ES2069755T3 - Preparacion de glutationa en aerosol y metodo para aumentar el nivel de glutationa en los pulmones. - Google Patents

Preparacion de glutationa en aerosol y metodo para aumentar el nivel de glutationa en los pulmones.

Info

Publication number
ES2069755T3
ES2069755T3 ES90917464T ES90917464T ES2069755T3 ES 2069755 T3 ES2069755 T3 ES 2069755T3 ES 90917464 T ES90917464 T ES 90917464T ES 90917464 T ES90917464 T ES 90917464T ES 2069755 T3 ES2069755 T3 ES 2069755T3
Authority
ES
Spain
Prior art keywords
glutation
level
preparation
lungs
increase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90917464T
Other languages
English (en)
Inventor
Ronald G Crystal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Department of Commerce
United States Department of Health and Human Services
Original Assignee
United States Department of Commerce
United States Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United States Department of Commerce, United States Department of Health and Human Services filed Critical United States Department of Commerce
Application granted granted Critical
Publication of ES2069755T3 publication Critical patent/ES2069755T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE PROPORCIONA UNA PREPARACION EN AEROSOL DE GLUTATIONA REDUCIDA (GSH) PARA AUMENTAR EL NIVEL DE GSH EN LOS PULMONES. SE DESCRIBE UN TRATAMIENTO PARA ENFERMEDADES PULMONARES, DONDE SE DESCUBRE UN NIVEL REDUCIDO DE GSH, MEDIANTE LA PREPARACION EN AEROSOL DE LA INVENCION.
ES90917464T 1989-11-24 1990-11-23 Preparacion de glutationa en aerosol y metodo para aumentar el nivel de glutationa en los pulmones. Expired - Lifetime ES2069755T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/441,521 US5238683A (en) 1989-11-24 1989-11-24 Aerosol preparation of glutathione and a method for augmenting glutathione level in lungs

Publications (1)

Publication Number Publication Date
ES2069755T3 true ES2069755T3 (es) 1995-05-16

Family

ID=23753204

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90917464T Expired - Lifetime ES2069755T3 (es) 1989-11-24 1990-11-23 Preparacion de glutationa en aerosol y metodo para aumentar el nivel de glutationa en los pulmones.

Country Status (11)

