ATE118222T1 - Lineare somatostatin-analoga. - Google Patents

Lineare somatostatin-analoga.

Info

Publication number: ATE118222T1
Authority: AT; Austria
Prior art keywords: phe; octapeptides; lower alkyl; ala; linear
Prior art date: 1989-04-26

Application number

AT90304551T

Other languages

English (en)

Inventor

David H Coy

William A Murphy

Original Assignee

Univ Tulane

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-26

Filing date

1990-04-26

Publication date

1995-02-15

1990-04-26 Application filed by Univ Tulane filed Critical Univ Tulane

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE118222T1 publication Critical patent/ATE118222T1/de

Links

NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title 1
229940075620 somatostatin analogue Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
102000051325 Glucagon Human genes 0.000 abstract 1
108060003199 Glucagon Proteins 0.000 abstract 1
102000018997 Growth Hormone Human genes 0.000 abstract 1
108010051696 Growth Hormone Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 1
108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 1
229960004666 glucagon Drugs 0.000 abstract 1
125000003147 glycosyl group Chemical group 0.000 abstract 1
239000000122 growth hormone Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT90304551T 1989-04-26 1990-04-26 Lineare somatostatin-analoga. ATE118222T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US34332589A	1989-04-26	1989-04-26

Publications (1)

Publication Number	Publication Date
ATE118222T1 true ATE118222T1 (de)	1995-02-15

Family

ID=23345640

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90304551T ATE118222T1 (de)	1989-04-26	1990-04-26	Lineare somatostatin-analoga.

Country Status (14)

Country	Link
EP (1)	EP0395417B1 (de)
JP (1)	JP2882679B2 (de)
KR (1)	KR0173119B1 (de)
AT (1)	ATE118222T1 (de)
CA (1)	CA2053250A1 (de)
CZ (1)	CZ284341B6 (de)
DD (1)	DD293832A5 (de)
DE (1)	DE69016691T2 (de)
DK (1)	DK0395417T3 (de)
ES (1)	ES2069684T3 (de)
HU (1)	HU217636B (de)
IE (1)	IE66113B1 (de)
SK (1)	SK211290A3 (de)
WO (1)	WO1990012811A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH05506254A (ja) *	1991-02-08	1993-09-16	バイオメジャー，インコーポレイテッド	良性および悪性増殖性皮膚病の治療方法
US5783170A (en) *	1991-11-27	1998-07-21	Diatide, Inc.	Peptide-metal chelate conjugates
US5716596A (en) *	1992-06-23	1998-02-10	Diatide, Inc.	Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5620675A (en) *	1992-06-23	1997-04-15	Diatech, Inc.	Radioactive peptides
US6017512A (en) *	1992-06-23	2000-01-25	Diatide, Inc.	Radiolabeled peptides
US5871711A (en) *	1992-06-23	1999-02-16	Diatide, Inc.	Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US5569741A (en) *	1992-07-27	1996-10-29	Biomeasure, Inc.	Cyclic octapeptide neuromedin B receptor antagonists
US5462926A (en) *	1992-07-27	1995-10-31	Biomeasure, Inc.	Neuromedin B receptor antagonists which demonstrate selectivity
DK0606463T3 (da) *	1992-07-27	2001-12-03	Univ Tulane	Antagonister for neuromedin-B-receptor
US6051206A (en) *	1994-06-03	2000-04-18	Diatide, Inc	Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US6051554A (en) *	1995-06-07	2000-04-18	Peptor Limited	Conformationally constrained backbone cyclized somatostatin analogs
US5770687A (en) *	1995-06-07	1998-06-23	Peptor Limited	Comformationally constrained backbone cyclized somatostatin analogs
MY147327A (en)	1995-06-29	2012-11-30	Novartis Ag	Somatostatin peptides
JP3869874B2 (ja) *	1995-11-15	2007-01-17	大日本住友製薬株式会社	急性肝不全治療剤
US6841533B1 (en)	1995-12-07	2005-01-11	Peptor Limited	Conformationally constrained backbone cyclized interleukin-6 antagonists
US5686418A (en) *	1996-04-08	1997-11-11	Biomeasure Incorporated	Prolonging survival of transplanted pancreatic cells
AU3215597A (en)	1996-08-30	1998-03-19	Biomeasure Incorporated	Method of inhibiting fibrosis with a somatostatin agonist
ATE330966T1 (de) *	1996-12-04	2006-07-15	Sod Conseils Rech Applic	Somatostatin-antagonisten
US6262229B1 (en)	1996-12-04	2001-07-17	Biomeasure Incorporated	Somatostatin antagonists
AU7655098A (en)	1997-05-13	1998-12-08	Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)	Somatostatin and somatostatin agonists for decreasing body weight
US7026289B2 (en)	1997-05-13	2006-04-11	Societe De Conseils De Recherches Et D'applications Scientifiques, Sas	Method and compositions for treating hyperlipidemia and other conditions
US6004928A (en) *	1997-05-13	1999-12-21	Biomeasure, Incorporated	Method of treating hyperlipidemia
US5968903A (en) *	1998-05-07	1999-10-19	Biomeasure, Incorporated	Inhibition of H. pylori proliferation
US6124263A (en) *	1998-11-16	2000-09-26	Asta Medica Ag	Treatment of tumors by administration of growth hormone releasing compounds and their antagonists
SE9804064D0 (sv) *	1998-11-25	1998-11-25	A & Science Invest Ab	Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells
US6903074B1 (en)	1999-06-04	2005-06-07	Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S.	Neuromedin b and somatostatin receptor agonists
GB0018891D0 (en)	2000-08-01	2000-09-20	Novartis Ag	Organic compounds
EP1397150A4 (de) *	2001-04-09	2005-01-26	Administrators Ofthe Tulane Ed	Somatostatin-agonisten
JP3996897B2 (ja)	2001-06-08	2007-10-24	ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス	ソマトスタチン−ドーパミンキメラ類似体
NZ564694A (en)	2003-04-22	2009-11-27	Sod Conseils Rech Applic	Peptide vectors
JP5799397B2 (ja)	2008-06-12	2015-10-28	イプセン・バイオイノベーション・リミテッドＩｐｓｅｎＢｉｏｉｎｎｏｖａｔｉｏｎＬｉｍｉｔｅｄ	癌の抑制
CA2727082C (en)	2008-06-12	2019-02-26	Syntaxin Limited	Fusion proteins for use in suppression of acromegaly
GB0820970D0 (en)	2008-11-17	2008-12-24	Syntaxin Ltd	Suppression of cancer
EP3007704B1 (de) *	2013-06-13	2021-01-06	Antisense Therapeutics Ltd	Kombinationstherapie der akromegalie

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LU78191A1 (de) *	1977-09-28	1979-05-25	Ciba Geigy Ag	Verfahren zur herstellung von neuen cyclopeptiden
US4185010A (en) *	1978-12-12	1980-01-22	American Home Products Corporation	Nonapeptides
US4369179A (en) *	1979-12-14	1983-01-18	Ciba-Geigy Corporation	Acylpeptides
FR2567524B1 (fr) *	1984-07-10	1987-11-27	Sanofi Sa	Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires
HUT42101A (en) *	1985-01-07	1987-06-29	Sandoz Ag	Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
US4871717A (en) *	1987-01-07	1989-10-03	Administrators Of The Tulane Educational Fund	Peptides
JP2568228B2 (ja) *	1987-02-03	1996-12-25	ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド	治療用ソマトスタチンアナログ
CH679045A5 (de) *	1987-06-29	1991-12-13	Sandoz Ag
JP2809403B2 (ja) *	1987-07-07	1998-10-08	ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド	治療用ソマトスタチンアナログ化合物

1990
- 1990-04-23 JP JP2507504A patent/JP2882679B2/ja not_active Expired - Lifetime
- 1990-04-23 CA CA002053250A patent/CA2053250A1/en not_active Abandoned
- 1990-04-23 HU HU481/90A patent/HU217636B/hu not_active IP Right Cessation
- 1990-04-23 WO PCT/US1990/002196 patent/WO1990012811A1/en not_active Ceased
- 1990-04-23 KR KR1019900702668A patent/KR0173119B1/ko not_active Expired - Fee Related
- 1990-04-25 IE IE147690A patent/IE66113B1/en not_active IP Right Cessation
- 1990-04-25 DD DD90340103A patent/DD293832A5/de not_active IP Right Cessation
- 1990-04-26 SK SK2112-90A patent/SK211290A3/sk unknown
- 1990-04-26 DE DE69016691T patent/DE69016691T2/de not_active Expired - Fee Related
- 1990-04-26 ES ES90304551T patent/ES2069684T3/es not_active Expired - Lifetime
- 1990-04-26 EP EP90304551A patent/EP0395417B1/de not_active Expired - Lifetime
- 1990-04-26 CZ CS902112A patent/CZ284341B6/cs not_active IP Right Cessation
- 1990-04-26 AT AT90304551T patent/ATE118222T1/de not_active IP Right Cessation
- 1990-04-26 DK DK90304551.6T patent/DK0395417T3/da active

