ATE117999T1 - Zentralnervensystem wirksame chromanderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen. - Google Patents

Zentralnervensystem wirksame chromanderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen.

Info

Publication number: ATE117999T1
Authority: AT; Austria
Prior art keywords: group; alk; denotes; nitro; alkyl group
Prior art date: 1988-11-23

Application number

AT89403220T

Other languages

English (en)

Inventor

Georges Garcia

Malta Alain Di

Philippe Soubrie

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-23

Filing date

1989-11-22

Publication date

1995-02-15

1989-11-22 Application filed by Sanofi Sa filed Critical Sanofi Sa

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE117999T1 publication Critical patent/ATE117999T1/de

Links

210000003169 central nervous system Anatomy 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
125000003277 amino group Chemical group 0.000 abstract 3
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 2
-1 cyano, acetyl Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000003016 chromanyl group Chemical class O1C(CCC2=CC=CC=C12)* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyrane Compounds (AREA)

AT89403220T 1988-11-23 1989-11-22 Zentralnervensystem wirksame chromanderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen. ATE117999T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8815284A FR2639349B1 (fr)	1988-11-23	1988-11-23	Nouveaux derives du chromane actifs sur le systeme nerveux central, leur procede de preparation et les compositions pharmaceutiques en contenant

Publications (1)

Publication Number	Publication Date
ATE117999T1 true ATE117999T1 (de)	1995-02-15

Family

ID=9372163

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89403220T ATE117999T1 (de)	1988-11-23	1989-11-22	Zentralnervensystem wirksame chromanderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen.

Country Status (8)

Country	Link
US (2)	US5082858A (de)
EP (1)	EP0370901B1 (de)
JP (1)	JPH0314574A (de)
AT (1)	ATE117999T1 (de)
CA (1)	CA2003697A1 (de)
DE (1)	DE68920965T2 (de)
FR (1)	FR2639349B1 (de)
PT (1)	PT92378B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5284838A (en) *	1987-06-23	1994-02-08	Elf Sanofi	Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma
US5420151A (en) *	1989-12-22	1995-05-30	Aktiebolaget Astra	Chroman derivatives
US5616610A (en) *	1989-12-22	1997-04-01	Astra Aktiebolag	(R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyrans
US5624954A (en) *	1991-06-13	1997-04-29	Smithkline Beecham P.L.C.	Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity
GB9112721D0 (en) *	1991-06-13	1991-07-31	Smithkline Beecham Plc	Novel treatment
GR1002276B (el) *	1992-10-08	1996-05-02	Smithkline Beecham P.L.C.	Παραγωγα βενζοπυρανιου τα οποια κεκτηνται δραση κνς.
US5393771A (en) *	1993-05-12	1995-02-28	Brisol-Myers Squibb Company	4-substituted benzopyran and related compounds
US5837702A (en) *	1993-10-07	1998-11-17	Bristol-Myers Squibb Co.	4-arylamino-benzopyran and related compounds
US5629429A (en) *	1995-06-07	1997-05-13	Bristol-Myers Squibb Company	Process for preparing 4-arylamino-benzopyran and related compounds
US5612370A (en) *	1995-06-07	1997-03-18	Bristol-Myers Squibb Company	Phenylglycine and phenylalaninen amido benzopyran derivatives
US5612323A (en) *	1995-06-07	1997-03-18	Bristol-Myers Squibb Company	Phosphinic ester substituted benzopyran derivatives
US5869478A (en) *	1995-06-07	1999-02-09	Bristol-Myers Squibb Company	Sulfonamido substituted benzopyran derivatives
TW496866B (en) *	1996-05-15	2002-08-01	Hoechst Ag	Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or a diagnostic, and medicament comprising them
US6191164B1 (en)	1996-05-15	2001-02-20	Hoechst Aktiengesellschaft	Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them
DE19619614A1 (de) *	1996-05-15	1997-11-20	Hoechst Ag	Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
NZ329200A (en) *	1996-12-16	1999-05-28	Hoechst Ag	Sulphonamide substituted quinazoline, isoquinoline, quinoline or benzo[1,3-]oxazine derivatives and medicaments
DE19706675A1 (de) *	1997-02-20	1998-08-27	Hoechst Ag	Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US6333349B1 (en)	1997-02-26	2001-12-25	Aventis Pharma Deutschland Gmbh	Sulfonamide-substituted fused 7-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them
DE19742508A1 (de) *	1997-09-26	1999-04-01	Hoechst Marion Roussel De Gmbh	Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
DE19749453A1 (de) *	1997-11-10	1999-05-12	Hoechst Marion Roussel De Gmbh	Sulfonamid-substituierte anellierte 5-Ring-Verbindungen, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
JP2002523451A (ja) *	1998-09-01	2002-07-30	ブリストル−マイヤーズスクイブカンパニー	カリウムチャネル抑制剤および方法
US20050143449A1 (en) *	2002-11-15	2005-06-30	The Salk Institute For Biological Studies	Non-steroidal farnesoid X receptor modulators and methods for the use thereof
WO2006066756A1 (en) *	2004-12-21	2006-06-29	F. Hoffmann-La Roche Ag	Chroman derivatives and uses thereof in the treatment of cns disorders
US7714150B2 (en) *	2005-04-12	2010-05-11	Solvay Pharmaceuticals Gmbh	Aminoalkyl-amidomethyl-substituted 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2H-chroman-6-yl derivatives
AR059075A1 (es) *	2006-01-20	2008-03-12	Schering Corp	Bencesulfonil - cromano , tiocromano tetrahidronaftaleno e inhibidores de gamma secretasa relacionados
TW201416908A (zh)	2012-10-23	2014-05-01	Pixart Imaging Inc	瞳孔追蹤裝置
EP4028028A4 (de) *	2019-09-13	2023-12-27	Massachusetts Institute of Technology	Systeme und tests zur identifizierung von pu-1-inhibitoren

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1495526A (en) *	1974-05-31	1977-12-21	Beecham Group Ltd	Chroman derivatives
EP0093535B1 (de) *	1982-04-28	1986-12-30	Beecham Group Plc	Chromenen und Chromanen
US4760088A (en) *	1986-09-15	1988-07-26	Board Of Control Of Michigan Technological University	Biocidal derivatives of catechins
FR2615191B1 (fr) *	1987-05-16	1991-01-11	Sandoz Sa	Nouveaux benzo(b)pyrannes et pyrannopyridines, leur preparation et leur utilisation comme medicaments
FR2639227A1 (fr) *	1988-11-23	1990-05-25	Sanofi Sa	Utilisation de derives du chromane pour le traitement des etats depressifs

1988
- 1988-11-23 FR FR8815284A patent/FR2639349B1/fr not_active Expired - Fee Related
1989
- 1989-11-22 US US07/440,090 patent/US5082858A/en not_active Expired - Fee Related
- 1989-11-22 EP EP89403220A patent/EP0370901B1/de not_active Expired - Lifetime
- 1989-11-22 DE DE68920965T patent/DE68920965T2/de not_active Expired - Fee Related
- 1989-11-22 PT PT92378A patent/PT92378B/pt not_active IP Right Cessation
- 1989-11-22 AT AT89403220T patent/ATE117999T1/de active
- 1989-11-23 CA CA002003697A patent/CA2003697A1/en not_active Abandoned
- 1989-11-24 JP JP1303475A patent/JPH0314574A/ja active Pending
1991
- 1991-10-23 US US07/781,414 patent/US5151442A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPH0314574A (ja)	1991-01-23
FR2639349B1 (fr)	1991-02-22
EP0370901A1 (de)	1990-05-30
DE68920965D1 (de)	1995-03-16
PT92378A (pt)	1990-05-31
US5151442A (en)	1992-09-29
PT92378B (pt)	1995-09-12
EP0370901B1 (de)	1995-02-01
FR2639349A1 (fr)	1990-05-25
US5082858A (en)	1992-01-21
CA2003697A1 (en)	1990-05-23
DE68920965T2 (de)	1995-05-24

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