ATE118010T1 - Dipyridoxyl-phosphat als magnetisches kernresonanz-bildgebungsmittel. - Google Patents

Dipyridoxyl-phosphat als magnetisches kernresonanz-bildgebungsmittel.

Info

Publication number: ATE118010T1
Authority: AT; Austria
Prior art keywords: resonance imaging; imaging agent; nuclear resonance; magnetic nuclear; dipyridoxyl
Prior art date: 1987-05-08

Application number

AT88107346T

Other languages

English (en)

Inventor

Scott M Rocklage

Steven C Quay

Original Assignee

Nycomed Salutar Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-08

Filing date

1988-05-06

Publication date

1995-02-15

1988-05-06 Application filed by Nycomed Salutar Inc filed Critical Nycomed Salutar Inc

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE118010T1 publication Critical patent/ATE118010T1/de

Links

229910019142 PO4 Inorganic materials 0.000 title 1
239000012216 imaging agent Substances 0.000 title 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title 1
239000010452 phosphate Substances 0.000 title 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Radiology & Medical Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
General Physics & Mathematics (AREA)
Molecular Biology (AREA)
Signal Processing (AREA)
Veterinary Medicine (AREA)
High Energy & Nuclear Physics (AREA)
Condensed Matter Physics & Semiconductors (AREA)
Public Health (AREA)
Epidemiology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Measuring And Recording Apparatus For Diagnosis (AREA)
Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT88107346T 1987-05-08 1988-05-06 Dipyridoxyl-phosphat als magnetisches kernresonanz-bildgebungsmittel. ATE118010T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/047,614 US4933456A (en)	1987-05-08	1987-05-08	Dipyridoxyl phosphate NMRI contrast agents

Publications (1)

Publication Number	Publication Date
ATE118010T1 true ATE118010T1 (de)	1995-02-15

Family

ID=21949962

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88107346T ATE118010T1 (de)	1987-05-08	1988-05-06	Dipyridoxyl-phosphat als magnetisches kernresonanz-bildgebungsmittel.

Country Status (20)

