ATE120087T1 - Aerosolzubereitung von glutathion und verfahren zur erhöhung des glutathionspiegels in der lunge. - Google Patents

Aerosolzubereitung von glutathion und verfahren zur erhöhung des glutathionspiegels in der lunge.

Info

Publication number: ATE120087T1
Authority: AT; Austria
Prior art keywords: glutathione; lungs; increasing; aerosol preparation; levels
Prior art date: 1989-11-24

Application number

AT90917464T

Other languages

English (en)

Inventor

Ronald G Crystal

Original Assignee

Us Health

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-24

Filing date

1990-11-23

Publication date

1995-04-15

1990-11-23 Application filed by Us Health filed Critical Us Health

1995-04-15 Application granted granted Critical

1995-04-15 Publication of ATE120087T1 publication Critical patent/ATE120087T1/de

Links

RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 title abstract 6
108010024636 Glutathione Proteins 0.000 title abstract 4
210000004072 lung Anatomy 0.000 title abstract 3
229960003180 glutathione Drugs 0.000 title 2
239000000443 aerosol Substances 0.000 title 1
208000030507 AIDS Diseases 0.000 abstract 2
201000003883 Cystic fibrosis Diseases 0.000 abstract 2
201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 abstract 2
230000003190 augmentative effect Effects 0.000 abstract 2
208000036971 interstitial lung disease 2 Diseases 0.000 abstract 2

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Otolaryngology (AREA)
Dispersion Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT90917464T 1989-11-24 1990-11-23 Aerosolzubereitung von glutathion und verfahren zur erhöhung des glutathionspiegels in der lunge. ATE120087T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/441,521 US5238683A (en)	1989-11-24	1989-11-24	Aerosol preparation of glutathione and a method for augmenting glutathione level in lungs

Publications (1)

Publication Number	Publication Date
ATE120087T1 true ATE120087T1 (de)	1995-04-15

Family

ID=23753204

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90917464T ATE120087T1 (de)	1989-11-24	1990-11-23	Aerosolzubereitung von glutathion und verfahren zur erhöhung des glutathionspiegels in der lunge.

Country Status (11)

