ATE118217T1 - Natrium-n-acetylneuraminat-trihydrat und verfahren zu dessen herstellung. - Google Patents

Natrium-n-acetylneuraminat-trihydrat und verfahren zu dessen herstellung.

Info

Publication number: ATE118217T1
Authority: AT; Austria
Prior art keywords: sodium; acetylneuraminate; trihydrate; production; water
Prior art date: 1989-03-08

Application number

AT90104335T

Other languages

English (en)

Inventor

Kinichi Saito

Hideo Mizu

Naokazu Sugiyama

Shikoh Minagawa

Motoaki Goto

Kenji Abiko

Original Assignee

Kanto Ishi Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-08

Filing date

1990-03-07

Publication date

1995-02-15

1990-03-07 Application filed by Kanto Ishi Pharma Co Ltd filed Critical Kanto Ishi Pharma Co Ltd

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE118217T1 publication Critical patent/ATE118217T1/de

Links

SGVNUGVAEIADTR-CPSXCUFQSA-M O.O.O.[Na+].CC(=O)N[C@@H]1[C@@H](O)CC(O)(C([O-])=O)O[C@H]1[C@H](O)[C@H](O)CO Chemical compound O.O.O.[Na+].CC(=O)N[C@@H]1[C@@H](O)CC(O)(C([O-])=O)O[C@H]1[C@H](O)[C@H](O)CO SGVNUGVAEIADTR-CPSXCUFQSA-M 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
239000013078 crystal Substances 0.000 abstract 2
QKFTYFYIYXTFBX-BKSOAOGQSA-M sodium;(2s,4s,5r,6r)-5-acetamido-2,4-dihydroxy-6-[(1r,2r)-1,2,3-trihydroxypropyl]oxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C([O-])=O)O[C@H]1[C@H](O)[C@H](O)CO QKFTYFYIYXTFBX-BKSOAOGQSA-M 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
238000001035 drying Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
239000000843 powder Substances 0.000 abstract 1
230000001376 precipitating effect Effects 0.000 abstract 1
150000004684 trihydrates Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT90104335T 1989-03-08 1990-03-07 Natrium-n-acetylneuraminat-trihydrat und verfahren zu dessen herstellung. ATE118217T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP1055388A JP2745059B2 (ja)	1989-03-08	1989-03-08	Ｎ―アセチルノイラミン酸ナトリウム・三水和物

Publications (1)

Publication Number	Publication Date
ATE118217T1 true ATE118217T1 (de)	1995-02-15

Family

ID=12997127

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90104335T ATE118217T1 (de)	1989-03-08	1990-03-07	Natrium-n-acetylneuraminat-trihydrat und verfahren zu dessen herstellung.

Country Status (16)

Country	Link
US (1)	US5231177A (de)
EP (1)	EP0386721B1 (de)
JP (1)	JP2745059B2 (de)
KR (1)	KR0128369B1 (de)
CN (1)	CN1026982C (de)
AT (1)	ATE118217T1 (de)
AU (1)	AU621203B2 (de)
CA (1)	CA2011468C (de)
DE (1)	DE69016683T2 (de)
DK (1)	DK0386721T3 (de)
ES (1)	ES2067580T3 (de)
FI (1)	FI95267C (de)
HU (1)	HU203247B (de)
IL (1)	IL93670A (de)
NO (1)	NO173701C (de)
NZ (1)	NZ232806A (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI291462B (en) *	2000-04-25	2007-12-21	Daiichi Sankyo Co Ltd	Hydrate crystal of neuraminic acid compound
EP2173759A4 (de)	2007-07-03	2014-01-29	Childrens Hosp & Res Ct Oak	Oligosialinsäúrederivate, verfahren zu ihrer herstellung und ihre immunologische verwendung
CA2692419C (en)	2007-07-03	2017-12-05	Children's Hospital & Research Center At Oakland	Inhibitors of polysialic acid de-n-acetylase and methods for using the same
JP5523313B2 (ja)	2007-07-03	2014-06-18	チルドレンズホスピタルアンドリサーチセンターアットオークランド	ポリシアル酸誘導体、製造方法、ならびにがん抗原産生の増強およびターゲティングにおける使用
CA2859296C (en) *	2011-12-16	2016-10-11	Daiichi Sankyo Company, Limited	Method for manufacturing neuraminic acid derivatives
AU2015297470B2 (en) *	2014-07-30	2019-05-02	Kyowa Hakko Bio Co., Ltd.	Crystal of alkali metal N-acetylneuraminate anhydrate, and process for producing same
JP6671305B2 (ja) *	2015-01-28	2020-03-25	協和発酵バイオ株式会社	Ｎ−アセチルノイラミン酸アンモニウム塩・無水和物の結晶及びその製造方法
CN109180749B (zh) *	2018-10-18	2022-04-22	中国科学院合肥物质科学研究院	一种利用过饱和结晶法制备高纯度n-乙酰神经氨酸水合物的方法
CN109232677B (zh) *	2018-10-18	2021-12-28	中国科学院合肥物质科学研究院	一种使n-乙酰神经氨酸水合物转化为n-乙酰神经氨酸的方法
CN109265497B (zh) *	2018-10-18	2022-04-19	武汉中科光谷绿色生物技术有限公司	一种利用有机溶剂转化n-乙酰神经氨酸水合物制备n-乙酰神经氨酸的方法
CN110606863B (zh) *	2019-10-08	2023-05-30	中国科学院合肥物质科学研究院	一种n-乙酰神经氨酸二水合物的制备方法
CN110627849B (zh) *	2019-10-15	2023-02-17	中国科学院合肥物质科学研究院	一种n-乙酰神经氨酸标准物质的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL8002823A (nl) *	1980-05-14	1981-12-16	Amsterdam Chem Comb	Lactitolmonohydraat, alsmede werkwijze voor het bereiden van kristallijn lactitol.
JPS6053039B2 (ja) *	1981-06-26	1985-11-22	メクト株式会社	Ｎ−アセチル／イラミン酸誘導体およびその製造方法
AU582758B2 (en) *	1984-06-28	1989-04-13	Mect Corporation	Sialic acid derivatives, galactose derivatives and method for producing the same
JPS61103889A (ja) *	1984-10-24	1986-05-22	Hayashibara Biochem Lab Inc	結晶エルロ−ス及びそれを含有する含蜜結晶並びにそれらの製造方法及び用途
JPS6344590A (ja) *	1986-08-12	1988-02-25	Mect Corp	シアル酸誘導体の製造方法
IT1223398B (it) *	1987-12-01	1990-09-19	Sirac Spa	Procedimento per la preparazione di lattulosio cristallino ad alta purezza
JPH01299294A (ja) *	1988-05-24	1989-12-04	Mect Corp	４，８−アンハイドロ−ｎ−アセチルノイラミン酸誘導体
DE68912721T2 (de) *	1988-11-16	1994-05-11	Nippon Kayaku Kk	Kristallines Hydrochlorid von einer Etoposid-2-dimethylamino-Verbindung und Verfahren zur Herstellung davon.

1989
- 1989-03-08 JP JP1055388A patent/JP2745059B2/ja not_active Expired - Fee Related
1990
- 1990-03-05 US US07/488,860 patent/US5231177A/en not_active Expired - Lifetime
- 1990-03-06 IL IL9367090A patent/IL93670A/en not_active IP Right Cessation
- 1990-03-06 NZ NZ232806A patent/NZ232806A/xx unknown
- 1990-03-07 DE DE69016683T patent/DE69016683T2/de not_active Expired - Fee Related
- 1990-03-07 NO NO901084A patent/NO173701C/no unknown
- 1990-03-07 HU HU901346A patent/HU203247B/hu not_active IP Right Cessation
- 1990-03-07 FI FI901150A patent/FI95267C/fi not_active IP Right Cessation
- 1990-03-07 AU AU50776/90A patent/AU621203B2/en not_active Ceased
- 1990-03-07 KR KR1019900002983A patent/KR0128369B1/ko not_active Expired - Fee Related
- 1990-03-07 AT AT90104335T patent/ATE118217T1/de not_active IP Right Cessation
- 1990-03-07 ES ES90104335T patent/ES2067580T3/es not_active Expired - Lifetime
- 1990-03-07 EP EP90104335A patent/EP0386721B1/de not_active Expired - Lifetime
- 1990-03-07 DK DK90104335.6T patent/DK0386721T3/da active
- 1990-03-07 CA CA002011468A patent/CA2011468C/en not_active Expired - Fee Related
- 1990-03-08 CN CN90101959A patent/CN1026982C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FI95267B (fi)	1995-09-29
FI95267C (fi)	1996-01-10
JP2745059B2 (ja)	1998-04-28
IL93670A (en)	1994-08-26
AU621203B2 (en)	1992-03-05
EP0386721B1 (de)	1995-02-08
FI901150A0 (fi)	1990-03-07
ES2067580T3 (es)	1995-04-01
KR0128369B1 (ko)	1998-04-03
HU901346D0 (en)	1990-05-28
CA2011468A1 (en)	1990-09-08
CN1026982C (zh)	1994-12-14
DK0386721T3 (da)	1995-07-10
NZ232806A (en)	1991-10-25
HUT53117A (en)	1990-09-28
HU203247B (en)	1991-06-28
JPH02235897A (ja)	1990-09-18
KR900014419A (ko)	1990-10-23
EP0386721A1 (de)	1990-09-12
NO901084D0 (no)	1990-03-07
DE69016683D1 (de)	1995-03-23
AU5077690A (en)	1990-09-20
NO901084L (no)	1990-09-10
US5231177A (en)	1993-07-27
CA2011468C (en)	1996-09-10
DE69016683T2 (de)	1995-06-08
NO173701B (no)	1993-10-11
NO173701C (no)	1994-01-19
CN1045584A (zh)	1990-09-26

Legal Events

Date	Code	Title	Description
1995-09-15	UEP	Publication of translation of european patent specification
1998-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE118217T1 (de)	1995-02-15	Natrium-n-acetylneuraminat-trihydrat und verfahren zu dessen herstellung.
BG92179A (bg)	1993-12-24	Метод за получаване на 7-заместена-хепт-6-еноена и -хептаноена киселина и техни производни и междинни съединения
NO874733D0 (no)	1987-11-12	Fremgangsmaate ved fremstilling av et salt av diclofenac med en cyklisk organisk base.
KR890003775A (ko)	1989-04-18	결정성 세파드록실 모노하이드레이트의 제조방법
DE3767094D1 (de)	1991-02-07	Neue naphtalin- und indanderivate, diese verbindungen enthaltende arzneimittel und verfahren zu deren herstellung.
DE69500481D1 (de)	1997-09-04	Verfahren zur Herstellung von N-Chloracetylglutamin
JPS6440467A (en)	1989-02-10	Novel substituted diphenylimidazole derivative
PL266361A1 (en)	1988-10-13	Method for manufacturing new tetrahydrobenyotiazole derivatives
SE7906681L (sv)	1980-02-12	Ftalazonderivat
DE3378980D1 (en)	1989-02-23	Benzazepine derivatives, process for their preparation and their use as pharmaceutical compounds
DK123089D0 (da)	1989-03-14	Fremgangsmaade til adskillese af alpha-l-asparagyl-l-phenylalaninmethylester fra en oploesning
JPS567756A (en)	1981-01-27	Preparation of optically active d-alpha-methyl-beta- mercaptopropionic acid derivative
HK70083A (en)	1983-12-23	Process for the preparation of sodium amoxycillin
ES471673A1 (es)	1979-02-01	Un procedimiento para la preparacion de amoxicilina de sodiosolida
JPS57197256A (en)	1982-12-03	Novel cyclohexanecarboxamide derivative and its preparation
JPS5246027A (en)	1977-04-12	Process for preparation of thiolcarbamates
JPS5422363A (en)	1979-02-20	Preparation of thiophene-substituted fatty acid halide
JPS51125309A (en)	1976-11-01	Process for preparation of glycerine
JPS51133291A (en)	1976-11-18	Process for preparing 3-metyl-3- trifluoroacetoxycephalosporanic acid derivatives
JPS5266685A (en)	1977-06-02	Purification and separarion of 2-keto-l-glonic acid
JPS53149975A (en)	1978-12-27	Preparation of imidazolylbenzophenones
JPH0217154A (ja)	1990-01-22	光学活性１−メチル−３−フェニルプロピルアミンの製造方法
NO904736D0 (no)	1990-10-31	Fremgangsmaate ved separasjon av r og s-2,2-r1, r2-1,3-dioksolan-4-karboksyl-syre.
JPS5268102A (en)	1977-06-06	Preparation ofn-acylamino acid derivative solution
JPS5217439A (en)	1977-02-09	Process for preparation of mephenum acid