T3 ES 90122309 T ES90122309 T ES 90122309T ES 90122309 T ES90122309 T ES 90122309T ES 2068969 T3 ES2068969 T3 ES 2068969T3
Authority
ES
Spain
Prior art keywords
heparines
supersulfated
heparin
supersulfation
depolmerization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90122309T
Other languages
English (en)
Inventor
Renato Conti
Paolo Casati
Maria Beatrice Gorini
Antonio Maggi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Iketon Farmaceutici Srl
Original Assignee
Iketon Farmaceutici Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iketon Farmaceutici Srl filed Critical Iketon Farmaceutici Srl
Application granted granted Critical
Publication of ES2068969T3 publication Critical patent/ES2068969T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE EXPONE EL PROCESO PARA LA DESPOLMERIZACION Y LA SUPERSULFATACION DE HEPARINA Y LAS HEPARINAS SUPERSULFATADAS ASI OBTENIDAS. EL PROCESO COMPRENDE TRATAR LA HEPARINA CON OLEUM QUE CONTENGA DE 2 A 6% DE ANHIDRIDO SULFURICO LIBRE A UNA TEMPERATURA DE -10 A +20 C. LAS HEPARINAS OBTENIDAS TIENEN PESOS MOLECULARES DE 2000 A 5000, Y UN GRADO DE SULFATACION DE 3,4 A 4,3. TODAS ELLAS ESTAN DOTADAS DE UNA MARCADA ACTIVIDAD ANTITROMBOTICA.
ES90122309T 1989-11-24 1990-11-22 Heparinas supersulfatadas. Expired - Lifetime ES2068969T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02250489A IT1237518B (it) 1989-11-24 1989-11-24 Eparine supersolfatate

Publications (1)

Publication Number Publication Date
ES2068969T3 true ES2068969T3 (es) 1995-05-01

Family

ID=11197161

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90122309T Expired - Lifetime ES2068969T3 (es) 1989-11-24 1990-11-22 Heparinas supersulfatadas.

Country Status (9)

Country Link
US (1) US5164378A (es)
EP (1) EP0432537B1 (es)
JP (1) JPH03210302A (es)
AT (1) ATE117697T1 (es)
DE (1) DE69016383T2 (es)
ES (1) ES2068969T3 (es)
IE (1) IE904225A1 (es)
IT (1) IT1237518B (es)
PT (1) PT95961B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1244373B (it) * 1991-01-18 1994-07-08 Sclavo Spa Composizioni farmaceutiche per uso orale contenenti eparina a basso peso molecolare, loro preparazione ed uso
SE9101155D0 (sv) * 1991-04-18 1991-04-18 Kabi Pharmacia Ab Novel heparin derivatives
US5514665A (en) * 1993-12-30 1996-05-07 University Of British Columbia Method of preventing or reducing the risk of infection by bacterial pathogens utilizing simple and conjugated dextrans
US5783568A (en) * 1994-06-10 1998-07-21 Sugen, Inc. Methods for treating cancer and other cell proliferative diseases
US6217863B1 (en) 1995-10-30 2001-04-17 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase I
IT1285546B1 (it) * 1996-01-16 1998-06-18 Alfa Wassermann Spa Uso del dermatano solfato a basso peso molecolare e delle specialita' medicinali che lo contengono nella terapia e nella prevenzione della
IT1290814B1 (it) * 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
JP2003527822A (ja) 1998-08-27 2003-09-24 マサチューセッツ インスティテュート オブ テクノロジー ヘパリナーゼｉおよびｉｉ由来の合理的に設計されたヘパリナーゼ
CA2370539C (en) * 1999-04-23 2009-01-06 Massachusetts Institute Of Technology System and method for notating polymers
CA2402160C (en) * 2000-03-08 2012-02-14 Massachusetts Institute Of Technology Heparinase iii and uses thereof
DE60138115D1 (de) * 2000-09-12 2009-05-07 Massachusetts Inst Technology Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind
AU2002224408B2 (en) 2000-10-18 2007-08-23 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
EP1238670A1 (en) * 2001-03-07 2002-09-11 Bruce Daniels Composition and method for treating and preventing cardiovascular disease and hypertension.
US7575886B2 (en) 2002-03-11 2009-08-18 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
EP1551852A4 (en) * 2002-04-25 2007-03-21 Momenta Pharmaceuticals Inc METHOD AND PRODUCTS FOR MUCOSAL DELIVERY
GB0306615D0 (en) * 2003-03-22 2003-04-30 Astrazeneca Ab New use
WO2007019554A2 (en) * 2005-08-08 2007-02-15 Momenta Pharmaceuticals, Inc. Polysaccharides for delivery of active agents
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US8435795B2 (en) * 2010-01-19 2013-05-07 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
JP6741277B2 (ja) * 2015-12-30 2020-08-19 シェンツェン ヘパリンク ファーマスーティカル グループ カンパニー リミテッドＳｈｅｎｚｈｅｎ Ｈｅｐａｌｉｎｋ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｇｒｏｕｐ Ｃｏ．， Ｌｔｄ． 硫酸化ヘパリン由来オリゴ糖及びその調製法と施用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2599172A (en) * 1948-11-29 1952-06-03 Searle & Co Sulfuric acid esters of hyaluronic acid and processes for the production thereof
FR1714M (fr) * 1960-12-29 1963-02-25 Chugai Pharmaceutical Co Ltd Sulfates de polysaccharides faiblement polymérisés.
DE1418844A1 (de) * 1961-05-24 1969-05-08 Hoechst Ag Verfahren zur Herstellung von gegebenenfalls Phosphatgruppen enthaltenden Polysacchariden
US3454560A (en) * 1966-03-01 1969-07-08 Seikagaku Kogyo Co Ltd Process for the production of chondroitin polysulfate
US3506642A (en) * 1967-07-03 1970-04-14 Canada Packers Ltd Stable orally active heparinoid complexes
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche
SE7811306L (sv) * 1978-11-01 1980-05-02 Rothman Gunnvor Antikoagulationsmedel samt sett for dess framstellning
JPS57134419A (en) * 1981-02-12 1982-08-19 Eisai Co Ltd Stable anticoagulant of blood
DE3244214A1 (de) * 1982-11-30 1984-05-30 B. Braun Melsungen Ag, 3508 Melsungen Verfahren zur reinigung und fraktionierung von heparin
FR2538404B1 (es) * 1982-12-28 1985-08-23 Anic Spa
US4948881A (en) * 1982-12-28 1990-08-14 Sanofi Process for the depolymerization and sulfation of polysaccharides
IL70511A (en) * 1982-12-28 1990-01-18 Anic Spa Process for the concurrent depolymerization and sulfation of polysaccharides at hydroxyl groups
FR2548672A1 (fr) * 1983-07-04 1985-01-11 Pharmuka Lab Oligosaccharides sulfates et leur utilisation comme medicaments
JPS6049001A (ja) * 1983-08-30 1985-03-18 Eisai Co Ltd アンチトロンビン３低親和性ヘパリン
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
DE3734815A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel
DE3744119A1 (de) * 1987-12-24 1989-07-06 Basf Ag Verwendung von polysulfatierten heparinen
US5264425A (en) * 1988-06-03 1993-11-23 Italfarmaco S.P.A. Glycosaminoglycan salts and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
JPH03210302A (ja) 1991-09-13
IT8922504A0 (it) 1989-11-24
ATE117697T1 (de) 1995-02-15
EP0432537B1 (en) 1995-01-25
IE904225A1 (en) 1991-06-05
EP0432537A3 (en) 1991-11-13
US5164378A (en) 1992-11-17
PT95961A (pt) 1991-09-13
IT8922504A1 (it) 1991-05-24
PT95961B (pt) 1996-12-31
EP0432537A2 (en) 1991-06-19
DE69016383D1 (de) 1995-03-09
IT1237518B (it) 1993-06-08
DE69016383T2 (de) 1995-07-13