Country	Link
US (1)	US4933456A (de)
EP (1)	EP0290047B1 (de)
JP (1)	JP2512524B2 (de)
AR (1)	AR246956A1 (de)
AT (1)	ATE118010T1 (de)
AU (1)	AU613363B2 (de)
BR (1)	BR1100623A (de)
CA (1)	CA1322003C (de)
DE (2)	DE3852906T2 (de)
DK (1)	DK173849B1 (de)
ES (1)	ES2066768T3 (de)
FI (1)	FI88164C (de)
GR (1)	GR3015884T3 (de)
HK (1)	HK55195A (de)
IE (1)	IE66368B1 (de)
IL (1)	IL86298A (de)
NL (1)	NL970040I2 (de)
NO (2)	NO177462C (de)
NZ (1)	NZ224537A (de)
SG (1)	SG30569G (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5250285A (en) *	1985-05-08	1993-10-05	The General Hospital Corporation	Hydroxy-aryl metal chelates for diagnostic NMR imaging
US5422096A (en) *	1985-05-08	1995-06-06	The General Hospital Corporation	Hydroxy-aryl metal chelates for diagnostic NMR imaging
US4994259A (en) *	1987-05-08	1991-02-19	Salutar, Inc.	Improvement in the method of NMR imaging employing a manganese II chelates of N,N'-bis[pyridoxal-alkylene (or cycloalkylene) (or arylene)]-N,N'-diacetic acid derivatives
US4827426A (en) *	1987-05-18	1989-05-02	The Coca-Cola Company	Data acquisition and processing system for post-mix beverage dispensers
US5087440A (en) *	1989-07-31	1992-02-11	Salutar, Inc.	Heterocyclic derivatives of DTPA used for magnetic resonance imaging
WO1991012822A1 (de) *	1990-03-02	1991-09-05	Byk Gulden Lomberg Chemische Fabrik Gmbh	Zubereitungen für die mr-diagnostik
DE4026103A1 (de) *	1990-08-17	1992-02-20	Byk Gulden Lomberg Chem Fab	Neue verwendung von komplexsalzen
JPH06500090A (ja) *	1990-08-15	1994-01-06	ビイク　グルデン　ロンベルク　ヒエーミツシエ　フアブリーク　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング	錯塩の新規使用
WO1992011840A1 (de) *	1991-01-07	1992-07-23	Byk Gulden Lomberg Chemische Fabrik Gmbh	Kontrastmittel für die mr-diagnostik
DE4107570A1 (de) *	1991-03-07	1992-11-19	Diagnostikforschung Inst	Chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie
CA2102605A1 (en) *	1991-05-23	1992-11-24	Evan C. Unger	Liposoluble compounds for magnetic resonance imaging
US5385719A (en) *	1991-09-24	1995-01-31	Unger; Evan C.	Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
US5582814A (en) *	1994-04-15	1996-12-10	Metasyn, Inc.	1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
CA2190727C (en) *	1994-05-19	2006-07-18	Sudhakar Kasina	Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
TW319763B (de)	1995-02-01	1997-11-11	Epix Medical Inc
SG81898A1 (en) *	1995-08-11	2001-07-24	Sumitomo Chemical Co	Olefin polymerization catalyst component, olefin polymerization catalyst and process for producing olefin polymer
US6005083A (en)	1997-03-28	1999-12-21	Neorx Corporation	Bridged aromatic substituted amine ligands with donor atoms
ES2297888T3 (es) *	1997-07-01	2008-05-01	Ge Healthcare As	Procedimiento diagnostico para la deteccion de isquemia miocardica.
AU1770299A (en) *	1997-12-23	1999-07-19	Nycomed Imaging As	Nitric oxide releasing chelating agents and their therapeutic use
FR2867473B1 (fr)	2004-03-12	2006-06-23	Guerbet Sa	Compose de porphyrines et utilisation a haut champ en irm
CN107353313B (zh) *	2012-01-05	2019-04-09	普莱制药公司	新化学实体钙锰福地吡和其他混合金属配合物、制备方法、组合物以及治疗方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3632637A (en) *	1968-02-13	1972-01-04	Arthur E Martell	Hydroxyaryl-containing aminocarboxylic chelating agents
AU485693B2 (en) *	1973-08-24	1976-02-05	The Council Ofthe Institute Of Medical And Veterinary Science, Andthe Universityof Adelaide Gariti Cancer Foundation	New radiopharmaceuticals for cholescintigraphy
JPS5569517A (en) *	1978-11-20	1980-05-26	Nippon Mejifuijitsukusu Kk	Labelling preparation for labelling of erythrocytes with radio-active technetium
JPS5791927A (en) *	1980-11-27	1982-06-08	Nippon Mejifuijitsukusu Kk	Technetium-99m labelled diagnosticum
US4647447A (en) *	1981-07-24	1987-03-03	Schering Aktiengesellschaft	Diagnostic media
JPS5896031A (ja) *	1981-12-03	1983-06-07	Nippon Mejifuijitsukusu Kk	放射性診断剤およびその製造用組成物
US4637929A (en) *	1985-01-04	1987-01-20	Salutar, Inc.	Ferrioxamine-paramagnetic contrast agents for MR imaging, composition, apparatus and use
US4842845A (en) *	1987-05-08	1989-06-27	Salutar, Inc.	Radioactive metal chelates for dipyridoxyl phosphate
US4935518A (en)	1987-05-08	1990-06-19	Salutar, Inc.	Manganese(II), chelate contrast agents derived from N,N'-bis-(pyridoxal ethylene diamine-N,N')-diacetic acid and derivatives thereof

1986
- 1986-05-04 AR AR86310757A patent/AR246956A1/es active
1987
- 1987-05-08 US US07/047,614 patent/US4933456A/en not_active Expired - Lifetime
1988
- 1988-04-28 CA CA000565428A patent/CA1322003C/en not_active Expired - Lifetime
- 1988-05-06 IL IL86298A patent/IL86298A/xx not_active IP Right Cessation
- 1988-05-06 AT AT88107346T patent/ATE118010T1/de active
- 1988-05-06 EP EP88107346A patent/EP0290047B1/de not_active Expired - Lifetime
- 1988-05-06 DK DK198802516A patent/DK173849B1/da not_active IP Right Cessation
- 1988-05-06 IE IE136688A patent/IE66368B1/en not_active IP Right Cessation
- 1988-05-06 FI FI882125A patent/FI88164C/fi not_active IP Right Cessation
- 1988-05-06 ES ES88107346T patent/ES2066768T3/es not_active Expired - Lifetime
- 1988-05-06 NO NO882004A patent/NO177462C/no not_active IP Right Cessation
- 1988-05-06 AU AU15680/88A patent/AU613363B2/en not_active Expired
- 1988-05-06 SG SG1995904462A patent/SG30569G/en unknown
- 1988-05-06 NZ NZ224537A patent/NZ224537A/en unknown
- 1988-05-06 DE DE3852906T patent/DE3852906T2/de not_active Expired - Lifetime
- 1988-05-06 DE DE1997175088 patent/DE19775088I2/de active Active
- 1988-05-07 JP JP63109931A patent/JP2512524B2/ja not_active Expired - Lifetime
1995
- 1995-04-11 HK HK55195A patent/HK55195A/en not_active IP Right Cessation
- 1995-04-19 GR GR950401021T patent/GR3015884T3/el unknown
1997
- 1997-05-13 BR BR1100623-4A patent/BR1100623A/pt active IP Right Grant
- 1997-11-14 NL NL970040C patent/NL970040I2/nl unknown
1998
- 1998-01-19 NO NO1998004C patent/NO1998004I1/no unknown

Also Published As

Publication number	Publication date
EP0290047A3 (en)	1990-04-25
DE19775088I2 (de)	2001-05-23
DE3852906D1 (de)	1995-03-16
DE3852906T2 (de)	1995-06-22
GR3015884T3 (en)	1995-07-31
DK251688D0 (da)	1988-05-06
FI88164C (fi)	1993-04-13
IL86298A0 (en)	1988-11-15
NO177462B (no)	1995-06-12
DK251688A (da)	1988-11-09
SG30569G (en)	1995-09-18
IL86298A (en)	1992-11-15
BR1100623A (pt)	1999-12-07
AU1568088A (en)	1988-11-10
DK173849B1 (da)	2001-12-27
HK55195A (en)	1995-04-21
JP2512524B2 (ja)	1996-07-03
JPS63280087A (ja)	1988-11-17
FI88164B (fi)	1992-12-31
NO177462C (no)	1995-09-20
NO882004D0 (no)	1988-05-06
NZ224537A (en)	1991-06-25
AU613363B2 (en)	1991-08-01
NL970040I2 (nl)	1998-06-02
FI882125A7 (fi)	1988-11-09
EP0290047A2 (de)	1988-11-09
NL970040I1 (nl)	1998-02-02
FI882125A0 (fi)	1988-05-06
AR246956A1 (es)	1994-10-31
CA1322003C (en)	1993-09-07
US4933456A (en)	1990-06-12
IE881366L (en)	1988-11-08
NO1998004I1 (no)	1998-01-19
IE66368B1 (en)	1995-12-27
NO882004L (no)	1988-11-09
ES2066768T3 (es)	1995-03-16
EP0290047B1 (de)	1995-02-01

Publication	Publication Date	Title
ATE118010T1 (de)	1995-02-15	Dipyridoxyl-phosphat als magnetisches kernresonanz-bildgebungsmittel.
FI875182A0 (fi)	1987-11-24	Magnetisk resonansavbildningsapparat omfattande ett diagonalt spolsystem.
DE69029692D1 (de)	1997-02-27	Magnetresonanzabbildung
GB2140569B (en)	1987-09-30	Nuclear magnetic resonance imaging
GB2089996B (en)	1984-05-02	Nuclear magnetic resonance imaging
DE3570924D1 (en)	1989-07-13	Nuclear magnetic resonance tomograph
GB2157832B (en)	1988-02-03	Nuclear magnetic resonance imaging
EP0223543A3 (en)	1989-07-12	Nuclear magnetic resonance imaging
GB2148013B (en)	1988-02-03	Nuclear magnetic resonance imaging
FI875274A7 (fi)	1988-06-04	Gradienttikela magneettista resonanssikuvauslaitetta varten.
DE3855944D1 (de)	1997-07-24	Kernresonanzabbildungssystem
DE58909771D1 (de)	1997-03-13	Kernresonanz-Spektrometer
GB2234594B (en)	1994-03-16	Nuclear magnetic resonance imaging methods
DE3480561D1 (en)	1989-12-28	Nuclear magnetic resonance tomograph
DE3574055D1 (en)	1989-12-07	Nuclear magnetic resonance imaging
EP0335981A4 (de)	1990-06-26	Magnetisches resonanzbildsystem.
EP0139102A3 (en)	1985-10-30	Nuclear magnetic resonance imaging system
DE3875530D1 (de)	1992-12-03	Nuklearmagnetischer resonanz-magnetfeldmesser.
GB8521791D0 (en)	1985-10-09	Nuclear magnetic resonance imaging
DE3785010D1 (de)	1993-04-29	Eichkoerper fuer magnetische kernresonanz-diagnose.
GB2234595B (en)	1993-10-20	Nuclear magnetic resonance imaging methods
GB8611963D0 (en)	1986-06-25	Nuclear magnetic resonance
GB8527021D0 (en)	1985-12-04	Nuclear magnetic resonance imaging
EP0175611A3 (en)	1987-06-03	Nuclear magnetic resonance imaging device
GB2091424B (en)	1985-06-26	Nuclear magnetic resonance imaging