ATE120492T1 - Fv antikörperfragment-herstellung. - Google Patents

Fv antikörperfragment-herstellung.

Info

Publication number
ATE120492T1
ATE120492T1 AT88907720T AT88907720T ATE120492T1 AT E120492 T1 ATE120492 T1 AT E120492T1 AT 88907720 T AT88907720 T AT 88907720T AT 88907720 T AT88907720 T AT 88907720T AT E120492 T1 ATE120492 T1 AT E120492T1
Authority
AT
Austria
Prior art keywords
bacterial host
production
polypeptide
antibody fragment
fragment production
Prior art date
Application number
AT88907720T
Other languages
English (en)
Inventor
Helen Field
Anthony Robert Rees
Geoffrey Thomas Yarranton
Original Assignee
Celltech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878721230A external-priority patent/GB8721230D0/en
Priority claimed from GB878727431A external-priority patent/GB8727431D0/en
Application filed by Celltech Ltd filed Critical Celltech Ltd
Application granted granted Critical
Publication of ATE120492T1 publication Critical patent/ATE120492T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT88907720T 1987-09-09 1988-09-09 Fv antikörperfragment-herstellung. ATE120492T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878721230A GB8721230D0 (en) 1987-09-09 1987-09-09 Polypeptide production
GB878727431A GB8727431D0 (en) 1987-11-23 1987-11-23 Polypeptide production

Publications (1)

Publication Number Publication Date
ATE120492T1 true ATE120492T1 (de) 1995-04-15

Family

ID=26292706

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88907720T ATE120492T1 (de) 1987-09-09 1988-09-09 Fv antikörperfragment-herstellung.

Country Status (5)

Country Link
EP (1) EP0393045B1 (de)
JP (1) JPH02501533A (de)
AT (1) ATE120492T1 (de)
DE (1) DE3853481T2 (de)
WO (1) WO1989002465A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958413A (en) * 1990-11-01 1999-09-28 Celltech Limited Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor
US5264365A (en) * 1990-11-09 1993-11-23 Board Of Regents, The University Of Texas System Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides
US5508192A (en) * 1990-11-09 1996-04-16 Board Of Regents, The University Of Texas System Bacterial host strains for producing proteolytically sensitive polypeptides
US5288931A (en) * 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
GB9215540D0 (en) * 1992-07-22 1992-09-02 Celltech Ltd Protein expression system
US5589364A (en) * 1994-07-29 1996-12-31 Magainin Pharmaceuticals Inc. Recombinant production of biologically active peptides and proteins
EP0909277B2 (de) 1996-06-07 2008-12-24 Poniard Pharmaceuticals, Inc. Humanisierte antikörper die an das gleiche antigen wie antikörper nr-lu-13 binden und deren verwendung in "pretargeting" verfahren
JPH10150984A (ja) * 1996-11-19 1998-06-09 Hagiwara Yoshihide 抗体分子の製造方法
GB0309126D0 (en) 2003-04-17 2003-05-28 Neutec Pharma Plc Clostridium difficile focussed antibodies
EP2783214A2 (de) 2011-11-23 2014-10-01 The Board of Regents of The University of Texas System Proteomischer nachweis von antikörpern
EP3774926A1 (de) 2018-04-05 2021-02-17 Bio-Rad ABD Serotec GmbH Anzeigesysteme für proteine von interesse
CN113874518B (zh) 2019-03-18 2025-04-25 生物辐射Abd瑟罗泰克有限公司 保护含SpyTag的周质融合蛋白免于蛋白酶Tsp和OmpT降解

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0088994B1 (de) * 1982-03-15 1991-06-19 Schering Corporation Hybride DNS, damit hergestellte Bindungszusammensetzung und Verfahren dafür
GB8308236D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Dna vectors
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4758512A (en) * 1984-03-06 1988-07-19 President And Fellows Of Harvard College Hosts and methods for producing recombinant products in high yields
GR862427B (en) * 1985-09-27 1987-01-26 Smithkline Beckman Corp Proteolytic deficient e. coli

Also Published As

Publication number Publication date
EP0393045A1 (de) 1990-10-24
EP0393045B1 (de) 1995-03-29
WO1989002465A2 (en) 1989-03-23
JPH02501533A (ja) 1990-05-31
DE3853481D1 (de) 1995-05-04
WO1989002465A3 (en) 1990-01-11
DE3853481T2 (de) 1995-10-19

Similar Documents

Publication Publication Date Title
AU542802B2 (en) Immunoassay for nonenzymatically glucosylated proteins and protein fragments
DE3853481D1 (de) Fv Antikörperfragment-Herstellung.
PT90574A (pt) Processo de preparacao de polipeptidos e de determinacao da presenca de anticorpos de proteina latente anti-virus do papiloma
ATE91714T1 (de) Transformation von trichoderma.
DE69322645D1 (de) Expression rekombinanter fusionsproteine in attenuierten bakterien
FI960392A0 (fi) Immunomääritys kollageenin tai kollageenifragmenttien osoittamiseksi
ES2129487T3 (es) Peptidos sinteticos, anticuerpos dirigidos contra ellos y su utilizacion.
DE69128273D1 (de) Für toxin b von clostridium difficile spezifische monoklonale antikörper
AU567747B2 (en) Early detection of mammalian pregnancy
ZA908778B (en) Immunoassays for and monoclonal antibodies to prothrombin activation peptides and their degradation products
ATE162311T1 (de) Immunoassay zum nachweis von kollagen oder kollagenfragmenten
NO891732L (no) Monoklonalt antistoff for selektiv immunologisk bestemmelse av intakt prokollagen-peptid (type iii) og prokollagen (type iii) i kroppsvaesker.
AU625398B2 (en) Monoclonal antibody recognizing gamma atrial natriuretic polypeptide
ATE133075T1 (de) Verwendung von antikörper gegen angiogenin: immunotherapeutische mittel
SE8502722D0 (sv) Sett att bestemma vissa polypeptider samt medel for anvendning derfor
NO881905L (no) Monoklonalt antistoff til selektiv immunologisk bestemmelse av intakt prokollagen peptid (type iii) og prokollagen (type iii) i kroppsvaesker.
DK162604C (da) Fremgangsmaade til fremstilling af humant immuninterferon samt farmaceutiske praeparater indeholdende immuninterferon fremstillet ved fremgangsmaaden ifoelge opfindelsen og anvendelse af humant interferon fremstillet ved fremgangsmaaden ifoelge opfindelsen til fremstilling af et terapeutisk middel
EP0276008A3 (en) Fibrin-specific antibody, method for its production and its use
EP0351244A3 (de) Antikörper und Methoden für ihre Verwendung in Immuntests
BR9105983A (pt) Anticorpos monoclonais que diferenciam entre proteinas de sequencias nativa e modificada
ATE128717T1 (de) Schizosaccharomyces-spezifische polypeptide.
IT1262998B (it) Corredo diagnostico immunologico e metodo per la sua utilizzazione.