ATE117978T1 - Herstellung von hyperizin. - Google Patents

Herstellung von hyperizin.

Info

Publication number: ATE117978T1
Authority: AT; Austria
Prior art keywords: hypericin; production; protohypericin; irradiation; preparing
Prior art date: 1989-11-15

Application number

AT90121796T

Other languages

English (en)

Inventor

Yehuda Mazur

Harald Bock

David Lavie

Original Assignee

Yeda Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-15

Filing date

1990-11-14

Publication date

1995-02-15

1990-11-14 Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE117978T1 publication Critical patent/ATE117978T1/de

Links

229940005608 hypericin Drugs 0.000 title abstract 3
PHOKTTKFQUYZPI-UHFFFAOYSA-N hypericin Natural products Cc1cc(O)c2c3C(=O)C(=Cc4c(O)c5c(O)cc(O)c6c7C(=O)C(=Cc8c(C)c1c2c(c78)c(c34)c56)O)O PHOKTTKFQUYZPI-UHFFFAOYSA-N 0.000 title abstract 3
SSKVDVBQSWQEGJ-UHFFFAOYSA-N pseudohypericin Natural products C12=C(O)C=C(O)C(C(C=3C(O)=CC(O)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 SSKVDVBQSWQEGJ-UHFFFAOYSA-N 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
YDOIFHVUBCIUHF-UHFFFAOYSA-N 9,11,13,16,18,20-hexahydroxy-5,24-dimethyloctacyclo[13.11.1.12,10.03,8.04,25.019,27.021,26.014,28]octacosa-1(26),2,4(25),5,8,10,12,14(28),15(27),16,18,20,23-tridecaene-7,22-dione Chemical compound OC1=CC(O)=C2C(O)=C3C(=O)C=C(C)C4=C5C(C)=CC(=O)C6=C(O)C7=C(O)C=C(O)C8=C7C(=C56)C(=C34)C2=C18 YDOIFHVUBCIUHF-UHFFFAOYSA-N 0.000 title 1
BTXNYTINYBABQR-UHFFFAOYSA-N hypericin Chemical compound C12=C(O)C=C(O)C(C(C=3C(O)=CC(C)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 BTXNYTINYBABQR-UHFFFAOYSA-N 0.000 abstract 2
YLILOANQCQKPOD-UHFFFAOYSA-N protohypericin Chemical compound C12=C(O)C=C(O)C(C(C3=C(O)C=C(C=C33)C)=O)=C2C3=C2C3=C1C(O)=CC(O)=C3C(=O)C1=C(O)C=C(C)C=C12 YLILOANQCQKPOD-UHFFFAOYSA-N 0.000 abstract 2
CBOKHFLBNZMMAA-UHFFFAOYSA-N Emodin anthrone Natural products OC1=CC(O)=CC2=CC3=CC(C)=CC(O)=C3C(O)=C21 CBOKHFLBNZMMAA-UHFFFAOYSA-N 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
LAJSXCAVRQXZIO-UHFFFAOYSA-N emodin anthrone Chemical compound C1=C(O)C=C2CC3=CC(C)=CC(O)=C3C(=O)C2=C1O LAJSXCAVRQXZIO-UHFFFAOYSA-N 0.000 abstract 1
238000006025 oxidative dimerization reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
- C07C50/36—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having four or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Hydrogenated Pyridines (AREA)

AT90121796T 1989-11-15 1990-11-14 Herstellung von hyperizin. ATE117978T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IL9231589A IL92315A (en)	1989-11-15	1989-11-15	Preparation of Hypericin from Amodin Enron

Publications (1)

Publication Number	Publication Date
ATE117978T1 true ATE117978T1 (de)	1995-02-15

Family

ID=11060574

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90121796T ATE117978T1 (de)	1989-11-15	1990-11-14	Herstellung von hyperizin.

Country Status (11)

