ATE120193T1 - Zellwachstum hemmende makrozyklische lactone namens combretastatin d-2. - Google Patents

Zellwachstum hemmende makrozyklische lactone namens combretastatin d-2.

Info

Publication number: ATE120193T1
Authority: AT; Austria
Prior art keywords: combretastatin; cell growth; called; macrocyclic lactones; growth inhibiting
Prior art date: 1989-04-26

Application number

AT90304290T

Other languages

English (en)

Inventor

George R Pettit

Sheo Bux Singh

Original Assignee

Univ Arizona

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-26

Filing date

1990-04-20

Publication date

1995-04-15

1990-04-20 Application filed by Univ Arizona filed Critical Univ Arizona

1995-04-15 Application granted granted Critical

1995-04-15 Publication of ATE120193T1 publication Critical patent/ATE120193T1/de

Links

150000002596 lactones Chemical class 0.000 title abstract 3
QXDPFEIJLOEFJN-UHFFFAOYSA-N Combretastatin D2 Natural products Oc1ccc2CCC(=O)OCC=C/c3cccc(Oc1c2)c3 QXDPFEIJLOEFJN-UHFFFAOYSA-N 0.000 title abstract 2
230000010261 cell growth Effects 0.000 title abstract 2
DTZHRIFDDQELBE-UPHRSURJSA-N combretastatin d-2 Chemical compound O1C(=C2)C(O)=CC=C2CCC(=O)OC\C=C/C2=CC=C1C=C2 DTZHRIFDDQELBE-UPHRSURJSA-N 0.000 title abstract 2
230000002401 inhibitory effect Effects 0.000 title abstract 2
UNKWNXAIWJJVFF-UHFFFAOYSA-N Combretastatin D-1 Natural products Oc1ccc2CCC(=O)OCC3OC3c4cccc(Oc1c2)c4 UNKWNXAIWJJVFF-UHFFFAOYSA-N 0.000 abstract 1
COGWIGJGNQCZPK-UHFFFAOYSA-N O1C(=C2)C(O)=CC=C2CCC(=O)OCC2OC2C2=CC=C1C=C2 Chemical compound O1C(=C2)C(O)=CC=C2CCC(=O)OCC2OC2C2=CC=C1C=C2 COGWIGJGNQCZPK-UHFFFAOYSA-N 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Plant Substances (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Detergent Compositions (AREA)
Lubricants (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Pyrane Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT90304290T 1989-04-26 1990-04-20 Zellwachstum hemmende makrozyklische lactone namens combretastatin d-2. ATE120193T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/344,005 US4940726A (en)	1989-04-26	1989-04-26	Cell growth inhibitory macrocyclic lactones denominated Combretastatin D-1 and Combretastatin D-2

Publications (1)

Publication Number	Publication Date
ATE120193T1 true ATE120193T1 (de)	1995-04-15

Family

ID=23348618

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90304290T ATE120193T1 (de)	1989-04-26	1990-04-20	Zellwachstum hemmende makrozyklische lactone namens combretastatin d-2.

Country Status (8)

Country	Link
US (1)	US4940726A (de)
EP (1)	EP0397336B1 (de)
JP (1)	JP2929025B2 (de)
AT (1)	ATE120193T1 (de)
CA (1)	CA2010886A1 (de)
DE (1)	DE69017946T2 (de)
DK (1)	DK0397336T3 (de)
ES (1)	ES2070276T3 (de)

Families Citing this family (26)

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DE3919255A1 (de) *	1989-06-13	1990-12-20	Bayer Ag	Dibenzo/1,5/dioxocin-5-one-derivate, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung
US5430062A (en) *	1992-05-21	1995-07-04	Research Corporation Technologies, Inc.	Stilbene derivatives as anticancer agents
US5393897A (en) *	1993-07-02	1995-02-28	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Isolation and structure of spongistatins 5,7,8 and 9
WO2000048606A1 (en)	1999-02-18	2000-08-24	Oxigene, Inc.	Compositions and methods for use in targeting vascular destruction
US6703020B1 (en) *	1999-04-28	2004-03-09	Board Of Regents, The University Of Texas System	Antibody conjugate methods for selectively inhibiting VEGF
IL145941A (en)	1999-04-28	2007-08-19	Univ Texas	Compositions and methods for cancer treatment by selectively inhibiting vegf
US7037906B1 (en) *	2000-12-22	2006-05-02	Oxigene, Inc.	Methods for modulating tumor growth and metastasis
US20050209310A1 (en) *	2000-12-22	2005-09-22	Chaplin David J	Methods for modulating tumor growth and metastasis
US7572442B2 (en)	2002-07-15	2009-08-11	Board Of Regents, The University Of Texas System	Selected antibody compositions for binding to aminophospholipids
US20040052868A1 (en)	2002-09-12	2004-03-18	William Asiedu	Composition treating for AIDS and associated conditions
US20090011060A1 (en) *	2007-07-06	2009-01-08	Peter Koepke	Campsiandra angustifolia extract and methods of extracting and using such extract
US20090017140A1 (en) *	2007-07-09	2009-01-15	Peter Koepke	Maytenus abenfolia extract and methods of extracting and using such extract
US20090035395A1 (en) *	2007-08-01	2009-02-05	Peter Koepke	Spondias mombin l. extract and methods of extracting and using such extract
US7879369B2 (en) *	2007-09-18	2011-02-01	Selvamedica, Llc	Combretum laurifolium Mart. extract and methods of extracting and using such extract
MX2010005104A (es)	2007-11-09	2010-08-04	Peregrine Pharmaceuticals Inc	Composiciones de anticuerpo anti-factor de crecimiento endotelial vascular y metodos.
US20090264382A1 (en)	2007-11-21	2009-10-22	David Chaplin	Methods for Treating Hematopoietic Neoplasms
WO2014089177A2 (en)	2012-12-04	2014-06-12	Massachusetts Institute Of Technology	Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
AU2014228822A1 (en)	2013-03-15	2015-10-01	Memorial Sloan-Kettering Cancer Center	HSP90-targeted cardiac imaging and therapy
WO2016130969A1 (en)	2015-02-13	2016-08-18	George Robert Pettit	Silstatin compounds
US11419934B2 (en)	2015-08-18	2022-08-23	Oncotelic Therapeutics, Inc.	Use of VDAS to enhance immunomodulating therapies against tumors
US10918627B2 (en)	2016-05-11	2021-02-16	Massachusetts Institute Of Technology	Convergent and enantioselective total synthesis of Communesin analogs
US11932650B2 (en)	2017-05-11	2024-03-19	Massachusetts Institute Of Technology	Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en)	2017-10-13	2020-05-05	Massachusetts Institute Of Technology	Diazene directed modular synthesis of compounds with quaternary carbon centers
US11629167B2 (en)	2017-11-09	2023-04-18	Arizona Board Of Regents On Behalf Of Arizona State University	Betulastatin compounds
US11535634B2 (en)	2019-06-05	2022-12-27	Massachusetts Institute Of Technology	Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
US12030888B2 (en)	2021-02-24	2024-07-09	Massachusetts Institute Of Technology	Himastatin derivatives, and processes of preparation thereof, and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4708962A (en) *	1984-12-17	1987-11-24	Harbor Branch Oceanographic Institution, Inc.	Antiviral and antitumor cyclohexadienone compositions

1989
- 1989-04-26 US US07/344,005 patent/US4940726A/en not_active Expired - Lifetime
1990
- 1990-02-26 CA CA002010886A patent/CA2010886A1/en not_active Abandoned
- 1990-03-19 JP JP2067412A patent/JP2929025B2/ja not_active Expired - Fee Related
- 1990-04-20 AT AT90304290T patent/ATE120193T1/de active
- 1990-04-20 DK DK90304290.1T patent/DK0397336T3/da active
- 1990-04-20 EP EP90304290A patent/EP0397336B1/de not_active Expired - Lifetime
- 1990-04-20 ES ES90304290T patent/ES2070276T3/es not_active Expired - Lifetime
- 1990-04-20 DE DE69017946T patent/DE69017946T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0397336A3 (de)	1991-03-27
DE69017946D1 (de)	1995-04-27
ES2070276T3 (es)	1995-06-01
JPH02295986A (ja)	1990-12-06
DE69017946T2 (de)	1995-09-14
EP0397336B1 (de)	1995-03-22
US4940726A (en)	1990-07-10
DK0397336T3 (da)	1995-06-06
EP0397336A2 (de)	1990-11-14
CA2010886A1 (en)	1990-10-26
JP2929025B2 (ja)	1999-08-03

Publication	Publication Date	Title
DE69017946D1 (de)	1995-04-27	Zellwachstum hemmende makrozyklische Lactone namens Combretastatin D-2.
ATE114463T1 (de)	1994-12-15	Azaspirane mit immunmodulierender wirkung.
ES2077138T3 (es)	1995-11-16	Derivados de aminocumarano, su produccion y su uso.
MY115307A (en)	2003-05-31	Preparation for epidermis
ATE289810T1 (de)	2005-03-15	Ecteinascidinderivate
ATE78465T1 (de)	1992-08-15	Kathartica.
ES2077071T3 (es)	1995-11-16	Derivados de quinolin-3-carboxamida.
IT1209415B (it)	1989-07-16	Composizioni di sterilizzanti di vinilalogenuri, di bassa tossicita'.
CA2037975A1 (en)	1991-09-13	5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors
GB1386992A (en)	1975-03-12	Pesticidal compounds and compositions
ATE74269T1 (de)	1992-04-15	Zellproliferationsinhibitor.
AU7809281A (en)	1982-05-11	Novel guanidine derivatives
IE40395B1 (en)	1979-05-23	2,3-dihydrobenzofuranyl-7-n-methylcarbamates, their preparation and their use as insecticides
DK471979A (da)	1980-05-08	Estere af 1,1,2-triphenylalkenderivater
NO904135D0 (no)	1990-09-21	Fremgangsmaate for fremstilling av nye alkylpiperidiner.
DE3882623D1 (de)	1993-09-02	Phosphorsaeurediester und salze davon.
FR2380272A1 (fr)	1978-09-08	Derives de la coumarine et d'indane-diode, utilisables comme medicament
ATE165089T1 (de)	1998-05-15	Thiocarbamoylverbindungen als mikrobizide
IE873442L (en)	1988-06-18	Cephalosporin derivative
JPS55164671A (en)	1980-12-22	Azetidine derivative and its preparation
FI922518A7 (fi)	1993-11-30	Menetelmä farmaseuttisesti käyttökelpoisten pilokarpiinijohdannaisten valmistamiseksi
FR2392985A1 (fr)	1978-12-29	N-formyl-phenylhydrazones, leur preparation et leur application comme fongicides
FR2452497A1 (fr)	1980-10-24	Fortimicine an et son application comme intermediaire dans la synthese d'antibiotiques
DE3781044D1 (de)	1992-09-17	Prophylaktische und heilende zusammensetzung enthaltende eine 8-chlorbenzothiazepin-verbindung und dessen verwendung.
JPS5419956A (en)	1979-02-15	Novel bicyclooctane derivative and its preparation