Country	Link
US (2)	US5238683A (de)
EP (1)	EP0502054B1 (de)
JP (1)	JPH0669957B2 (de)
AT (1)	ATE120087T1 (de)
AU (1)	AU631711B2 (de)
CA (1)	CA2069440A1 (de)
DE (1)	DE69018092T2 (de)
DK (1)	DK0502054T3 (de)
ES (1)	ES2069755T3 (de)
GR (1)	GR3015530T3 (de)
WO (1)	WO1991007997A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6030950A (en) *	1987-07-09	2000-02-29	Ohlenschlaeger; Gerhard	Pharmaceutical therapeutic use of glutathione derivative
US5653685A (en) *	1990-10-10	1997-08-05	Lrt, Inc.	Method of providing circulation via lung expansion and deflation
USRE36460E (en) *	1990-10-10	1999-12-21	Life Science Holdings, Inc.	Method of providing circulation via lung expansion and deflation
US6180596B1 (en)	1995-05-18	2001-01-30	Wisconsin Alumni Research Foundation	Methods of inhibiting phospholipase A2 and phospholipase A2 stimulator activities
US5658877A (en) *	1995-05-18	1997-08-19	Wisconsin Alumni Research Foundation	Method to treat endotoxin effects by administration of 33 kilodalton phospholipid binding protein
EP0910423A4 (de) *	1996-03-08	1999-12-29	Life Resuscitation Tech	Verfahren und vorrichtung zur flüssigen beatmung
US6896899B2 (en) *	1996-12-31	2005-05-24	Antioxidant Pharmaceuticals Corp.	Pharmaceutical preparations of glutathione and methods of administration thereof
EP0957901B1 (de)	1996-12-31	2009-11-18	Antioxidant Pharmaceuticals Corporation	Pharmazeutische glutathionpräparate und methoden zu dern verabreichung
JP4578578B2 (ja) *	1997-01-13	2010-11-10	エモリー、ユニバーシティ	インフルエンザ感染の治療用化合物及びそれらの組み合わせ
KR100585242B1 (ko) *	1998-06-23	2006-12-05	교와 핫꼬 고교 가부시끼가이샤	인플루엔자감염증치료용화합물및조성물
MXPA02010747A (es)	2000-05-02	2003-03-10	Hoffmann La Roche	Nuevos agonistas de retinoides selectivos.
US7179791B2 (en) *	2001-01-11	2007-02-20	Duke University	Inhibiting GS-FDH to modulate NO bioactivity
US20040087527A1 (en) *	2002-10-31	2004-05-06	Day Brian J.	Methods for treatment of thiol-containing compound deficient conditions
US7790762B2 (en) *	2002-10-31	2010-09-07	National Jewish Health	Compounds and methods for thiol-containing compound efflux and cancer treatment
US20080221029A1 (en) *	2002-10-31	2008-09-11	Regents Of The University Of Colorado	Methods for treatment of thiol-containing compound deficient conditions
JP5112876B2 (ja) *	2004-11-07	2013-01-09	エフ．ギルフォードティモシー	還元型グルタチオン経口投与のためのリポソーム処方物
WO2007030492A2 (en) *	2005-09-06	2007-03-15	Guilford F Timothy	Method for the treatment of infection with hhv-6 virus and the amelioration of symptoms related to virus using liposomal encapsulation for delivery of reduced glutathione
WO2014070769A1 (en)	2012-10-29	2014-05-08	The University Of North Carolina At Chapel Hill	Methods and compositions for treating mucosal tissue disorders
US9913801B2 (en) *	2013-02-15	2018-03-13	Your Energy Systems, LLC	Treatment of evolving bacterial resistance diseases including Klebsiella pneumoniae with liposomally formulated glutathione
KR20230117644A (ko)	2016-11-17	2023-08-08	레노비온, 아이엔씨.	글루타티온 조성물에 의한 호흡기 질환 및 감염 치료
ES3008699T3 (en)	2017-11-17	2025-03-24	Renovion Inc	Stable ascorbic acid compositions and methods of using the same
US10722465B1 (en)	2017-12-08	2020-07-28	Quicksilber Scientific, Inc.	Transparent colloidal vitamin supplement
US11344497B1 (en)	2017-12-08	2022-05-31	Quicksilver Scientific, Inc.	Mitochondrial performance enhancement nanoemulsion
CA3117213A1 (en) *	2018-10-23	2020-04-30	George Edward Hoag	Composition and method for treating the lungs
US11291702B1 (en)	2019-04-15	2022-04-05	Quicksilver Scientific, Inc.	Liver activation nanoemulsion, solid binding composition, and toxin excretion enhancement method
IT202000009553A1 (it)	2020-04-30	2021-10-30	Innbiotec Pharma S R L	Composizione farmaceutica di derivati del glutatione per l’uso nel trattamento di sindromi respiratorie
CN113252896B (zh) *	2021-05-13	2022-08-09	四川大学华西医院	一款利用肺泡灌洗液中nd1预测急性呼吸窘迫综合征预后的试剂盒
IL313997A (en)	2022-01-04	2024-08-01	Renovion Inc	Aqueous solution including glutathione salt

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA909679A (en) *		1972-09-12	Calbiochem	Process of and composition for mucolysis
BE788945A (de) *	1971-09-20	1973-03-19	Oreal
US4424216A (en) *	1979-07-31	1984-01-03	The Rockefeller University	Method for the reduction of mucin viscosity
DK283180A (da) *	1980-07-01	1982-01-02	Novo Industri As	Polypeptider og derivater deraf
US4513005A (en) *	1981-06-18	1985-04-23	Lilly Industries Limited	SRS-A antagonists
IT1176983B (it) *	1984-10-16	1987-08-26	Zambon Spa	Dipeptidi ad attivita' farmacologica
GB8505285D0 (en) *	1985-03-01	1985-04-03	Beecham Group Plc	Compounds
US4710489A (en) *	1985-04-22	1987-12-01	Cornell Research Foundation, Inc.	Glutathione delivery system
DE3872635T2 (de) *	1987-04-09	1992-12-17	Fisons Plc	Pentamidin enthaltende pharmazeutische zusammensetzungen.

1989
- 1989-11-24 US US07/441,521 patent/US5238683A/en not_active Expired - Lifetime
1990
- 1990-11-23 AU AU68857/91A patent/AU631711B2/en not_active Expired
- 1990-11-23 AT AT90917464T patent/ATE120087T1/de not_active IP Right Cessation
- 1990-11-23 DK DK90917464.1T patent/DK0502054T3/da active
- 1990-11-23 DE DE69018092T patent/DE69018092T2/de not_active Expired - Lifetime
- 1990-11-23 ES ES90917464T patent/ES2069755T3/es not_active Expired - Lifetime
- 1990-11-23 JP JP3500599A patent/JPH0669957B2/ja not_active Expired - Fee Related
- 1990-11-23 EP EP90917464A patent/EP0502054B1/de not_active Expired - Lifetime
- 1990-11-23 WO PCT/US1990/006825 patent/WO1991007997A1/en not_active Ceased
- 1990-11-23 CA CA002069440A patent/CA2069440A1/en not_active Abandoned
1991
- 1991-12-31 US US07/814,885 patent/US5989521A/en not_active Expired - Fee Related
1995
- 1995-03-23 GR GR940402884T patent/GR3015530T3/el unknown

Also Published As

Publication number	Publication date
GR3015530T3 (en)	1995-06-30
US5989521A (en)	1999-11-23
US5238683A (en)	1993-08-24
AU631711B2 (en)	1992-12-03
EP0502054A4 (en)	1993-02-24
DK0502054T3 (da)	1995-06-06
JPH0669957B2 (ja)	1994-09-07
JPH05501263A (ja)	1993-03-11
AU6885791A (en)	1991-06-26
EP0502054B1 (de)	1995-03-22
ES2069755T3 (es)	1995-05-16
EP0502054A1 (de)	1992-09-09
DE69018092D1 (de)	1995-04-27
CA2069440A1 (en)	1991-05-25
DE69018092T2 (de)	1995-07-27
WO1991007997A1 (en)	1991-06-13

Legal Events

Date	Code	Title	Description
2007-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE120087T1 (de)	1995-04-15	Aerosolzubereitung von glutathion und verfahren zur erhöhung des glutathionspiegels in der lunge.
GR3019901T3 (en)	1996-08-31	Osteoinductive pharmaceutical formulations
DK1025124T3 (da)	2008-10-06	Human interferon-alfa-analoge med lav toksicitet
BG100974A (en)	1998-04-30	Vaccines against papillomavirus
FI906212A7 (fi)	1991-06-19	HIV-proteaasin inhibiittoreita, jotka ovat käyttökelpoisia AIDSin hoidossa
DE59509642D1 (de)	2001-10-31	Verfahren zur modifizierung der stabilität von antikörpern
DE59103750D1 (de)	1995-01-19	Verfahren zur teilweisen elektrolytischen Enthalogenierung von Di-und Trichloressigsäure sowie Elektrolyselösung.
DE69131929D1 (de)	2000-02-24	Methoden zur trans-destabilisierung von spezifischen proteinen in vivo
ATE164065T1 (de)	1998-04-15	Neues verfahren zur behandlung von depression
ATE231522T1 (de)	2003-02-15	Fragmente eines oberflächenaktiven lungenproteins
EP0161007A3 (de)	1988-09-14	Retro-inverso C-Terminal-Hexapeptid-Analoga von der Verbindung P
ATE254176T1 (de)	2003-11-15	Erhöhte produktion von beta-galaktosidase in aspergillus oryzae
DE69013011D1 (de)	1994-11-03	Bcrf1-proteine als inhibitoren von interferon-g(g).
ES557463A0 (es)	1987-12-16	Procedimiento de preparar proteinas.
DE69512674D1 (de)	1999-11-11	Konversion von nylon und/oder nylon 6,6 zur adipinsäure
DE69103473D1 (de)	1994-09-22	Verfahren zur Herstellung von 1-Chlor-1,2,2-trifluorethylen oder von 1,2,2-trifluorethylen.
DE3875359D1 (de)	1992-11-26	Dipeptide, verfahren zur herstellung und verwendung in der bestimmung von proteasen.
DE59003390D1 (de)	1993-12-16	Verfahren zur Herstellung von Butandiol-1,4 und Tetrahydrofuran.
ATE113986T1 (de)	1994-11-15	Verfahren zur herstellung von aprotinin und aprotinin-homologen in hefe.
DE69205535D1 (de)	1995-11-23	Verfahren zur Herstellung von Phenylbutyronitrilen und Verwendung in der Parfümerie des 2,2-Dimethyl-4-Phenyl-Valeriannitrile.
DE68912809D1 (de)	1994-03-17	Verfahren zur Herstellung von Bis(2,2,6,6-tetramethyl-4-piperidyl)amin.
EP0439542A4 (en)	1991-11-06	Filamentous hemagglutinin of b. pertussis
DE69002558D1 (de)	1993-09-09	Zusammensetzungen und methoden zur verhinderung von inkrustierungen.
NZ229401A (en)	1991-10-25	Protein extracted from 'hard ticks' having thrombin-inhibitary action
SE8503771D0 (sv)	1985-08-12	Novel pharmaceutical preparations