Country	Link
US (1)	US5120412A (de)
EP (1)	EP0432496B1 (de)
JP (1)	JP2896224B2 (de)
AT (1)	ATE117978T1 (de)
AU (1)	AU629066B2 (de)
CA (1)	CA2029993C (de)
DE (1)	DE69016620T2 (de)
DK (1)	DK0432496T3 (de)
ES (1)	ES2070244T3 (de)
GR (1)	GR3015919T3 (de)
IL (1)	IL92315A (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL92315A (en) *	1989-11-15	1996-12-05	Yeda Res & Dev	Preparation of Hypericin from Amodin Enron
US5418130A (en) *	1990-04-16	1995-05-23	Cryopharm Corporation	Method of inactivation of viral and bacterial blood contaminants
US6187572B1 (en)	1990-04-16	2001-02-13	Baxter International Inc.	Method of inactivation of viral and bacterial blood contaminants
WO1994014427A2 (en) *	1992-12-23	1994-07-07	Zymogenetics, Inc.	Use of skyrin and analogues for the treatment of diabetes mellitus and process for their preparation
DE19547317A1 (de) *	1995-12-18	1998-12-24	Dreluso Pharm Dr Elten & Sohn	Antivirales Medikament
US6001882A (en) *	1997-07-03	1999-12-14	The Trustees Of The University Of Pennsylvania	Photoactivated hypericin and the use thereof
IL121440A0 (en)	1997-07-31	1998-01-04	Yeda Res & Dev	The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
US6238671B1 (en) *	1998-04-22	2001-05-29	Bionorica Arzneimittel Gmbh	Process for the gentle recovery of extract fractions from hypericum, pharmaceutical preparations containing the same and their use
JP2002520260A (ja) *	1998-07-09	2002-07-09	シーヴイテクノロジーズインコーポレイテッド	ヒペリシンおよびヒペリスム抽出物：特定のｔ型カルシウムチャネル遮断剤、およびそれらのｔ型カルシウムチャネルを標的にした治療法としての使用
DE19838377C2 (de) *	1998-08-24	2000-10-26	Fiegert Seibt Edda	Verfahren und Vorrichtung zur Extraktherstellung aus pflanzlichem Material
US7195783B2 (en) *	1999-07-09	2007-03-27	Fx Life Sciences International Gmbh	Hypericin and hypericum extract: specific T-type calcium channel blocker, and their use as T-type calcium channel targeted therapeutics
RU2333675C2 (ru) *	2002-05-14	2008-09-20	Джей-Ойл Миллз, Инк.	Добавка для улучшения основного вкуса, содержащая высоконенасыщенную жирную кислоту с длинной цепью и/или ее сложный эфир, и содержащая ее композиция на основе растительного жира и масла
MXPA06000319A (es) *	2003-07-09	2006-03-30	J Oil Mills Inc	Mejorador de sabor y cuerpo que comprende sustancias descompuestas o sus extractos de acido graso altamente insaturado de cadena larga.
TW200526131A (en) *	2003-11-12	2005-08-16	J Oil Mills Inc	Method of application of body taste enhancer comprising long-chain highly unsaturated fatty acid and/or its ester
TWI356681B (en) *	2003-11-12	2012-01-21	J Oil Mills Inc	Body taste improver comprising long-chain highly u
JP5023322B2 (ja) *	2006-06-08	2012-09-12	国立大学法人高知大学	縮合多環化合物の製造方法
EP2046314A4 (de) *	2006-08-03	2009-12-30	Hy Biopharma Inc	Polycyclische dianthrachinone als hemmer von entzündlichen zytokinen
EP2477957A4 (de) *	2009-09-15	2013-07-03	Hy Biopharma Inc	Verfahren zur herstellung von hypericin
CN103274920B (zh) *	2013-06-14	2014-12-17	西北农林科技大学	一种单色光引发高效合成金丝桃素的方法
CN104193610B (zh) *	2014-08-05	2015-12-02	中南大学	金丝桃素的合成方法
EP4414354A3 (de)	2016-03-01	2024-10-30	Soligenix, Inc.	Systeme und verfahren zur herstellung von synthetischem hypericin
US10053413B2 (en) *	2016-03-01	2018-08-21	Soligenix, Inc.	Systems and methods for producing synthetic hypericin
CN108997104A (zh) *	2018-09-18	2018-12-14	湖北博瑞生物科技股份有限公司	一种原金丝桃素的合成方法
FR3111640B1 (fr)	2020-06-22	2022-07-22	Total Marketing Services	Composition aqueuse pour la lubrification des systèmes mécaniques
FR3111639B1 (fr)	2020-06-22	2022-08-19	Total Marketing Services	Composition aqueuse pour la lubrification des systèmes mécaniques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1935721A (en) *	1928-12-01	1933-11-21	Gen Aniline Works Inc	Manufacture of nitrogenous compounds derived from perylene quinone
US2707704A (en) *	1951-09-29	1955-05-03	Schenley Ind Inc	Process for the preparation of hypericin
IL92315A (en) *	1989-11-15	1996-12-05	Yeda Res & Dev	Preparation of Hypericin from Amodin Enron

1989
- 1989-11-15 IL IL9231589A patent/IL92315A/en not_active IP Right Cessation
1990
- 1990-11-09 US US07/613,604 patent/US5120412A/en not_active Expired - Lifetime
- 1990-11-14 AU AU66652/90A patent/AU629066B2/en not_active Ceased
- 1990-11-14 DK DK90121796.8T patent/DK0432496T3/da active
- 1990-11-14 CA CA002029993A patent/CA2029993C/en not_active Expired - Lifetime
- 1990-11-14 EP EP90121796A patent/EP0432496B1/de not_active Expired - Lifetime
- 1990-11-14 ES ES90121796T patent/ES2070244T3/es not_active Expired - Lifetime
- 1990-11-14 DE DE69016620T patent/DE69016620T2/de not_active Expired - Fee Related
- 1990-11-14 AT AT90121796T patent/ATE117978T1/de not_active IP Right Cessation
- 1990-11-15 JP JP2310109A patent/JP2896224B2/ja not_active Expired - Fee Related
1995
- 1995-04-25 GR GR950401040T patent/GR3015919T3/el unknown

Also Published As

Publication number	Publication date
EP0432496A2 (de)	1991-06-19
EP0432496A3 (en)	1991-10-23
AU629066B2 (en)	1992-09-24
DE69016620D1 (de)	1995-03-16
CA2029993C (en)	2001-01-16
CA2029993A1 (en)	1991-05-16
IL92315A (en)	1996-12-05
IL92315A0 (en)	1990-07-26
US5120412A (en)	1992-06-09
JP2896224B2 (ja)	1999-05-31
GR3015919T3 (en)	1995-07-31
ES2070244T3 (es)	1995-06-01
AU6665290A (en)	1991-05-23
DK0432496T3 (da)	1995-06-26
JPH03220155A (ja)	1991-09-27
EP0432496B1 (de)	1995-02-01
DE69016620T2 (de)	1995-05-24

Legal Events

Date	Code	Title	Description
2004-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69016620D1 (de)	1995-03-16	Herstellung von Hyperizin.
AU626430B2 (en)	1992-07-30	Chemiluminescent solution based on substituted perylene
DE3774771D1 (de)	1992-01-09	Herstellung von leichtolefinen.
IT1111874B (it)	1986-01-13	Pezzo intermedio con un detettore di luce per un collegamento disimpegnabile ad innesto,impiegato per il collegamento di una fibra per la conduzione di luce con una sorgente di luce a semiconduttore
JPS559696A (en)	1980-01-23	Polycarbonate having end group with uv light crosslinkable double bond
ATE157093T1 (de)	1997-09-15	Rs-thioctsäure mit neuartiger morphologie
ATE79856T1 (de)	1992-09-15	Verfahren zur herstellung von dihydroxybenzolen.
IT1264545B1 (it)	1996-10-02	Procedimento per la preparazione della diacereina
DE59003144D1 (de)	1993-11-25	Destillationsanlage zur Herstellung von Wasserstoff-Peroxid.
JPS564289A (en)	1981-01-17	Light emitting element coupled to optical fiber
JPS5511573A (en)	1980-01-26	Novel naphthoquinones*their manufacture and medical composition containing them
GB2025134B (en)	1983-03-02	Light emitting diode
ATE11036T1 (de)	1985-01-15	Methacrylsaeureester als reaktivverduenner fuer oxidativ vernetzbare alkydharze und deren herstellung.
ATE58519T1 (de)	1990-12-15	Herstellung von trichlorphenol.
JPS5693382A (en)	1981-07-28	Light emitting diode
DE69204755D1 (de)	1995-10-19	Herstellung von Alkansulfonamiden.
ES2071731T3 (es)	1995-07-01	Procedimiento para la preparacion de 2-acilamino-9-acil-6-halogeno-purinas.
ATE97651T1 (de)	1993-12-15	Reinigung von diphenylphtalaten.
ATE57520T1 (de)	1990-11-15	Verfahren zur herstellung von bromierten bisphenolen.
ES2026676T3 (es)	1992-05-01	Procedimiento enantioselectivo para preparar derivados del aldehido hemicaronico de estructura trans o cis.
ATE18922T1 (de)	1986-04-15	Texturiertes nylon-6 filament.
IT1228981B (it)	1991-07-11	Isomeri ottici del trans sobrerolo e procedimento per ottenerli a partire dal composto racemico.
JPS6483028A (en)	1989-03-28	Production of cyclic organic compound by laser beam irradiation
JPS53126884A (en)	1978-11-06	Light emitting diode
IT8024852A0 (it)	1980-09-23	Derivati della s-adenostilmetionina a spiccata attivita'antidepressiva.