Country Link
US (2) US5238683A (es)
EP (1) EP0502054B1 (es)
JP (1) JPH0669957B2 (es)
AT (1) ATE120087T1 (es)
AU (1) AU631711B2 (es)
CA (1) CA2069440A1 (es)
DE (1) DE69018092T2 (es)
DK (1) DK0502054T3 (es)
ES (1) ES2069755T3 (es)
GR (1) GR3015530T3 (es)
WO (1) WO1991007997A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030950A (en) * 1987-07-09 2000-02-29 Ohlenschlaeger; Gerhard Pharmaceutical therapeutic use of glutathione derivative
USRE36460E (en) * 1990-10-10 1999-12-21 Life Science Holdings, Inc. Method of providing circulation via lung expansion and deflation
US5653685A (en) * 1990-10-10 1997-08-05 Lrt, Inc. Method of providing circulation via lung expansion and deflation
US5658877A (en) * 1995-05-18 1997-08-19 Wisconsin Alumni Research Foundation Method to treat endotoxin effects by administration of 33 kilodalton phospholipid binding protein
US6180596B1 (en) 1995-05-18 2001-01-30 Wisconsin Alumni Research Foundation Methods of inhibiting phospholipase A2 and phospholipase A2 stimulator activities
CA2247876A1 (en) * 1996-03-08 1997-09-12 Ronald M. Klatz Liquid ventilation method and apparatus
WO1998029101A1 (en) 1996-12-31 1998-07-09 Antioxidant Pharmaceuticals Corporation Pharmaceutical preparations of glutathione and methods of administration thereof
US6896899B2 (en) * 1996-12-31 2005-05-24 Antioxidant Pharmaceuticals Corp. Pharmaceutical preparations of glutathione and methods of administration thereof
CA2277911C (en) * 1997-01-13 2010-09-14 Emory University Compounds and their combinations for the treatment of influenza infection
KR100585242B1 (ko) * 1998-06-23 2006-12-05 교와 핫꼬 고교 가부시끼가이샤 인플루엔자감염증치료용화합물및조성물
KR100582806B1 (ko) 2000-05-02 2006-05-23 에프. 호프만-라 로슈 아게 신규한 감마 선택적인 레티노이드
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
US20040087527A1 (en) * 2002-10-31 2004-05-06 Day Brian J. Methods for treatment of thiol-containing compound deficient conditions
US7790762B2 (en) * 2002-10-31 2010-09-07 National Jewish Health Compounds and methods for thiol-containing compound efflux and cancer treatment
US20080221029A1 (en) * 2002-10-31 2008-09-11 Regents Of The University Of Colorado Methods for treatment of thiol-containing compound deficient conditions
ES2395555T3 (es) * 2004-11-07 2013-02-13 Your Energy Systems, LLC Formulación liposomal para la administración oral de glutatión (reducido)
WO2007030492A2 (en) * 2005-09-06 2007-03-15 Guilford F Timothy Method for the treatment of infection with hhv-6 virus and the amelioration of symptoms related to virus using liposomal encapsulation for delivery of reduced glutathione
CA3153463A1 (en) 2012-10-29 2014-05-08 The University Of North Carolina At Chapel Hill Methods and compositions for treating mucosal tissue disorders
EP2956153A4 (en) * 2013-02-15 2017-03-22 Your Energy Systems, LLC Treatment of evolving bacterial resistance diseases including klebsiella pneumoniae with liposomally formulated glutathione
CN110198728A (zh) 2016-11-17 2019-09-03 莱诺翁股份有限公司 用谷胱甘肽组合物治疗呼吸道疾病和感染
CN111615395B (zh) 2017-11-17 2024-08-06 莱诺翁股份有限公司 稳定的抗坏血酸组合物及其使用方法
US11344497B1 (en) 2017-12-08 2022-05-31 Quicksilver Scientific, Inc. Mitochondrial performance enhancement nanoemulsion
US10722465B1 (en) 2017-12-08 2020-07-28 Quicksilber Scientific, Inc. Transparent colloidal vitamin supplement
EP3869985A4 (en) * 2018-10-23 2022-07-27 George Edward Hoag COMPOSITION AND METHOD OF TREATMENT OF THE LUNGS
US12653854B2 (en) 2019-04-15 2026-06-16 Quicksilver Scientific, Inc. Intra-oral nanoemulsion including monolayer surfactant bound particles for balancing histamine response
US11291702B1 (en) 2019-04-15 2022-04-05 Quicksilver Scientific, Inc. Liver activation nanoemulsion, solid binding composition, and toxin excretion enhancement method
IT202000009553A1 (it) 2020-04-30 2021-10-30 Innbiotec Pharma S R L Composizione farmaceutica di derivati del glutatione per l’uso nel trattamento di sindromi respiratorie
CN113252896B (zh) * 2021-05-13 2022-08-09 四川大学华西医院 一款利用肺泡灌洗液中nd1预测急性呼吸窘迫综合征预后的试剂盒
KR20240131358A (ko) 2022-01-04 2024-08-30 레노비온, 아이엔씨. 글루타치온 염을 포함하는 수용액

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA909679A (en) * 1972-09-12 Calbiochem Process of and composition for mucolysis
BE788945A (es) * 1971-09-20 1973-03-19 Oreal
US4424216A (en) * 1979-07-31 1984-01-03 The Rockefeller University Method for the reduction of mucin viscosity
DK283180A (da) * 1980-07-01 1982-01-02 Novo Industri As Polypeptider og derivater deraf
US4513005A (en) * 1981-06-18 1985-04-23 Lilly Industries Limited SRS-A antagonists
IT1176983B (it) * 1984-10-16 1987-08-26 Zambon Spa Dipeptidi ad attivita' farmacologica
GB8505285D0 (en) * 1985-03-01 1985-04-03 Beecham Group Plc Compounds
US4710489A (en) * 1985-04-22 1987-12-01 Cornell Research Foundation, Inc. Glutathione delivery system
DE3872635T2 (de) * 1987-04-09 1992-12-17 Fisons Plc Pentamidin enthaltende pharmazeutische zusammensetzungen.

Also Published As

Publication number Publication date
ATE120087T1 (de) 1995-04-15
AU631711B2 (en) 1992-12-03
DE69018092T2 (de) 1995-07-27
JPH0669957B2 (ja) 1994-09-07
JPH05501263A (ja) 1993-03-11
GR3015530T3 (en) 1995-06-30
DE69018092D1 (de) 1995-04-27
DK0502054T3 (da) 1995-06-06
US5238683A (en) 1993-08-24
AU6885791A (en) 1991-06-26
EP0502054A1 (en) 1992-09-09
EP0502054A4 (en) 1993-02-24
WO1991007997A1 (en) 1991-06-13
US5989521A (en) 1999-11-23
CA2069440A1 (en) 1991-05-25
EP0502054B1 (en) 1995-03-22

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