ATE354577T1 - Vinylpyrrolidinon-cephalosporin-derivate - Google Patents

Vinylpyrrolidinon-cephalosporin-derivate

Info

Publication number: ATE354577T1
Authority: AT; Austria
Prior art keywords: lower alkyl; hydrogen; phenyl; hydroxy; optionally substituted
Prior art date: 1996-11-06

Application number

AT97118780T

Other languages

English (en)

Inventor

Peter Angehrn

Ingrid Heinze-Krauss

Hans G F Richter

Original Assignee

Basilea Pharmaceutica Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-06

Filing date

1997-10-29

Publication date

2007-03-15

1997-10-29 Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag

2007-03-15 Application granted granted Critical

2007-03-15 Publication of ATE354577T1 publication Critical patent/ATE354577T1/de

Links

229930186147 Cephalosporin Natural products 0.000 title abstract 2
-1 VINYLPYRROLIDINONE CEPHALOSPORIN Chemical class 0.000 title abstract 2
229940124587 cephalosporin Drugs 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 11
229910052739 hydrogen Inorganic materials 0.000 abstract 7
239000001257 hydrogen Substances 0.000 abstract 7
125000000623 heterocyclic group Chemical group 0.000 abstract 6
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
125000003545 alkoxy group Chemical group 0.000 abstract 5
150000002431 hydrogen Chemical class 0.000 abstract 5
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical class 0.000 abstract 4
125000001624 naphthyl group Chemical group 0.000 abstract 4
125000003342 alkenyl group Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000003282 alkyl amino group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000004104 aryloxy group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000005504 styryl group Chemical group 0.000 abstract 2
208000035473 Communicable disease Diseases 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
125000005157 alkyl carboxy group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000006244 carboxylic acid protecting group Chemical group 0.000 abstract 1
150000001780 cephalosporins Chemical class 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Photoreceptors In Electrophotography (AREA)
Separation Using Semi-Permeable Membranes (AREA)

AT97118780T 1996-11-06 1997-10-29 Vinylpyrrolidinon-cephalosporin-derivate ATE354577T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP96117710		1996-11-06
EP97115996		1997-09-15

Publications (1)

Publication Number	Publication Date
ATE354577T1 true ATE354577T1 (de)	2007-03-15

Family

ID=26142279

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97118780T ATE354577T1 (de)	1996-11-06	1997-10-29	Vinylpyrrolidinon-cephalosporin-derivate

Country Status (18)

Country	Link
US (1)	US6294668B1 (de)
EP (1)	EP0841339B1 (de)
JP (1)	JP3065289B2 (de)
KR (1)	KR100273611B1 (de)
CN (1)	CN1081639C (de)
AT (1)	ATE354577T1 (de)
AU (1)	AU727014B2 (de)
CA (1)	CA2220188C (de)
CZ (1)	CZ350197A3 (de)
DE (1)	DE69737382T2 (de)
DK (1)	DK0841339T3 (de)
ES (1)	ES2281090T3 (de)
HU (1)	HUP9701835A3 (de)
IL (1)	IL122098A0 (de)
MA (1)	MA26446A1 (de)
NO (1)	NO975094L (de)
NZ (1)	NZ329106A (de)
SG (1)	SG71055A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6150350A (en) *	1997-09-15	2000-11-21	Hoffman-La Roche Inc.	Antimicrobial compositions
JP3872955B2 (ja) *	1998-06-15	2007-01-24	バジリアファルマスーチカアーゲー	３−（２−オキソ−〔１，３′〕ビピロリジニル−３−イリデンメチル）−セフェムの誘導体
US6232306B1 (en)	1998-06-15	2001-05-15	Hoffmann-La Roche Inc.	Derivatives of 3-(2-oxo-[1,3′]bipyrrolidinyl-3-ylidenemethyl)-cephams
CA2335288A1 (en)	1998-06-22	1999-12-29	F. Hoffmann-La Roche Ag	Propenyl cephalosporin derivatives
WO2000032605A1 (en) *	1998-12-03	2000-06-08	F. Hoffmann-La Roche Ag	Bi-pyrrolidinylvinl (carba) cephalosporins
AU6267100A (en) *	1999-07-07	2001-01-30	F. Hoffmann-La Roche Ag	Vinylpyrrolidinone derivatives with substituted thiazole ring
KR100931745B1 (ko) *	2000-02-15	2009-12-14	히다치 가세고교 가부시끼가이샤	접착제 조성물, 그 제조 방법, 이것을 이용한 접착 필름, 반도체 탑재용 기판 및 반도체 장치
WO2006010978A1 (en) *	2004-06-30	2006-02-02	Wockhardt Limited	Cefdinir polymorphic forms, and imidazole salt
ES2745411T3 (es) *	2006-07-27	2020-03-02	Wang Nai Fang	Compuestos y composiciones de arilsulfanilo para administración de agentes activos
MX2011001333A (es) *	2008-08-04	2011-03-15	Astrazeneca Ab	Derivados de pirazolo [3, 4] pirimidin-4-ilo y sus usos para tratar la diabetes y obesidad.
WO2010116176A1 (en)	2009-04-09	2010-10-14	Astrazeneca Ab	Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity
AR076220A1 (es)	2009-04-09	2011-05-26	Astrazeneca Ab	Derivados de pirazol [4,5 - e] pirimidina
JP2012528102A (ja)	2009-05-25	2012-11-12	サンド・アクチエンゲゼルシヤフト	セフトビプロールメドカリルの製造方法
UY35103A (es)	2012-10-29	2014-05-30	Glaxo Group Ltd	Compuestos de cefem 2-sustituidos
CN111471058A (zh) *	2019-01-23	2020-07-31	中国医学科学院药物研究所	用于制备头孢吡普类似物的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4255423A (en) *	1977-07-27	1981-03-10	Merck & Co., Inc.	Cephalosporin compounds
FR2457296A1 (fr)	1979-05-23	1980-12-19	Rhone Poulenc Ind	Nouveaux derives de vinyl-3 cephalosporines et leur preparation
IL94946A0 (en)	1989-07-13	1991-06-10	Eisai Co Ltd	3-substituted vinyl cephalosporin derivatives,their preparation and pharmaceutical compositions containing them
DE69016719T2 (de)	1989-09-04	1995-06-01	Beecham Group Plc	Cephalosporinderivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate und Zwischenverbindungen.
KR0174535B1 (ko)	1989-09-04	1999-02-01	알렌 제이 스피글	베타-락탐 함유 화합물 및 그의 제조방법
GB9019743D0 (en)	1990-09-10	1990-10-24	Beecham Group Plc	Novel compounds
CA2147609A1 (en)	1992-10-23	1994-05-11	Kohji Kawabata	Cephem compounds, and their pharmaceutical compositions
PT620225E (pt) *	1993-04-16	2003-03-31	Basilea Pharmaceutica Ag	Derivados de cefalosporina
US5523400A (en)	1993-04-16	1996-06-04	Hoffmann-La Roche Inc.	Cephalosporin antibiotics
WO1995009171A1 (en)	1993-09-29	1995-04-06	Meiji Seika Kaisha, Ltd.	Novel cephalosporin derivative
US5559108A (en)	1994-09-02	1996-09-24	Bristol-Myers Squibb Company	Cephalosporin derivatives
US5567698A (en)	1995-02-15	1996-10-22	Bristol-Myers Squibb Company	Pyridinium thiomethyl substituted chepholosporin derivatives
TR199700859T1 (xx) *	1995-02-27	1998-02-21	F. Hoffmann-La Roche Ag	3-Pirolidiliden-2-on-sefalosporin t�revleri.
JPH08319291A (ja)	1995-05-25	1996-12-03	Meiji Seika Kaisha Ltd	新規セフェム誘導体
AT403161B (de)	1995-07-19	1997-11-25	Biochemie Gmbh	Verfahren zur herstellung von cephemverbindungen
EP0761673A1 (de) *	1995-09-12	1997-03-12	F. Hoffmann-La Roche Ag	Cephalosporin-Derivate
US5883247A (en)	1996-06-10	1999-03-16	Hoffmann-La Roche Inc.	Preparation of cephem and isooxacephem derivatives
EP0831093A1 (de)	1996-09-23	1998-03-25	F. Hoffmann-La Roche Ag	1-Carba-(desthia)-cephalosporinderivate