Similar Documents

Publication Publication Date Title
ES2068969T3 (es) Heparinas supersulfatadas.
IE811074L (en) Sulphated polysaccharides
ES8601247A1 (es) Procedimiento para la obtencion de nuevos derivados de sulfuros de policarbono
BR7803712A (pt) Sutura sintetica de multifilamento,e processo para melhorar as caracteristicas de amarracao de uma sutura de multifilamento
ES2000871A6 (es) Un procedimiento para producir un copolimero de bloques selectivamente hidrogenado y fuoncionalizado
BR7903443A (pt) Estrutura de mancal lubrificado e processo de realizacao da alimentacao forcada respectiva
ES2164968T3 (es) Agentes herbicidas sinergicos.
ATE38389T1 (de) Block-copolymer.
IT7823200A0 (it) Processo e reagente per la determinazione dell'acido ascorbico.
SE8207224D0 (sv) Nouveaux derives aminoalkoxy aromatiques, leur procede de preparation et leur application en therapeutique
BR8800930A (pt) Liga de polimero de poli-cicloolefina,mistura de poli-cicloolefina e processo para preparar um polimero ligado de poli-cicloolefina
ES2083449T3 (es) Copolimero de estireno y su produccion.
PT82778B (pt) Processo de preparacao de uma liga de chumbo e calcio
ES2070364T3 (es) Mezclas polimeras homogeneas de polimeros de polimetacrilimida.
BR7807239A (pt) Processo de anti-redeposicao de sujeiras sobre fibras naturais,sinteticas artificiais ou de suas misturas e composicao ou banho anti-redeposicao
BR7905514A (pt) Composicao polimera, composicao lubrificante e aditivo concentrado
FR2324309A1 (fr) G-lactones d'acide 6b,17 -dihydroxy-7a-(alcoxy inferieur)carbonyl-3-oxo-17a-pregn-4-ene-21-carboxylique et homologues
BR7807475A (pt) Processo de obtencao de correntes gasosas ricas em eteno
IT1092701B (it) Etere cis-e trans-3,3,5-trimetilcicloesiletilic o e loro miscugli come profumi,composizioni di profumi che li contengono e processo di produzione migliorato dell'etere trans-3,3,5-trimetil-cicloesil-etilico
BR8503973A (pt) Processo para produzir um polimero de enxerto de sacarideo essencialmente livre de copolimero
BG34454A3 (bg) Метод за получаване на производни на 7 бета- аминотиазолилацетамидо- 3- цефем- 4- карбоновата киселина
IT8220306A0 (it) Derivati dell'acido 2 o 4-tiazolidin-carbossilico 3-acilsostituiti ad azione fitoregolatrice e biostimolanti.
BR8600122A (pt) Processo de preparacao de composicoes de misturas de polimeros,expandidas e curadas com enxofre
ES2052253T3 (es) Proceso para recuperar el germanio.
BR8707562A (pt) Processo para preparar um produto sbsbs4 tendo um baixo nivel de impureza de enxofre livre e composicao

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 432537

Country of ref document: ES