Also Published As

Publication number	Publication date
HU904481D0 (en)	1992-02-28
CZ284341B6 (cs)	1998-10-14
SK279231B6 (sk)	1998-08-05
DK0395417T3 (da)	1995-06-12
ES2069684T3 (es)	1995-05-16
CA2053250A1 (en)	1990-10-27
DE69016691T2 (de)	1995-10-05
CZ211290A3 (en)	1995-03-15
EP0395417A1 (de)	1990-10-31
KR0173119B1 (ko)	1999-02-01
HUT60287A (en)	1992-08-28
DD293832A5 (de)	1991-09-12
JP2882679B2 (ja)	1999-04-12
DE69016691D1 (de)	1995-03-23
WO1990012811A1 (en)	1990-11-01
KR920700226A (ko)	1992-02-19
EP0395417B1 (de)	1995-02-08
IE66113B1 (en)	1995-12-13
IE901476L (en)	1990-10-26
JPH04504723A (ja)	1992-08-20
HU217636B (hu)	2000-03-28
SK211290A3 (en)	1998-08-05

Legal Events

Date	Code	Title	Description
1995-08-15	UEP	Publication of translation of european patent specification
2001-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE118222T1 (de)	1995-02-15	Lineare somatostatin-analoga.
PT93502A (pt)	1990-11-07	Processo para a preparacao de novos derivados de insulina e de composicoes farmaceuticas que os contem
YU46023B (sh)	1992-12-21	Postupak za dobijanje novih analoga insulina
IL71326A (en)	1987-11-30	Corticotropin releasing factor analogs and pharmaceutical compositions containing them
EP0346429A4 (en)	1990-10-10	Peptide analogues of insulin-like growth factor 1 (igf-1) or factor 2 (igf-2)
GB2208200B (en)	1991-11-27	Pharmaceutical compositions of somatostatin analogues
DE68922405D1 (de)	1995-06-01	Deletionsanaloga von magaininpeptiden.
IL79534A0 (en)	1986-10-31	Synthetic peptides being grf analogs and pharmaceutical compositions containing them
SG102892G (en)	1992-12-04	Composition of pregnanolole comprising a stable oil-in-water emulsion
TW286320B (de)	1996-09-21
EP0339549A3 (de)	1991-01-16	Tyr-Peptid-Analoge
DK375784D0 (da)	1984-08-02	Fremgangsmaade til fremstilling af insulinderivater
NZ221066A (en)	1991-02-26	Trichokirin and derivatives
JPS6470500A (en)	1989-03-15	Somatostatin analogue compound for treatment
EP0403591A4 (en)	1991-11-21	Crf analogs
KR900007433A (ko)	1990-06-01	폐 보호제
KR890700673A (ko)	1989-04-26	돼지 성장호르몬 아날로그
EP0968721A3 (de)	2004-02-04	Anwendung einer peptide enthaltende zusammensetzung zur hiv hemmung
ES2051750T3 (es)	1994-07-01	Procedimiento para la preparacion de nuevos compuestos.
DK87090D0 (da)	1990-04-06	Vasotocin-derivater og farmaceutiske midler indeholdende saadanne derivater
EP0464549A1 (de)	1992-01-08	Analoga von Calcitonin und Verwendung davon
HU911358D0 (en)	1991-10-28	Grf analogues
GR3015492T3 (en)	1995-06-30	ZNS-active hexapeptides with antiamnestic activity.
ES2036561T3 (es)	1993-06-01	Un procedimiento para preparar un grupo de compuestos que son acidos 4-hidroxi-4-(alquenil sustituido)ciclohexanocarboxilicos.