1997
- 1997-10-29 AT AT97118780T patent/ATE354577T1/de active
- 1997-10-29 DK DK97118780T patent/DK0841339T3/da active
- 1997-10-29 DE DE69737382T patent/DE69737382T2/de not_active Expired - Lifetime
- 1997-10-29 ES ES97118780T patent/ES2281090T3/es not_active Expired - Lifetime
- 1997-10-29 EP EP97118780A patent/EP0841339B1/de not_active Expired - Lifetime
- 1997-11-03 MA MA24852A patent/MA26446A1/fr unknown
- 1997-11-04 IL IL12209897A patent/IL122098A0/xx unknown
- 1997-11-04 NZ NZ329106A patent/NZ329106A/xx unknown
- 1997-11-04 CA CA002220188A patent/CA2220188C/en not_active Expired - Fee Related
- 1997-11-05 NO NO975094A patent/NO975094L/no not_active Application Discontinuation
- 1997-11-05 SG SG1997003954A patent/SG71055A1/en unknown
- 1997-11-05 US US08/964,640 patent/US6294668B1/en not_active Expired - Fee Related
- 1997-11-05 CN CN97122431A patent/CN1081639C/zh not_active Expired - Fee Related
- 1997-11-05 HU HU9701835A patent/HUP9701835A3/hu unknown
- 1997-11-05 KR KR1019970058137A patent/KR100273611B1/ko not_active Expired - Fee Related
- 1997-11-05 CZ CZ973501A patent/CZ350197A3/cs unknown
- 1997-11-05 AU AU44356/97A patent/AU727014B2/en not_active Ceased
- 1997-11-06 JP JP9304115A patent/JP3065289B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2220188C (en)	2008-04-08
KR100273611B1 (ko)	2000-12-15
KR19980042094A (ko)	1998-08-17
ES2281090T3 (es)	2007-09-16
IL122098A0 (en)	1998-04-05
NO975094L (no)	1998-05-07
NO975094D0 (no)	1997-11-05
DK0841339T3 (da)	2007-07-02
HUP9701835A2 (hu)	1999-05-28
US6294668B1 (en)	2001-09-25
EP0841339A1 (de)	1998-05-13
JP3065289B2 (ja)	2000-07-17
HUP9701835A3 (en)	2001-04-28
NZ329106A (en)	1998-12-23
MA26446A1 (fr)	2004-12-20
AU727014B2 (en)	2000-11-30
DE69737382D1 (de)	2007-04-05
CN1081639C (zh)	2002-03-27
CZ350197A3 (cs)	1998-05-13
HU9701835D0 (en)	1997-12-29
CA2220188A1 (en)	1998-05-06
AU4435697A (en)	1998-05-14
SG71055A1 (en)	2000-03-21
JPH10139783A (ja)	1998-05-26
EP0841339B1 (de)	2007-02-21
CN1181382A (zh)	1998-05-13
DE69737382T2 (de)	2007-10-31

Legal Events

Date

Code

Title

Description

2007-08-15

UEP

Publication of translation of european patent specification

Ref document number: 0841339

Country of ref document: EP

Publication	Publication Date	Title
DK0841339T3 (da)	2007-07-02	Vinylpyrrolidinon-cephalosporinderivater
AU675695B2 (en)	1997-02-13	Cephalosporin derivatives
NO882036L (no)	1988-11-14	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske ketoner.
RU94012924A (ru)	1995-12-20	Производные цефалоспорина
AU1060592A (en)	1992-08-06	N-(aryloxyalkyl)heteroaryl-8-azabicyclo(3,2,1)octanes, intermediates and a process for the preparation thereof and their use as medicaments
ES2001031A6 (es)	1988-04-16	Un procedimiento para la preparacion de penicilinas que contienen un grupo oximino
JPH11140087A5 (de)	2005-11-04
MX9708525A (es)	1998-05-31	Derivados de vinilpirrolidinon-cefalosporina.
PL304334A1 (en)	1995-01-23	Pharmaceutical composition of gastric protective action, including antiulceric one and method of treating diseases of gastrointestinal tract