ATE119387T1 - Stabile wässerige zubereitung. - Google Patents
Stabile wässerige zubereitung.Info
- Publication number
- ATE119387T1 ATE119387T1 AT91114550T AT91114550T ATE119387T1 AT E119387 T1 ATE119387 T1 AT E119387T1 AT 91114550 T AT91114550 T AT 91114550T AT 91114550 T AT91114550 T AT 91114550T AT E119387 T1 ATE119387 T1 AT E119387T1
- Authority
- AT
- Austria
- Prior art keywords
- acid
- vitamin
- stable aqueous
- aqueous preparation
- epsilon
- Prior art date
Links
- -1 alkali metal salts Chemical class 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 abstract 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 abstract 2
- 235000019155 vitamin A Nutrition 0.000 abstract 2
- 239000011719 vitamin A Substances 0.000 abstract 2
- 229940045997 vitamin a Drugs 0.000 abstract 2
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 abstract 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 abstract 1
- 206010013774 Dry eye Diseases 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 239000004743 Polypropylene Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 229960002684 aminocaproic acid Drugs 0.000 abstract 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 abstract 1
- 239000004327 boric acid Substances 0.000 abstract 1
- 230000003139 buffering effect Effects 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 229920000139 polyethylene terephthalate Polymers 0.000 abstract 1
- 239000005020 polyethylene terephthalate Substances 0.000 abstract 1
- 229920001155 polypropylene Polymers 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22988890 | 1990-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE119387T1 true ATE119387T1 (de) | 1995-03-15 |
Family
ID=16899290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91114550T ATE119387T1 (de) | 1990-08-30 | 1991-08-29 | Stabile wässerige zubereitung. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5185372A (de) |
| EP (1) | EP0473159B1 (de) |
| JP (1) | JP3256997B2 (de) |
| AT (1) | ATE119387T1 (de) |
| CA (1) | CA2049822C (de) |
| DE (1) | DE69107932T2 (de) |
| DK (1) | DK0473159T3 (de) |
| ES (1) | ES2069150T3 (de) |
| GR (1) | GR3015340T3 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830508A (en) | 1992-08-06 | 1998-11-03 | Deo Corporation | Composition for treating dry eye |
| US5366739A (en) * | 1992-08-06 | 1994-11-22 | Deo Corporation | Method of ophthalmic drug delivery |
| TW252974B (de) * | 1993-03-23 | 1995-08-01 | Takeda Dharm Industry Co Ltd | |
| US20020173547A1 (en) | 1994-03-22 | 2002-11-21 | Jones Christopher Buchan | Pharmaceuticals compositions |
| US6011062A (en) * | 1994-12-22 | 2000-01-04 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| US5631287A (en) * | 1994-12-22 | 1997-05-20 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| US5706542A (en) * | 1995-06-27 | 1998-01-13 | Okada; Eiji | Electrically driven toothbrush |
| US5617602A (en) * | 1995-06-27 | 1997-04-08 | Okada; Eiji | Motor-driven toothbrush |
| JPH09124484A (ja) * | 1995-10-27 | 1997-05-13 | Schering Purau Kk | 点眼剤 |
| CA2288726C (en) * | 1997-04-25 | 2008-04-01 | Schering-Plough Kabushiki Kaisha | Eyedrops containing a loratadine metabolite |
| BR9906597A (pt) * | 1998-07-14 | 2000-07-18 | Alcon Lab Inc | Produto de prostaglandina |
| US6235781B1 (en) | 1998-07-14 | 2001-05-22 | Alcon Laboratories, Inc. | Prostaglandin product |
| US6291519B1 (en) * | 1998-10-14 | 2001-09-18 | Novartis Ag | Method of preventing damage to eye tissue |
| WO2001012225A1 (en) * | 1999-08-10 | 2001-02-22 | Santen Pharmaceutical Co., Ltd. | Water channel opener compositions and medicinal compositions for ophthalmic use |
| JP4880808B2 (ja) * | 1999-11-15 | 2012-02-22 | 久光製薬株式会社 | 人工涙液型点眼剤組成物 |
| WO2002022106A2 (en) * | 2000-09-14 | 2002-03-21 | Novartis Ag | Stable ophthalmic preparation |
| JP4849288B2 (ja) * | 2000-09-29 | 2012-01-11 | ライオン株式会社 | 点眼剤及び涙液膜の安定化剤 |
| US6774100B2 (en) | 2000-12-06 | 2004-08-10 | Imaginative Research Associates, Inc. | Anhydrous creams, lotions and gels |
| US6462025B2 (en) | 2000-12-12 | 2002-10-08 | Imaginative Research Associates, Inc. | Antibiotic/benzoyl peroxide dispenser |
| US20060189552A1 (en) * | 2000-12-12 | 2006-08-24 | Mohan Vishnupad | Dispenser for dispensing three or more actives |
| US7060732B2 (en) * | 2000-12-12 | 2006-06-13 | Imaginative Research Associates, Inc. | Antibiotic/benzoyl peroxide dispenser |
| WO2002049613A2 (en) * | 2000-12-19 | 2002-06-27 | Bausch & Lomb Incorporated | Method for enhancing integrity of epithelium using retinoic acid |
| TW586946B (en) * | 2000-12-22 | 2004-05-11 | Novartis Ag | Process to improve stability |
| AU2002228449B2 (en) * | 2001-01-09 | 2007-12-06 | Louis Johan Wagenaar | Procedure and composition of treatment and/or care of the eye |
| US20030165546A1 (en) * | 2002-03-04 | 2003-09-04 | The Procter & Gamble Company | Stable personal care compositions containing a retinoid |
| US6984628B2 (en) * | 2003-07-15 | 2006-01-10 | Allergan, Inc. | Ophthalmic compositions comprising trefoil factor family peptides |
| DE10355715A1 (de) * | 2003-11-26 | 2005-06-16 | Beiersdorf Ag | Wirkstoffkombinationen Kreatin und/oder Kreatinderivaten und/oder Kreatinin und/oder Kreatininderivaten und einer wirksamen Menge an Retinoiden, insbesondere Retinol bzw. Retinylpalmitat und Zubereitungen, solche Wirkstoffkombinationen enthaltend |
| US9161905B2 (en) * | 2005-01-12 | 2015-10-20 | Ocular Research Of Boston, Inc. | Dry eye treatment |
| DE102005012176A1 (de) * | 2005-03-15 | 2006-09-28 | Zarrin Anna Buchheim | Gerät zur reinigenden Behandlung der Augenlider |
| US20070249727A1 (en) | 2006-04-21 | 2007-10-25 | The Proctor & Gamble Company | Compositions and kits useful for treatment of respiratory illness |
| US10022339B2 (en) | 2006-04-21 | 2018-07-17 | The Procter & Gamble Company | Compositions and methods useful for treatment of respiratory illness |
| WO2008052037A2 (en) * | 2006-10-24 | 2008-05-02 | Alcon Research, Ltd. | Packaging materials for formulations containing 2-pyrrolidone derivatives |
| US9034843B2 (en) * | 2007-09-14 | 2015-05-19 | Rohto Pharmaceutical Co., Ltd. | Ophthalmic composition |
| GB2471304B (en) | 2009-06-24 | 2013-12-11 | Oval Medical Technologies Ltd | A pre-filled syringe or autoinjector |
| GB2471726B (en) * | 2009-07-10 | 2013-09-11 | Oval Medical Technologies Ltd | A pre-filled syringe including an oxygen absorber |
| JP5518608B2 (ja) * | 2010-07-09 | 2014-06-11 | ロート製薬株式会社 | 粘膜適用液状組成物 |
| US20130281390A1 (en) * | 2010-12-29 | 2013-10-24 | Kurt E. Brubaker | Method for treating dry eye |
| JP2012006962A (ja) * | 2011-08-22 | 2012-01-12 | Lion Corp | 眼科用組成物 |
| JP5345743B1 (ja) * | 2012-02-27 | 2013-11-20 | ロート製薬株式会社 | 眼科用組成物キット |
| WO2016172712A2 (en) * | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
| KR102887267B1 (ko) | 2018-11-26 | 2025-11-17 | 오파닉스 게엠베하 | 수성 소아용 레티놀 제형 |
| EP4013461A4 (de) * | 2019-08-18 | 2023-08-23 | IVIEW Therapeutics, Inc. | Stabile pharmazeutische artikel mit verdünnten povidon-iod-formulierungen |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4199567A (en) * | 1979-01-02 | 1980-04-22 | Burton, Parsons & Company, Inc. | Method for imparting freeze stability to chlorhexidine-containing medicaments |
| US5032392A (en) * | 1986-09-04 | 1991-07-16 | Vision Pharmaceuticals | Aqueous ophthalmic solutions for the treatment of dryness and/or irritation of human or animal eyes |
| US4966773A (en) * | 1986-11-25 | 1990-10-30 | Alcon Laboratories, Inc. | Topical ophthalmic compositions containing microfine retinoid particles |
-
1991
- 1991-08-21 JP JP29396491A patent/JP3256997B2/ja not_active Expired - Fee Related
- 1991-08-26 CA CA002049822A patent/CA2049822C/en not_active Expired - Fee Related
- 1991-08-29 ES ES91114550T patent/ES2069150T3/es not_active Expired - Lifetime
- 1991-08-29 AT AT91114550T patent/ATE119387T1/de not_active IP Right Cessation
- 1991-08-29 DK DK91114550.6T patent/DK0473159T3/da active
- 1991-08-29 EP EP91114550A patent/EP0473159B1/de not_active Expired - Lifetime
- 1991-08-29 US US07/751,885 patent/US5185372A/en not_active Expired - Fee Related
- 1991-08-29 DE DE69107932T patent/DE69107932T2/de not_active Expired - Fee Related
-
1995
- 1995-03-09 GR GR940403826T patent/GR3015340T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH054918A (ja) | 1993-01-14 |
| DE69107932D1 (de) | 1995-04-13 |
| JP3256997B2 (ja) | 2002-02-18 |
| ES2069150T3 (es) | 1995-05-01 |
| CA2049822A1 (en) | 1992-03-01 |
| EP0473159A1 (de) | 1992-03-04 |
| DE69107932T2 (de) | 1995-07-27 |
| US5185372A (en) | 1993-02-09 |
| EP0473159B1 (de) | 1995-03-08 |
| DK0473159T3 (da) | 1995-05-22 |
| GR3015340T3 (en) | 1995-06-30 |
| CA2049822C (en) | 2001-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |