IL86298A - N,n'-dipyridoxyldiamine-n-acetic(or n,n'-diacetic)acid phosphates,metal chelates thereof and their use as nmri contrast agents - Google Patents

N,n'-dipyridoxyldiamine-n-acetic(or n,n'-diacetic)acid phosphates,metal chelates thereof and their use as nmri contrast agents

Info

Publication number
IL86298A
IL86298A IL86298A IL8629888A IL86298A IL 86298 A IL86298 A IL 86298A IL 86298 A IL86298 A IL 86298A IL 8629888 A IL8629888 A IL 8629888A IL 86298 A IL86298 A IL 86298A
Authority
IL
Israel
Prior art keywords
dipyridoxyldiamine
diacetic
acetic
contrast agents
metal chelates
Prior art date
Application number
IL86298A
Other languages
English (en)
Other versions
IL86298A0 (en
Original Assignee
Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salutar Inc filed Critical Salutar Inc
Publication of IL86298A0 publication Critical patent/IL86298A0/xx
Priority to IL100640A priority Critical patent/IL100640A0/xx
Publication of IL86298A publication Critical patent/IL86298A/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Signal Processing (AREA)
  • Veterinary Medicine (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL86298A 1987-05-08 1988-05-06 N,n'-dipyridoxyldiamine-n-acetic(or n,n'-diacetic)acid phosphates,metal chelates thereof and their use as nmri contrast agents IL86298A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL100640A IL100640A0 (en) 1987-05-08 1992-01-13 Dipyridoxyl phosphates and metal chelates thereof useful as nmri contrast agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/047,614 US4933456A (en) 1987-05-08 1987-05-08 Dipyridoxyl phosphate NMRI contrast agents

Publications (2)

Publication Number Publication Date
IL86298A0 IL86298A0 (en) 1988-11-15
IL86298A true IL86298A (en) 1992-11-15

Family

ID=21949962

Family Applications (1)

Application Number Title Priority Date Filing Date
IL86298A IL86298A (en) 1987-05-08 1988-05-06 N,n'-dipyridoxyldiamine-n-acetic(or n,n'-diacetic)acid phosphates,metal chelates thereof and their use as nmri contrast agents

Country Status (20)

Country Link
US (1) US4933456A (de)
EP (1) EP0290047B1 (de)
JP (1) JP2512524B2 (de)
AR (1) AR246956A1 (de)
AT (1) ATE118010T1 (de)
AU (1) AU613363B2 (de)
BR (1) BR1100623A (de)
CA (1) CA1322003C (de)
DE (2) DE3852906T2 (de)
DK (1) DK173849B1 (de)
ES (1) ES2066768T3 (de)
FI (1) FI88164C (de)
GR (1) GR3015884T3 (de)
HK (1) HK55195A (de)
IE (1) IE66368B1 (de)
IL (1) IL86298A (de)
NL (1) NL970040I2 (de)
NO (2) NO177462C (de)
NZ (1) NZ224537A (de)
SG (1) SG30569G (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US5422096A (en) * 1985-05-08 1995-06-06 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US4994259A (en) * 1987-05-08 1991-02-19 Salutar, Inc. Improvement in the method of NMR imaging employing a manganese II chelates of N,N'-bis[pyridoxal-alkylene (or cycloalkylene) (or arylene)]-N,N'-diacetic acid derivatives
US4827426A (en) * 1987-05-18 1989-05-02 The Coca-Cola Company Data acquisition and processing system for post-mix beverage dispensers
US5087440A (en) * 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
WO1991012822A1 (de) * 1990-03-02 1991-09-05 Byk Gulden Lomberg Chemische Fabrik Gmbh Zubereitungen für die mr-diagnostik
DE4026103A1 (de) * 1990-08-17 1992-02-20 Byk Gulden Lomberg Chem Fab Neue verwendung von komplexsalzen
JPH06500090A (ja) * 1990-08-15 1994-01-06 ビイク　グルデン　ロンベルク　ヒエーミツシエ　フアブリーク　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング 錯塩の新規使用
WO1992011840A1 (de) * 1991-01-07 1992-07-23 Byk Gulden Lomberg Chemische Fabrik Gmbh Kontrastmittel für die mr-diagnostik
DE4107570A1 (de) * 1991-03-07 1992-11-19 Diagnostikforschung Inst Chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie
CA2102605A1 (en) * 1991-05-23 1992-11-24 Evan C. Unger Liposoluble compounds for magnetic resonance imaging
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
TW319763B (de) 1995-02-01 1997-11-11 Epix Medical Inc
SG81898A1 (en) * 1995-08-11 2001-07-24 Sumitomo Chemical Co Olefin polymerization catalyst component, olefin polymerization catalyst and process for producing olefin polymer
US6005083A (en) 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
ES2297888T3 (es) * 1997-07-01 2008-05-01 Ge Healthcare As Procedimiento diagnostico para la deteccion de isquemia miocardica.
AU1770299A (en) * 1997-12-23 1999-07-19 Nycomed Imaging As Nitric oxide releasing chelating agents and their therapeutic use
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
CN107353313B (zh) * 2012-01-05 2019-04-09 普莱制药公司 新化学实体钙锰福地吡和其他混合金属配合物、制备方法、组合物以及治疗方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632637A (en) * 1968-02-13 1972-01-04 Arthur E Martell Hydroxyaryl-containing aminocarboxylic chelating agents
AU485693B2 (en) * 1973-08-24 1976-02-05 The Council Ofthe Institute Of Medical And Veterinary Science, Andthe Universityof Adelaide Gariti Cancer Foundation New radiopharmaceuticals for cholescintigraphy
JPS5569517A (en) * 1978-11-20 1980-05-26 Nippon Mejifuijitsukusu Kk Labelling preparation for labelling of erythrocytes with radio-active technetium
JPS5791927A (en) * 1980-11-27 1982-06-08 Nippon Mejifuijitsukusu Kk Technetium-99m labelled diagnosticum
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
JPS5896031A (ja) * 1981-12-03 1983-06-07 Nippon Mejifuijitsukusu Kk 放射性診断剤およびその製造用組成物
US4637929A (en) * 1985-01-04 1987-01-20 Salutar, Inc. Ferrioxamine-paramagnetic contrast agents for MR imaging, composition, apparatus and use
US4842845A (en) * 1987-05-08 1989-06-27 Salutar, Inc. Radioactive metal chelates for dipyridoxyl phosphate
US4935518A (en) 1987-05-08 1990-06-19 Salutar, Inc. Manganese(II), chelate contrast agents derived from N,N'-bis-(pyridoxal ethylene diamine-N,N')-diacetic acid and derivatives thereof

Also Published As

Publication number Publication date
EP0290047A3 (en) 1990-04-25
DE19775088I2 (de) 2001-05-23
DE3852906D1 (de) 1995-03-16
DE3852906T2 (de) 1995-06-22
GR3015884T3 (en) 1995-07-31
DK251688D0 (da) 1988-05-06
FI88164C (fi) 1993-04-13
IL86298A0 (en) 1988-11-15
NO177462B (no) 1995-06-12
DK251688A (da) 1988-11-09
SG30569G (en) 1995-09-18
BR1100623A (pt) 1999-12-07
AU1568088A (en) 1988-11-10
DK173849B1 (da) 2001-12-27
HK55195A (en) 1995-04-21
JP2512524B2 (ja) 1996-07-03
JPS63280087A (ja) 1988-11-17
FI88164B (fi) 1992-12-31
NO177462C (no) 1995-09-20
NO882004D0 (no) 1988-05-06
NZ224537A (en) 1991-06-25
AU613363B2 (en) 1991-08-01
ATE118010T1 (de) 1995-02-15
NL970040I2 (nl) 1998-06-02
FI882125A7 (fi) 1988-11-09
EP0290047A2 (de) 1988-11-09
NL970040I1 (nl) 1998-02-02
FI882125A0 (fi) 1988-05-06
AR246956A1 (es) 1994-10-31
CA1322003C (en) 1993-09-07
US4933456A (en) 1990-06-12
IE881366L (en) 1988-11-08
NO1998004I1 (no) 1998-01-19
IE66368B1 (en) 1995-12-27
NO882004L (no) 1988-11-09
ES2066768T3 (es) 1995-03-16
EP0290047B1 (de) 1995-02-01

Similar Documents

Publication Publication Date Title
IL86298A (en) N,n'-dipyridoxyldiamine-n-acetic(or n,n'-diacetic)acid phosphates,metal chelates thereof and their use as nmri contrast agents
IL86299A (en) Manganese (ii) chelates of n, n) -dipyridoxyldiamine- n-acetic (or n,n)-diacetic)- acid derivatives and their use as nmri contrast agents
IL81672A0 (en) N,n'-dihalo-2-imidazolidinones and their use as disinfectants
ZA855467B (en) Pickling agent
EP0177158A3 (en) Thickening agents and the manufacture and use thereof
JPS6471889A (en) Novel 6-acyl-(6h)-dibenzo(c,e)(1,2)oxaphosphorine- 6-oxide, manufacture and use as photoinitiator
IL86901A0 (en) 6,7-dihydropyrazolo-(1,5-a)(1,3,5)triazine-2-sulphonamide derivatives and herbicidal compositions containing the same
GB2207866B (en) Use of metal chelates as mulluscicides
IL86028A0 (en) Novel pyrrolidine-2-(1,3-dicarbonyl)derivatives,their preparation,agents containing them,and their use
EP0406416A4 (en) Anti-hiv agent
GB2238317B (en) Fe-Cr-Ni-Al ferritic alloys
DE3561945D1 (en) Diaminoalcohols, their preparation and their use as acid gas removal agents
PH27414A (en) 1,2,4-oxadiazolyl-phenoxy-alkylisoxazoles and their use as antiviral agents
IL85254A0 (en) 14,15-substituted lanosterols and pharmaceutical compositions containing them
ZA889251B (en) 8,9-annelated-beta-carbolines and 8,9-annelated-3,4-dihydro-beta-carbolines
AU629651B2 (en) 5-phenyl-2-furan ketones and use as antiepileptic agents
NZ220339A (en) 2-phenylacetyl-1,3,5-cyclohexanetrione derivatives and herbicidal compositions
ZA885123B (en) Pest-combating agents based on derivatives of 2,3-diaminomaleonitrile
JPS6434993A (en) Hydroxyacetonitrilephosphonic acid, manufacture and chelating agent and limiting agent therefrom
JPS646223A (en) Perfluoro-2,3,4-trimethylpentane and manufacture
EP0312873A3 (en) N,n'-bis(trans-4-isocyanato-cyclohexyl)urea, process for its preparation and use
JPS6466148A (en) Manufacture of 1,5-diaminoheptanol-6, manufacture and use
EP0419308A3 (en) Use of glutamic acid or gum arabic as anti-complement agent
IL85449A (en) 26,27-mono-and 14,15:26,27-diepoxide 23-deoxy-ll-f28249 derivatives and parasiticidal use
DE69031409D1 (de) 8-Carboxy-1,2,3,4-tetrahydroquinolin-6-yl-essigsäure und Verfahren zu dessen Herstellung

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
HCA Change of name of proprietor(s) after amalgamation
KB Patent renewed
EXP Patent expired