ATE118215T1 - Cephalosporinderivate, verfahren zu ihrer herstellung, pharmazeutische präparate und zwischenverbindungen. - Google Patents

Cephalosporinderivate, verfahren zu ihrer herstellung, pharmazeutische präparate und zwischenverbindungen.

Info

Publication number: ATE118215T1
Authority: AT; Austria
Prior art keywords: production; pharmaceutical preparations; intermediate compounds; cephalosporine derivatives; derivatives
Prior art date: 1989-09-04

Application number

AT90309483T

Other languages

English (en)

Inventor

Clive Leslie Branch

Park

Angela Wendy Guest

Stephen Christopher Finch

Park Brockham

Original Assignee

Beecham Group Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-04

Filing date

1990-08-30

Publication date

1995-02-15

1989-09-04 Priority claimed from GB898919944A external-priority patent/GB8919944D0/en

1990-05-08 Priority claimed from GB909010264A external-priority patent/GB9010264D0/en

1990-08-30 Application filed by Beecham Group Plc filed Critical Beecham Group Plc

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE118215T1 publication Critical patent/ATE118215T1/de

Links

238000000034 method Methods 0.000 title abstract 3
HOKIDJSKDBPKTQ-UHFFFAOYSA-N 3-(acetyloxymethyl)-7-[(5-amino-5-carboxypentanoyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical class S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C(NC(=O)CCCC(N)C(O)=O)C12 HOKIDJSKDBPKTQ-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
239000012450 pharmaceutical intermediate Substances 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
230000000844 anti-bacterial effect Effects 0.000 abstract 2
229930186147 Cephalosporin Natural products 0.000 abstract 1
125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 abstract 1
229940124587 cephalosporin Drugs 0.000 abstract 1
150000001780 cephalosporins Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT90309483T 1989-09-04 1990-08-30 Cephalosporinderivate, verfahren zu ihrer herstellung, pharmazeutische präparate und zwischenverbindungen. ATE118215T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB898919944A GB8919944D0 (en)	1989-09-04	1989-09-04	Novel compounds
GB909010264A GB9010264D0 (en)	1990-05-08	1990-05-08	Novel compounds

Publications (1)

Publication Number	Publication Date
ATE118215T1 true ATE118215T1 (de)	1995-02-15

Family

ID=26295866

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90309483T ATE118215T1 (de)	1989-09-04	1990-08-30	Cephalosporinderivate, verfahren zu ihrer herstellung, pharmazeutische präparate und zwischenverbindungen.

Country Status (9)

Country	Link
US (1)	US5275816A (de)
EP (1)	EP0416810B1 (de)
JP (1)	JPH03141287A (de)
KR (1)	KR910006300A (de)
AT (1)	ATE118215T1 (de)
AU (1)	AU6210790A (de)
CA (1)	CA2024396A1 (de)
DE (1)	DE69016719T2 (de)
IE (1)	IE903171A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5403835A (en) *	1986-03-20	1995-04-04	Banyu Pharmaceutical Co., Ltd.	Cephalosporin derivatives
KR0174535B1 (ko) *	1989-09-04	1999-02-01	알렌 제이 스피글	베타-락탐 함유 화합물 및 그의 제조방법
TW446707B (en) *	1996-10-22	2001-07-21	Hoffmann La Roche	Cephalosporin pyridinium derivatives
ATE354577T1 (de)	1996-11-06	2007-03-15	Basilea Pharmaceutica Ag	Vinylpyrrolidinon-cephalosporin-derivate
US6329363B1 (en) *	1997-12-12	2001-12-11	Eli Lilly And Company	Cephalosporin antibiotics
US6369049B1 (en)	1998-04-30	2002-04-09	Eli Lilly And Company	Treatment of mastitis
WO2013002215A1 (ja) *	2011-06-27	2013-01-03	塩野義製薬株式会社	ピリジニウム基を有するセフェム化合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3176517D1 (en) *	1980-04-24	1987-12-17	Beecham Group Plc	Beta-lactam compounds, their preparation and use
DE3278878D1 (en) *	1981-07-25	1988-09-15	Beecham Group Plc	Beta-lactam antibacterial agents
GR79174B (de) *	1983-01-21	1984-10-02	Beecham Group Plc
EP0114750A3 (de) *	1983-01-24	1985-07-31	Beecham Group Plc	Antibakterielle beta-Lactam-Mittel
DE3479731D1 (en) *	1983-07-07	1989-10-19	Beecham Group Plc	Substituted phenylglycine derivatives of beta-lactam antibiotics
FI82471C (fi) *	1984-01-26	1991-03-11	Beecham Group Plc	Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater.
EP0219926A3 (de) *	1985-06-25	1988-08-31	Beecham Group Plc	Cephalosporine, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
EP0211656A3 (de) *	1985-08-10	1988-03-09	Beecham Group Plc	Cephalosporinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende Präparate
JPS63107989A (ja) *	1986-06-04	1988-05-12	Tanabe Seiyaku Co Ltd	セファロスポリン化合物
GB8722477D0 (en) *	1987-09-24	1987-10-28	Beecham Group Plc	Compounds
US5134138A (en) *	1989-07-18	1992-07-28	Shionogi & Co., Ltd.	Phenacylpyridiniothiocephalosporins

1990
- 1990-08-30 DE DE69016719T patent/DE69016719T2/de not_active Expired - Fee Related
- 1990-08-30 AT AT90309483T patent/ATE118215T1/de not_active IP Right Cessation
- 1990-08-30 EP EP90309483A patent/EP0416810B1/de not_active Expired - Lifetime
- 1990-08-31 IE IE317190A patent/IE903171A1/en unknown
- 1990-08-31 CA CA002024396A patent/CA2024396A1/en not_active Abandoned
- 1990-09-03 AU AU62107/90A patent/AU6210790A/en not_active Abandoned
- 1990-09-03 KR KR1019900013879A patent/KR910006300A/ko not_active Withdrawn
- 1990-09-04 US US07/578,662 patent/US5275816A/en not_active Expired - Fee Related
- 1990-09-04 JP JP2232622A patent/JPH03141287A/ja active Pending

Also Published As

Publication number	Publication date
DE69016719T2 (de)	1995-06-01
EP0416810B1 (de)	1995-02-08
JPH03141287A (ja)	1991-06-17
US5275816A (en)	1994-01-04
IE903171A1 (en)	1991-03-13
AU6210790A (en)	1991-03-07
CA2024396A1 (en)	1991-03-05
EP0416810A2 (de)	1991-03-13
KR910006300A (ko)	1991-04-29
EP0416810A3 (en)	1992-04-01
DE69016719D1 (de)	1995-03-23

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Legal Events

Date	Code	Title	Description
1995-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties