ES2069150T3 - Preparacion acuosa estable. - Google Patents
Preparacion acuosa estable.Info
- Publication number
- ES2069150T3 ES2069150T3 ES91114550T ES91114550T ES2069150T3 ES 2069150 T3 ES2069150 T3 ES 2069150T3 ES 91114550 T ES91114550 T ES 91114550T ES 91114550 T ES91114550 T ES 91114550T ES 2069150 T3 ES2069150 T3 ES 2069150T3
- Authority
- ES
- Spain
- Prior art keywords
- acid
- vitamin
- water preparation
- stable water
- epsilon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- -1 alkali metal salts Chemical class 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 abstract 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 abstract 2
- 235000019155 vitamin A Nutrition 0.000 abstract 2
- 239000011719 vitamin A Substances 0.000 abstract 2
- 229940045997 vitamin a Drugs 0.000 abstract 2
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 abstract 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 abstract 1
- 206010013774 Dry eye Diseases 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 239000004743 Polypropylene Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 229960002684 aminocaproic acid Drugs 0.000 abstract 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 abstract 1
- 239000004327 boric acid Substances 0.000 abstract 1
- 230000003139 buffering effect Effects 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 229920000139 polyethylene terephthalate Polymers 0.000 abstract 1
- 239000005020 polyethylene terephthalate Substances 0.000 abstract 1
- 229920001155 polypropylene Polymers 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
SE DESCRIBE UNA PREPARACION ACUOSA ESTABLE PARA LA ADMINISTRACION OFTALMOLOGICA TOPICA QUE CONTIENE VITAMINA A O UN DERIVADO DE LA VITAMINA A TENIENDO PROPIEDADES DE LA VITAMINA A PARA SER UTILIZADA EN EL TRATAMIENTO DEL SINDROME DEL OJO SECO, CARACTERIZADA PORQUE CONTIENE UN COMPONENTE DE AMORTIGUAMIENTO SELECCIONADO ENTRE LOS DE UN GRUPO QUE CONSTA DE ACIDO FOSFORICO, ACIDO BORICO, ACIDO CITRICO, ACIDO GLUTAMICO, ACIDO E-AMINOCAPROICO Y LAS SALES METALICAS ALCALINAS DE LOS ANTERIORES, UN REVESTIDOR NO-IONICO Y UN AGENTE QUELANTE, SU ACIDEZ ESTA AJUSTADA ENTRE UN PH DE 5 A 8 Y ESTA CONTENIDA EN UN RECIPIENTE HERMETICO HECHO DE POLIPROPILENO O TEREFTALATO DE POLIPROPILENO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22988890 | 1990-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2069150T3 true ES2069150T3 (es) | 1995-05-01 |
Family
ID=16899290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91114550T Expired - Lifetime ES2069150T3 (es) | 1990-08-30 | 1991-08-29 | Preparacion acuosa estable. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5185372A (es) |
| EP (1) | EP0473159B1 (es) |
| JP (1) | JP3256997B2 (es) |
| AT (1) | ATE119387T1 (es) |
| CA (1) | CA2049822C (es) |
| DE (1) | DE69107932T2 (es) |
| DK (1) | DK0473159T3 (es) |
| ES (1) | ES2069150T3 (es) |
| GR (1) | GR3015340T3 (es) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830508A (en) | 1992-08-06 | 1998-11-03 | Deo Corporation | Composition for treating dry eye |
| US5366739A (en) * | 1992-08-06 | 1994-11-22 | Deo Corporation | Method of ophthalmic drug delivery |
| TW252974B (es) * | 1993-03-23 | 1995-08-01 | Takeda Dharm Industry Co Ltd | |
| US20020173547A1 (en) | 1994-03-22 | 2002-11-21 | Jones Christopher Buchan | Pharmaceuticals compositions |
| US6011062A (en) * | 1994-12-22 | 2000-01-04 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| US5631287A (en) * | 1994-12-22 | 1997-05-20 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| US5706542A (en) * | 1995-06-27 | 1998-01-13 | Okada; Eiji | Electrically driven toothbrush |
| US5617602A (en) * | 1995-06-27 | 1997-04-08 | Okada; Eiji | Motor-driven toothbrush |
| JPH09124484A (ja) * | 1995-10-27 | 1997-05-13 | Schering Purau Kk | 点眼剤 |
| CA2288726C (en) * | 1997-04-25 | 2008-04-01 | Schering-Plough Kabushiki Kaisha | Eyedrops containing a loratadine metabolite |
| BR9906597A (pt) * | 1998-07-14 | 2000-07-18 | Alcon Lab Inc | Produto de prostaglandina |
| US6235781B1 (en) | 1998-07-14 | 2001-05-22 | Alcon Laboratories, Inc. | Prostaglandin product |
| US6291519B1 (en) * | 1998-10-14 | 2001-09-18 | Novartis Ag | Method of preventing damage to eye tissue |
| WO2001012225A1 (en) * | 1999-08-10 | 2001-02-22 | Santen Pharmaceutical Co., Ltd. | Water channel opener compositions and medicinal compositions for ophthalmic use |
| JP4880808B2 (ja) * | 1999-11-15 | 2012-02-22 | 久光製薬株式会社 | 人工涙液型点眼剤組成物 |
| WO2002022106A2 (en) * | 2000-09-14 | 2002-03-21 | Novartis Ag | Stable ophthalmic preparation |
| JP4849288B2 (ja) * | 2000-09-29 | 2012-01-11 | ライオン株式会社 | 点眼剤及び涙液膜の安定化剤 |
| US6774100B2 (en) | 2000-12-06 | 2004-08-10 | Imaginative Research Associates, Inc. | Anhydrous creams, lotions and gels |
| US6462025B2 (en) | 2000-12-12 | 2002-10-08 | Imaginative Research Associates, Inc. | Antibiotic/benzoyl peroxide dispenser |
| US20060189552A1 (en) * | 2000-12-12 | 2006-08-24 | Mohan Vishnupad | Dispenser for dispensing three or more actives |
| US7060732B2 (en) * | 2000-12-12 | 2006-06-13 | Imaginative Research Associates, Inc. | Antibiotic/benzoyl peroxide dispenser |
| WO2002049613A2 (en) * | 2000-12-19 | 2002-06-27 | Bausch & Lomb Incorporated | Method for enhancing integrity of epithelium using retinoic acid |
| TW586946B (en) * | 2000-12-22 | 2004-05-11 | Novartis Ag | Process to improve stability |
| AU2002228449B2 (en) * | 2001-01-09 | 2007-12-06 | Louis Johan Wagenaar | Procedure and composition of treatment and/or care of the eye |
| US20030165546A1 (en) * | 2002-03-04 | 2003-09-04 | The Procter & Gamble Company | Stable personal care compositions containing a retinoid |
| US6984628B2 (en) * | 2003-07-15 | 2006-01-10 | Allergan, Inc. | Ophthalmic compositions comprising trefoil factor family peptides |
| DE10355715A1 (de) * | 2003-11-26 | 2005-06-16 | Beiersdorf Ag | Wirkstoffkombinationen Kreatin und/oder Kreatinderivaten und/oder Kreatinin und/oder Kreatininderivaten und einer wirksamen Menge an Retinoiden, insbesondere Retinol bzw. Retinylpalmitat und Zubereitungen, solche Wirkstoffkombinationen enthaltend |
| US9161905B2 (en) * | 2005-01-12 | 2015-10-20 | Ocular Research Of Boston, Inc. | Dry eye treatment |
| DE102005012176A1 (de) * | 2005-03-15 | 2006-09-28 | Zarrin Anna Buchheim | Gerät zur reinigenden Behandlung der Augenlider |
| US20070249727A1 (en) | 2006-04-21 | 2007-10-25 | The Proctor & Gamble Company | Compositions and kits useful for treatment of respiratory illness |
| US10022339B2 (en) | 2006-04-21 | 2018-07-17 | The Procter & Gamble Company | Compositions and methods useful for treatment of respiratory illness |
| WO2008052037A2 (en) * | 2006-10-24 | 2008-05-02 | Alcon Research, Ltd. | Packaging materials for formulations containing 2-pyrrolidone derivatives |
| US9034843B2 (en) * | 2007-09-14 | 2015-05-19 | Rohto Pharmaceutical Co., Ltd. | Ophthalmic composition |
| GB2471304B (en) | 2009-06-24 | 2013-12-11 | Oval Medical Technologies Ltd | A pre-filled syringe or autoinjector |
| GB2471726B (en) * | 2009-07-10 | 2013-09-11 | Oval Medical Technologies Ltd | A pre-filled syringe including an oxygen absorber |
| JP5518608B2 (ja) * | 2010-07-09 | 2014-06-11 | ロート製薬株式会社 | 粘膜適用液状組成物 |
| US20130281390A1 (en) * | 2010-12-29 | 2013-10-24 | Kurt E. Brubaker | Method for treating dry eye |
| JP2012006962A (ja) * | 2011-08-22 | 2012-01-12 | Lion Corp | 眼科用組成物 |
| JP5345743B1 (ja) * | 2012-02-27 | 2013-11-20 | ロート製薬株式会社 | 眼科用組成物キット |
| WO2016172712A2 (en) * | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
| KR102887267B1 (ko) | 2018-11-26 | 2025-11-17 | 오파닉스 게엠베하 | 수성 소아용 레티놀 제형 |
| EP4013461A4 (en) * | 2019-08-18 | 2023-08-23 | IVIEW Therapeutics, Inc. | STABLE PHARMACEUTICAL ARTICLES CONTAINING DILUTE FORMULATIONS OF POVIDONE-IODINE |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4199567A (en) * | 1979-01-02 | 1980-04-22 | Burton, Parsons & Company, Inc. | Method for imparting freeze stability to chlorhexidine-containing medicaments |
| US5032392A (en) * | 1986-09-04 | 1991-07-16 | Vision Pharmaceuticals | Aqueous ophthalmic solutions for the treatment of dryness and/or irritation of human or animal eyes |
| US4966773A (en) * | 1986-11-25 | 1990-10-30 | Alcon Laboratories, Inc. | Topical ophthalmic compositions containing microfine retinoid particles |
-
1991
- 1991-08-21 JP JP29396491A patent/JP3256997B2/ja not_active Expired - Fee Related
- 1991-08-26 CA CA002049822A patent/CA2049822C/en not_active Expired - Fee Related
- 1991-08-29 ES ES91114550T patent/ES2069150T3/es not_active Expired - Lifetime
- 1991-08-29 AT AT91114550T patent/ATE119387T1/de not_active IP Right Cessation
- 1991-08-29 DK DK91114550.6T patent/DK0473159T3/da active
- 1991-08-29 EP EP91114550A patent/EP0473159B1/en not_active Expired - Lifetime
- 1991-08-29 US US07/751,885 patent/US5185372A/en not_active Expired - Fee Related
- 1991-08-29 DE DE69107932T patent/DE69107932T2/de not_active Expired - Fee Related
-
1995
- 1995-03-09 GR GR940403826T patent/GR3015340T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH054918A (ja) | 1993-01-14 |
| DE69107932D1 (de) | 1995-04-13 |
| JP3256997B2 (ja) | 2002-02-18 |
| ATE119387T1 (de) | 1995-03-15 |
| CA2049822A1 (en) | 1992-03-01 |
| EP0473159A1 (en) | 1992-03-04 |
| DE69107932T2 (de) | 1995-07-27 |
| US5185372A (en) | 1993-02-09 |
| EP0473159B1 (en) | 1995-03-08 |
| DK0473159T3 (da) | 1995-05-22 |
| GR3015340T3 (en) | 1995-06-30 |
| CA2049822C (en) | 2001-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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